{"meta": {"count": 165514, "db_response_time_ms": 393, "page": 1, "per_page": 25, "groups_count": null, "cost_usd": 0.001}, "results": [{"id": "https://openalex.org/W2556159813", "doi": "https://doi.org/10.1038/nature.2016.20988", "title": "CRISPR gene-editing tested in a person for the first time", "display_name": "CRISPR gene-editing tested in a person for the first time", "relevance_score": 2339.3806, "publication_year": 2016, "publication_date": "2016-11-15", "ids": {"openalex": "https://openalex.org/W2556159813", "doi": "https://doi.org/10.1038/nature.2016.20988", "mag": "2556159813", "pmid": "https://pubmed.ncbi.nlm.nih.gov/27882996"}, "language": "en", "primary_location": {"id": "doi:10.1038/nature.2016.20988", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nature.2016.20988", "pdf_url": null, "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5089997422", "display_name": "David Cyranoski", "orcid": "https://orcid.org/0000-0002-5853-019X"}, "institutions": [], "countries": [], "is_corresponding": true, "raw_author_name": "David Cyranoski", "raw_affiliation_strings": [], "affiliations": []}], "institutions": [], "countries_distinct_count": 0, "institutions_distinct_count": 1, "corresponding_author_ids": ["https://openalex.org/A5089997422"], "corresponding_institution_ids": [], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 62.0581, "has_fulltext": false, "cited_by_count": 440, "citation_normalized_percentile": {"value": 0.99900074, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 89, "max": 100}, "biblio": {"volume": "539", "issue": "7630", "first_page": "479", "last_page": "479"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T14293", "display_name": "Biotechnology and Related Fields", "score": 0.9398999810218811, "subfield": {"id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, "topics": [{"id": "https://openalex.org/T14293", "display_name": "Biotechnology and Related Fields", "score": 0.9398999810218811, "subfield": {"id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.6998098492622375}, {"id": "https://openalex.org/keywords/spark", "display_name": "SPARK (programming language)", "score": 0.6217365264892578}, {"id": "https://openalex.org/keywords/china", "display_name": "China", "score": 0.601436972618103}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.4791635572910309}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.4080169200897217}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.40505728125572205}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.3807376027107239}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.3794109523296356}, {"id": "https://openalex.org/keywords/geography", "display_name": "Geography", "score": 0.25854402780532837}, {"id": "https://openalex.org/keywords/computer-science", "display_name": "Computer science", "score": 0.24999243021011353}, {"id": "https://openalex.org/keywords/archaeology", "display_name": "Archaeology", "score": 0.10268956422805786}, {"id": "https://openalex.org/keywords/programming-language", "display_name": "Programming language", "score": 0.061163246631622314}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.6998098492622375}, {"id": "https://openalex.org/C2781215313", "wikidata": "https://www.wikidata.org/wiki/Q3493345", "display_name": "SPARK (programming language)", "level": 2, "score": 0.6217365264892578}, {"id": "https://openalex.org/C191935318", "wikidata": "https://www.wikidata.org/wiki/Q148", "display_name": "China", "level": 2, "score": 0.601436972618103}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.4791635572910309}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.4080169200897217}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.40505728125572205}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.3807376027107239}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.3794109523296356}, {"id": "https://openalex.org/C205649164", "wikidata": "https://www.wikidata.org/wiki/Q1071", "display_name": "Geography", "level": 0, "score": 0.25854402780532837}, {"id": "https://openalex.org/C41008148", "wikidata": "https://www.wikidata.org/wiki/Q21198", "display_name": "Computer science", "level": 0, "score": 0.24999243021011353}, {"id": "https://openalex.org/C166957645", "wikidata": "https://www.wikidata.org/wiki/Q23498", "display_name": "Archaeology", "level": 1, "score": 0.10268956422805786}, {"id": "https://openalex.org/C199360897", "wikidata": "https://www.wikidata.org/wiki/Q9143", "display_name": "Programming language", "level": 1, "score": 0.061163246631622314}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": true}, {"descriptor_ui": "D002681", "descriptor_name": "China", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002681", "descriptor_name": "China", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002681", "descriptor_name": "China", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002986", "descriptor_name": "Clinical Trials as Topic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D002986", "descriptor_name": "Clinical Trials as Topic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D002986", "descriptor_name": "Clinical Trials as Topic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D003163", "descriptor_name": "Competitive Behavior", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D003163", "descriptor_name": "Competitive Behavior", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D003163", "descriptor_name": "Competitive Behavior", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 3, "locations": [{"id": "doi:10.1038/nature.2016.20988", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nature.2016.20988", "pdf_url": null, "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, {"id": "pmid:27882996", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/27882996", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": null}, {"id": "pmh:oai:RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature.2016.20988", "is_oa": false, "landing_page_url": "https://www.nature.com/articles/nature.2016.20988", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401271", "display_name": "RePEc: Research Papers in Economics", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I77793887", "host_organization_name": "Federal Reserve Bank of St. Louis", "host_organization_lineage": ["https://openalex.org/I77793887"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "article"}], "best_oa_location": null, "sustainable_development_goals": [], "awards": [], "funders": [], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 0, "referenced_works": [], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W2960163646"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 5}, {"year": 2025, "cited_by_count": 26}, {"year": 2024, "cited_by_count": 27}, {"year": 2023, "cited_by_count": 49}, {"year": 2022, "cited_by_count": 39}, {"year": 2021, "cited_by_count": 41}, {"year": 2020, "cited_by_count": 46}, {"year": 2019, "cited_by_count": 60}, {"year": 2018, "cited_by_count": 77}, {"year": 2017, "cited_by_count": 60}, {"year": 2016, "cited_by_count": 8}, {"year": 2013, "cited_by_count": 1}], "updated_date": "2026-04-05T17:49:38.594831", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2888449128", "doi": "https://doi.org/10.1038/s41467-018-05843-9", "title": "Cas9 immunity creates challenges for CRISPR gene editing therapies", "display_name": "Cas9 immunity creates challenges for CRISPR gene editing therapies", "relevance_score": 1834.9664, "publication_year": 2018, "publication_date": "2018-08-23", "ids": {"openalex": "https://openalex.org/W2888449128", "doi": "https://doi.org/10.1038/s41467-018-05843-9", "mag": "2888449128"}, "language": "en", "primary_location": {"id": "doi:10.1038/s41467-018-05843-9", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41467-018-05843-9", "pdf_url": "https://www.nature.com/articles/s41467-018-05843-9.pdf", "source": {"id": "https://openalex.org/S64187185", "display_name": "Nature Communications", "issn_l": "2041-1723", "issn": ["2041-1723"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Communications", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "doaj"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://www.nature.com/articles/s41467-018-05843-9.pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5070848755", "display_name": "Julie M. Crudele", "orcid": "https://orcid.org/0000-0003-4472-0125"}, "institutions": [{"id": "https://openalex.org/I201448701", "display_name": "University of Washington", "ror": "https://ror.org/00cvxb145", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I201448701"]}, {"id": "https://openalex.org/I1303526167", "display_name": "Muscular Dystrophy Association", "ror": "https://ror.org/01frxsf98", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I1303526167"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Julie M. Crudele", "raw_affiliation_strings": ["Department of Neurology, University of Washington, Seattle, WA, 98195-7720, USA", "Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, WA, 98195-7720, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Neurology, University of Washington, Seattle, WA, 98195-7720, USA", "institution_ids": ["https://openalex.org/I201448701"]}, {"raw_affiliation_string": "Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, WA, 98195-7720, USA", "institution_ids": ["https://openalex.org/I1303526167"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5052317872", "display_name": "Jeffrey S. Chamberlain", "orcid": "https://orcid.org/0000-0001-5299-0059"}, "institutions": [{"id": "https://openalex.org/I201448701", "display_name": "University of Washington", "ror": "https://ror.org/00cvxb145", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I201448701"]}, {"id": "https://openalex.org/I1303526167", "display_name": "Muscular Dystrophy Association", "ror": "https://ror.org/01frxsf98", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I1303526167"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Jeffrey S. Chamberlain", "raw_affiliation_strings": ["Department of Neurology, University of Washington, Seattle, WA, 98195-7720, USA", "Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, WA, 98195-7720, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Neurology, University of Washington, Seattle, WA, 98195-7720, USA", "institution_ids": ["https://openalex.org/I201448701"]}, {"raw_affiliation_string": "Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, WA, 98195-7720, USA", "institution_ids": ["https://openalex.org/I1303526167"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5070848755"], "corresponding_institution_ids": ["https://openalex.org/I1303526167", "https://openalex.org/I201448701"], "apc_list": {"value": 3920, "currency": "GBP", "value_usd": 4808}, "apc_paid": {"value": 3920, "currency": "GBP", "value_usd": 4808}, "fwci": 9.6507, "has_fulltext": true, "cited_by_count": 249, "citation_normalized_percentile": {"value": 0.98774157, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 98, "max": 100}, "biblio": {"volume": "9", "issue": "1", "first_page": null, "last_page": null}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.9800000190734863, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T10613", "display_name": "Virus-based gene therapy research", "score": 0.9613999724388123, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.9628512859344482}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8550862669944763}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.8258657455444336}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5696691274642944}, {"id": "https://openalex.org/keywords/genetic-enhancement", "display_name": "Genetic enhancement", "score": 0.5520628690719604}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.5405560731887817}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.5334261655807495}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.4849298298358917}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.39551785588264465}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.9628512859344482}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8550862669944763}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.8258657455444336}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5696691274642944}, {"id": "https://openalex.org/C111599444", "wikidata": "https://www.wikidata.org/wiki/Q213901", "display_name": "Genetic enhancement", "level": 3, "score": 0.5520628690719604}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.5405560731887817}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.5334261655807495}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.4849298298358917}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.39551785588264465}], "mesh": [], "locations_count": 6, "locations": [{"id": "doi:10.1038/s41467-018-05843-9", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41467-018-05843-9", "pdf_url": "https://www.nature.com/articles/s41467-018-05843-9.pdf", "source": {"id": "https://openalex.org/S64187185", "display_name": "Nature Communications", "issn_l": "2041-1723", "issn": ["2041-1723"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Communications", "raw_type": "journal-article"}, {"id": "pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05843-9", "is_oa": false, "landing_page_url": "https://www.nature.com/articles/s41467-018-05843-9", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401271", "display_name": "RePEc: Research Papers in Economics", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I77793887", "host_organization_name": "Federal Reserve Bank of St. Louis", "host_organization_lineage": ["https://openalex.org/I77793887"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "article"}, {"id": "pmh:oai:doaj.org/article:8e67d4e12eff4d74904f744b8aa300c1", "is_oa": false, "landing_page_url": "https://doaj.org/article/8e67d4e12eff4d74904f744b8aa300c1", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nature Communications, Vol 9, Iss 1, Pp 1-3 (2018)", "raw_type": "article"}, {"id": "pmh:oai:doaj.org/article:e6e102c06f9f4413a3b861226fafa27a", "is_oa": true, "landing_page_url": "https://doaj.org/article/e6e102c06f9f4413a3b861226fafa27a", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-sa", "license_id": "https://openalex.org/licenses/cc-by-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nature Communications, Vol 9, Iss 1, Pp 1-3 (2018)", "raw_type": "article"}, {"id": "pmh:oai:europepmc.org:5071750", "is_oa": true, "landing_page_url": "http://europepmc.org/pmc/articles/PMC6115392", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400806", "display_name": "Europe PMC (PubMed Central)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1303153112", "host_organization_name": "European Bioinformatics Institute", "host_organization_lineage": ["https://openalex.org/I1303153112"], "host_organization_lineage_names": [], "type": "repository"}, "license": "other-oa", "license_id": "https://openalex.org/licenses/other-oa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "", "raw_type": "Text"}, {"id": "pmh:oai:pubmedcentral.nih.gov:6115392", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/6115392", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat Commun", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1038/s41467-018-05843-9", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41467-018-05843-9", "pdf_url": "https://www.nature.com/articles/s41467-018-05843-9.pdf", "source": {"id": "https://openalex.org/S64187185", "display_name": "Nature Communications", "issn_l": "2041-1723", "issn": ["2041-1723"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Communications", "raw_type": "journal-article"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/3", "display_name": "Good health and well-being", "score": 0.699999988079071}], "awards": [{"id": "https://openalex.org/G3741941119", "display_name": null, "funder_award_id": "AR44533", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G4801690951", "display_name": null, "funder_award_id": "409968", "funder_id": "https://openalex.org/F4320308306", "funder_display_name": "Muscular Dystrophy Association"}], "funders": [{"id": "https://openalex.org/F4320308306", "display_name": "Muscular Dystrophy Association", "ror": "https://ror.org/01frxsf98"}, {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W2888449128.pdf", "grobid_xml": "https://content.openalex.org/works/W2888449128.grobid-xml"}, "referenced_works_count": 15, "referenced_works": ["https://openalex.org/W1971494439", "https://openalex.org/W1976158989", "https://openalex.org/W2003171404", "https://openalex.org/W2004707499", "https://openalex.org/W2005294321", "https://openalex.org/W2064815984", "https://openalex.org/W2073371551", "https://openalex.org/W2115330656", "https://openalex.org/W2164754609", "https://openalex.org/W2170107546", "https://openalex.org/W2508903105", "https://openalex.org/W2547658608", "https://openalex.org/W2588637030", "https://openalex.org/W2784919037", "https://openalex.org/W2806820493"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4311501380", "https://openalex.org/W2603161682", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W3052741125", "https://openalex.org/W2466284841"], "abstract_inverted_index": {"Clustered": [0], "regularly": [1], "interspaced": [2], "short": [3], "palindromic": [4], "repeats": [5], "(CRISPR)-Cas9": [6], "is": [7, 47, 53], "a": [8, 56, 62, 118], "genome-editing": [9], "technology1,2": [10], "that": [11, 76, 83], "utilizes": [12], "archaeal": [13], "and": [14, 49, 101, 114, 127], "bacterial": [15], "Cas9": [16, 112, 153], "nucleases": [17], "to": [18, 32, 79, 109, 117, 140, 152], "introduce": [19], "double-stranded": [20], "breaks": [21, 28], "in": [22, 67, 132, 173], "DNA": [23], "at": [24], "targeted": [25], "sites.": [26], "These": [27], "can": [29], "be": [30], "used": [31], "remove,": [33], "replace,": [34], "or": [35], "add": [36], "pieces": [37], "of": [38, 58, 106, 120, 129, 148, 165, 171], "DNA.": [39], "While": [40], "not": [41], "the": [42, 98, 104, 111, 125, 146, 163, 169], "first": [43], "genome": [44], "editor,": [45], "CRISPR-Cas9": [46, 130], "efficient": [48], "cost-effective": [50], "because": [51], "cutting": [52], "guided": [54], "by": [55], "strand": [57], "RNA": [59, 116], "rather": [60], "than": [61], "protein.": [63], "The": [64], "potential": [65], "uses": [66], "health": [68], "care": [69], "are": [70], "plentiful,": [71], "from": [72], "disrupting": [73], "dominant": [74], "genes": [75, 82], "cause": [77, 84], "cancer3": [78], "repairing": [80], "mutated": [81], "genetic": [85], "diseases,": [86], "such": [87], "as": [88], "muscular": [89], "dystrophy4.": [90], "Therapeutic": [91], "approaches": [92], "based": [93], "on": [94, 103], "this": [95, 166], "technology": [96], "fill": [97], "preclinical": [99], "pipeline,": [100], "rely": [102], "use": [105, 131], "viral": [107], "vectors": [108], "deliver": [110], "gene": [113, 119, 133, 174], "guide": [115], "interest.": [121], "However,": [122], "concerns": [123], "regarding": [124], "safety": [126], "efficacy": [128], "therapy": [134], "remain.": [135], "A": [136], "pre-print": [137], "released": [138], "prior": [139], "peer": [141], "review": [142], "has": [143], "recently": [144], "underlined": [145], "question": [147], "whether": [149], "immunological": [150], "responses": [151], "may": [154], "negatively": [155], "impact": [156], "its": [157], "clinical": [158], "use5.": [159], "Here": [160], "we": [161], "discuss": [162], "implications": [164], "finding": [167], "for": [168], "application": [170], "CRISPR/Cas": [172], "therapy.": [175]}, "counts_by_year": [{"year": 2026, "cited_by_count": 9}, {"year": 2025, "cited_by_count": 32}, {"year": 2024, "cited_by_count": 35}, {"year": 2023, "cited_by_count": 31}, {"year": 2022, "cited_by_count": 38}, {"year": 2021, "cited_by_count": 44}, {"year": 2020, "cited_by_count": 29}, {"year": 2019, "cited_by_count": 25}, {"year": 2018, "cited_by_count": 6}], "updated_date": "2026-05-07T13:39:58.223016", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3015140168", "doi": "https://doi.org/10.1038/s41565-020-0669-6", "title": "Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR\u2013Cas gene editing", "display_name": "Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR\u2013Cas gene editing", "relevance_score": 1610.9452, "publication_year": 2020, "publication_date": "2020-04-01", "ids": {"openalex": "https://openalex.org/W3015140168", "doi": "https://doi.org/10.1038/s41565-020-0669-6", "mag": "3015140168", "pmid": "https://pubmed.ncbi.nlm.nih.gov/32251383"}, "language": "en", "primary_location": {"id": "doi:10.1038/s41565-020-0669-6", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/s41565-020-0669-6", "pdf_url": null, "source": {"id": "https://openalex.org/S7822423", "display_name": "Nature Nanotechnology", "issn_l": "1748-3387", "issn": ["1748-3387", "1748-3395"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Nanotechnology", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "green", "oa_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/7735425", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5087586345", "display_name": "Qiang Cheng", "orcid": "https://orcid.org/0000-0002-5213-5084"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Qiang Cheng", "raw_affiliation_strings": ["Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA"], "raw_orcid": "https://orcid.org/0000-0002-5213-5084", "affiliations": [{"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5102981940", "display_name": "Tuo Wei", "orcid": "https://orcid.org/0000-0002-2823-9721"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Tuo Wei", "raw_affiliation_strings": ["Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA"], "raw_orcid": "https://orcid.org/0000-0002-2823-9721", "affiliations": [{"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5005965579", "display_name": "Lukas Farbiak", "orcid": "https://orcid.org/0000-0003-4107-1676"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Lukas Farbiak", "raw_affiliation_strings": ["Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5050045575", "display_name": "Lindsay T. Johnson", "orcid": "https://orcid.org/0000-0002-4563-5486"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Lindsay T. Johnson", "raw_affiliation_strings": ["Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA"], "raw_orcid": "https://orcid.org/0000-0002-4563-5486", "affiliations": [{"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5004807344", "display_name": "Sean A. Dilliard", "orcid": "https://orcid.org/0000-0002-5884-8392"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Sean A. Dilliard", "raw_affiliation_strings": ["Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5005939714", "display_name": "Daniel J. Siegwart", "orcid": "https://orcid.org/0000-0003-3823-1931"}, "institutions": [{"id": "https://openalex.org/I4210096815", "display_name": "Southwestern Medical Center", "ror": "https://ror.org/00t9vx427", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I4210096815"]}, {"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Daniel J. Siegwart", "raw_affiliation_strings": ["Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Daniel.Siegwart@UTSouthwestern.edu", "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA"], "raw_orcid": "https://orcid.org/0000-0003-3823-1931", "affiliations": [{"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Daniel.Siegwart@UTSouthwestern.edu", "institution_ids": ["https://openalex.org/I4210096815", "https://openalex.org/I867280407"]}, {"raw_affiliation_string": "Department of Biochemistry, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 6, "corresponding_author_ids": ["https://openalex.org/A5087586345"], "corresponding_institution_ids": ["https://openalex.org/I867280407"], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 71.5151, "has_fulltext": false, "cited_by_count": 2117, "citation_normalized_percentile": {"value": 0.99968091, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 99, "max": 100}, "biblio": {"volume": "15", "issue": "4", "first_page": "313", "last_page": "320"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10725", "display_name": "RNA Interference and Gene Delivery", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10725", "display_name": "RNA Interference and Gene Delivery", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10207", "display_name": "Advanced biosensing and bioanalysis techniques", "score": 0.9958999752998352, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.6793988943099976}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.6251540780067444}, {"id": "https://openalex.org/keywords/ribonucleoprotein", "display_name": "Ribonucleoprotein", "score": 0.5546780228614807}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.5201999545097351}, {"id": "https://openalex.org/keywords/messenger-rna", "display_name": "Messenger RNA", "score": 0.4908202588558197}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.46712878346443176}, {"id": "https://openalex.org/keywords/rna", "display_name": "RNA", "score": 0.4524378776550293}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.4491083025932312}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.42623740434646606}, {"id": "https://openalex.org/keywords/cell-biology", "display_name": "Cell biology", "score": 0.41620680689811707}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.15847206115722656}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.6793988943099976}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.6251540780067444}, {"id": "https://openalex.org/C75934600", "wikidata": "https://www.wikidata.org/wiki/Q419245", "display_name": "Ribonucleoprotein", "level": 4, "score": 0.5546780228614807}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.5201999545097351}, {"id": "https://openalex.org/C105580179", "wikidata": "https://www.wikidata.org/wiki/Q188928", "display_name": "Messenger RNA", "level": 3, "score": 0.4908202588558197}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.46712878346443176}, {"id": "https://openalex.org/C67705224", "wikidata": "https://www.wikidata.org/wiki/Q11053", "display_name": "RNA", "level": 3, "score": 0.4524378776550293}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.4491083025932312}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.42623740434646606}, {"id": "https://openalex.org/C95444343", "wikidata": "https://www.wikidata.org/wiki/Q7141", "display_name": "Cell biology", "level": 1, "score": 0.41620680689811707}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.15847206115722656}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009928", "descriptor_name": "Organ Specificity", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009928", "descriptor_name": "Organ Specificity", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009928", "descriptor_name": "Organ Specificity", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": true}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": true}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": true}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": true}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": true}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": true}, {"descriptor_ui": "D016503", "descriptor_name": "Drug Delivery Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D016503", "descriptor_name": "Drug Delivery Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D016503", "descriptor_name": "Drug Delivery Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 3, "locations": [{"id": "doi:10.1038/s41565-020-0669-6", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/s41565-020-0669-6", "pdf_url": null, "source": {"id": "https://openalex.org/S7822423", "display_name": "Nature Nanotechnology", "issn_l": "1748-3387", "issn": ["1748-3387", "1748-3395"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Nanotechnology", "raw_type": "journal-article"}, {"id": "pmid:32251383", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/32251383", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature nanotechnology", "raw_type": null}, {"id": "pmh:oai:pubmedcentral.nih.gov:7735425", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/7735425", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat Nanotechnol", "raw_type": "Text"}], "best_oa_location": {"id": "pmh:oai:pubmedcentral.nih.gov:7735425", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/7735425", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat Nanotechnol", "raw_type": "Text"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/3", "display_name": "Good health and well-being", "score": 0.6200000047683716}], "awards": [{"id": "https://openalex.org/G5088952775", "display_name": null, "funder_award_id": "R01 EB025192-01A1", "funder_id": "https://openalex.org/F4320337363", "funder_display_name": "National Institute of Biomedical Imaging and Bioengineering"}], "funders": [{"id": "https://openalex.org/F4320337363", "display_name": "National Institute of Biomedical Imaging and Bioengineering", "ror": "https://ror.org/00372qc85"}], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 56, "referenced_works": ["https://openalex.org/W1844274376", "https://openalex.org/W1963706689", "https://openalex.org/W1995770815", "https://openalex.org/W2002050544", "https://openalex.org/W2003171404", "https://openalex.org/W2007347651", "https://openalex.org/W2024102779", "https://openalex.org/W2039705224", "https://openalex.org/W2045435533", "https://openalex.org/W2050480410", "https://openalex.org/W2064815984", "https://openalex.org/W2073217307", "https://openalex.org/W2089150369", "https://openalex.org/W2106885643", "https://openalex.org/W2110634891", "https://openalex.org/W2119771879", "https://openalex.org/W2134288637", "https://openalex.org/W2140022328", "https://openalex.org/W2143743183", "https://openalex.org/W2159431217", "https://openalex.org/W2192049920", "https://openalex.org/W2203460689", "https://openalex.org/W2209402024", "https://openalex.org/W2222906166", "https://openalex.org/W2249755146", "https://openalex.org/W2260024370", "https://openalex.org/W2344644350", "https://openalex.org/W2401221324", "https://openalex.org/W2412158473", "https://openalex.org/W2511907480", "https://openalex.org/W2525553968", "https://openalex.org/W2560987571", "https://openalex.org/W2587871737", "https://openalex.org/W2588309240", "https://openalex.org/W2626298693", "https://openalex.org/W2667943050", "https://openalex.org/W2725326379", "https://openalex.org/W2754401101", "https://openalex.org/W2770127492", "https://openalex.org/W2770318482", "https://openalex.org/W2780234747", "https://openalex.org/W2788997515", "https://openalex.org/W2791854174", "https://openalex.org/W2830843390", "https://openalex.org/W2867029183", "https://openalex.org/W2888899523", "https://openalex.org/W2889510460", "https://openalex.org/W2893976143", "https://openalex.org/W2898487406", "https://openalex.org/W2911354827", "https://openalex.org/W2914060533", "https://openalex.org/W2992823069", "https://openalex.org/W3115990586", "https://openalex.org/W6651296210", "https://openalex.org/W6672721343", "https://openalex.org/W6705139393"], "related_works": ["https://openalex.org/W4311501380", "https://openalex.org/W2603161682", "https://openalex.org/W2960163646", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W2337751047", "https://openalex.org/W3052741125"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 204}, {"year": 2025, "cited_by_count": 541}, {"year": 2024, "cited_by_count": 512}, {"year": 2023, "cited_by_count": 368}, {"year": 2022, "cited_by_count": 246}, {"year": 2021, "cited_by_count": 177}, {"year": 2020, "cited_by_count": 67}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3016959969", "doi": "https://doi.org/10.1016/j.ymthe.2020.04.017", "title": "AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9", "display_name": "AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9", "relevance_score": 1537.1465, "publication_year": 2020, "publication_date": "2020-04-19", "ids": {"openalex": "https://openalex.org/W3016959969", "doi": "https://doi.org/10.1016/j.ymthe.2020.04.017", "mag": "3016959969", "pmid": "https://pubmed.ncbi.nlm.nih.gov/32348718"}, "language": "en", "primary_location": {"id": "doi:10.1016/j.ymthe.2020.04.017", "is_oa": true, "landing_page_url": "https://doi.org/10.1016/j.ymthe.2020.04.017", "pdf_url": "http://www.cell.com/article/S1525001620301982/pdf", "source": {"id": "https://openalex.org/S51596929", "display_name": "Molecular Therapy", "issn_l": "1525-0016", "issn": ["1525-0016", "1525-0024"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Molecular Therapy", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "datacite", "pubmed"], "open_access": {"is_oa": true, "oa_status": "hybrid", "oa_url": "http://www.cell.com/article/S1525001620301982/pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5100413637", "display_name": "Ang Li", "orcid": "https://orcid.org/0000-0002-8992-3914"}, "institutions": [{"id": "https://openalex.org/I74775410", "display_name": "Rice University", "ror": "https://ror.org/008zs3103", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I74775410"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Ang Li", "raw_affiliation_strings": ["Department of Bioengineering, Rice University, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Bioengineering, Rice University, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I74775410"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5037963602", "display_name": "Mark R. Tanner", "orcid": "https://orcid.org/0000-0002-6516-0166"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Mark R. Tanner", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5044985085", "display_name": "Ciaran M. Lee", "orcid": "https://orcid.org/0000-0002-0789-9149"}, "institutions": [{"id": "https://openalex.org/I74775410", "display_name": "Rice University", "ror": "https://ror.org/008zs3103", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I74775410"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Ciaran M. Lee", "raw_affiliation_strings": ["Department of Bioengineering, Rice University, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Bioengineering, Rice University, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I74775410"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5033561638", "display_name": "Ayrea Hurley", "orcid": "https://orcid.org/0000-0002-8697-8610"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Ayrea E. Hurley", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5057900534", "display_name": "Marco De Giorgi", "orcid": "https://orcid.org/0000-0002-9823-1397"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Marco De Giorgi", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5028255931", "display_name": "Kelsey E. Jarrett", "orcid": "https://orcid.org/0000-0001-5358-8280"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Kelsey E. Jarrett", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5015684733", "display_name": "Timothy Davis", "orcid": null}, "institutions": [{"id": "https://openalex.org/I74775410", "display_name": "Rice University", "ror": "https://ror.org/008zs3103", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I74775410"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Timothy H. Davis", "raw_affiliation_strings": ["Department of Bioengineering, Rice University, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Bioengineering, Rice University, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I74775410"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5043071233", "display_name": "Alexandria M. Doerfler", "orcid": "https://orcid.org/0000-0003-2297-6103"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Alexandria M. Doerfler", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5051621625", "display_name": "Gang Bao", "orcid": "https://orcid.org/0000-0001-5501-554X"}, "institutions": [{"id": "https://openalex.org/I74775410", "display_name": "Rice University", "ror": "https://ror.org/008zs3103", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I74775410"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Gang Bao", "raw_affiliation_strings": ["Department of Bioengineering, Rice University, Houston, TX 77030, USA. Electronic address: gang.bao@rice.edu", "Department of Bioengineering, Rice University, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Bioengineering, Rice University, Houston, TX 77030, USA. Electronic address: gang.bao@rice.edu", "institution_ids": ["https://openalex.org/I74775410"]}, {"raw_affiliation_string": "Department of Bioengineering, Rice University, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I74775410"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5014582592", "display_name": "Christine Beeton", "orcid": "https://orcid.org/0000-0002-2500-5874"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Christine Beeton", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: beeton@bcm.edu", "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: beeton@bcm.edu", "institution_ids": ["https://openalex.org/I181547552"]}, {"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5039846981", "display_name": "William R. Lagor", "orcid": "https://orcid.org/0000-0002-1703-5125"}, "institutions": [{"id": "https://openalex.org/I181547552", "display_name": "Baylor College of Medicine", "ror": "https://ror.org/02pttbw34", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I181547552", "https://openalex.org/I2801539370"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "William R. Lagor", "raw_affiliation_strings": ["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: william.lagor@bcm.edu", "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: william.lagor@bcm.edu", "institution_ids": ["https://openalex.org/I181547552"]}, {"raw_affiliation_string": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA", "institution_ids": ["https://openalex.org/I181547552"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 11, "corresponding_author_ids": ["https://openalex.org/A5014582592", "https://openalex.org/A5039846981", "https://openalex.org/A5051621625"], "corresponding_institution_ids": ["https://openalex.org/I181547552", "https://openalex.org/I74775410"], "apc_list": {"value": 3900, "currency": "USD", "value_usd": 3900}, "apc_paid": {"value": 3900, "currency": "USD", "value_usd": 3900}, "fwci": 12.0091, "has_fulltext": false, "cited_by_count": 225, "citation_normalized_percentile": {"value": 0.99225715, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 94, "max": 100}, "biblio": {"volume": "28", "issue": "6", "first_page": "1432", "last_page": "1441"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10613", "display_name": "Virus-based gene therapy research", "score": 0.9904999732971191, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T11112", "display_name": "Viral Infections and Immunology Research", "score": 0.9876999855041504, "subfield": {"id": "https://openalex.org/subfields/2705", "display_name": "Cardiology and Cardiovascular Medicine"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.8586832880973816}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8304501175880432}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7890202403068542}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.7481999397277832}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.5788806676864624}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5312126874923706}, {"id": "https://openalex.org/keywords/virology", "display_name": "Virology", "score": 0.4829684793949127}, {"id": "https://openalex.org/keywords/immunity", "display_name": "Immunity", "score": 0.4814683496952057}, {"id": "https://openalex.org/keywords/streptococcus-pyogenes", "display_name": "Streptococcus pyogenes", "score": 0.42480435967445374}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.33385413885116577}, {"id": "https://openalex.org/keywords/staphylococcus-aureus", "display_name": "Staphylococcus aureus", "score": 0.3048379421234131}, {"id": "https://openalex.org/keywords/immune-system", "display_name": "Immune system", "score": 0.2243686318397522}, {"id": "https://openalex.org/keywords/bacteria", "display_name": "Bacteria", "score": 0.07796493172645569}], "concepts": [{"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.8586832880973816}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8304501175880432}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7890202403068542}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.7481999397277832}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.5788806676864624}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5312126874923706}, {"id": "https://openalex.org/C159047783", "wikidata": "https://www.wikidata.org/wiki/Q7215", "display_name": "Virology", "level": 1, "score": 0.4829684793949127}, {"id": "https://openalex.org/C2779341262", "wikidata": "https://www.wikidata.org/wiki/Q182581", "display_name": "Immunity", "level": 3, "score": 0.4814683496952057}, {"id": "https://openalex.org/C2779306812", "wikidata": "https://www.wikidata.org/wiki/Q131271", "display_name": "Streptococcus pyogenes", "level": 4, "score": 0.42480435967445374}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.33385413885116577}, {"id": "https://openalex.org/C2779489039", "wikidata": "https://www.wikidata.org/wiki/Q188121", "display_name": "Staphylococcus aureus", "level": 3, "score": 0.3048379421234131}, {"id": "https://openalex.org/C8891405", "wikidata": "https://www.wikidata.org/wiki/Q1059", "display_name": "Immune system", "level": 2, "score": 0.2243686318397522}, {"id": "https://openalex.org/C523546767", "wikidata": "https://www.wikidata.org/wiki/Q10876", "display_name": "Bacteria", "level": 2, "score": 0.07796493172645569}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000229", "descriptor_name": "Dependovirus", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005822", "descriptor_name": "Genetic Vectors", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007114", "descriptor_name": "Immunization", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007156", "descriptor_name": "Immunologic Memory", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015415", "descriptor_name": "Biomarkers", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015870", "descriptor_name": "Gene Expression", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016130", "descriptor_name": "Immunophenotyping", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D016176", "descriptor_name": "T-Lymphocyte Subsets", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D017394", "descriptor_name": "RNA, Guide, Kinetoplastida", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D019076", "descriptor_name": "Transgenes", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D022781", "descriptor_name": "Hepatocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D023061", "descriptor_name": "Gene Order", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 6, "locations": [{"id": "doi:10.1016/j.ymthe.2020.04.017", "is_oa": true, "landing_page_url": "https://doi.org/10.1016/j.ymthe.2020.04.017", "pdf_url": "http://www.cell.com/article/S1525001620301982/pdf", "source": {"id": "https://openalex.org/S51596929", "display_name": "Molecular Therapy", "issn_l": "1525-0016", "issn": ["1525-0016", "1525-0024"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Molecular Therapy", "raw_type": "journal-article"}, {"id": "pmid:32348718", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/32348718", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Molecular therapy : the journal of the American Society of Gene Therapy", "raw_type": null}, {"id": "pmh:oai:digitalcommons.library.tmc.edu:baylor_docs-1723", "is_oa": false, "landing_page_url": "https://digitalcommons.library.tmc.edu/baylor_docs/731", "pdf_url": null, "source": {"id": "https://openalex.org/S4377196655", "display_name": "Digital Commons-TMC (Texas Medical Center)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1337852284", "host_organization_name": "Texas Medical Center", "host_organization_lineage": ["https://openalex.org/I1337852284"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Faculty and Staff Publications", "raw_type": "text"}, {"id": "pmh:oai:figshare.com:article/22041545", "is_oa": true, "landing_page_url": "https://figshare.com/articles/journal_contribution/AAV-CRISPR_gene_editing_is_negated_by_pre-existing_immunity_to_Cas9/22041545", "pdf_url": null, "source": {"id": "https://openalex.org/S4377196282", "display_name": "Figshare", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I4210132348", "host_organization_name": "Figshare (United Kingdom)", "host_organization_lineage": ["https://openalex.org/I4210132348"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "", "raw_type": "Text"}, {"id": "pmh:oai:pubmedcentral.nih.gov:7264438", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/7264438", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Mol Ther", "raw_type": "Text"}, {"id": "doi:10.25376/hra.22041545.v1", "is_oa": true, "landing_page_url": "https://doi.org/10.25376/hra.22041545.v1", "pdf_url": null, "source": {"id": "https://openalex.org/S7407051367", "display_name": "Health Research Alliance", "issn_l": null, "issn": [], "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": null, "is_accepted": false, "is_published": null, "raw_source_name": null, "raw_type": "article-journal"}], "best_oa_location": {"id": "doi:10.1016/j.ymthe.2020.04.017", "is_oa": true, "landing_page_url": "https://doi.org/10.1016/j.ymthe.2020.04.017", "pdf_url": "http://www.cell.com/article/S1525001620301982/pdf", "source": {"id": "https://openalex.org/S51596929", "display_name": "Molecular Therapy", "issn_l": "1525-0016", "issn": ["1525-0016", "1525-0024"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Molecular Therapy", "raw_type": "journal-article"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/3", "display_name": "Good health and well-being", "score": 0.49000000953674316}], "awards": [{"id": "https://openalex.org/G1464867074", "display_name": null, "funder_award_id": "HL132840", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G3549828030", "display_name": null, "funder_award_id": "NIH T32", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G5060956145", "display_name": null, "funder_award_id": "CA125123", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G5486463816", "display_name": null, "funder_award_id": "HL007676", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G5791892145", "display_name": null, "funder_award_id": "19PRE34380467", "funder_id": "https://openalex.org/F4320306230", "funder_display_name": "American Heart Association"}, {"id": "https://openalex.org/G5867912739", "display_name": null, "funder_award_id": "RR140081", "funder_id": "https://openalex.org/F4320308129", "funder_display_name": "Cancer Prevention and Research Institute of Texas"}, {"id": "https://openalex.org/G6025816609", "display_name": null, "funder_award_id": "U42OD026645", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G6523649295", "display_name": null, "funder_award_id": "19POST34430092", "funder_id": "https://openalex.org/F4320306230", "funder_display_name": "American Heart Association"}, {"id": "https://openalex.org/G7525696429", "display_name": null, "funder_award_id": "RP180672", "funder_id": "https://openalex.org/F4320308129", "funder_display_name": "Cancer Prevention and Research Institute of Texas"}, {"id": "https://openalex.org/G7660856095", "display_name": null, "funder_award_id": "CA125123 and RR024574", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G767018064", "display_name": null, "funder_award_id": "RR024574", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G7837447426", "display_name": null, "funder_award_id": "CA125123", "funder_id": "https://openalex.org/F4320308129", "funder_display_name": "Cancer Prevention and Research Institute of Texas"}, {"id": "https://openalex.org/G7939066973", "display_name": null, "funder_award_id": "UG3HL151545", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G8153776008", "display_name": null, "funder_award_id": "RR024574", "funder_id": "https://openalex.org/F4320308129", "funder_display_name": "Cancer Prevention and Research Institute of Texas"}, {"id": "https://openalex.org/G8300092331", "display_name": null, "funder_award_id": "19PRE34380467", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}], "funders": [{"id": "https://openalex.org/F4320306230", "display_name": "American Heart Association", "ror": "https://ror.org/013kjyp64"}, {"id": "https://openalex.org/F4320308129", "display_name": "Cancer Prevention and Research Institute of Texas", "ror": "https://ror.org/0003xa228"}, {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W3016959969.pdf", "grobid_xml": "https://content.openalex.org/works/W3016959969.grobid-xml"}, "referenced_works_count": 40, "referenced_works": ["https://openalex.org/W1964184380", "https://openalex.org/W1972911163", "https://openalex.org/W1991453997", "https://openalex.org/W2007261697", "https://openalex.org/W2025240311", "https://openalex.org/W2053820810", "https://openalex.org/W2070614858", "https://openalex.org/W2075653203", "https://openalex.org/W2107277218", "https://openalex.org/W2128758977", "https://openalex.org/W2144151756", "https://openalex.org/W2148223197", "https://openalex.org/W2196662084", "https://openalex.org/W2203460689", "https://openalex.org/W2208696160", "https://openalex.org/W2253584908", "https://openalex.org/W2260024370", "https://openalex.org/W2399977797", "https://openalex.org/W2508903105", "https://openalex.org/W2592177978", "https://openalex.org/W2596889486", "https://openalex.org/W2770127492", "https://openalex.org/W2788997515", "https://openalex.org/W2803895514", "https://openalex.org/W2808713119", "https://openalex.org/W2883442429", "https://openalex.org/W2897403793", "https://openalex.org/W2905407323", "https://openalex.org/W2906461396", "https://openalex.org/W2914658811", "https://openalex.org/W2949380898", "https://openalex.org/W2949907681", "https://openalex.org/W2950183003", "https://openalex.org/W2954423091", "https://openalex.org/W2963548588", "https://openalex.org/W2964394511", "https://openalex.org/W2982416790", "https://openalex.org/W2993027330", "https://openalex.org/W4286856180", "https://openalex.org/W6643256180"], "related_works": ["https://openalex.org/W4311501380", "https://openalex.org/W2603161682", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W3052741125", "https://openalex.org/W2466284841", "https://openalex.org/W2357872089"], "abstract_inverted_index": {"Adeno-associated": [0, 155], "viral": [1, 156], "(AAV)": [2, 157], "vectors": [3, 158], "are": [4, 159], "a": [5, 29, 35, 64, 74, 160, 184, 190, 219, 229], "leading": [6, 161], "candidate": [7, 162], "for": [8, 13, 146, 163, 168, 301], "the": [9, 26, 46, 108, 153, 164, 181, 201, 263, 308], "delivery": [10, 21, 165, 176], "of": [11, 25, 38, 103, 121, 128, 166, 180, 193, 258, 276, 283], "CRISPR-Cas9": [12, 167], "therapeutic": [14, 169], "genome": [15, 78, 86, 150, 170, 233, 241, 305], "editing": [16, 79, 87, 151, 171, 234, 242, 306], "in": [17, 59, 63, 89, 107, 148, 152, 172, 214, 218, 244, 262, 303, 307], "vivo.": [18, 173], "However,": [19, 174], "AAV-based": [20, 175], "involves": [22, 177], "persistent": [23, 178], "expression": [24, 179], "Cas9": [27, 49, 182, 204], "nuclease,": [28, 183], "bacterial": [30, 185], "protein.": [31, 186], "Recent": [32, 187], "studies": [33, 188], "indicate": [34, 189], "high": [36, 191], "prevalence": [37, 192], "neutralizing": [39, 194], "antibodies": [40, 195], "and": [41, 55, 125, 131, 143, 196, 210, 280, 286, 298], "T": [42, 105, 112, 197, 260, 267], "cells": [43, 106, 198, 261], "specific": [44, 199], "to": [45, 70, 76, 200, 225, 231], "commonly": [47, 202], "used": [48, 203], "orthologs": [50, 205], "from": [51, 206], "Streptococcus": [52, 207], "pyogenes": [53, 208], "(SpCas9)": [54, 209], "Staphylococcus": [56, 211], "aureus": [57, 212], "(SaCas9)": [58, 213], "humans.": [60, 215], "We": [61, 216], "tested": [62, 217], "mouse": [65, 90, 220, 245], "model": [66, 221], "whether": [67, 222], "pre-existing": [68, 93, 223, 248], "immunity": [69, 224], "SaCas9": [71, 94, 226, 249], "would": [72, 227], "pose": [73, 228], "barrier": [75, 230], "liver": [77, 91, 136, 232, 246, 291], "with": [80, 92, 235, 247], "AAV": [81, 123, 236, 278], "packaging": [82, 237], "CRISPR-Cas9.": [83, 238], "Although": [84, 239], "efficient": [85, 240], "occurred": [88, 243], "immunity,": [95, 250], "this": [96, 251], "was": [97, 115, 132, 252, 270, 287], "accompanied": [98, 253], "by": [99, 117, 134, 254, 272, 289], "an": [100, 255], "increased": [101, 256], "proportion": [102, 257], "CD8+": [104, 259], "liver.": [109, 154, 264, 309], "This": [110, 265], "cytotoxic": [111, 266], "cell": [113, 268], "response": [114, 269], "characterized": [116, 271], "hepatocyte": [118, 273], "apoptosis,": [119, 274], "loss": [120, 275], "recombinant": [122, 277], "genomes,": [124, 279], "complete": [126, 281], "elimination": [127, 282], "genome-edited": [129, 284], "cells,": [130, 285], "followed": [133, 288], "compensatory": [135, 290], "regeneration.": [137, 292], "Our": [138, 293], "results": [139, 294], "raise": [140, 295], "important": [141, 296], "efficacy": [142, 297], "safety": [144, 299], "concerns": [145, 300], "CRISPR-Cas9-based": [147, 302], "vivo": [149, 304]}, "counts_by_year": [{"year": 2026, "cited_by_count": 10}, {"year": 2025, "cited_by_count": 34}, {"year": 2024, "cited_by_count": 35}, {"year": 2023, "cited_by_count": 44}, {"year": 2022, "cited_by_count": 38}, {"year": 2021, "cited_by_count": 45}, {"year": 2020, "cited_by_count": 17}, {"year": 2019, "cited_by_count": 2}], "updated_date": "2026-05-16T08:24:45.110214", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3177445623", "doi": "https://doi.org/10.1056/nejmoa2107454", "title": "CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis", "display_name": "CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis", "relevance_score": 1496.2081, "publication_year": 2021, "publication_date": "2021-06-26", "ids": {"openalex": "https://openalex.org/W3177445623", "doi": "https://doi.org/10.1056/nejmoa2107454", "mag": "3177445623", "pmid": "https://pubmed.ncbi.nlm.nih.gov/34215024"}, "language": "en", "primary_location": {"id": "doi:10.1056/nejmoa2107454", "is_oa": true, "landing_page_url": "https://doi.org/10.1056/nejmoa2107454", "pdf_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2107454?articleTools=true", "source": {"id": "https://openalex.org/S62468778", "display_name": "New England Journal of Medicine", "issn_l": "0028-4793", "issn": ["0028-4793", "1533-4406"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320239", "host_organization_name": "Massachusetts Medical Society", "host_organization_lineage": ["https://openalex.org/P4310320239"], "host_organization_lineage_names": ["Massachusetts Medical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "New England Journal of Medicine", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "bronze", "oa_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2107454?articleTools=true", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5057365396", "display_name": "Julian D. Gillmore", "orcid": "https://orcid.org/0000-0001-6174-9232"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I2801138448", "display_name": "The Royal Free Hospital", "ror": "https://ror.org/01ge67z96", "country_code": "GB", "type": "healthcare", "lineage": ["https://openalex.org/I169248724", "https://openalex.org/I2801138448"]}, {"id": "https://openalex.org/I4210109810", "display_name": "Amyloidosis Foundation", "ror": "https://ror.org/01pfv2y33", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I4210109810"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": true, "raw_author_name": "Julian D. Gillmore", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital", "institution_ids": ["https://openalex.org/I4210109810", "https://openalex.org/I2801138448", "https://openalex.org/I45129253"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5110599195", "display_name": "Ed Gane", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210126381", "display_name": "Clinical Trials New Zealand", "ror": "https://ror.org/0312ka630", "country_code": "NZ", "type": "facility", "lineage": ["https://openalex.org/I4210126381"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ"], "is_corresponding": false, "raw_author_name": "Ed Gane", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "New Zealand Clinical Research", "University of Auckland"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "New Zealand Clinical Research", "institution_ids": ["https://openalex.org/I4210126381"]}, {"raw_affiliation_string": "University of Auckland", "institution_ids": ["https://openalex.org/I154130895"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5083601745", "display_name": "J\u00f6rg T\u00e4ubel", "orcid": "https://orcid.org/0000-0002-0010-207X"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I165862685", "display_name": "St George's, University of London", "ror": "https://ror.org/040f08y74", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I165862685"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ"], "is_corresponding": false, "raw_author_name": "Jorg Taubel", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Richmond Pharmacology, St. George's University of London"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Richmond Pharmacology, St. George's University of London", "institution_ids": ["https://openalex.org/I165862685"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5109164244", "display_name": "Justin Kao", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I2801418622", "display_name": "Auckland City Hospital", "ror": "https://ror.org/05e8jge82", "country_code": "NZ", "type": "healthcare", "lineage": ["https://openalex.org/I2801418622", "https://openalex.org/I4405259026"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ"], "is_corresponding": false, "raw_author_name": "Justin Kao", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Department of Neurology, Auckland City Hospital"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Department of Neurology, Auckland City Hospital", "institution_ids": ["https://openalex.org/I2801418622"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5050125018", "display_name": "Marianna Fontana", "orcid": "https://orcid.org/0000-0002-9233-9831"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I2801138448", "display_name": "The Royal Free Hospital", "ror": "https://ror.org/01ge67z96", "country_code": "GB", "type": "healthcare", "lineage": ["https://openalex.org/I169248724", "https://openalex.org/I2801138448"]}, {"id": "https://openalex.org/I4210109810", "display_name": "Amyloidosis Foundation", "ror": "https://ror.org/01pfv2y33", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I4210109810"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Marianna Fontana", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital", "institution_ids": ["https://openalex.org/I4210109810", "https://openalex.org/I2801138448", "https://openalex.org/I45129253"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5036578095", "display_name": "Michael L. Maitland", "orcid": "https://orcid.org/0000-0002-2476-5732"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Michael L. Maitland", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5006228299", "display_name": "Jessica Seitzer", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Jessica Seitzer", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5080685676", "display_name": "Daniel J. O\u2019Connell", "orcid": "https://orcid.org/0000-0002-4742-683X"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Daniel O\u2019Connell", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5102113001", "display_name": "Kathryn Walsh", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Kathryn R. Walsh", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5035600368", "display_name": "Kristy Wood", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Kristy Wood", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5013190744", "display_name": "Jonathan A. Phillips", "orcid": "https://orcid.org/0000-0001-7290-754X"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Jonathan Phillips", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": "https://orcid.org/0000-0001-7290-754X", "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5048689879", "display_name": "Yuanxin Xu", "orcid": "https://orcid.org/0000-0002-4878-1294"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Yuanxin Xu", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5051443263", "display_name": "Adam Amaral", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Adam Amaral", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5104088626", "display_name": "Adam P. Boyd", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Adam P. Boyd", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5114037251", "display_name": "Jeffrey Cehelsky", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Jeffrey E. Cehelsky", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5103167295", "display_name": "Mark D. McKee", "orcid": "https://orcid.org/0000-0003-1061-915X"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Mark D. McKee", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5008093177", "display_name": "Andrew Schiermeier", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Andrew Schiermeier", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5021704245", "display_name": "Olivier Harari", "orcid": "https://orcid.org/0000-0001-8214-489X"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I186523950", "display_name": "Regeneron (United States)", "ror": "https://ror.org/02f51rf24", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I186523950"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Olivier Harari", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Regeneron Pharmaceuticals, Tarrytown, NY"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Regeneron Pharmaceuticals, Tarrytown, NY", "institution_ids": ["https://openalex.org/I186523950"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5001459606", "display_name": "Andrew Murphy", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I186523950", "display_name": "Regeneron (United States)", "ror": "https://ror.org/02f51rf24", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I186523950"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Andrew Murphy", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Regeneron Pharmaceuticals, Tarrytown, NY"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Regeneron Pharmaceuticals, Tarrytown, NY", "institution_ids": ["https://openalex.org/I186523950"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5067322377", "display_name": "Christos A. Kyratsous", "orcid": "https://orcid.org/0000-0002-2596-2906"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I186523950", "display_name": "Regeneron (United States)", "ror": "https://ror.org/02f51rf24", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I186523950"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Christos A. Kyratsous", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Regeneron Pharmaceuticals, Tarrytown, NY"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Regeneron Pharmaceuticals, Tarrytown, NY", "institution_ids": ["https://openalex.org/I186523950"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5041036914", "display_name": "Brian Zambrowicz", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I186523950", "display_name": "Regeneron (United States)", "ror": "https://ror.org/02f51rf24", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I186523950"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Brian Zambrowicz", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Regeneron Pharmaceuticals, Tarrytown, NY"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Regeneron Pharmaceuticals, Tarrytown, NY", "institution_ids": ["https://openalex.org/I186523950"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5038309405", "display_name": "Randy Soltys", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I186523950", "display_name": "Regeneron (United States)", "ror": "https://ror.org/02f51rf24", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I186523950"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Randy Soltys", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Regeneron Pharmaceuticals, Tarrytown, NY"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Regeneron Pharmaceuticals, Tarrytown, NY", "institution_ids": ["https://openalex.org/I186523950"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5014707733", "display_name": "David E. Gutstein", "orcid": "https://orcid.org/0000-0001-7776-3477"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I186523950", "display_name": "Regeneron (United States)", "ror": "https://ror.org/02f51rf24", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I186523950"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "David E. Gutstein", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Regeneron Pharmaceuticals, Tarrytown, NY"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Regeneron Pharmaceuticals, Tarrytown, NY", "institution_ids": ["https://openalex.org/I186523950"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5111203086", "display_name": "John P. Leonard", "orcid": null}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "John Leonard", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5045900351", "display_name": "Laura Sepp\u2010Lorenzino", "orcid": "https://orcid.org/0000-0002-1901-8863"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "Laura Sepp-Lorenzino", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5062128184", "display_name": "David Lebwohl", "orcid": "https://orcid.org/0000-0002-4578-1977"}, "institutions": [{"id": "https://openalex.org/I154130895", "display_name": "University of Auckland", "ror": "https://ror.org/03b94tp07", "country_code": "NZ", "type": "education", "lineage": ["https://openalex.org/I154130895"]}, {"id": "https://openalex.org/I4210131291", "display_name": "Intellia Therapeutics (United States)", "ror": "https://ror.org/03b368668", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210131291"]}, {"id": "https://openalex.org/I45129253", "display_name": "University College London", "ror": "https://ror.org/02jx3x895", "country_code": "GB", "type": "education", "lineage": ["https://openalex.org/I124357947", "https://openalex.org/I45129253"]}], "countries": ["GB", "NZ", "US"], "is_corresponding": false, "raw_author_name": "David Lebwohl", "raw_affiliation_strings": ["From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "Intellia Therapeutics, Cambridge, MA"], "raw_orcid": "https://orcid.org/0000-0002-4578-1977", "affiliations": [{"raw_affiliation_string": "From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (J.D.G., M.F.) and Richmond Pharmacology, St. George\u2019s University of London (J.T.) \u2014 both in London; New Zealand Clinical Research (E.G.), University of Auckland (E.G.), and the Department of Neurology, Auckland City Hospital (J.K.) \u2014 all in Auckland, New Zealand; Intellia Therapeutics, Cambridge, MA (M.L.M., J.S., D.O., K.R.W., K.W., J.P., Y.X., A.A., A.P.B., J.E.C., M.D.M., A.S., J.L., L.S.-L., D.L.); and Regeneron Pharmaceuticals, Tarrytown, NY (O.H., A.M., C.A.K., B.Z., R.S., D.E.G.)", "institution_ids": ["https://openalex.org/I45129253", "https://openalex.org/I154130895"]}, {"raw_affiliation_string": "Intellia Therapeutics, Cambridge, MA", "institution_ids": ["https://openalex.org/I4210131291"]}]}], "institutions": [], "countries_distinct_count": 3, "institutions_distinct_count": 26, "corresponding_author_ids": ["https://openalex.org/A5057365396"], "corresponding_institution_ids": ["https://openalex.org/I154130895", "https://openalex.org/I2801138448", "https://openalex.org/I4210109810", "https://openalex.org/I45129253"], "apc_list": null, "apc_paid": null, "fwci": 92.8897, "has_fulltext": true, "cited_by_count": 1611, "citation_normalized_percentile": {"value": 0.99978269, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 96, "max": 100}, "biblio": {"volume": "385", "issue": "6", "first_page": "493", "last_page": "502"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T11305", "display_name": "Amyloidosis: Diagnosis, Treatment, Outcomes", "score": 0.9027000069618225, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T11305", "display_name": "Amyloidosis: Diagnosis, Treatment, Outcomes", "score": 0.9027000069618225, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10945", "display_name": "Lysosomal Storage Disorders Research", "score": 0.010900000110268593, "subfield": {"id": "https://openalex.org/subfields/2737", "display_name": "Physiology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T11571", "display_name": "Sarcoidosis and Beryllium Toxicity Research", "score": 0.0052999998442828655, "subfield": {"id": "https://openalex.org/subfields/2737", "display_name": "Physiology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/transthyretin", "display_name": "Transthyretin", "score": 0.8892937898635864}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8396375775337219}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7509298324584961}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.7362523078918457}, {"id": "https://openalex.org/keywords/amyloidosis", "display_name": "Amyloidosis", "score": 0.6155555844306946}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5366306900978088}, {"id": "https://openalex.org/keywords/in-vivo", "display_name": "In vivo", "score": 0.5264107584953308}, {"id": "https://openalex.org/keywords/endonuclease", "display_name": "Endonuclease", "score": 0.5026371479034424}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.46481403708457947}, {"id": "https://openalex.org/keywords/genetic-enhancement", "display_name": "Genetic enhancement", "score": 0.4565039575099945}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.344193696975708}, {"id": "https://openalex.org/keywords/molecular-biology", "display_name": "Molecular biology", "score": 0.32503268122673035}, {"id": "https://openalex.org/keywords/biochemistry", "display_name": "Biochemistry", "score": 0.22399380803108215}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.2220948338508606}, {"id": "https://openalex.org/keywords/medicine", "display_name": "Medicine", "score": 0.19868946075439453}, {"id": "https://openalex.org/keywords/pathology", "display_name": "Pathology", "score": 0.1397586166858673}], "concepts": [{"id": "https://openalex.org/C121157162", "wikidata": "https://www.wikidata.org/wiki/Q419999", "display_name": "Transthyretin", "level": 2, "score": 0.8892937898635864}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8396375775337219}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7509298324584961}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.7362523078918457}, {"id": "https://openalex.org/C2779951007", "wikidata": "https://www.wikidata.org/wiki/Q816798", "display_name": "Amyloidosis", "level": 2, "score": 0.6155555844306946}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5366306900978088}, {"id": "https://openalex.org/C207001950", "wikidata": "https://www.wikidata.org/wiki/Q141124", "display_name": "In vivo", "level": 2, "score": 0.5264107584953308}, {"id": "https://openalex.org/C2777028655", "wikidata": "https://www.wikidata.org/wiki/Q415601", "display_name": "Endonuclease", "level": 3, "score": 0.5026371479034424}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.46481403708457947}, {"id": "https://openalex.org/C111599444", "wikidata": "https://www.wikidata.org/wiki/Q213901", "display_name": "Genetic enhancement", "level": 3, "score": 0.4565039575099945}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.344193696975708}, {"id": "https://openalex.org/C153911025", "wikidata": "https://www.wikidata.org/wiki/Q7202", "display_name": "Molecular biology", "level": 1, "score": 0.32503268122673035}, {"id": "https://openalex.org/C55493867", "wikidata": "https://www.wikidata.org/wiki/Q7094", "display_name": "Biochemistry", "level": 1, "score": 0.22399380803108215}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.2220948338508606}, {"id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.19868946075439453}, {"id": "https://openalex.org/C142724271", "wikidata": "https://www.wikidata.org/wiki/Q7208", "display_name": "Pathology", "level": 1, "score": 0.1397586166858673}, {"id": "https://openalex.org/C134018914", "wikidata": "https://www.wikidata.org/wiki/Q162606", "display_name": "Endocrinology", "level": 1, "score": 0.0}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007262", "descriptor_name": "Infusions, Intravenous", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007262", "descriptor_name": "Infusions, Intravenous", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007262", "descriptor_name": "Infusions, Intravenous", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007262", "descriptor_name": "Infusions, Intravenous", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007262", "descriptor_name": "Infusions, Intravenous", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007262", "descriptor_name": "Infusions, Intravenous", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008081", "descriptor_name": "Liposomes", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D008081", "descriptor_name": "Liposomes", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D008081", "descriptor_name": "Liposomes", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D008081", "descriptor_name": "Liposomes", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D008081", "descriptor_name": "Liposomes", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D008081", "descriptor_name": "Liposomes", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008875", "descriptor_name": "Middle Aged", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008875", "descriptor_name": "Middle Aged", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008875", "descriptor_name": "Middle Aged", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008875", "descriptor_name": "Middle Aged", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008875", "descriptor_name": "Middle Aged", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008875", "descriptor_name": "Middle Aged", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011228", "descriptor_name": "Prealbumin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012333", "descriptor_name": "RNA, Messenger", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017394", "descriptor_name": "RNA, Guide, Kinetoplastida", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017394", "descriptor_name": "RNA, Guide, Kinetoplastida", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D028227", "descriptor_name": "Amyloid Neuropathies, Familial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D053758", "descriptor_name": "Nanoparticles", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 5, "locations": [{"id": "doi:10.1056/nejmoa2107454", "is_oa": true, "landing_page_url": "https://doi.org/10.1056/nejmoa2107454", "pdf_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2107454?articleTools=true", "source": {"id": "https://openalex.org/S62468778", "display_name": "New England Journal of Medicine", "issn_l": "0028-4793", "issn": ["0028-4793", "1533-4406"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320239", "host_organization_name": "Massachusetts Medical Society", "host_organization_lineage": ["https://openalex.org/P4310320239"], "host_organization_lineage_names": ["Massachusetts Medical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "New England Journal of Medicine", "raw_type": "journal-article"}, {"id": "pmid:34215024", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/34215024", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "The New England journal of medicine", "raw_type": null}, {"id": "pmid:34706181", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/34706181", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "The New England journal of medicine", "raw_type": null}, {"id": "pmh:oai:eprints.ucl.ac.uk.OAI2:10133469", "is_oa": true, "landing_page_url": "https://discovery.ucl.ac.uk/id/eprint/10133469/", "pdf_url": "https://discovery.ucl.ac.uk/10133469/1/Gillmore_nejmoa2107454.pdf", "source": {"id": "https://openalex.org/S4306400024", "display_name": "UCL Discovery (University College London)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I45129253", "host_organization_name": "University College London", "host_organization_lineage": ["https://openalex.org/I45129253"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "   New England Journal of Medicine , 385    pp. 493-502.   (2021)      ", "raw_type": "Article"}, {"id": "pmh:oai:eprints.ucl.ac.uk.OAI2:10137681", "is_oa": false, "landing_page_url": "https://discovery.ucl.ac.uk/id/eprint/10137681/", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400024", "display_name": "UCL Discovery (University College London)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I45129253", "host_organization_name": "University College London", "host_organization_lineage": ["https://openalex.org/I45129253"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "   New England Journal of Medicine , 385    pp. 1722-1723.   (2021)      ", "raw_type": "Article"}], "best_oa_location": {"id": "doi:10.1056/nejmoa2107454", "is_oa": true, "landing_page_url": "https://doi.org/10.1056/nejmoa2107454", "pdf_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2107454?articleTools=true", "source": {"id": "https://openalex.org/S62468778", "display_name": "New England Journal of Medicine", "issn_l": "0028-4793", "issn": ["0028-4793", "1533-4406"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320239", "host_organization_name": "Massachusetts Medical Society", "host_organization_lineage": ["https://openalex.org/P4310320239"], "host_organization_lineage_names": ["Massachusetts Medical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "New England Journal of Medicine", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [], "funders": [{"id": "https://openalex.org/F4320311600", "display_name": "Regeneron Pharmaceuticals", "ror": "https://ror.org/02f51rf24"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W3177445623.pdf", "grobid_xml": "https://content.openalex.org/works/W3177445623.grobid-xml"}, "referenced_works_count": 35, "referenced_works": ["https://openalex.org/W2003797386", "https://openalex.org/W2033005195", "https://openalex.org/W2033805890", "https://openalex.org/W2038935930", "https://openalex.org/W2045435533", "https://openalex.org/W2096261947", "https://openalex.org/W2115603949", "https://openalex.org/W2115862827", "https://openalex.org/W2124037827", "https://openalex.org/W2128758977", "https://openalex.org/W2130902107", "https://openalex.org/W2148373528", "https://openalex.org/W2158048479", "https://openalex.org/W2188931003", "https://openalex.org/W2199765595", "https://openalex.org/W2611134270", "https://openalex.org/W2774176529", "https://openalex.org/W2788997515", "https://openalex.org/W2791854174", "https://openalex.org/W2806820493", "https://openalex.org/W2809989268", "https://openalex.org/W2810909862", "https://openalex.org/W2888036721", "https://openalex.org/W2912435333", "https://openalex.org/W2955523092", "https://openalex.org/W2971824914", "https://openalex.org/W2992823069", "https://openalex.org/W2998881619", "https://openalex.org/W2999063362", "https://openalex.org/W3007098257", "https://openalex.org/W3024591577", "https://openalex.org/W3048467449", "https://openalex.org/W3097605950", "https://openalex.org/W3106443431", "https://openalex.org/W3139182093"], "related_works": ["https://openalex.org/W4210472704", "https://openalex.org/W2084731390", "https://openalex.org/W2077316781", "https://openalex.org/W2607140347", "https://openalex.org/W2805908680", "https://openalex.org/W2109513774", "https://openalex.org/W4400599931", "https://openalex.org/W270527095", "https://openalex.org/W2333479840", "https://openalex.org/W4221065483"], "abstract_inverted_index": {"BACKGROUND:": [0], ".": [1, 146], "METHODS:": [2], "After": [3], "conducting": [4], "preclinical": [5], "in": [6, 9, 25, 35, 75, 88, 103, 114, 133], "vitro": [7], "and": [8, 16, 47, 81, 126, 151], "vivo": [10], "studies,": [11], "we": [12], "evaluated": [13], "the": [14, 38, 69, 98, 115, 134], "safety": [15, 67], "pharmacodynamic": [17, 91], "effects": [18, 92], "of": [19, 23, 37, 66, 121, 140], "single": [20, 62], "escalating": [21], "doses": [22], "NTLA-2001": [24], "six": [26], "patients": [27, 76], "with": [28, 32], "hereditary": [29], "ATTR": [30], "amyloidosis": [31], "polyneuropathy,": [33], "three": [34], "each": [36], "two": [39], "initial": [40], "dose": [41, 120, 139], "groups": [42], "(0.1": [43], "mg": [44, 49, 123, 142], "per": [45, 50, 124, 143], "kilogram": [46, 125], "0.3": [48, 141], "kilogram),": [51], "within": [52], "an": [53], "ongoing": [54], "phase": [55], "1": [56], "clinical": [57], "study.": [58], "RESULTS:": [59], "after": [60, 73], "a": [61, 119, 138], "dose.": [63], "Serial": [64], "assessments": [65], "during": [68], "first": [70], "28": [71], "days": [72], "infusion": [74], "revealed": [77], "few": [78], "adverse": [79], "events,": [80], "those": [82], "that": [83, 117, 136], "did": [84], "occur": [85], "were": [86, 93], "mild": [87], "grade.": [89], "Dose-dependent": [90], "observed.": [94], "At": [95], "day": [96], "28,": [97], "mean": [99], "reduction": [100], "from": [101], "baseline": [102], "serum": [104], "TTR": [105], "protein": [106], "concentration": [107], "was": [108, 127], "52%": [109], "(range,": [110, 129], "47": [111], "to": [112, 131], "56)": [113], "group": [116, 135], "received": [118, 137], "0.1": [122], "87%": [128], "80": [130], "96)": [132], "kilogram.": [144], "CONCLUSIONS:": [145], "(Funded": [147], "by": [148], "Intellia": [149], "Therapeutics": [150], "Regeneron": [152], "Pharmaceuticals;": [153], "ClinicalTrials.gov": [154], "number,": [155], "NCT04601051.).": [156]}, "counts_by_year": [{"year": 2026, "cited_by_count": 141}, {"year": 2025, "cited_by_count": 322}, {"year": 2024, "cited_by_count": 373}, {"year": 2023, "cited_by_count": 345}, {"year": 2022, "cited_by_count": 334}, {"year": 2021, "cited_by_count": 89}, {"year": 2020, "cited_by_count": 3}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2141825721", "doi": "https://doi.org/10.1007/s13238-015-0153-5", "title": "CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes", "display_name": "CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes", "relevance_score": 1476.3851, "publication_year": 2015, "publication_date": "2015-04-17", "ids": {"openalex": "https://openalex.org/W2141825721", "doi": "https://doi.org/10.1007/s13238-015-0153-5", "mag": "2141825721", "pmid": "https://pubmed.ncbi.nlm.nih.gov/25894090"}, "language": "en", "primary_location": {"id": "doi:10.1007/s13238-015-0153-5", "is_oa": true, "landing_page_url": "https://doi.org/10.1007/s13238-015-0153-5", "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13238-015-0153-5.pdf", "source": {"id": "https://openalex.org/S126440360", "display_name": "Protein & Cell", "issn_l": "1674-800X", "issn": ["1674-800X", "1674-8018"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319900", "host_organization_name": "Springer Science+Business Media", "host_organization_lineage": ["https://openalex.org/P4310319900", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Springer Science+Business Media", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Protein &amp; Cell", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "diamond", "oa_url": "https://link.springer.com/content/pdf/10.1007/s13238-015-0153-5.pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5061192275", "display_name": "Puping Liang", "orcid": "https://orcid.org/0000-0003-3593-2599"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": true, "raw_author_name": "Puping Liang", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5065159857", "display_name": "Yanwen Xu", "orcid": "https://orcid.org/0000-0002-8308-9383"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yanwen Xu", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5103244496", "display_name": "Xiya Zhang", "orcid": "https://orcid.org/0000-0001-5834-8104"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Xiya Zhang", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5000429208", "display_name": "Chenhui Ding", "orcid": null}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Chenhui Ding", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5101439373", "display_name": "Rui Huang", "orcid": "https://orcid.org/0000-0003-3009-2535"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Rui Huang", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100390126", "display_name": "Zhen Zhang", "orcid": "https://orcid.org/0000-0001-5028-6447"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Zhen Zhang", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5014952999", "display_name": "Jie Lv", "orcid": "https://orcid.org/0000-0002-0239-9188"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Jie Lv", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5101673849", "display_name": "Xiaowei Xie", "orcid": null}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Xiaowei Xie", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100764264", "display_name": "Yuxi Chen", "orcid": "https://orcid.org/0000-0001-9450-8793"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yuxi Chen", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100425015", "display_name": "Yujing Li", "orcid": "https://orcid.org/0000-0002-4363-2484"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yujing Li", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, China", "institution_ids": ["https://openalex.org/I157773358"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100355558", "display_name": "Ying Sun", "orcid": "https://orcid.org/0000-0002-2042-6514"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Ying Sun", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5102349844", "display_name": "Yaofu Bai", "orcid": "https://orcid.org/0000-0001-6203-9320"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yaofu Bai", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5047145856", "display_name": "Zhou Songyang", "orcid": "https://orcid.org/0000-0002-7824-3761"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Zhou Songyang", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5102124993", "display_name": "Wenbin Ma", "orcid": "https://orcid.org/0000-0001-8774-7593"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Wenbin Ma", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5084606295", "display_name": "Canquan Zhou", "orcid": "https://orcid.org/0000-0001-6798-9552"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Canquan Zhou", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5022536823", "display_name": "Junjiu Huang", "orcid": "https://orcid.org/0000-0002-3417-1196"}, "institutions": [{"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210128921", "display_name": "The First Affiliated Hospital, Sun Yat-sen University", "ror": "https://ror.org/037p24858", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210128921"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Junjiu Huang", "raw_affiliation_strings": ["Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "Sun Yat-Sen University"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Guangdong Province Key Laboratory of Reproductive Medicine, the First Affiliated Hospital, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275 China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"]}, {"raw_affiliation_string": "Sun Yat-Sen University", "institution_ids": []}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 16, "corresponding_author_ids": ["https://openalex.org/A5061192275"], "corresponding_institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210128921"], "apc_list": null, "apc_paid": null, "fwci": 83.2673, "has_fulltext": true, "cited_by_count": 1115, "citation_normalized_percentile": {"value": 0.9997922, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "6", "issue": "5", "first_page": "363", "last_page": "372"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10505", "display_name": "Pluripotent Stem Cells Research", "score": 0.9980999827384949, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10613", "display_name": "Virus-based gene therapy research", "score": 0.967199981212616, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.9498945474624634}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8639163970947266}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.7826104164123535}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.7257483005523682}, {"id": "https://openalex.org/keywords/homologous-recombination", "display_name": "Homologous recombination", "score": 0.6150049567222595}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.5543057918548584}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5312174558639526}, {"id": "https://openalex.org/keywords/gene-targeting", "display_name": "Gene targeting", "score": 0.47484591603279114}, {"id": "https://openalex.org/keywords/zygote", "display_name": "Zygote", "score": 0.46033841371536255}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.442336767911911}, {"id": "https://openalex.org/keywords/homology-directed-repair", "display_name": "Homology directed repair", "score": 0.41263440251350403}, {"id": "https://openalex.org/keywords/dna-repair", "display_name": "DNA repair", "score": 0.2230774462223053}, {"id": "https://openalex.org/keywords/nucleotide-excision-repair", "display_name": "Nucleotide excision repair", "score": 0.09097257256507874}, {"id": "https://openalex.org/keywords/embryogenesis", "display_name": "Embryogenesis", "score": 0.07013532519340515}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.9498945474624634}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8639163970947266}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.7826104164123535}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.7257483005523682}, {"id": "https://openalex.org/C102744134", "wikidata": "https://www.wikidata.org/wiki/Q22280388", "display_name": "Homologous recombination", "level": 3, "score": 0.6150049567222595}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.5543057918548584}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5312174558639526}, {"id": "https://openalex.org/C111829913", "wikidata": "https://www.wikidata.org/wiki/Q211083", "display_name": "Gene targeting", "level": 3, "score": 0.47484591603279114}, {"id": "https://openalex.org/C28748434", "wikidata": "https://www.wikidata.org/wiki/Q170145", "display_name": "Zygote", "level": 4, "score": 0.46033841371536255}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.442336767911911}, {"id": "https://openalex.org/C74054111", "wikidata": "https://www.wikidata.org/wiki/Q5891445", "display_name": "Homology directed repair", "level": 5, "score": 0.41263440251350403}, {"id": "https://openalex.org/C134935766", "wikidata": "https://www.wikidata.org/wiki/Q210538", "display_name": "DNA repair", "level": 3, "score": 0.2230774462223053}, {"id": "https://openalex.org/C104451858", "wikidata": "https://www.wikidata.org/wiki/Q2714458", "display_name": "Nucleotide excision repair", "level": 4, "score": 0.09097257256507874}, {"id": "https://openalex.org/C87073359", "wikidata": "https://www.wikidata.org/wiki/Q33196", "display_name": "Embryogenesis", "level": 3, "score": 0.07013532519340515}], "mesh": [{"descriptor_ui": "D001755", "descriptor_name": "Blastocyst", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D001755", "descriptor_name": "Blastocyst", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D001755", "descriptor_name": "Blastocyst", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D006455", "descriptor_name": "Hemoglobins, Abnormal", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D006455", "descriptor_name": "Hemoglobins, Abnormal", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D006455", "descriptor_name": "Hemoglobins, Abnormal", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D006455", "descriptor_name": "Hemoglobins, Abnormal", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D006455", "descriptor_name": "Hemoglobins, Abnormal", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D006455", "descriptor_name": "Hemoglobins, Abnormal", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015053", "descriptor_name": "Zygote", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D015053", "descriptor_name": "Zygote", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D015053", "descriptor_name": "Zygote", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 3, "locations": [{"id": "doi:10.1007/s13238-015-0153-5", "is_oa": true, "landing_page_url": "https://doi.org/10.1007/s13238-015-0153-5", "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13238-015-0153-5.pdf", "source": {"id": "https://openalex.org/S126440360", "display_name": "Protein & Cell", "issn_l": "1674-800X", "issn": ["1674-800X", "1674-8018"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319900", "host_organization_name": "Springer Science+Business Media", "host_organization_lineage": ["https://openalex.org/P4310319900", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Springer Science+Business Media", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Protein &amp; Cell", "raw_type": "journal-article"}, {"id": "pmid:25894090", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/25894090", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Protein & cell", "raw_type": null}, {"id": "pmh:oai:pubmedcentral.nih.gov:4417674", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/4417674", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Protein Cell", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1007/s13238-015-0153-5", "is_oa": true, "landing_page_url": "https://doi.org/10.1007/s13238-015-0153-5", "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13238-015-0153-5.pdf", "source": {"id": "https://openalex.org/S126440360", "display_name": "Protein & Cell", "issn_l": "1674-800X", "issn": ["1674-800X", "1674-8018"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319900", "host_organization_name": "Springer Science+Business Media", "host_organization_lineage": ["https://openalex.org/P4310319900", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Springer Science+Business Media", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Protein &amp; Cell", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G1591205043", "display_name": null, "funder_award_id": "91019020", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G4254817937", "display_name": null, "funder_award_id": "31371508", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G5142411983", "display_name": null, "funder_award_id": "81330055", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G5253937017", "display_name": null, "funder_award_id": "2010CB945401", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G6609870569", "display_name": null, "funder_award_id": "2012CB911201", "funder_id": "https://openalex.org/F4320335777", "funder_display_name": "National Key Research and Development Program of China"}], "funders": [{"id": "https://openalex.org/F4320321001", "display_name": "National Natural Science Foundation of China", "ror": "https://ror.org/01h0zpd94"}, {"id": "https://openalex.org/F4320335777", "display_name": "National Key Research and Development Program of China", "ror": null}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W2141825721.pdf", "grobid_xml": "https://content.openalex.org/works/W2141825721.grobid-xml"}, "referenced_works_count": 59, "referenced_works": ["https://openalex.org/W1567182672", "https://openalex.org/W1974343902", "https://openalex.org/W1974421923", "https://openalex.org/W1976391205", "https://openalex.org/W1980913087", "https://openalex.org/W1982831423", "https://openalex.org/W1984068087", "https://openalex.org/W1987635127", "https://openalex.org/W1987739153", "https://openalex.org/W1992321244", "https://openalex.org/W1999688054", "https://openalex.org/W2001497035", "https://openalex.org/W2003171404", "https://openalex.org/W2007818617", "https://openalex.org/W2014639769", "https://openalex.org/W2026520402", "https://openalex.org/W2028030005", "https://openalex.org/W2036176224", "https://openalex.org/W2038659500", "https://openalex.org/W2039705224", "https://openalex.org/W2045435533", "https://openalex.org/W2058792860", "https://openalex.org/W2064815984", "https://openalex.org/W2071411482", "https://openalex.org/W2072309186", "https://openalex.org/W2077379243", "https://openalex.org/W2077381938", "https://openalex.org/W2077436902", "https://openalex.org/W2077659966", "https://openalex.org/W2086814185", "https://openalex.org/W2089589904", "https://openalex.org/W2089929813", "https://openalex.org/W2096261947", "https://openalex.org/W2096581331", "https://openalex.org/W2097348296", "https://openalex.org/W2103441770", "https://openalex.org/W2108512070", "https://openalex.org/W2119180969", "https://openalex.org/W2119413407", "https://openalex.org/W2120994513", "https://openalex.org/W2121260094", "https://openalex.org/W2123746851", "https://openalex.org/W2126374378", "https://openalex.org/W2127497550", "https://openalex.org/W2130389986", "https://openalex.org/W2132401721", "https://openalex.org/W2133702185", "https://openalex.org/W2140754284", "https://openalex.org/W2149402050", "https://openalex.org/W2153344788", "https://openalex.org/W2163445749", "https://openalex.org/W2166150935", "https://openalex.org/W2169741450", "https://openalex.org/W2170039745", "https://openalex.org/W2230304704", "https://openalex.org/W3187992181", "https://openalex.org/W4210970197", "https://openalex.org/W4211225058", "https://openalex.org/W4247053599"], "related_works": ["https://openalex.org/W2901315592", "https://openalex.org/W4311710403", "https://openalex.org/W2626278962", "https://openalex.org/W4288777264", "https://openalex.org/W4311501380", "https://openalex.org/W3137982617", "https://openalex.org/W2991384854", "https://openalex.org/W2390994276", "https://openalex.org/W4309388531", "https://openalex.org/W2646003346"], "abstract_inverted_index": {"Genome": [0], "editing": [1, 91], "tools": [2], "such": [3, 71], "as": [4, 72, 135, 162], "the": [5, 62, 102, 108, 121, 138, 145, 163, 177, 186, 195, 201, 206], "clustered": [6], "regularly": [7], "interspaced": [8], "short": [9], "palindromic": [10], "repeat": [11], "(CRISPR)-associated": [12], "system": [13], "(Cas)": [14], "have": [15], "been": [16], "widely": [17], "used": [18, 82], "to": [19, 86, 153, 160, 167, 198], "modify": [20], "genes": [21], "in": [22, 49, 56, 61, 74, 92, 131, 180], "model": [23], "systems": [24], "including": [25], "animal": [26], "zygotes": [27, 85, 134], "and": [28, 31, 39, 60, 64, 120, 141, 203], "human": [29, 57, 75, 93], "cells,": [30], "hold": [32], "tremendous": [33], "promise": [34], "for": [35, 211], "both": [36], "basic": [37], "research": [38], "clinical": [40, 213], "applications.": [41], "To": [42], "date,": [43], "a": [44, 209], "serious": [45], "knowledge": [46], "gap": [47], "remains": [48], "our": [50, 192], "understanding": [51], "of": [52, 68, 110, 116, 176, 205, 215], "DNA": [53], "repair": [54, 114, 164, 175], "mechanisms": [55], "early": [58], "embryos,": [59], "efficiency": [63, 109], "potential": [65], "off-target": [66], "effects": [67], "using": [69], "technologies": [70], "CRISPR/Cas9": [73, 98, 207], "pre-implantation": [76], "embryos.": [77], "In": [78], "this": [79], "report,": [80], "we": [81], "tripronuclear": [83], "(3PN)": [84], "further": [87, 199], "investigate": [88], "CRISPR/Cas9-mediated": [89], "gene": [90, 105, 148], "cells.": [94], "We": [95], "found": [96], "that": [97, 174], "could": [99], "effectively": [100], "cleave": [101], "endogenous": [103, 146], "\u03b2-globin": [104], "(HBB).": [106], "However,": [107], "homologous": [111, 152], "recombination": [112], "directed": [113], "(HDR)": [115], "HBB": [117, 178], "was": [118, 128], "low": [119], "edited": [122], "embryos": [123, 182], "were": [124], "mosaic.": [125], "Off-target": [126], "cleavage": [127], "also": [129, 172], "apparent": [130], "these": [132, 181], "3PN": [133], "revealed": [136], "by": [137], "T7E1": [139], "assay": [140], "whole-exome": [142], "sequencing.": [143], "Furthermore,": [144], "delta-globin": [147], "(HBD),": [149], "which": [150], "is": [151], "HBB,": [154], "competed": [155], "with": [156], "exogenous": [157], "donor": [158], "oligos": [159], "act": [161], "template,": [165], "leading": [166], "untoward": [168], "mutations.": [169], "Our": [170], "data": [171], "indicated": [173], "locus": [179], "occurred": [183], "preferentially": [184], "through": [185], "non-crossover": [187], "HDR": [188], "pathway.": [189], "Taken": [190], "together,": [191], "work": [193], "highlights": [194], "pressing": [196], "need": [197], "improve": [200], "fidelity": [202], "specificity": [204], "platform,": [208], "prerequisite": [210], "any": [212], "applications": [214], "CRSIPR/Cas9-mediated": [216], "editing.": [217]}, "counts_by_year": [{"year": 2026, "cited_by_count": 17}, {"year": 2025, "cited_by_count": 46}, {"year": 2024, "cited_by_count": 60}, {"year": 2023, "cited_by_count": 61}, {"year": 2022, "cited_by_count": 56}, {"year": 2021, "cited_by_count": 86}, {"year": 2020, "cited_by_count": 114}, {"year": 2019, "cited_by_count": 122}, {"year": 2018, "cited_by_count": 146}, {"year": 2017, "cited_by_count": 147}, {"year": 2016, "cited_by_count": 156}, {"year": 2015, "cited_by_count": 103}, {"year": 2013, "cited_by_count": 1}], "updated_date": "2026-05-18T08:16:58.900851", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3112179900", "doi": "https://doi.org/10.1056/nejmoa2031054", "title": "CRISPR-Cas9 Gene Editing for Sickle Cell Disease and \u03b2-Thalassemia", "display_name": "CRISPR-Cas9 Gene Editing for Sickle Cell Disease and \u03b2-Thalassemia", "relevance_score": 1440.9371, "publication_year": 2020, "publication_date": "2020-12-05", "ids": {"openalex": "https://openalex.org/W3112179900", "doi": "https://doi.org/10.1056/nejmoa2031054", "mag": "3112179900", "pmid": "https://pubmed.ncbi.nlm.nih.gov/33283989"}, "language": "en", "primary_location": {"id": "doi:10.1056/nejmoa2031054", "is_oa": true, "landing_page_url": "https://doi.org/10.1056/nejmoa2031054", "pdf_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2031054?articleTools=true", "source": {"id": "https://openalex.org/S62468778", "display_name": "New England Journal of Medicine", "issn_l": "0028-4793", "issn": ["0028-4793", "1533-4406"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320239", "host_organization_name": "Massachusetts Medical Society", "host_organization_lineage": ["https://openalex.org/P4310320239"], "host_organization_lineage_names": ["Massachusetts Medical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "New England Journal of Medicine", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "bronze", "oa_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2031054?articleTools=true", "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5021909393", "display_name": "Haydar Frangoul", "orcid": "https://orcid.org/0000-0002-0590-2826"}, "institutions": [{"id": "https://openalex.org/I4210100810", "display_name": "Sarah Cannon", "ror": "https://ror.org/014t21j89", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I4210100810"]}, {"id": "https://openalex.org/I4210100556", "display_name": "Children\u2019s Hospital at TriStar Centennial", "ror": "https://ror.org/00yvr3a11", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I4210100556"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Haydar Frangoul", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Sarah Cannon Center for Blood Cancer at the Children's Hospital at TriStar Centennial, Nashville"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Sarah Cannon Center for Blood Cancer at the Children's Hospital at TriStar Centennial, Nashville", "institution_ids": ["https://openalex.org/I4210100556", "https://openalex.org/I4210100810"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100340817", "display_name": "David Altshuler", "orcid": "https://orcid.org/0000-0002-7250-4107"}, "institutions": [{"id": "https://openalex.org/I61970326", "display_name": "Vertex Pharmaceuticals (United States)", "ror": "https://ror.org/00anb1726", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I61970326"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "David Altshuler", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Vertex Pharmaceuticals"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Vertex Pharmaceuticals", "institution_ids": ["https://openalex.org/I61970326"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5064506274", "display_name": "Maria Domenica Cappellini", "orcid": "https://orcid.org/0000-0001-8676-6864"}, "institutions": [{"id": "https://openalex.org/I4210142437", "display_name": "Mylan (Switzerland)", "ror": "https://ror.org/045sjkt56", "country_code": "CH", "type": "company", "lineage": ["https://openalex.org/I4210142437", "https://openalex.org/I4210159288"]}, {"id": "https://openalex.org/I189158943", "display_name": "University of Milan", "ror": "https://ror.org/00wjc7c48", "country_code": "IT", "type": "education", "lineage": ["https://openalex.org/I189158943"]}], "countries": ["CH", "IT"], "is_corresponding": false, "raw_author_name": "M. Domenica Cappellini", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "University of Milan, Milan"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "University of Milan, Milan", "institution_ids": ["https://openalex.org/I4210142437", "https://openalex.org/I189158943"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5022485745", "display_name": "Yi-Shan Chen", "orcid": null}, "institutions": [{"id": "https://openalex.org/I4210146681", "display_name": "CRISPR Therapeutics (Switzerland)", "ror": "https://ror.org/04ewmsk50", "country_code": "CH", "type": "company", "lineage": ["https://openalex.org/I4210146681"]}], "countries": ["CH"], "is_corresponding": false, "raw_author_name": "Yi-Shan Chen", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Boston, and CRISPR Therapeutics, Cambridge"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Boston, and CRISPR Therapeutics, Cambridge", "institution_ids": ["https://openalex.org/I4210146681"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5026587448", "display_name": "Jennifer Domm", "orcid": null}, "institutions": [{"id": "https://openalex.org/I4210100556", "display_name": "Children\u2019s Hospital at TriStar Centennial", "ror": "https://ror.org/00yvr3a11", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I4210100556"]}, {"id": "https://openalex.org/I4210100810", "display_name": "Sarah Cannon", "ror": "https://ror.org/014t21j89", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I4210100810"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Jennifer Domm", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Sarah Cannon Center for Blood Cancer at the Children's Hospital at TriStar Centennial, Nashville"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Sarah Cannon Center for Blood Cancer at the Children's Hospital at TriStar Centennial, Nashville", "institution_ids": ["https://openalex.org/I4210100556", "https://openalex.org/I4210100810"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5068119691", "display_name": "Brenda K. Eustace", "orcid": null}, "institutions": [{"id": "https://openalex.org/I61970326", "display_name": "Vertex Pharmaceuticals (United States)", "ror": "https://ror.org/00anb1726", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I61970326"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Brenda K. Eustace", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Vertex Pharmaceuticals"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Vertex Pharmaceuticals", "institution_ids": ["https://openalex.org/I61970326"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5007362584", "display_name": "Juergen Foell", "orcid": null}, "institutions": [{"id": "https://openalex.org/I60668342", "display_name": "University of Regensburg", "ror": "https://ror.org/01eezs655", "country_code": "DE", "type": "education", "lineage": ["https://openalex.org/I60668342"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Juergen Foell", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "University of Regensburg, Regensburg"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "University of Regensburg, Regensburg", "institution_ids": ["https://openalex.org/I60668342"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5000049478", "display_name": "Josu de la Fuente", "orcid": "https://orcid.org/0000-0002-0974-1249"}, "institutions": [{"id": "https://openalex.org/I4210133745", "display_name": "St. Mary\u2019s Hospital", "ror": "https://ror.org/041j39g66", "country_code": "ZA", "type": "healthcare", "lineage": ["https://openalex.org/I4210133745"]}, {"id": "https://openalex.org/I153355300", "display_name": "Imperial College Healthcare NHS Trust", "ror": "https://ror.org/056ffv270", "country_code": "GB", "type": "healthcare", "lineage": ["https://openalex.org/I153355300"]}], "countries": ["GB", "ZA"], "is_corresponding": false, "raw_author_name": "Josu de la Fuente", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Imperial College Healthcare NHS Trust, St. Mary's Hospital, London"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Imperial College Healthcare NHS Trust, St. Mary's Hospital, London", "institution_ids": ["https://openalex.org/I153355300", "https://openalex.org/I4210133745"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5077440294", "display_name": "Stephan A. Grupp", "orcid": "https://orcid.org/0000-0001-8030-7595"}, "institutions": [{"id": "https://openalex.org/I1335321130", "display_name": "Children's Hospital of Philadelphia", "ror": "https://ror.org/01z7r7q48", "country_code": "US", "type": "funder", "lineage": ["https://openalex.org/I1335321130"]}, {"id": "https://openalex.org/I79576946", "display_name": "University of Pennsylvania", "ror": "https://ror.org/00b30xv10", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I79576946"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Stephan Grupp", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia", "institution_ids": ["https://openalex.org/I1335321130", "https://openalex.org/I79576946"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5035626095", "display_name": "Rupert Handgretinger", "orcid": "https://orcid.org/0000-0003-1838-8990"}, "institutions": [{"id": "https://openalex.org/I4210125796", "display_name": "University Children's Hospital T\u00fcbingen", "ror": "https://ror.org/03esvmb28", "country_code": "DE", "type": "healthcare", "lineage": ["https://openalex.org/I4210094118", "https://openalex.org/I4210125796"]}, {"id": "https://openalex.org/I8087733", "display_name": "University of T\u00fcbingen", "ror": "https://ror.org/03a1kwz48", "country_code": "DE", "type": "education", "lineage": ["https://openalex.org/I8087733"]}, {"id": "https://openalex.org/I3019103622", "display_name": "Temple Street Children's University Hospital", "ror": "https://ror.org/0527gjc91", "country_code": "IE", "type": "healthcare", "lineage": ["https://openalex.org/I3019103622"]}], "countries": ["DE", "IE"], "is_corresponding": false, "raw_author_name": "Rupert Handgretinger", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Children's University Hospital, University of T\u00fcbingen, T\u00fcbingen"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Children's University Hospital, University of T\u00fcbingen, T\u00fcbingen", "institution_ids": ["https://openalex.org/I4210125796", "https://openalex.org/I3019103622", "https://openalex.org/I8087733"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5050461006", "display_name": "Tony W. Ho", "orcid": "https://orcid.org/0000-0002-3489-3594"}, "institutions": [{"id": "https://openalex.org/I4210146681", "display_name": "CRISPR Therapeutics (Switzerland)", "ror": "https://ror.org/04ewmsk50", "country_code": "CH", "type": "company", "lineage": ["https://openalex.org/I4210146681"]}], "countries": ["CH"], "is_corresponding": false, "raw_author_name": "Tony W. Ho", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Boston, and CRISPR Therapeutics, Cambridge"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Boston, and CRISPR Therapeutics, Cambridge", "institution_ids": ["https://openalex.org/I4210146681"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5053053769", "display_name": "Antonis Kattamis", "orcid": "https://orcid.org/0000-0002-5178-0655"}, "institutions": [{"id": "https://openalex.org/I200777214", "display_name": "National and Kapodistrian University of Athens", "ror": "https://ror.org/04gnjpq42", "country_code": "GR", "type": "education", "lineage": ["https://openalex.org/I200777214"]}], "countries": ["GR"], "is_corresponding": false, "raw_author_name": "Antonis Kattamis", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "University of Athens, Athens"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "University of Athens, Athens", "institution_ids": ["https://openalex.org/I200777214"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5010395023", "display_name": "Andrew Kernytsky", "orcid": null}, "institutions": [{"id": "https://openalex.org/I4210146681", "display_name": "CRISPR Therapeutics (Switzerland)", "ror": "https://ror.org/04ewmsk50", "country_code": "CH", "type": "company", "lineage": ["https://openalex.org/I4210146681"]}], "countries": ["CH"], "is_corresponding": false, "raw_author_name": "Andrew Kernytsky", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Boston, and CRISPR Therapeutics, Cambridge"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Boston, and CRISPR Therapeutics, Cambridge", "institution_ids": ["https://openalex.org/I4210146681"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5065202836", "display_name": "Julie Lekstrom-Himes", "orcid": null}, "institutions": [{"id": "https://openalex.org/I61970326", "display_name": "Vertex Pharmaceuticals (United States)", "ror": "https://ror.org/00anb1726", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I61970326"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Julie Lekstrom-Himes", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Vertex Pharmaceuticals"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Vertex Pharmaceuticals", "institution_ids": ["https://openalex.org/I61970326"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5061945652", "display_name": "Amanda M. Li", "orcid": "https://orcid.org/0000-0001-8099-9501"}, "institutions": [{"id": "https://openalex.org/I4210153200", "display_name": "BC Children's Hospital", "ror": "https://ror.org/04n901w50", "country_code": "CA", "type": "healthcare", "lineage": ["https://openalex.org/I4210153200"]}, {"id": "https://openalex.org/I141945490", "display_name": "University of British Columbia", "ror": "https://ror.org/03rmrcq20", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I141945490"]}], "countries": ["CA"], "is_corresponding": false, "raw_author_name": "Amanda M. Li", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "BC Children's Hospital, University of British Columbia, Vancouver"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "BC Children's Hospital, University of British Columbia, Vancouver", "institution_ids": ["https://openalex.org/I4210153200", "https://openalex.org/I141945490"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5022712318", "display_name": "Franco Locatelli", "orcid": "https://orcid.org/0000-0002-7976-3654"}, "institutions": [{"id": "https://openalex.org/I861853513", "display_name": "Sapienza University of Rome", "ror": "https://ror.org/02be6w209", "country_code": "IT", "type": "education", "lineage": ["https://openalex.org/I861853513"]}, {"id": "https://openalex.org/I4210123352", "display_name": "Bambino Ges\u00f9 Children's Hospital", "ror": "https://ror.org/02sy42d13", "country_code": "IT", "type": "healthcare", "lineage": ["https://openalex.org/I4210123352", "https://openalex.org/I4210153126"]}], "countries": ["IT"], "is_corresponding": false, "raw_author_name": "Franco Locatelli", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza, University of Rome, Rome"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza, University of Rome, Rome", "institution_ids": ["https://openalex.org/I4210123352", "https://openalex.org/I861853513"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5002240997", "display_name": "Markus Y. Mapara", "orcid": "https://orcid.org/0000-0002-8547-8905"}, "institutions": [{"id": "https://openalex.org/I78577930", "display_name": "Columbia University", "ror": "https://ror.org/00hj8s172", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I78577930"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Markus Y. Mapara", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Columbia University, New York"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Columbia University, New York", "institution_ids": ["https://openalex.org/I78577930"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5007220235", "display_name": "Mariane de Montalembert", "orcid": "https://orcid.org/0000-0002-4900-4753"}, "institutions": [{"id": "https://openalex.org/I1288880153", "display_name": "H\u00f4pital Necker-Enfants Malades", "ror": "https://ror.org/05tr67282", "country_code": "FR", "type": "healthcare", "lineage": ["https://openalex.org/I1288880153", "https://openalex.org/I4210097159", "https://openalex.org/I4210120235"]}, {"id": "https://openalex.org/I4210097159", "display_name": "Assistance Publique \u2013 H\u00f4pitaux de Paris", "ror": "https://ror.org/00pg5jh14", "country_code": "FR", "type": "healthcare", "lineage": ["https://openalex.org/I4210097159"]}, {"id": "https://openalex.org/I204730241", "display_name": "Universit\u00e9 Paris Cit\u00e9", "ror": "https://ror.org/05f82e368", "country_code": "FR", "type": "education", "lineage": ["https://openalex.org/I204730241"]}], "countries": ["FR"], "is_corresponding": false, "raw_author_name": "Mariane de Montalembert", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Necker\u2013Enfants Malades Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University of Paris, Paris"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Necker\u2013Enfants Malades Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, University of Paris, Paris", "institution_ids": ["https://openalex.org/I1288880153", "https://openalex.org/I204730241", "https://openalex.org/I4210097159"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5029836748", "display_name": "Damiano Rondelli", "orcid": "https://orcid.org/0000-0001-5243-401X"}, "institutions": [{"id": "https://openalex.org/I39422238", "display_name": "University of Illinois Chicago", "ror": "https://ror.org/02mpq6x41", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I39422238"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Damiano Rondelli", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "University of Illinois at Chicago, Chicago"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "University of Illinois at Chicago, Chicago", "institution_ids": ["https://openalex.org/I39422238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5068720519", "display_name": "Akshay Sharma", "orcid": "https://orcid.org/0000-0003-3281-2081"}, "institutions": [{"id": "https://openalex.org/I1313298211", "display_name": "St. Jude Children's Research Hospital", "ror": "https://ror.org/02r3e0967", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I1313298211", "https://openalex.org/I2802152183"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Akshay Sharma", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "St. Jude Children's Research Hospital, Memphis"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "St. Jude Children's Research Hospital, Memphis", "institution_ids": ["https://openalex.org/I1313298211"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5042897295", "display_name": "Sujit Sheth", "orcid": "https://orcid.org/0000-0002-7640-1244"}, "institutions": [{"id": "https://openalex.org/I205783295", "display_name": "Cornell University", "ror": "https://ror.org/05bnh6r87", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I205783295"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Sujit Sheth", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Joan and Sanford I. Weill Medical College of Cornell University, New York"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Joan and Sanford I. Weill Medical College of Cornell University, New York", "institution_ids": ["https://openalex.org/I205783295"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5101628918", "display_name": "Sandeep Soni", "orcid": "https://orcid.org/0000-0001-9524-0442"}, "institutions": [{"id": "https://openalex.org/I4210146681", "display_name": "CRISPR Therapeutics (Switzerland)", "ror": "https://ror.org/04ewmsk50", "country_code": "CH", "type": "company", "lineage": ["https://openalex.org/I4210146681"]}], "countries": ["CH"], "is_corresponding": false, "raw_author_name": "Sandeep Soni", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Boston, and CRISPR Therapeutics, Cambridge"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Boston, and CRISPR Therapeutics, Cambridge", "institution_ids": ["https://openalex.org/I4210146681"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5065128454", "display_name": "Martin H. Steinberg", "orcid": "https://orcid.org/0000-0001-8800-8020"}, "institutions": [{"id": "https://openalex.org/I4210153792", "display_name": "University School", "ror": "https://ror.org/05ap66461", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I4210153792"]}, {"id": "https://openalex.org/I111088046", "display_name": "Boston University", "ror": "https://ror.org/05qwgg493", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I111088046"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Martin H. Steinberg", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Boston University School of Medicine"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Boston University School of Medicine", "institution_ids": ["https://openalex.org/I111088046", "https://openalex.org/I4210153792"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5003706795", "display_name": "Donna A. Wall", "orcid": "https://orcid.org/0000-0002-5442-5536"}, "institutions": [{"id": "https://openalex.org/I185261750", "display_name": "University of Toronto", "ror": "https://ror.org/03dbr7087", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I185261750"]}, {"id": "https://openalex.org/I4210141030", "display_name": "SickKids Foundation", "ror": "https://ror.org/04374qe70", "country_code": "CA", "type": "funder", "lineage": ["https://openalex.org/I4210141030"]}, {"id": "https://openalex.org/I2801317318", "display_name": "Hospital for Sick Children", "ror": "https://ror.org/057q4rt57", "country_code": "CA", "type": "healthcare", "lineage": ["https://openalex.org/I2801317318"]}], "countries": ["CA"], "is_corresponding": false, "raw_author_name": "Donna Wall", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Hospital for Sick Children\u2013University of Toronto, Toronto"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Hospital for Sick Children\u2013University of Toronto, Toronto", "institution_ids": ["https://openalex.org/I185261750", "https://openalex.org/I2801317318", "https://openalex.org/I4210141030"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5064122320", "display_name": "Angela Yen", "orcid": "https://orcid.org/0000-0002-9802-7679"}, "institutions": [{"id": "https://openalex.org/I61970326", "display_name": "Vertex Pharmaceuticals (United States)", "ror": "https://ror.org/00anb1726", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I61970326"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Angela Yen", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "Vertex Pharmaceuticals"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "Vertex Pharmaceuticals", "institution_ids": ["https://openalex.org/I61970326"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5078683084", "display_name": "Selim Corbacioglu", "orcid": "https://orcid.org/0000-0003-1070-8486"}, "institutions": [{"id": "https://openalex.org/I60668342", "display_name": "University of Regensburg", "ror": "https://ror.org/01eezs655", "country_code": "DE", "type": "education", "lineage": ["https://openalex.org/I60668342"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Selim Corbacioglu", "raw_affiliation_strings": ["From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "University of Regensburg, Regensburg"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "From the Sarah Cannon Center for Blood Cancer at the Children\u2019s Hospital at TriStar Centennial, Nashville (H.F., J.D.), and St. Jude Children\u2019s Research Hospital, Memphis (A.S.) \u2014 both in Tennessee; Vertex Pharmaceuticals (D.A., B.K.E., J.L.-H., A.Y.) and Boston University School of Medicine (M.H.S.), Boston, and CRISPR Therapeutics, Cambridge (Y.-S.C., T.W.H., A. Kernytsky, S. Soni) \u2014 both in Massachusetts; the University of Milan, Milan (M.D.C.), and Ospedale Pediatrico Bambino Ges\u00f9 Rome, Sapienza", "institution_ids": []}, {"raw_affiliation_string": "University of Regensburg, Regensburg", "institution_ids": ["https://openalex.org/I60668342"]}]}], "institutions": [], "countries_distinct_count": 10, "institutions_distinct_count": 26, "corresponding_author_ids": ["https://openalex.org/A5021909393"], "corresponding_institution_ids": ["https://openalex.org/I4210100556", "https://openalex.org/I4210100810"], "apc_list": null, "apc_paid": null, "fwci": 117.3299, "has_fulltext": true, "cited_by_count": 1808, "citation_normalized_percentile": {"value": 0.99990502, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "384", "issue": "3", "first_page": "252", "last_page": "260"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10554", "display_name": "Hemoglobinopathies and Related Disorders", "score": 0.9997000098228455, "subfield": {"id": "https://openalex.org/subfields/2716", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, "topics": [{"id": "https://openalex.org/T10554", "display_name": "Hemoglobinopathies and Related Disorders", "score": 0.9997000098228455, "subfield": {"id": "https://openalex.org/subfields/2716", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T10452", "display_name": "Iron Metabolism and Disorders", "score": 0.9805999994277954, "subfield": {"id": "https://openalex.org/subfields/2720", "display_name": "Hematology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T12849", "display_name": "Parvovirus B19 Infection Studies", "score": 0.9768000245094299, "subfield": {"id": "https://openalex.org/subfields/2725", "display_name": "Infectious Diseases"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8779888153076172}, {"id": "https://openalex.org/keywords/thalassemia", "display_name": "Thalassemia", "score": 0.7358150482177734}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.5711923241615295}, {"id": "https://openalex.org/keywords/disease", "display_name": "Disease", "score": 0.5140088796615601}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.440758615732193}, {"id": "https://openalex.org/keywords/medicine", "display_name": "Medicine", "score": 0.4236387014389038}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.40009063482284546}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.3941608667373657}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.3323262929916382}, {"id": "https://openalex.org/keywords/internal-medicine", "display_name": "Internal medicine", "score": 0.10430893301963806}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8779888153076172}, {"id": "https://openalex.org/C2777799968", "wikidata": "https://www.wikidata.org/wiki/Q185137", "display_name": "Thalassemia", "level": 2, "score": 0.7358150482177734}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.5711923241615295}, {"id": "https://openalex.org/C2779134260", "wikidata": "https://www.wikidata.org/wiki/Q12136", "display_name": "Disease", "level": 2, "score": 0.5140088796615601}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.440758615732193}, {"id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.4236387014389038}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.40009063482284546}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.3941608667373657}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.3323262929916382}, {"id": "https://openalex.org/C126322002", "wikidata": "https://www.wikidata.org/wiki/Q11180", "display_name": "Internal medicine", "level": 1, "score": 0.10430893301963806}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000328", "descriptor_name": "Adult", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000328", "descriptor_name": "Adult", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000328", "descriptor_name": "Adult", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000755", "descriptor_name": "Anemia, Sickle Cell", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000755", "descriptor_name": "Anemia, Sickle Cell", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000755", "descriptor_name": "Anemia, Sickle Cell", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000755", "descriptor_name": "Anemia, Sickle Cell", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D000755", "descriptor_name": "Anemia, Sickle Cell", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D000755", "descriptor_name": "Anemia, Sickle Cell", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005319", "descriptor_name": "Fetal Hemoglobin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D005319", "descriptor_name": "Fetal Hemoglobin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D005319", "descriptor_name": "Fetal Hemoglobin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D005319", "descriptor_name": "Fetal Hemoglobin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005319", "descriptor_name": "Fetal Hemoglobin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005319", "descriptor_name": "Fetal Hemoglobin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012097", "descriptor_name": "Repressor Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012097", "descriptor_name": "Repressor Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012097", "descriptor_name": "Repressor Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012097", "descriptor_name": "Repressor Proteins", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D012097", "descriptor_name": "Repressor Proteins", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D012097", "descriptor_name": "Repressor Proteins", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D017086", "descriptor_name": "beta-Thalassemia", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017086", "descriptor_name": "beta-Thalassemia", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017086", "descriptor_name": "beta-Thalassemia", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017086", "descriptor_name": "beta-Thalassemia", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D017086", "descriptor_name": "beta-Thalassemia", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D017086", "descriptor_name": "beta-Thalassemia", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D055815", "descriptor_name": "Young Adult", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D055815", "descriptor_name": "Young Adult", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D055815", "descriptor_name": "Young Adult", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 3, "locations": [{"id": "doi:10.1056/nejmoa2031054", "is_oa": true, "landing_page_url": "https://doi.org/10.1056/nejmoa2031054", "pdf_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2031054?articleTools=true", "source": {"id": "https://openalex.org/S62468778", "display_name": "New England Journal of Medicine", "issn_l": "0028-4793", "issn": ["0028-4793", "1533-4406"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320239", "host_organization_name": "Massachusetts Medical Society", "host_organization_lineage": ["https://openalex.org/P4310320239"], "host_organization_lineage_names": ["Massachusetts Medical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "New England Journal of Medicine", "raw_type": "journal-article"}, {"id": "pmid:33283989", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/33283989", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "The New England journal of medicine", "raw_type": null}, {"id": "pmid:34107197", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/34107197", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "The New England journal of medicine", "raw_type": null}], "best_oa_location": {"id": "doi:10.1056/nejmoa2031054", "is_oa": true, "landing_page_url": "https://doi.org/10.1056/nejmoa2031054", "pdf_url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2031054?articleTools=true", "source": {"id": "https://openalex.org/S62468778", "display_name": "New England Journal of Medicine", "issn_l": "0028-4793", "issn": ["0028-4793", "1533-4406"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320239", "host_organization_name": "Massachusetts Medical Society", "host_organization_lineage": ["https://openalex.org/P4310320239"], "host_organization_lineage_names": ["Massachusetts Medical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "New England Journal of Medicine", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [], "funders": [{"id": "https://openalex.org/F4320310040", "display_name": "St. Jude Children's Research Hospital", "ror": "https://ror.org/02r3e0967"}, {"id": "https://openalex.org/F4320313426", "display_name": "BC Children's Hospital", "ror": "https://ror.org/04n901w50"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W3112179900.pdf", "grobid_xml": "https://content.openalex.org/works/W3112179900.grobid-xml"}, "referenced_works_count": 35, "referenced_works": ["https://openalex.org/W1779344217", "https://openalex.org/W1855348513", "https://openalex.org/W2008989169", "https://openalex.org/W2010758038", "https://openalex.org/W2049129790", "https://openalex.org/W2064631448", "https://openalex.org/W2155829072", "https://openalex.org/W2170845283", "https://openalex.org/W2172655914", "https://openalex.org/W2185201235", "https://openalex.org/W2209402024", "https://openalex.org/W2238351347", "https://openalex.org/W2267505671", "https://openalex.org/W2323549005", "https://openalex.org/W2334263927", "https://openalex.org/W2335972680", "https://openalex.org/W2407278011", "https://openalex.org/W2513179752", "https://openalex.org/W2559643145", "https://openalex.org/W2562103559", "https://openalex.org/W2593923181", "https://openalex.org/W2784423079", "https://openalex.org/W2802087233", "https://openalex.org/W2898244567", "https://openalex.org/W2923636118", "https://openalex.org/W2954515500", "https://openalex.org/W2971545858", "https://openalex.org/W3010975733", "https://openalex.org/W3014005795", "https://openalex.org/W3111094104", "https://openalex.org/W4210970197", "https://openalex.org/W4211089719", "https://openalex.org/W4211225058", "https://openalex.org/W4251903243", "https://openalex.org/W4253879795"], "related_works": ["https://openalex.org/W4311501380", "https://openalex.org/W2603161682", "https://openalex.org/W2960163646", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W2337751047", "https://openalex.org/W3052741125"], "abstract_inverted_index": {"Transfusion-dependent": [0], "-thalassemia": [1], "(TDT)": [2], "and": [3, 14, 27, 40, 78, 111, 123, 137, 146, 172, 178, 184, 231, 242, 250, 254, 267, 278, 312], "sickle": [4, 218], "cell": [5], "disease": [6, 298, 302], "(SCD)": [7], "are": [8], "severe": [9, 13], "monogenic": [10], "diseases": [11], "with": [12, 47, 64, 76, 81, 88, 127, 208, 247, 258, 276, 286], "potentially": [15], "life-threatening": [16], "manifestations.": [17, 303], "BCL11A": [18, 51, 93], "is": [19, 195], "a": [20, 97, 199, 232], "transcription": [21], "factor": [22], "that": [23, 117, 155, 204], "represses": [24], "-globin": [25, 170], "expression": [26], "fetal": [28, 115], "hemoglobin": [29, 116, 194, 219], "in": [30, 108, 114, 153, 160, 202, 245, 256, 274, 284], "erythroid": [31], "cells.": [32], "We": [33], "performed": [34], "electroporation": [35], "of": [36, 56, 67, 105, 130, 187, 198, 216, 240, 281, 296], "CD34+": [37, 85], "hematopoietic": [38], "stem": [39], "progenitor": [41], "cells": [42, 86], "obtained": [43], "from": [44], "healthy": [45], "donors,": [46], "CRISPR-Cas9": [48, 89], "targeting": [49, 90], "the": [50, 57, 79, 91, 125, 176, 196, 279, 293, 297], "erythroid-specific": [52], "enhancer.": [53, 94], "Approximately": [54], "80%": [55], "alleles": [58], "at": [59, 210], "this": [60], "locus": [61], "were": [62, 118], "modified,": [63], "no": [65], "evidence": [66], "off-target": [68], "editing.": [69], "After": [70], "undergoing": [71], "myeloablation,": [72], "two": [73], "patients": [74, 101, 246, 275], "-one": [75], "TDT": [77, 157, 248, 277, 311], "other": [80], "SCD": [82], "-received": [83], "autologous": [84], "edited": [87], "same": [92], "More": [95], "than": [96], "year": [98], "later,": [99], "both": [100, 310], "had": [102], "high": [103], "levels": [104], "allelic": [106], "editing": [107], "bone": [109, 305], "marrow": [110, 306], "blood,": [112], "increases": [113], "distributed": [119], "pancellularly,": [120], "transfusion": [121, 241, 272], "independence,": [122], "(in": [124], "patient": [126], "SCD)": [128], "elimination": [129], "vaso-occlusive": [131, 226, 282], "episodes.": [132], "(Funded": [133], "by": [134], "CRISPR": [135], "Therapeutics": [136], "Vertex": [138], "Pharmaceuticals;": [139], "ClinicalTrials.gov": [140], "numbers,": [141], "NCT03655678": [142], "for": [143, 148], "CLIMB": [144, 149], "THAL-111": [145], "NCT03745287": [147], "SCD-121.)": [150], "2]": [151], "Mutations": [152], "HBB": [154, 203], "cause": [156, 295], "4": [158], "result": [159, 197], "reduced": [161, 233, 271], "(": [162, 167], "+": [163], ")": [164, 169, 185], "or": [165], "absent": [166], "0": [168], "synthesis": [171], "an": [173], "imbalance": [174], "between": [175], "-like": [177, 179], "globin": [180], "(e.g.,": [181], ",": [182, 183], "chains": [186], "hemoglobin,": [188], "which": [189], "causes": [190, 220], "ineffective": [191], "erythropoiesis.": [192], "Sickle": [193], "point": [200], "mutation": [201], "replaces": [205], "glutamic": [206], "acid": [207, 212], "valine": [209], "amino": [211], "position": [213], "6.": [214], "Polymerization": [215], "deoxygenated": [217], "erythrocyte": [221], "deformation,": [222], "hemolysis,": [223], "anemia,": [224], "painful": [225], "episodes,": [227], "irreversible": [228], "end-organ": [229], "damage,": [230], "life": [234], "expectancy.": [235], "reatment": [236], "options": [237], "primarily": [238], "consist": [239], "iron": [243], "chelation": [244], "7": [249], "pain": [251], "management,": [252], "transfusion,": [253], "hydroxyurea": [255], "those": [257, 285], "SCD.": [259], "8": [260], "Recently": [261], "approved": [262], "therapies,": [263], "including": [264], "luspatercept": [265], "9": [266], "crizanlizumab,": [268], "10": [269], "have": [270], "requirements": [273], "incidence": [280], "episodes": [283], "SCD,": [287], "respectively,": [288], "but": [289], "neither": [290], "treatment": [291], "addresses": [292], "underlying": [294], "nor": [299], "fully": [300], "ameliorates": [301], "Allogeneic": [304], "transplantation": [307], "can": [308], "cure": [309]}, "counts_by_year": [{"year": 2026, "cited_by_count": 127}, {"year": 2025, "cited_by_count": 347}, {"year": 2024, "cited_by_count": 405}, {"year": 2023, "cited_by_count": 344}, {"year": 2022, "cited_by_count": 335}, {"year": 2021, "cited_by_count": 238}, {"year": 2020, "cited_by_count": 10}, {"year": 2019, "cited_by_count": 1}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2174849886", "doi": "https://doi.org/10.1186/s13059-015-0823-x", "title": "Resources for the design of CRISPR gene editing experiments", "display_name": "Resources for the design of CRISPR gene editing experiments", "relevance_score": 1348.6927, "publication_year": 2015, "publication_date": "2015-11-23", "ids": {"openalex": "https://openalex.org/W2174849886", "doi": "https://doi.org/10.1186/s13059-015-0823-x", "mag": "2174849886", "pmid": "https://pubmed.ncbi.nlm.nih.gov/26612492"}, "language": "en", "primary_location": {"id": "doi:10.1186/s13059-015-0823-x", "is_oa": true, "landing_page_url": "https://doi.org/10.1186/s13059-015-0823-x", "pdf_url": "https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-015-0823-x", "source": {"id": "https://openalex.org/S81160022", "display_name": "Genome biology", "issn_l": "1474-7596", "issn": ["1474-7596", "1474-760X"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320256", "host_organization_name": "BioMed Central", "host_organization_lineage": ["https://openalex.org/P4310320256", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["BioMed Central", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Genome Biology", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-015-0823-x", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5026016872", "display_name": "Daniel B. Graham", "orcid": "https://orcid.org/0000-0002-8403-8115"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "funder", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I4210087915", "display_name": "Massachusetts General Hospital", "ror": "https://ror.org/002pd6e78", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I4210087915", "https://openalex.org/I48633490"]}, {"id": "https://openalex.org/I136199984", "display_name": "Harvard University", "ror": "https://ror.org/03vek6s52", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I136199984"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Daniel B. Graham", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA", "Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, 02114, USA", "Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA"], "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, 02114, USA", "institution_ids": ["https://openalex.org/I4210087915"]}, {"raw_affiliation_string": "Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA", "institution_ids": ["https://openalex.org/I4210087915", "https://openalex.org/I136199984"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5086771961", "display_name": "David E. Root", "orcid": "https://orcid.org/0000-0001-5122-861X"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "funder", "lineage": ["https://openalex.org/I107606265"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "David E. Root", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. droot@broadinstitute.org", "Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA"], "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. droot@broadinstitute.org", "institution_ids": []}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5026016872"], "corresponding_institution_ids": ["https://openalex.org/I107606265", "https://openalex.org/I136199984", "https://openalex.org/I4210087915"], "apc_list": {"value": 4090, "currency": "EUR", "value_usd": 5030}, "apc_paid": {"value": 4090, "currency": "EUR", "value_usd": 5030}, "fwci": 7.5463, "has_fulltext": true, "cited_by_count": 105, "citation_normalized_percentile": {"value": 0.97952614, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "16", "issue": "1", "first_page": "260", "last_page": "260"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10521", "display_name": "RNA and protein synthesis mechanisms", "score": 0.9771000146865845, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10613", "display_name": "Virus-based gene therapy research", "score": 0.9606999754905701, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.9258104562759399}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8521859049797058}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.7679961919784546}, {"id": "https://openalex.org/keywords/human-genetics", "display_name": "Human genetics", "score": 0.6284060478210449}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.5858320593833923}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.47543931007385254}, {"id": "https://openalex.org/keywords/key", "display_name": "Key (lock)", "score": 0.46982812881469727}, {"id": "https://openalex.org/keywords/genome-biology", "display_name": "Genome Biology", "score": 0.46664857864379883}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.4228837490081787}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.39026910066604614}, {"id": "https://openalex.org/keywords/genomics", "display_name": "Genomics", "score": 0.3715173602104187}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.9258104562759399}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8521859049797058}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.7679961919784546}, {"id": "https://openalex.org/C47042493", "wikidata": "https://www.wikidata.org/wiki/Q265799", "display_name": "Human genetics", "level": 3, "score": 0.6284060478210449}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.5858320593833923}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.47543931007385254}, {"id": "https://openalex.org/C26517878", "wikidata": "https://www.wikidata.org/wiki/Q228039", "display_name": "Key (lock)", "level": 2, "score": 0.46982812881469727}, {"id": "https://openalex.org/C64015301", "wikidata": "https://www.wikidata.org/wiki/Q5533480", "display_name": "Genome Biology", "level": 5, "score": 0.46664857864379883}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.4228837490081787}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.39026910066604614}, {"id": "https://openalex.org/C189206191", "wikidata": "https://www.wikidata.org/wiki/Q222046", "display_name": "Genomics", "level": 4, "score": 0.3715173602104187}, {"id": "https://openalex.org/C18903297", "wikidata": "https://www.wikidata.org/wiki/Q7150", "display_name": "Ecology", "level": 1, "score": 0.0}], "mesh": [{"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004720", "descriptor_name": "Endonucleases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004720", "descriptor_name": "Endonucleases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004720", "descriptor_name": "Endonucleases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004720", "descriptor_name": "Endonucleases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004926", "descriptor_name": "Escherichia coli", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004926", "descriptor_name": "Escherichia coli", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004926", "descriptor_name": "Escherichia coli", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004926", "descriptor_name": "Escherichia coli", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017394", "descriptor_name": "RNA, Guide, Kinetoplastida", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018390", "descriptor_name": "Gene Targeting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018390", "descriptor_name": "Gene Targeting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018390", "descriptor_name": "Gene Targeting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018390", "descriptor_name": "Gene Targeting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 4, "locations": [{"id": "doi:10.1186/s13059-015-0823-x", "is_oa": true, "landing_page_url": "https://doi.org/10.1186/s13059-015-0823-x", "pdf_url": "https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-015-0823-x", "source": {"id": "https://openalex.org/S81160022", "display_name": "Genome biology", "issn_l": "1474-7596", "issn": ["1474-7596", "1474-760X"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320256", "host_organization_name": "BioMed Central", "host_organization_lineage": ["https://openalex.org/P4310320256", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["BioMed Central", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Genome Biology", "raw_type": "journal-article"}, {"id": "pmid:26612492", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/26612492", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Genome biology", "raw_type": null}, {"id": "pmh:oai:dash.harvard.edu:1/23845203", "is_oa": true, "landing_page_url": "http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845203", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401540", "display_name": "Digital Access to Scholarship at Harvard (DASH) (Harvard University)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I136199984", "host_organization_name": "Harvard University", "host_organization_lineage": ["https://openalex.org/I136199984"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "Journal Article"}, {"id": "pmh:oai:pubmedcentral.nih.gov:4661947", "is_oa": true, "landing_page_url": "http://doi.org/10.1186/s13059-015-0823-x", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "other-oa", "license_id": "https://openalex.org/licenses/other-oa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1186/s13059-015-0823-x", "is_oa": true, "landing_page_url": "https://doi.org/10.1186/s13059-015-0823-x", "pdf_url": "https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-015-0823-x", "source": {"id": "https://openalex.org/S81160022", "display_name": "Genome biology", "issn_l": "1474-7596", "issn": ["1474-7596", "1474-760X"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320256", "host_organization_name": "BioMed Central", "host_organization_lineage": ["https://openalex.org/P4310320256", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["BioMed Central", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Genome Biology", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [], "funders": [{"id": "https://openalex.org/F4320314070", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W2174849886.pdf", "grobid_xml": "https://content.openalex.org/works/W2174849886.grobid-xml"}, "referenced_works_count": 108, "referenced_works": ["https://openalex.org/W572949249", "https://openalex.org/W930226034", "https://openalex.org/W1013691583", "https://openalex.org/W1024663572", "https://openalex.org/W1045432066", "https://openalex.org/W1496067884", "https://openalex.org/W1505917984", "https://openalex.org/W1555684022", "https://openalex.org/W1600677671", "https://openalex.org/W1608084731", "https://openalex.org/W1616809472", "https://openalex.org/W1635615463", "https://openalex.org/W1636931877", "https://openalex.org/W1710257910", "https://openalex.org/W1722722895", "https://openalex.org/W1863795766", "https://openalex.org/W1869792624", "https://openalex.org/W1932780354", "https://openalex.org/W1968342623", "https://openalex.org/W1972476556", "https://openalex.org/W1973260880", "https://openalex.org/W1982846895", "https://openalex.org/W1982873976", "https://openalex.org/W1990149668", "https://openalex.org/W1997281938", "https://openalex.org/W2002764930", "https://openalex.org/W2003082286", "https://openalex.org/W2003171404", "https://openalex.org/W2003797386", "https://openalex.org/W2006373538", "https://openalex.org/W2007594606", "https://openalex.org/W2008147758", "https://openalex.org/W2022321112", "https://openalex.org/W2025412492", "https://openalex.org/W2026592619", "https://openalex.org/W2027694180", "https://openalex.org/W2030994161", "https://openalex.org/W2031211461", "https://openalex.org/W2035420256", "https://openalex.org/W2036176224", "https://openalex.org/W2039705224", "https://openalex.org/W2043369680", "https://openalex.org/W2045435533", "https://openalex.org/W2050480410", "https://openalex.org/W2051088451", "https://openalex.org/W2051255304", "https://openalex.org/W2064815984", "https://openalex.org/W2065897880", "https://openalex.org/W2070134501", "https://openalex.org/W2070614858", "https://openalex.org/W2072299899", "https://openalex.org/W2073217307", "https://openalex.org/W2077381938", "https://openalex.org/W2085993152", "https://openalex.org/W2096261947", "https://openalex.org/W2099062342", "https://openalex.org/W2101123699", "https://openalex.org/W2101749257", "https://openalex.org/W2101932407", "https://openalex.org/W2103081715", "https://openalex.org/W2104654654", "https://openalex.org/W2106070783", "https://openalex.org/W2106296224", "https://openalex.org/W2109707799", "https://openalex.org/W2109879947", "https://openalex.org/W2112518633", "https://openalex.org/W2115189270", "https://openalex.org/W2115603949", "https://openalex.org/W2117924928", "https://openalex.org/W2126374378", "https://openalex.org/W2127749855", "https://openalex.org/W2127862779", "https://openalex.org/W2130221528", "https://openalex.org/W2131395804", "https://openalex.org/W2131539955", "https://openalex.org/W2132654115", "https://openalex.org/W2133836136", "https://openalex.org/W2134298288", "https://openalex.org/W2138435462", "https://openalex.org/W2139314409", "https://openalex.org/W2140754284", "https://openalex.org/W2144664559", "https://openalex.org/W2145782793", "https://openalex.org/W2150690792", "https://openalex.org/W2152505144", "https://openalex.org/W2153344788", "https://openalex.org/W2154283358", "https://openalex.org/W2154396655", "https://openalex.org/W2156319424", "https://openalex.org/W2157205823", "https://openalex.org/W2160051211", "https://openalex.org/W2163248265", "https://openalex.org/W2164934988", "https://openalex.org/W2164995160", "https://openalex.org/W2167380395", "https://openalex.org/W2168143397", "https://openalex.org/W2169373177", "https://openalex.org/W2170039745", "https://openalex.org/W2172149993", "https://openalex.org/W2209402024", "https://openalex.org/W2220694776", "https://openalex.org/W2236005851", "https://openalex.org/W2252568502", "https://openalex.org/W2274986902", "https://openalex.org/W2281811181", "https://openalex.org/W2396047778", "https://openalex.org/W2411786988", "https://openalex.org/W4245053291"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W3030388918", "https://openalex.org/W4200005163", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W3165203721", "https://openalex.org/W4388296936", "https://openalex.org/W2960163646"], "abstract_inverted_index": {"CRISPR-based": [0], "approaches": [1], "have": [2], "quickly": [3], "become": [4], "a": [5], "favored": [6], "method": [7], "to": [8, 11, 36], "perturb": [9], "genes": [10], "uncover": [12], "their": [13], "functions.": [14], "Here,": [15], "we": [16], "review": [17], "the": [18, 22, 30], "key": [19], "considerations": [20], "in": [21], "design": [23], "of": [24, 39], "genome": [25], "editing": [26], "experiments,": [27], "and": [28, 32], "survey": [29], "tools": [31], "resources": [33], "currently": [34], "available": [35], "assist": [37], "users": [38], "this": [40], "technology.": [41]}, "counts_by_year": [{"year": 2025, "cited_by_count": 2}, {"year": 2024, "cited_by_count": 7}, {"year": 2023, "cited_by_count": 4}, {"year": 2022, "cited_by_count": 9}, {"year": 2021, "cited_by_count": 6}, {"year": 2020, "cited_by_count": 10}, {"year": 2019, "cited_by_count": 17}, {"year": 2018, "cited_by_count": 12}, {"year": 2017, "cited_by_count": 19}, {"year": 2016, "cited_by_count": 18}, {"year": 2015, "cited_by_count": 1}], "updated_date": "2026-04-21T08:09:41.155169", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2560230043", "doi": "https://doi.org/10.1038/nbt.3737", "title": "Multiplex gene editing by CRISPR\u2013Cpf1 using a single crRNA array", "display_name": "Multiplex gene editing by CRISPR\u2013Cpf1 using a single crRNA array", "relevance_score": 1325.6936, "publication_year": 2016, "publication_date": "2016-12-05", "ids": {"openalex": "https://openalex.org/W2560230043", "doi": "https://doi.org/10.1038/nbt.3737", "mag": "2560230043", "pmid": "https://pubmed.ncbi.nlm.nih.gov/27918548"}, "language": "en", "primary_location": {"id": "doi:10.1038/nbt.3737", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/nbt.3737", "pdf_url": "https://www.nature.com/articles/nbt.3737.pdf", "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "bronze", "oa_url": "https://www.nature.com/articles/nbt.3737.pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5057978685", "display_name": "Bernd Zetsche", "orcid": null}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I135140700", "display_name": "University of Bonn", "ror": "https://ror.org/041nas322", "country_code": "DE", "type": "education", "lineage": ["https://openalex.org/I135140700"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["DE", "US"], "is_corresponding": true, "raw_author_name": "Bernd Zetsche", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Developmental Pathology, Institute of Pathology, Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Developmental Pathology, Institute of Pathology, Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany", "institution_ids": ["https://openalex.org/I135140700"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5004735970", "display_name": "Matthias Heidenreich", "orcid": null}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Matthias Heidenreich", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5055499513", "display_name": "Prarthana Mohanraju", "orcid": "https://orcid.org/0000-0002-4766-8660"}, "institutions": [{"id": "https://openalex.org/I913481162", "display_name": "Wageningen University & Research", "ror": "https://ror.org/04qw24q55", "country_code": "NL", "type": "education", "lineage": ["https://openalex.org/I913481162"]}], "countries": ["NL"], "is_corresponding": false, "raw_author_name": "Prarthana Mohanraju", "raw_affiliation_strings": ["Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}, {"raw_affiliation_string": "Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5029919793", "display_name": "Iana Fedorova", "orcid": "https://orcid.org/0000-0001-6144-173X"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I125989756", "display_name": "Skolkovo Institute of Science and Technology", "ror": "https://ror.org/03f9nc143", "country_code": "RU", "type": "education", "lineage": ["https://openalex.org/I125989756"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I212220629", "display_name": "Peter the Great St. Petersburg Polytechnic University", "ror": "https://ror.org/02x91aj62", "country_code": "RU", "type": "education", "lineage": ["https://openalex.org/I212220629"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["RU", "US"], "is_corresponding": false, "raw_author_name": "Iana Fedorova", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Peter the Great St.Petersburg Polytechinc University, St. Petersburg, 195251, Russia", "Skolkovo Institute of Science and Technology, Skolkovo, 143025, Russia", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Peter the Great St.Petersburg Polytechinc University, St. Petersburg, 195251, Russia", "institution_ids": ["https://openalex.org/I212220629"]}, {"raw_affiliation_string": "Skolkovo Institute of Science and Technology, Skolkovo, 143025, Russia", "institution_ids": ["https://openalex.org/I125989756"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5054834988", "display_name": "Jeroen Kneppers", "orcid": "https://orcid.org/0000-0002-6548-2480"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I913481162", "display_name": "Wageningen University & Research", "ror": "https://ror.org/04qw24q55", "country_code": "NL", "type": "education", "lineage": ["https://openalex.org/I913481162"]}], "countries": ["NL", "US"], "is_corresponding": false, "raw_author_name": "Jeroen Kneppers", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5042872079", "display_name": "Ellen M. DeGennaro", "orcid": "https://orcid.org/0000-0001-5506-6451"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I4210092658", "display_name": "Harvard\u2013MIT Division of Health Sciences and Technology", "ror": "https://ror.org/00jjeh629", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I4210092658"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Ellen M DeGennaro", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": "https://orcid.org/0000-0001-5506-6451", "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I4210092658", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5038893330", "display_name": "Nerges Winblad", "orcid": null}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Nerges Winblad", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5065454360", "display_name": "Sourav Choudhury", "orcid": "https://orcid.org/0000-0001-9678-8688"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Sourav R Choudhury", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5033170303", "display_name": "Omar O. Abudayyeh", "orcid": "https://orcid.org/0000-0002-7979-3220"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I4210092658", "display_name": "Harvard\u2013MIT Division of Health Sciences and Technology", "ror": "https://ror.org/00jjeh629", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I4210092658"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Omar O Abudayyeh", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I4210092658", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5063743060", "display_name": "Jonathan S. Gootenberg", "orcid": "https://orcid.org/0000-0003-2757-2175"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I136199984", "display_name": "Harvard University", "ror": "https://ror.org/03vek6s52", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I136199984"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I4210155419", "display_name": "Center for Systems Biology", "ror": "https://ror.org/05r3dyn47", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I136199984", "https://openalex.org/I4210087915", "https://openalex.org/I4210155419", "https://openalex.org/I48633490"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Jonathan S Gootenberg", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Systems Biology, Harvard Medical School, Boston, MA 02115", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Systems Biology, Harvard Medical School, Boston, MA 02115", "institution_ids": ["https://openalex.org/I4210155419", "https://openalex.org/I136199984"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5007907314", "display_name": "Wen Y. Wu", "orcid": "https://orcid.org/0000-0001-7147-7293"}, "institutions": [{"id": "https://openalex.org/I913481162", "display_name": "Wageningen University & Research", "ror": "https://ror.org/04qw24q55", "country_code": "NL", "type": "education", "lineage": ["https://openalex.org/I913481162"]}], "countries": ["NL"], "is_corresponding": false, "raw_author_name": "Wen Y Wu", "raw_affiliation_strings": ["Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}, {"raw_affiliation_string": "Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5014584828", "display_name": "David Scott", "orcid": "https://orcid.org/0000-0001-7323-2169"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "David A Scott", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I107606265"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5056880626", "display_name": "Konstantin Severinov", "orcid": "https://orcid.org/0000-0001-9706-450X"}, "institutions": [{"id": "https://openalex.org/I102322142", "display_name": "Rutgers, The State University of New Jersey", "ror": "https://ror.org/05vt9qd57", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I102322142"]}, {"id": "https://openalex.org/I125989756", "display_name": "Skolkovo Institute of Science and Technology", "ror": "https://ror.org/03f9nc143", "country_code": "RU", "type": "education", "lineage": ["https://openalex.org/I125989756"]}, {"id": "https://openalex.org/I4210131892", "display_name": "Institute of Molecular Genetics", "ror": "https://ror.org/03apz2q12", "country_code": "RU", "type": "facility", "lineage": ["https://openalex.org/I1313323035", "https://openalex.org/I4210129690", "https://openalex.org/I4210131892"]}], "countries": ["RU", "US"], "is_corresponding": false, "raw_author_name": "Konstantin Severinov", "raw_affiliation_strings": ["Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia", "Skolkovo Institute of Science and Technology, Skolkovo, 143025, Russia", "Waksman Institute for Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA", "Skolkovo Institute of Science and Technology, Skolkovo, Russia"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia", "institution_ids": ["https://openalex.org/I4210131892"]}, {"raw_affiliation_string": "Skolkovo Institute of Science and Technology, Skolkovo, 143025, Russia", "institution_ids": ["https://openalex.org/I125989756"]}, {"raw_affiliation_string": "Waksman Institute for Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA", "institution_ids": ["https://openalex.org/I102322142"]}, {"raw_affiliation_string": "Skolkovo Institute of Science and Technology, Skolkovo, Russia", "institution_ids": ["https://openalex.org/I125989756"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5010586842", "display_name": "John van der Oost", "orcid": "https://orcid.org/0000-0001-5024-1871"}, "institutions": [{"id": "https://openalex.org/I913481162", "display_name": "Wageningen University & Research", "ror": "https://ror.org/04qw24q55", "country_code": "NL", "type": "education", "lineage": ["https://openalex.org/I913481162"]}], "countries": ["NL"], "is_corresponding": false, "raw_author_name": "John van der Oost", "raw_affiliation_strings": ["Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708 WE Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}, {"raw_affiliation_string": "Department of Agrotechnology and Food Sciences, Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands", "institution_ids": ["https://openalex.org/I913481162"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5100401298", "display_name": "Feng Zhang", "orcid": "https://orcid.org/0000-0003-0178-7995"}, "institutions": [{"id": "https://openalex.org/I107606265", "display_name": "Broad Institute", "ror": "https://ror.org/05a0ya142", "country_code": "US", "type": "nonprofit", "lineage": ["https://openalex.org/I107606265"]}, {"id": "https://openalex.org/I144112489", "display_name": "McGovern Institute for Brain Research", "ror": "https://ror.org/05ymca674", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"id": "https://openalex.org/I63966007", "display_name": "Massachusetts Institute of Technology", "ror": "https://ror.org/042nb2s44", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I63966007"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Feng Zhang", "raw_affiliation_strings": ["Broad Institute of MIT and Harvard, Cambridge, MA 02142", "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Broad Institute of MIT and Harvard, Cambridge, MA 02142", "institution_ids": ["https://openalex.org/I107606265"]}, {"raw_affiliation_string": "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}, {"raw_affiliation_string": "McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA", "institution_ids": ["https://openalex.org/I144112489", "https://openalex.org/I63966007"]}]}], "institutions": [], "countries_distinct_count": 4, "institutions_distinct_count": 15, "corresponding_author_ids": ["https://openalex.org/A5057978685"], "corresponding_institution_ids": ["https://openalex.org/I107606265", "https://openalex.org/I135140700", "https://openalex.org/I144112489", "https://openalex.org/I63966007"], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 52.0495, "has_fulltext": true, "cited_by_count": 975, "citation_normalized_percentile": {"value": 0.99927221, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "35", "issue": "1", "first_page": "31", "last_page": "34"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12610", "display_name": "RNA regulation and disease", "score": 0.9930999875068665, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10521", "display_name": "RNA and protein synthesis mechanisms", "score": 0.9815000295639038, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/trans-activating-crrna", "display_name": "Trans-activating crRNA", "score": 0.9942735433578491}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8931773900985718}, {"id": "https://openalex.org/keywords/multiplex", "display_name": "Multiplex", "score": 0.8036113977432251}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7349364757537842}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.6456921696662903}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.5465705990791321}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5049925446510315}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.47706687450408936}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.44538065791130066}, {"id": "https://openalex.org/keywords/rna", "display_name": "RNA", "score": 0.42743220925331116}, {"id": "https://openalex.org/keywords/crispr-interference", "display_name": "CRISPR interference", "score": 0.4207402169704437}], "concepts": [{"id": "https://openalex.org/C84356384", "wikidata": "https://www.wikidata.org/wiki/Q7833575", "display_name": "Trans-activating crRNA", "level": 5, "score": 0.9942735433578491}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8931773900985718}, {"id": "https://openalex.org/C2781188995", "wikidata": "https://www.wikidata.org/wiki/Q6934982", "display_name": "Multiplex", "level": 2, "score": 0.8036113977432251}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7349364757537842}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.6456921696662903}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.5465705990791321}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5049925446510315}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.47706687450408936}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.44538065791130066}, {"id": "https://openalex.org/C67705224", "wikidata": "https://www.wikidata.org/wiki/Q11053", "display_name": "RNA", "level": 3, "score": 0.42743220925331116}, {"id": "https://openalex.org/C154055011", "wikidata": "https://www.wikidata.org/wiki/Q28208918", "display_name": "CRISPR interference", "level": 5, "score": 0.4207402169704437}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D001426", "descriptor_name": "Bacterial Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012329", "descriptor_name": "RNA, Bacterial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012329", "descriptor_name": "RNA, Bacterial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012329", "descriptor_name": "RNA, Bacterial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017423", "descriptor_name": "Sequence Analysis, RNA", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D017423", "descriptor_name": "Sequence Analysis, RNA", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D017423", "descriptor_name": "Sequence Analysis, RNA", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064130", "descriptor_name": "CRISPR-Associated Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064130", "descriptor_name": "CRISPR-Associated Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064130", "descriptor_name": "CRISPR-Associated Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 6, "locations": [{"id": "doi:10.1038/nbt.3737", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/nbt.3737", "pdf_url": "https://www.nature.com/articles/nbt.3737.pdf", "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, {"id": "pmid:27918548", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/27918548", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature biotechnology", "raw_type": null}, {"id": "pmh:oai:dash.harvard.edu:1/33490901", "is_oa": true, "landing_page_url": "http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490901", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401540", "display_name": "Digital Access to Scholarship at Harvard (DASH) (Harvard University)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I136199984", "host_organization_name": "Harvard University", "host_organization_lineage": ["https://openalex.org/I136199984"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "", "raw_type": "Journal Article"}, {"id": "pmh:oai:dspace.mit.edu:1721.1/112728", "is_oa": true, "landing_page_url": "http://hdl.handle.net/1721.1/112728", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400425", "display_name": "DSpace@MIT (Massachusetts Institute of Technology)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I63966007", "host_organization_name": "Massachusetts Institute of Technology", "host_organization_lineage": ["https://openalex.org/I63966007"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-nc-sa", "license_id": "https://openalex.org/licenses/cc-by-nc-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "PMC", "raw_type": "http://purl.org/eprint/type/JournalArticle"}, {"id": "pmh:oai:europepmc.org:4308197", "is_oa": false, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/5225075", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400806", "display_name": "Europe PMC (PubMed Central)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1303153112", "host_organization_name": "European Bioinformatics Institute", "host_organization_lineage": ["https://openalex.org/I1303153112"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "Text"}, {"id": "pmh:wur:oai:library.wur.nl:wurpubs/515177", "is_oa": false, "landing_page_url": "https://research.wur.nl/en/publications/multiplex-gene-editing-by-crispr-cpf1-using-a-single-crrna-array", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401843", "display_name": "Data Archiving and Networked Services (DANS)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1322597698", "host_organization_name": "Royal Netherlands Academy of Arts and Sciences", "host_organization_lineage": ["https://openalex.org/I1322597698"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nature Biotechnology, 35(1), 31 - 34", "raw_type": "info:eu-repo/semantics/article"}], "best_oa_location": {"id": "doi:10.1038/nbt.3737", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/nbt.3737", "pdf_url": "https://www.nature.com/articles/nbt.3737.pdf", "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G1860631963", "display_name": null, "funder_award_id": "1R01-MH110049", "funder_id": "https://openalex.org/F4320337346", "funder_display_name": "National Institute of Mental Health"}, {"id": "https://openalex.org/G2748894717", "display_name": null, "funder_award_id": "1R01-MH110049", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G3273498006", "display_name": null, "funder_award_id": "5DP1-MH100706", "funder_id": "https://openalex.org/F4320337346", "funder_display_name": "National Institute of Mental Health"}, {"id": "https://openalex.org/G3397940999", "display_name": null, "funder_award_id": "GM10407", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G3431063522", "display_name": null, "funder_award_id": "5T32EB1680", "funder_id": "https://openalex.org/F4320337363", "funder_display_name": "National Institute of Biomedical Imaging and Bioengineering"}, {"id": "https://openalex.org/G6849282048", "display_name": null, "funder_award_id": "714.015.001", "funder_id": "https://openalex.org/F4320321800", "funder_display_name": "Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}, {"id": "https://openalex.org/G7754754430", "display_name": null, "funder_award_id": "14-14-00988", "funder_id": "https://openalex.org/F4320324099", "funder_display_name": "Russian Science Foundation"}, {"id": "https://openalex.org/G7777413872", "display_name": null, "funder_award_id": "5DP1-MH100706", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G8062297747", "display_name": null, "funder_award_id": "5T32EB1680", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}], "funders": [{"id": "https://openalex.org/F4320321800", "display_name": "Nederlandse Organisatie voor Wetenschappelijk Onderzoek", "ror": "https://ror.org/04jsz6e67"}, {"id": "https://openalex.org/F4320324099", "display_name": "Russian Science Foundation", "ror": "https://ror.org/03y2gwe85"}, {"id": "https://openalex.org/F4320324442", "display_name": "Skolkovo Institute of Science and Technology", "ror": "https://ror.org/03f9nc143"}, {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}, {"id": "https://openalex.org/F4320334399", "display_name": "McGovern Institute for Brain Research, Massachusetts Institute of Technology", "ror": "https://ror.org/05ymca674"}, {"id": "https://openalex.org/F4320337346", "display_name": "National Institute of Mental Health", "ror": "https://ror.org/04xeg9z08"}, {"id": "https://openalex.org/F4320337363", "display_name": "National Institute of Biomedical Imaging and Bioengineering", "ror": "https://ror.org/00372qc85"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W2560230043.pdf", "grobid_xml": "https://content.openalex.org/works/W2560230043.grobid-xml"}, "referenced_works_count": 15, "referenced_works": ["https://openalex.org/W1992783297", "https://openalex.org/W2008282952", "https://openalex.org/W2028543816", "https://openalex.org/W2036176224", "https://openalex.org/W2056512830", "https://openalex.org/W2070172761", "https://openalex.org/W2107959600", "https://openalex.org/W2111648798", "https://openalex.org/W2126259097", "https://openalex.org/W2156319424", "https://openalex.org/W2161645441", "https://openalex.org/W2165869860", "https://openalex.org/W2341405505", "https://openalex.org/W2407657213", "https://openalex.org/W4239521868"], "related_works": ["https://openalex.org/W2901315592", "https://openalex.org/W2567387264", "https://openalex.org/W4311710403", "https://openalex.org/W2914820709", "https://openalex.org/W2470941003", "https://openalex.org/W4220960485", "https://openalex.org/W3156022767", "https://openalex.org/W2317788533", "https://openalex.org/W1988378555", "https://openalex.org/W2564226239"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 20}, {"year": 2025, "cited_by_count": 69}, {"year": 2024, "cited_by_count": 98}, {"year": 2023, "cited_by_count": 125}, {"year": 2022, "cited_by_count": 113}, {"year": 2021, "cited_by_count": 131}, {"year": 2020, "cited_by_count": 121}, {"year": 2019, "cited_by_count": 113}, {"year": 2018, "cited_by_count": 96}, {"year": 2017, "cited_by_count": 88}, {"year": 2016, "cited_by_count": 1}], "updated_date": "2026-05-19T08:33:51.333923", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2066783444", "doi": "https://doi.org/10.1038/nbt.3199", "title": "Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers", "display_name": "Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers", "relevance_score": 1306.094, "publication_year": 2015, "publication_date": "2015-04-06", "ids": {"openalex": "https://openalex.org/W2066783444", "doi": "https://doi.org/10.1038/nbt.3199", "mag": "2066783444", "pmid": "https://pubmed.ncbi.nlm.nih.gov/25849900"}, "language": "en", "primary_location": {"id": "doi:10.1038/nbt.3199", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nbt.3199", "pdf_url": null, "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "green", "oa_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/4430400", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5017014314", "display_name": "Isaac B. Hilton", "orcid": "https://orcid.org/0000-0002-3064-8532"}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Isaac B Hilton", "raw_affiliation_strings": ["1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA", "Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA"], "raw_orcid": "https://orcid.org/0000-0002-3064-8532", "affiliations": [{"raw_affiliation_string": "1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5055542392", "display_name": "Anthony D\u2019Ippolito", "orcid": "https://orcid.org/0000-0001-9245-762X"}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Anthony M D'Ippolito", "raw_affiliation_strings": ["1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] University Program in Genetics and Genomics, Duke University Medical Center, Durham, North Carolina, USA", "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] University Program in Genetics and Genomics, Duke University Medical Center, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5043105557", "display_name": "Christopher M. Vockley", "orcid": "https://orcid.org/0000-0003-1532-6786"}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Christopher M Vockley", "raw_affiliation_strings": ["1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA", "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5039325927", "display_name": "Pratiksha I. Thakore", "orcid": null}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Pratiksha I Thakore", "raw_affiliation_strings": ["1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA", "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5040856457", "display_name": "Gregory E. Crawford", "orcid": "https://orcid.org/0000-0001-6106-2772"}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}, {"id": "https://openalex.org/I4210126298", "display_name": "Duke Medical Center", "ror": "https://ror.org/03njmea73", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I4210126298", "https://openalex.org/I4210144876"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Gregory E Crawford", "raw_affiliation_strings": ["1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Durham, North Carolina, USA", "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I4210126298", "https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5018030255", "display_name": "Timothy E. Reddy", "orcid": "https://orcid.org/0000-0002-7629-061X"}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Timothy E Reddy", "raw_affiliation_strings": ["1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Biostatistics &Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA", "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA"], "raw_orcid": "https://orcid.org/0000-0002-7629-061X", "affiliations": [{"raw_affiliation_string": "1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Biostatistics &Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5076902342", "display_name": "Charles A. Gersbach", "orcid": "https://orcid.org/0000-0003-1478-4013"}, "institutions": [{"id": "https://openalex.org/I170897317", "display_name": "Duke University", "ror": "https://ror.org/00py81415", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I170897317"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Charles A Gersbach", "raw_affiliation_strings": ["1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [3] Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA", "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [3] Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}, {"raw_affiliation_string": "Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA", "institution_ids": ["https://openalex.org/I170897317"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 7, "corresponding_author_ids": ["https://openalex.org/A5017014314"], "corresponding_institution_ids": ["https://openalex.org/I170897317"], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 100.8861, "has_fulltext": false, "cited_by_count": 1861, "citation_normalized_percentile": {"value": 0.99986294, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 94, "max": 100}, "biblio": {"volume": "33", "issue": "5", "first_page": "510", "last_page": "517"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10207", "display_name": "Advanced biosensing and bioanalysis techniques", "score": 0.9955000281333923, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12610", "display_name": "RNA regulation and disease", "score": 0.9919999837875366, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/enhancer", "display_name": "Enhancer", "score": 0.707273006439209}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.686532199382782}, {"id": "https://openalex.org/keywords/acetyltransferase", "display_name": "Acetyltransferase", "score": 0.6763702630996704}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.6234729290008545}, {"id": "https://openalex.org/keywords/promoter", "display_name": "Promoter", "score": 0.573410153388977}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.5694168210029602}, {"id": "https://openalex.org/keywords/epigenome", "display_name": "Epigenome", "score": 0.5340648293495178}, {"id": "https://openalex.org/keywords/histone-acetyltransferase", "display_name": "Histone acetyltransferase", "score": 0.530469536781311}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.44970178604125977}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.4482477307319641}, {"id": "https://openalex.org/keywords/regulation-of-gene-expression", "display_name": "Regulation of gene expression", "score": 0.4453500211238861}, {"id": "https://openalex.org/keywords/epigenetics", "display_name": "Epigenetics", "score": 0.44513097405433655}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.4298282861709595}, {"id": "https://openalex.org/keywords/acetylation", "display_name": "Acetylation", "score": 0.291853666305542}, {"id": "https://openalex.org/keywords/gene-expression", "display_name": "Gene expression", "score": 0.2775634229183197}, {"id": "https://openalex.org/keywords/dna-methylation", "display_name": "DNA methylation", "score": 0.2514105439186096}], "concepts": [{"id": "https://openalex.org/C111936080", "wikidata": "https://www.wikidata.org/wiki/Q913367", "display_name": "Enhancer", "level": 4, "score": 0.707273006439209}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.686532199382782}, {"id": "https://openalex.org/C2779649592", "wikidata": "https://www.wikidata.org/wiki/Q2655970", "display_name": "Acetyltransferase", "level": 4, "score": 0.6763702630996704}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.6234729290008545}, {"id": "https://openalex.org/C101762097", "wikidata": "https://www.wikidata.org/wiki/Q224093", "display_name": "Promoter", "level": 4, "score": 0.573410153388977}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.5694168210029602}, {"id": "https://openalex.org/C117717151", "wikidata": "https://www.wikidata.org/wiki/Q3589155", "display_name": "Epigenome", "level": 5, "score": 0.5340648293495178}, {"id": "https://openalex.org/C2778001298", "wikidata": "https://www.wikidata.org/wiki/Q1036906", "display_name": "Histone acetyltransferase", "level": 4, "score": 0.530469536781311}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.44970178604125977}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.4482477307319641}, {"id": "https://openalex.org/C165864922", "wikidata": "https://www.wikidata.org/wiki/Q411391", "display_name": "Regulation of gene expression", "level": 3, "score": 0.4453500211238861}, {"id": "https://openalex.org/C41091548", "wikidata": "https://www.wikidata.org/wiki/Q26939", "display_name": "Epigenetics", "level": 3, "score": 0.44513097405433655}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.4298282861709595}, {"id": "https://openalex.org/C119157956", "wikidata": "https://www.wikidata.org/wiki/Q796604", "display_name": "Acetylation", "level": 3, "score": 0.291853666305542}, {"id": "https://openalex.org/C150194340", "wikidata": "https://www.wikidata.org/wiki/Q26972", "display_name": "Gene expression", "level": 3, "score": 0.2775634229183197}, {"id": "https://openalex.org/C190727270", "wikidata": "https://www.wikidata.org/wiki/Q874745", "display_name": "DNA methylation", "level": 4, "score": 0.2514105439186096}], "mesh": [{"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000123", "descriptor_name": "Acetyltransferases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000123", "descriptor_name": "Acetyltransferases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000123", "descriptor_name": "Acetyltransferases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000123", "descriptor_name": "Acetyltransferases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004742", "descriptor_name": "Enhancer Elements, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D004742", "descriptor_name": "Enhancer Elements, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D004742", "descriptor_name": "Enhancer Elements, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D004742", "descriptor_name": "Enhancer Elements, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011401", "descriptor_name": "Promoter Regions, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011401", "descriptor_name": "Promoter Regions, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011401", "descriptor_name": "Promoter Regions, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011401", "descriptor_name": "Promoter Regions, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015533", "descriptor_name": "Transcriptional Activation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015533", "descriptor_name": "Transcriptional Activation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015533", "descriptor_name": "Transcriptional Activation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015533", "descriptor_name": "Transcriptional Activation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017393", "descriptor_name": "RNA Editing", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017394", "descriptor_name": "RNA, Guide, Kinetoplastida", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D050881", "descriptor_name": "E1A-Associated p300 Protein", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D050881", "descriptor_name": "E1A-Associated p300 Protein", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D050881", "descriptor_name": "E1A-Associated p300 Protein", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D050881", "descriptor_name": "E1A-Associated p300 Protein", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D057809", "descriptor_name": "HEK293 Cells", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D057809", "descriptor_name": "HEK293 Cells", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D057809", "descriptor_name": "HEK293 Cells", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D057809", "descriptor_name": "HEK293 Cells", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D057890", "descriptor_name": "Epigenomics", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057890", "descriptor_name": "Epigenomics", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057890", "descriptor_name": "Epigenomics", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057890", "descriptor_name": "Epigenomics", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 4, "locations": [{"id": "doi:10.1038/nbt.3199", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nbt.3199", "pdf_url": null, "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, {"id": "pmid:25849900", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/25849900", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature biotechnology", "raw_type": null}, {"id": "pmh:oai:CiteSeerX.psu:10.1.1.795.11", "is_oa": false, "landing_page_url": "http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.795.11", "pdf_url": null, "source": null, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/53/d2/nihms672873.PMC4430400.pdf", "raw_type": "text"}, {"id": "pmh:oai:pubmedcentral.nih.gov:4430400", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/4430400", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat Biotechnol", "raw_type": "Text"}], "best_oa_location": {"id": "pmh:oai:pubmedcentral.nih.gov:4430400", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/4430400", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat Biotechnol", "raw_type": "Text"}, "sustainable_development_goals": [], "awards": [], "funders": [], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 60, "referenced_works": ["https://openalex.org/W1965423091", "https://openalex.org/W1968342623", "https://openalex.org/W1971439989", "https://openalex.org/W1980744841", "https://openalex.org/W1985063313", "https://openalex.org/W2003171404", "https://openalex.org/W2004335766", "https://openalex.org/W2016161982", "https://openalex.org/W2017745115", "https://openalex.org/W2020977773", "https://openalex.org/W2025995838", "https://openalex.org/W2026520402", "https://openalex.org/W2030994161", "https://openalex.org/W2032141669", "https://openalex.org/W2037056861", "https://openalex.org/W2037573370", "https://openalex.org/W2038849570", "https://openalex.org/W2045435533", "https://openalex.org/W2050480410", "https://openalex.org/W2051520501", "https://openalex.org/W2055916860", "https://openalex.org/W2059244281", "https://openalex.org/W2061650108", "https://openalex.org/W2062186651", "https://openalex.org/W2064815984", "https://openalex.org/W2075230442", "https://openalex.org/W2077381938", "https://openalex.org/W2081904494", "https://openalex.org/W2084160423", "https://openalex.org/W2085090468", "https://openalex.org/W2094339263", "https://openalex.org/W2096261947", "https://openalex.org/W2101749257", "https://openalex.org/W2103081715", "https://openalex.org/W2108234281", "https://openalex.org/W2111648798", "https://openalex.org/W2114570899", "https://openalex.org/W2121659981", "https://openalex.org/W2122836421", "https://openalex.org/W2127862779", "https://openalex.org/W2128029143", "https://openalex.org/W2129194497", "https://openalex.org/W2135832165", "https://openalex.org/W2146527422", "https://openalex.org/W2149142532", "https://openalex.org/W2151754128", "https://openalex.org/W2152102410", "https://openalex.org/W2152505144", "https://openalex.org/W2154746182", "https://openalex.org/W2155809137", "https://openalex.org/W2155968127", "https://openalex.org/W2160051211", "https://openalex.org/W2163173465", "https://openalex.org/W2165195079", "https://openalex.org/W2167124481", "https://openalex.org/W2169373177", "https://openalex.org/W2170551349", "https://openalex.org/W2259938310", "https://openalex.org/W4206892629", "https://openalex.org/W4292230674"], "related_works": ["https://openalex.org/W2901315592", "https://openalex.org/W4311710403", "https://openalex.org/W2067886088", "https://openalex.org/W1995910339", "https://openalex.org/W2626278962", "https://openalex.org/W4288777264", "https://openalex.org/W4311501380", "https://openalex.org/W3137982617", "https://openalex.org/W2390994276", "https://openalex.org/W2603161682"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 52}, {"year": 2025, "cited_by_count": 130}, {"year": 2024, "cited_by_count": 154}, {"year": 2023, "cited_by_count": 144}, {"year": 2022, "cited_by_count": 181}, {"year": 2021, "cited_by_count": 181}, {"year": 2020, "cited_by_count": 154}, {"year": 2019, "cited_by_count": 196}, {"year": 2018, "cited_by_count": 205}, {"year": 2017, "cited_by_count": 198}, {"year": 2016, "cited_by_count": 190}, {"year": 2015, "cited_by_count": 74}, {"year": 2014, "cited_by_count": 2}], "updated_date": "2026-05-20T08:49:12.498775", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3030186330", "doi": "https://doi.org/10.1172/jci136873", "title": "Correction of muscular dystrophies by CRISPR gene editing", "display_name": "Correction of muscular dystrophies by CRISPR gene editing", "relevance_score": 1303.5555, "publication_year": 2020, "publication_date": "2020-05-31", "ids": {"openalex": "https://openalex.org/W3030186330", "doi": "https://doi.org/10.1172/jci136873", "mag": "3030186330", "pmid": "https://pubmed.ncbi.nlm.nih.gov/32478678"}, "language": "en", "primary_location": {"id": "doi:10.1172/jci136873", "is_oa": true, "landing_page_url": "https://doi.org/10.1172/jci136873", "pdf_url": "http://www.jci.org/articles/view/136873/files/pdf", "source": {"id": "https://openalex.org/S114430552", "display_name": "Journal of Clinical Investigation", "issn_l": "0021-9738", "issn": ["0021-9738", "1558-8238"], "is_oa": false, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320279", "host_organization_name": "American Society for Clinical Investigation", "host_organization_lineage": ["https://openalex.org/P4310320279"], "host_organization_lineage_names": ["American Society for Clinical Investigation"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Journal of Clinical Investigation", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "bronze", "oa_url": "http://www.jci.org/articles/view/136873/files/pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5071880908", "display_name": "Francesco Chemello", "orcid": "https://orcid.org/0000-0002-3877-527X"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Francesco Chemello", "raw_affiliation_strings": ["Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5024308650", "display_name": "Rhonda Bassel\u2010Duby", "orcid": "https://orcid.org/0000-0001-7568-410X"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Rhonda Bassel-Duby", "raw_affiliation_strings": ["Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5084182062", "display_name": "Eric N. Olson", "orcid": "https://orcid.org/0000-0003-1151-8262"}, "institutions": [{"id": "https://openalex.org/I867280407", "display_name": "The University of Texas Southwestern Medical Center", "ror": "https://ror.org/05byvp690", "country_code": "US", "type": "healthcare", "lineage": ["https://openalex.org/I867280407"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Eric N. Olson", "raw_affiliation_strings": ["Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, and Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA", "institution_ids": ["https://openalex.org/I867280407"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 3, "corresponding_author_ids": ["https://openalex.org/A5071880908"], "corresponding_institution_ids": ["https://openalex.org/I867280407"], "apc_list": {"value": 5200, "currency": "USD", "value_usd": 5200}, "apc_paid": null, "fwci": 5.5846, "has_fulltext": true, "cited_by_count": 96, "citation_normalized_percentile": {"value": 0.97048236, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 96, "max": 100}, "biblio": {"volume": "130", "issue": "6", "first_page": "2766", "last_page": "2776"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10505", "display_name": "Pluripotent Stem Cells Research", "score": 0.983299970626831, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10613", "display_name": "Virus-based gene therapy research", "score": 0.9818000197410583, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8637462258338928}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8450973033905029}, {"id": "https://openalex.org/keywords/duchenne-muscular-dystrophy", "display_name": "Duchenne muscular dystrophy", "score": 0.7210380434989929}, {"id": "https://openalex.org/keywords/muscular-dystrophy", "display_name": "Muscular dystrophy", "score": 0.7018393874168396}, {"id": "https://openalex.org/keywords/dystrophin", "display_name": "Dystrophin", "score": 0.5627655982971191}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5256052017211914}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.5019435882568359}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.4766203463077545}, {"id": "https://openalex.org/keywords/neuromuscular-disease", "display_name": "Neuromuscular disease", "score": 0.4736967086791992}, {"id": "https://openalex.org/keywords/mutation", "display_name": "Mutation", "score": 0.4591182768344879}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.4391811788082123}, {"id": "https://openalex.org/keywords/bioinformatics", "display_name": "Bioinformatics", "score": 0.4288833737373352}, {"id": "https://openalex.org/keywords/disease", "display_name": "Disease", "score": 0.34839850664138794}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.3438689112663269}, {"id": "https://openalex.org/keywords/medicine", "display_name": "Medicine", "score": 0.3434688448905945}, {"id": "https://openalex.org/keywords/pathology", "display_name": "Pathology", "score": 0.1720663607120514}], "concepts": [{"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8637462258338928}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8450973033905029}, {"id": "https://openalex.org/C2778943923", "wikidata": "https://www.wikidata.org/wiki/Q1648484", "display_name": "Duchenne muscular dystrophy", "level": 2, "score": 0.7210380434989929}, {"id": "https://openalex.org/C2779030066", "wikidata": "https://www.wikidata.org/wiki/Q1137767", "display_name": "Muscular dystrophy", "level": 2, "score": 0.7018393874168396}, {"id": "https://openalex.org/C2780394045", "wikidata": "https://www.wikidata.org/wiki/Q412285", "display_name": "Dystrophin", "level": 3, "score": 0.5627655982971191}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5256052017211914}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.5019435882568359}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.4766203463077545}, {"id": "https://openalex.org/C2776356578", "wikidata": "https://www.wikidata.org/wiki/Q2246789", "display_name": "Neuromuscular disease", "level": 3, "score": 0.4736967086791992}, {"id": "https://openalex.org/C501734568", "wikidata": "https://www.wikidata.org/wiki/Q42918", "display_name": "Mutation", "level": 3, "score": 0.4591182768344879}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.4391811788082123}, {"id": "https://openalex.org/C60644358", "wikidata": "https://www.wikidata.org/wiki/Q128570", "display_name": "Bioinformatics", "level": 1, "score": 0.4288833737373352}, {"id": "https://openalex.org/C2779134260", "wikidata": "https://www.wikidata.org/wiki/Q12136", "display_name": "Disease", "level": 2, "score": 0.34839850664138794}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.3438689112663269}, {"id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.3434688448905945}, {"id": "https://openalex.org/C142724271", "wikidata": "https://www.wikidata.org/wiki/Q7208", "display_name": "Pathology", "level": 1, "score": 0.1720663607120514}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009154", "descriptor_name": "Mutation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D009154", "descriptor_name": "Mutation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D009154", "descriptor_name": "Mutation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D009154", "descriptor_name": "Mutation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D016189", "descriptor_name": "Dystrophin", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D020388", "descriptor_name": "Muscular Dystrophy, Duchenne", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 4, "locations": [{"id": "doi:10.1172/jci136873", "is_oa": true, "landing_page_url": "https://doi.org/10.1172/jci136873", "pdf_url": "http://www.jci.org/articles/view/136873/files/pdf", "source": {"id": "https://openalex.org/S114430552", "display_name": "Journal of Clinical Investigation", "issn_l": "0021-9738", "issn": ["0021-9738", "1558-8238"], "is_oa": false, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320279", "host_organization_name": "American Society for Clinical Investigation", "host_organization_lineage": ["https://openalex.org/P4310320279"], "host_organization_lineage_names": ["American Society for Clinical Investigation"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Journal of Clinical Investigation", "raw_type": "journal-article"}, {"id": "pmid:32478678", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/32478678", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "The Journal of clinical investigation", "raw_type": null}, {"id": "pmh:oai:cris.unibo.it:11585/956189", "is_oa": true, "landing_page_url": "https://hdl.handle.net/11585/956189", "pdf_url": null, "source": {"id": "https://openalex.org/S4306402579", "display_name": "Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I4210117483", "host_organization_name": "Istituto di Ematologia di Bologna", "host_organization_lineage": ["https://openalex.org/I4210117483"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "info:eu-repo/semantics/article"}, {"id": "pmh:oai:pubmedcentral.nih.gov:7259998", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/7259998", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "J Clin Invest", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1172/jci136873", "is_oa": true, "landing_page_url": "https://doi.org/10.1172/jci136873", "pdf_url": "http://www.jci.org/articles/view/136873/files/pdf", "source": {"id": "https://openalex.org/S114430552", "display_name": "Journal of Clinical Investigation", "issn_l": "0021-9738", "issn": ["0021-9738", "1558-8238"], "is_oa": false, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320279", "host_organization_name": "American Society for Clinical Investigation", "host_organization_lineage": ["https://openalex.org/P4310320279"], "host_organization_lineage_names": ["American Society for Clinical Investigation"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Journal of Clinical Investigation", "raw_type": "journal-article"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/3", "display_name": "Good health and well-being", "score": 0.7200000286102295}], "awards": [{"id": "https://openalex.org/G3937595052", "display_name": null, "funder_award_id": "U54 HD 087351", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G4663413786", "display_name": null, "funder_award_id": "1-0025", "funder_id": "https://openalex.org/F4320306196", "funder_display_name": "Welch Foundation"}, {"id": "https://openalex.org/G5109713484", "display_name": null, "funder_award_id": "HD 087351", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G5371541093", "display_name": null, "funder_award_id": "HL-138426", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G6640290487", "display_name": null, "funder_award_id": "AR-067294", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}], "funders": [{"id": "https://openalex.org/F4320306196", "display_name": "Welch Foundation", "ror": "https://ror.org/00np6vq88"}, {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W3030186330.pdf", "grobid_xml": "https://content.openalex.org/works/W3030186330.grobid-xml"}, "referenced_works_count": 115, "referenced_works": ["https://openalex.org/W147075648", "https://openalex.org/W1636931877", "https://openalex.org/W1970196890", "https://openalex.org/W1987745724", "https://openalex.org/W1993432023", "https://openalex.org/W1997490017", "https://openalex.org/W1998867833", "https://openalex.org/W1999882780", "https://openalex.org/W2001962483", "https://openalex.org/W2008289270", "https://openalex.org/W2012145036", "https://openalex.org/W2014639769", "https://openalex.org/W2045435533", "https://openalex.org/W2046556168", "https://openalex.org/W2047474870", "https://openalex.org/W2050480410", "https://openalex.org/W2053820810", "https://openalex.org/W2055759663", "https://openalex.org/W2072832813", "https://openalex.org/W2082025265", "https://openalex.org/W2082328650", "https://openalex.org/W2085993152", "https://openalex.org/W2097136884", "https://openalex.org/W2129171086", "https://openalex.org/W2140188816", "https://openalex.org/W2141509764", "https://openalex.org/W2149644790", "https://openalex.org/W2169244146", "https://openalex.org/W2174602966", "https://openalex.org/W2188223075", "https://openalex.org/W2191094967", "https://openalex.org/W2196662084", "https://openalex.org/W2203460689", "https://openalex.org/W2205893844", "https://openalex.org/W2208696160", "https://openalex.org/W2224398381", "https://openalex.org/W2257132471", "https://openalex.org/W2278995756", "https://openalex.org/W2320983896", "https://openalex.org/W2321124448", "https://openalex.org/W2336828812", "https://openalex.org/W2401496253", "https://openalex.org/W2484964216", "https://openalex.org/W2508903105", "https://openalex.org/W2550079706", "https://openalex.org/W2568585891", "https://openalex.org/W2588637030", "https://openalex.org/W2593497080", "https://openalex.org/W2593956993", "https://openalex.org/W2607120679", "https://openalex.org/W2611661371", "https://openalex.org/W2611963233", "https://openalex.org/W2614090736", "https://openalex.org/W2726053863", "https://openalex.org/W2744732723", "https://openalex.org/W2755839104", "https://openalex.org/W2759402071", "https://openalex.org/W2762666183", "https://openalex.org/W2766599608", "https://openalex.org/W2775147596", "https://openalex.org/W2787206763", "https://openalex.org/W2792675259", "https://openalex.org/W2793661486", "https://openalex.org/W2794666622", "https://openalex.org/W2801038244", "https://openalex.org/W2801589383", "https://openalex.org/W2803581084", "https://openalex.org/W2810979552", "https://openalex.org/W2884946171", "https://openalex.org/W2885580646", "https://openalex.org/W2885949612", "https://openalex.org/W2889510460", "https://openalex.org/W2891962863", "https://openalex.org/W2895383514", "https://openalex.org/W2896386549", "https://openalex.org/W2897295193", "https://openalex.org/W2903482897", "https://openalex.org/W2904491638", "https://openalex.org/W2912550398", "https://openalex.org/W2912970291", "https://openalex.org/W2914658811", "https://openalex.org/W2916364858", "https://openalex.org/W2918808095", "https://openalex.org/W2939749480", "https://openalex.org/W2941626971", "https://openalex.org/W2943918361", "https://openalex.org/W2947777875", "https://openalex.org/W2948440285", "https://openalex.org/W2949380898", "https://openalex.org/W2950183003", "https://openalex.org/W2951012505", "https://openalex.org/W2954277806", "https://openalex.org/W2963548588", "https://openalex.org/W2964749670", "https://openalex.org/W2969567695", "https://openalex.org/W2970098032", "https://openalex.org/W2976425815", "https://openalex.org/W2978341767", "https://openalex.org/W2978626045", "https://openalex.org/W2979165129", "https://openalex.org/W2980405523", "https://openalex.org/W2981137429", "https://openalex.org/W2992446669", "https://openalex.org/W2993362393", "https://openalex.org/W3000375097", "https://openalex.org/W3002203125", "https://openalex.org/W3003248214", "https://openalex.org/W3004568198", "https://openalex.org/W3008434296", "https://openalex.org/W3032206113", "https://openalex.org/W6605997107", "https://openalex.org/W6650333006", "https://openalex.org/W6733677837", "https://openalex.org/W6758325983", "https://openalex.org/W6779116359"], "related_works": ["https://openalex.org/W2027588464", "https://openalex.org/W4380290265", "https://openalex.org/W2025620776", "https://openalex.org/W2794581573", "https://openalex.org/W1978523507", "https://openalex.org/W2328102844", "https://openalex.org/W1984951731", "https://openalex.org/W2108474119", "https://openalex.org/W2889220630", "https://openalex.org/W2043317882"], "abstract_inverted_index": {"Muscular": [0], "dystrophies": [1, 100, 125], "are": [2, 28, 113], "debilitating": [3], "disorders": [4], "that": [5], "result": [6], "in": [7, 69, 77], "progressive": [8], "weakness": [9], "and": [10, 19, 80, 95, 132], "degeneration": [11], "of": [12, 22, 25, 41, 136], "skeletal": [13], "muscle.": [14], "Although": [15], "the": [16, 50, 70, 92, 106, 128, 137], "genetic": [17], "mutations": [18, 52, 68, 104, 131], "clinical": [20], "abnormalities": [21], "a": [23, 120], "variety": [24], "neuromuscular": [26, 57], "diseases": [27], "well": [29], "known,": [30], "no": [31], "curative": [32], "therapies": [33], "have": [34], "been": [35, 74], "developed": [36], "to": [37, 48], "date.": [38], "The": [39], "advent": [40], "genome": [42], "editing": [43, 102], "technology": [44, 117], "provides": [45], "new": [46], "opportunities": [47], "correct": [49], "underlying": [51], "responsible": [53], "for": [54, 123], "many": [55], "monogenic": [56], "diseases.": [58], "For": [59], "example,": [60], "Duchenne": [61], "muscular": [62, 99, 124], "dystrophy,": [63], "which": [64], "is": [65], "caused": [66], "by": [67, 101, 126], "dystrophin": [71], "gene,": [72], "has": [73], "successfully": [75], "corrected": [76], "mice,": [78], "dogs,": [79], "human": [81], "cells": [82], "through": [83], "CRISPR/Cas9": [84], "editing.": [85], "In": [86], "this": [87], "Review,": [88], "we": [89], "focus": [90], "on": [91], "potential": [93], "for,": [94], "challenges": [96], "of,": [97], "correcting": [98, 127], "disease-causing": [103], "at": [105], "genomic": [107, 130], "level.": [108], "Ideally,": [109], "because": [110], "muscle": [111], "tissues": [112], "extremely": [114], "long-lived,": [115], "CRISPR": [116], "could": [118], "offer": [119], "one-time": [121], "treatment": [122], "culprit": [129], "enabling": [133], "normal": [134], "expression": [135], "repaired": [138], "gene.": [139]}, "counts_by_year": [{"year": 2026, "cited_by_count": 2}, {"year": 2025, "cited_by_count": 10}, {"year": 2024, "cited_by_count": 13}, {"year": 2023, "cited_by_count": 12}, {"year": 2022, "cited_by_count": 30}, {"year": 2021, "cited_by_count": 21}, {"year": 2020, "cited_by_count": 4}, {"year": 2019, "cited_by_count": 3}], "updated_date": "2026-05-19T08:33:51.333923", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2794543671", "doi": "https://doi.org/10.1053/j.ajkd.2018.02.347", "title": "CRISPR Gene Editing in the Kidney", "display_name": "CRISPR Gene Editing in the Kidney", "relevance_score": 1233.0077, "publication_year": 2018, "publication_date": "2018-03-30", "ids": {"openalex": "https://openalex.org/W2794543671", "doi": "https://doi.org/10.1053/j.ajkd.2018.02.347", "mag": "2794543671", "pmid": "https://pubmed.ncbi.nlm.nih.gov/29606501"}, "language": "en", "primary_location": {"id": "doi:10.1053/j.ajkd.2018.02.347", "is_oa": false, "landing_page_url": "https://doi.org/10.1053/j.ajkd.2018.02.347", "pdf_url": null, "source": {"id": "https://openalex.org/S18197459", "display_name": "American Journal of Kidney Diseases", "issn_l": "0272-6386", "issn": ["0272-6386", "1523-6838"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "American Journal of Kidney Diseases", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "green", "oa_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/6029248", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5033953081", "display_name": "Nelly M. Cruz", "orcid": "https://orcid.org/0000-0002-9040-6957"}, "institutions": [{"id": "https://openalex.org/I201448701", "display_name": "University of Washington", "ror": "https://ror.org/00cvxb145", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I201448701"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Nelly M. Cruz", "raw_affiliation_strings": ["Division of Nephrology, University of Washington School of Medicine, Seattle WA; Kidney Research Institute, University of Washington School of Medicine, Seattle WA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle WA; Department of Medicine, University of Washington School of Medicine, Seattle WA", "Kidney Research Institute, University of Washington School of Medicine, Seattle WA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Nephrology, University of Washington School of Medicine, Seattle WA; Kidney Research Institute, University of Washington School of Medicine, Seattle WA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle WA; Department of Medicine, University of Washington School of Medicine, Seattle WA", "institution_ids": []}, {"raw_affiliation_string": "Kidney Research Institute, University of Washington School of Medicine, Seattle WA", "institution_ids": ["https://openalex.org/I201448701"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5089043211", "display_name": "Benjamin Freedman", "orcid": "https://orcid.org/0000-0003-2228-7383"}, "institutions": [{"id": "https://openalex.org/I201448701", "display_name": "University of Washington", "ror": "https://ror.org/00cvxb145", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I201448701"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Benjamin S. Freedman", "raw_affiliation_strings": ["Division of Nephrology, University of Washington School of Medicine, Seattle WA; Kidney Research Institute, University of Washington School of Medicine, Seattle WA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle WA; Department of Medicine, University of Washington School of Medicine, Seattle WA. Electronic address: benof@uw.edu", "Division of Nephrology, University of Washington School of Medicine, Seattle WA", "Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle WA", "Department of Medicine, University of Washington School of Medicine, Seattle WA", "Kidney Research Institute, University of Washington School of Medicine, Seattle WA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Nephrology, University of Washington School of Medicine, Seattle WA; Kidney Research Institute, University of Washington School of Medicine, Seattle WA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle WA; Department of Medicine, University of Washington School of Medicine, Seattle WA. Electronic address: benof@uw.edu", "institution_ids": []}, {"raw_affiliation_string": "Division of Nephrology, University of Washington School of Medicine, Seattle WA", "institution_ids": ["https://openalex.org/I201448701"]}, {"raw_affiliation_string": "Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle WA", "institution_ids": ["https://openalex.org/I201448701"]}, {"raw_affiliation_string": "Department of Medicine, University of Washington School of Medicine, Seattle WA", "institution_ids": ["https://openalex.org/I201448701"]}, {"raw_affiliation_string": "Kidney Research Institute, University of Washington School of Medicine, Seattle WA", "institution_ids": ["https://openalex.org/I201448701"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5089043211"], "corresponding_institution_ids": ["https://openalex.org/I201448701"], "apc_list": {"value": 3700, "currency": "USD", "value_usd": 3700}, "apc_paid": null, "fwci": 2.1343, "has_fulltext": false, "cited_by_count": 68, "citation_normalized_percentile": {"value": 0.87919383, "is_in_top_1_percent": false, "is_in_top_10_percent": false}, "cited_by_percentile_year": {"min": 94, "max": 100}, "biblio": {"volume": "71", "issue": "6", "first_page": "874", "last_page": "883"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9995999932289124, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9995999932289124, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10505", "display_name": "Pluripotent Stem Cells Research", "score": 0.9868000149726868, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T13417", "display_name": "Biomedical Ethics and Regulation", "score": 0.9854000210762024, "subfield": {"id": "https://openalex.org/subfields/2737", "display_name": "Physiology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/medicine", "display_name": "Medicine", "score": 0.8446023464202881}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.7926180362701416}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.6579705476760864}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5368860960006714}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.47269749641418457}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.43014922738075256}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.0949108898639679}], "concepts": [{"id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.8446023464202881}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.7926180362701416}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.6579705476760864}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5368860960006714}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.47269749641418457}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.43014922738075256}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.0949108898639679}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005544", "descriptor_name": "Forecasting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005544", "descriptor_name": "Forecasting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005544", "descriptor_name": "Forecasting", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000453", "qualifier_name": "epidemiology", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000453", "qualifier_name": "epidemiology", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000453", "qualifier_name": "epidemiology", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D007674", "descriptor_name": "Kidney Diseases", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008297", "descriptor_name": "Male", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D016030", "descriptor_name": "Kidney Transplantation", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D016030", "descriptor_name": "Kidney Transplantation", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D016030", "descriptor_name": "Kidney Transplantation", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D016030", "descriptor_name": "Kidney Transplantation", "qualifier_ui": "Q000706", "qualifier_name": "statistics & numerical data", "is_major_topic": false}, {"descriptor_ui": "D016030", "descriptor_name": "Kidney Transplantation", "qualifier_ui": "Q000706", "qualifier_name": "statistics & numerical data", "is_major_topic": false}, {"descriptor_ui": "D016030", "descriptor_name": "Kidney Transplantation", "qualifier_ui": "Q000706", "qualifier_name": "statistics & numerical data", "is_major_topic": false}, {"descriptor_ui": "D016896", "descriptor_name": "Treatment Outcome", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016896", "descriptor_name": "Treatment Outcome", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016896", "descriptor_name": "Treatment Outcome", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018570", "descriptor_name": "Risk Assessment", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018570", "descriptor_name": "Risk Assessment", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018570", "descriptor_name": "Risk Assessment", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D039904", "descriptor_name": "Pluripotent Stem Cells", "qualifier_ui": "Q000637", "qualifier_name": "transplantation", "is_major_topic": false}, {"descriptor_ui": "D039904", "descriptor_name": "Pluripotent Stem Cells", "qualifier_ui": "Q000637", "qualifier_name": "transplantation", "is_major_topic": false}, {"descriptor_ui": "D039904", "descriptor_name": "Pluripotent Stem Cells", "qualifier_ui": "Q000637", "qualifier_name": "transplantation", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 3, "locations": [{"id": "doi:10.1053/j.ajkd.2018.02.347", "is_oa": false, "landing_page_url": "https://doi.org/10.1053/j.ajkd.2018.02.347", "pdf_url": null, "source": {"id": "https://openalex.org/S18197459", "display_name": "American Journal of Kidney Diseases", "issn_l": "0272-6386", "issn": ["0272-6386", "1523-6838"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "American Journal of Kidney Diseases", "raw_type": "journal-article"}, {"id": "pmid:29606501", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/29606501", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "American journal of kidney diseases : the official journal of the National Kidney Foundation", "raw_type": null}, {"id": "pmh:oai:pubmedcentral.nih.gov:6029248", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/6029248", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Am J Kidney Dis", "raw_type": "Text"}], "best_oa_location": {"id": "pmh:oai:pubmedcentral.nih.gov:6029248", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/6029248", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Am J Kidney Dis", "raw_type": "Text"}, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G4070432688", "display_name": null, "funder_award_id": "DK102826", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}], "funders": [{"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 82, "referenced_works": ["https://openalex.org/W1623951127", "https://openalex.org/W1802574002", "https://openalex.org/W1954897628", "https://openalex.org/W1963885877", "https://openalex.org/W1969418855", "https://openalex.org/W1973260880", "https://openalex.org/W1974343902", "https://openalex.org/W1982882278", "https://openalex.org/W1986094205", "https://openalex.org/W1986171241", "https://openalex.org/W1990487336", "https://openalex.org/W1991062831", "https://openalex.org/W2003171404", "https://openalex.org/W2010986636", "https://openalex.org/W2019670881", "https://openalex.org/W2023034253", "https://openalex.org/W2028030005", "https://openalex.org/W2031600175", "https://openalex.org/W2045435533", "https://openalex.org/W2058755882", "https://openalex.org/W2064815984", "https://openalex.org/W2068128688", "https://openalex.org/W2077190448", "https://openalex.org/W2084223203", "https://openalex.org/W2086943348", "https://openalex.org/W2090650873", "https://openalex.org/W2097932685", "https://openalex.org/W2107175020", "https://openalex.org/W2110623684", "https://openalex.org/W2114317477", "https://openalex.org/W2116228354", "https://openalex.org/W2127862779", "https://openalex.org/W2138977668", "https://openalex.org/W2141825721", "https://openalex.org/W2152426454", "https://openalex.org/W2160051211", "https://openalex.org/W2163248265", "https://openalex.org/W2167380395", "https://openalex.org/W2168245648", "https://openalex.org/W2169244146", "https://openalex.org/W2170039745", "https://openalex.org/W2176166968", "https://openalex.org/W2192723508", "https://openalex.org/W2196662084", "https://openalex.org/W2199356015", "https://openalex.org/W2203460689", "https://openalex.org/W2208696160", "https://openalex.org/W2230359219", "https://openalex.org/W2288966576", "https://openalex.org/W2289206353", "https://openalex.org/W2320086560", "https://openalex.org/W2418233049", "https://openalex.org/W2469359910", "https://openalex.org/W2470812035", "https://openalex.org/W2483515213", "https://openalex.org/W2520737352", "https://openalex.org/W2550079706", "https://openalex.org/W2555520932", "https://openalex.org/W2555626897", "https://openalex.org/W2557775641", "https://openalex.org/W2582801455", "https://openalex.org/W2588637030", "https://openalex.org/W2593766584", "https://openalex.org/W2595006106", "https://openalex.org/W2598118151", "https://openalex.org/W2604964915", "https://openalex.org/W2606091185", "https://openalex.org/W2616215756", "https://openalex.org/W2620315774", "https://openalex.org/W2626238587", "https://openalex.org/W2740810575", "https://openalex.org/W2742842976", "https://openalex.org/W2744732723", "https://openalex.org/W2753937826", "https://openalex.org/W2761500126", "https://openalex.org/W2762200378", "https://openalex.org/W2772697618", "https://openalex.org/W2775796188", "https://openalex.org/W2781260670", "https://openalex.org/W2952775612", "https://openalex.org/W4251402105", "https://openalex.org/W6689703947"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W4401335721"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 1}, {"year": 2025, "cited_by_count": 17}, {"year": 2024, "cited_by_count": 7}, {"year": 2023, "cited_by_count": 11}, {"year": 2022, "cited_by_count": 9}, {"year": 2021, "cited_by_count": 9}, {"year": 2020, "cited_by_count": 9}, {"year": 2019, "cited_by_count": 3}, {"year": 2018, "cited_by_count": 2}], "updated_date": "2026-05-16T08:24:45.110214", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2296396974", "doi": "https://doi.org/10.1038/531156a", "title": "CRISPR: gene editing is just the beginning", "display_name": "CRISPR: gene editing is just the beginning", "relevance_score": 1203.2164, "publication_year": 2016, "publication_date": "2016-03-07", "ids": {"openalex": "https://openalex.org/W2296396974", "doi": "https://doi.org/10.1038/531156a", "mag": "2296396974", "pmid": "https://pubmed.ncbi.nlm.nih.gov/26961639"}, "language": "en", "primary_location": {"id": "doi:10.1038/531156a", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/531156a", "pdf_url": "https://www.nature.com/news/polopoly_fs/1.19510!/menu/main/topColumns/topLeftColumn/pdf/531156a.pdf", "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "bronze", "oa_url": "https://www.nature.com/news/polopoly_fs/1.19510!/menu/main/topColumns/topLeftColumn/pdf/531156a.pdf", "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5051432932", "display_name": "Heidi Ledford", "orcid": null}, "institutions": [], "countries": [], "is_corresponding": true, "raw_author_name": "Heidi Ledford", "raw_affiliation_strings": [], "affiliations": []}], "institutions": [], "countries_distinct_count": 0, "institutions_distinct_count": 1, "corresponding_author_ids": ["https://openalex.org/A5051432932"], "corresponding_institution_ids": [], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 9.9357, "has_fulltext": false, "cited_by_count": 85, "citation_normalized_percentile": {"value": 0.98508916, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "531", "issue": "7593", "first_page": "156", "last_page": "159"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.986299991607666, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T12929", "display_name": "Animal Genetics and Reproduction", "score": 0.9348999857902527, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8530847430229187}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8052696585655212}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.5317234992980957}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.5269941687583923}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.4526297450065613}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.41337424516677856}, {"id": "https://openalex.org/keywords/computer-science", "display_name": "Computer science", "score": 0.3933877646923065}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.3244253695011139}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8530847430229187}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8052696585655212}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.5317234992980957}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.5269941687583923}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.4526297450065613}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.41337424516677856}, {"id": "https://openalex.org/C41008148", "wikidata": "https://www.wikidata.org/wiki/Q21198", "display_name": "Computer science", "level": 0, "score": 0.3933877646923065}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.3244253695011139}], "mesh": [{"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002144", "descriptor_name": "Callithrix", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D002144", "descriptor_name": "Callithrix", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D002144", "descriptor_name": "Callithrix", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004195", "descriptor_name": "Disease Models, Animal", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D004195", "descriptor_name": "Disease Models, Animal", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D004195", "descriptor_name": "Disease Models, Animal", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D004247", "descriptor_name": "DNA", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004247", "descriptor_name": "DNA", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004247", "descriptor_name": "DNA", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004260", "descriptor_name": "DNA Repair", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004260", "descriptor_name": "DNA Repair", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004260", "descriptor_name": "DNA Repair", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012313", "descriptor_name": "RNA", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012313", "descriptor_name": "RNA", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012313", "descriptor_name": "RNA", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D013379", "descriptor_name": "Substrate Specificity", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D013379", "descriptor_name": "Substrate Specificity", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D013379", "descriptor_name": "Substrate Specificity", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D013698", "descriptor_name": "Templates, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D013698", "descriptor_name": "Templates, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D013698", "descriptor_name": "Templates, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016678", "descriptor_name": "Genome", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D016678", "descriptor_name": "Genome", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D016678", "descriptor_name": "Genome", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D044127", "descriptor_name": "Epigenesis, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D044127", "descriptor_name": "Epigenesis, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D044127", "descriptor_name": "Epigenesis, Genetic", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D058615", "descriptor_name": "Synthetic Biology", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D058615", "descriptor_name": "Synthetic Biology", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D058615", "descriptor_name": "Synthetic Biology", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D058615", "descriptor_name": "Synthetic Biology", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D058615", "descriptor_name": "Synthetic Biology", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D058615", "descriptor_name": "Synthetic Biology", "qualifier_ui": "Q000639", "qualifier_name": "trends", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064130", "descriptor_name": "CRISPR-Associated Proteins", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D064130", "descriptor_name": "CRISPR-Associated Proteins", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D064130", "descriptor_name": "CRISPR-Associated Proteins", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}], "locations_count": 3, "locations": [{"id": "doi:10.1038/531156a", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/531156a", "pdf_url": "https://www.nature.com/news/polopoly_fs/1.19510!/menu/main/topColumns/topLeftColumn/pdf/531156a.pdf", "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, {"id": "pmid:26961639", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/26961639", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": null}, {"id": "pmh:oai:RePEc:nat:nature:v:531:y:2016:i:7593:d:10.1038_531156a", "is_oa": false, "landing_page_url": "https://www.nature.com/articles/531156a", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401271", "display_name": "RePEc: Research Papers in Economics", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I77793887", "host_organization_name": "Federal Reserve Bank of St. Louis", "host_organization_lineage": ["https://openalex.org/I77793887"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "article"}], "best_oa_location": {"id": "doi:10.1038/531156a", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/531156a", "pdf_url": "https://www.nature.com/news/polopoly_fs/1.19510!/menu/main/topColumns/topLeftColumn/pdf/531156a.pdf", "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/2", "display_name": "Zero hunger", "score": 0.47999998927116394}], "awards": [], "funders": [], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W2296396974.pdf", "grobid_xml": "https://content.openalex.org/works/W2296396974.grobid-xml"}, "referenced_works_count": 16, "referenced_works": ["https://openalex.org/W1999358641", "https://openalex.org/W2003171404", "https://openalex.org/W2035420256", "https://openalex.org/W2059244281", "https://openalex.org/W2064815984", "https://openalex.org/W2066783444", "https://openalex.org/W2067135569", "https://openalex.org/W2091772801", "https://openalex.org/W2134288637", "https://openalex.org/W2152505144", "https://openalex.org/W2153344788", "https://openalex.org/W2160051211", "https://openalex.org/W2165869860", "https://openalex.org/W2204875887", "https://openalex.org/W2254864826", "https://openalex.org/W2777615768"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W2960163646"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2025, "cited_by_count": 2}, {"year": 2024, "cited_by_count": 3}, {"year": 2023, "cited_by_count": 3}, {"year": 2022, "cited_by_count": 6}, {"year": 2021, "cited_by_count": 6}, {"year": 2020, "cited_by_count": 7}, {"year": 2019, "cited_by_count": 9}, {"year": 2018, "cited_by_count": 20}, {"year": 2017, "cited_by_count": 16}, {"year": 2016, "cited_by_count": 12}, {"year": 2015, "cited_by_count": 1}], "updated_date": "2026-04-05T17:49:38.594831", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2072299899", "doi": "https://doi.org/10.1038/nbt.3198", "title": "Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells", "display_name": "Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells", "relevance_score": 1192.4321, "publication_year": 2015, "publication_date": "2015-03-24", "ids": {"openalex": "https://openalex.org/W2072299899", "doi": "https://doi.org/10.1038/nbt.3198", "mag": "2072299899", "pmid": "https://pubmed.ncbi.nlm.nih.gov/25803306"}, "language": "en", "primary_location": {"id": "doi:10.1038/nbt.3198", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nbt.3198", "pdf_url": null, "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5006227902", "display_name": "Van Trung Chu", "orcid": "https://orcid.org/0000-0003-1327-8696"}, "institutions": [{"id": "https://openalex.org/I205582932", "display_name": "Max Delbr\u00fcck Center", "ror": "https://ror.org/04p5ggc03", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I205582932"]}], "countries": ["DE"], "is_corresponding": true, "raw_author_name": "Van Trung Chu", "raw_affiliation_strings": ["Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany", "institution_ids": ["https://openalex.org/I205582932"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5058111270", "display_name": "Timm Weber", "orcid": "https://orcid.org/0000-0003-2079-842X"}, "institutions": [{"id": "https://openalex.org/I205582932", "display_name": "Max Delbr\u00fcck Center", "ror": "https://ror.org/04p5ggc03", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I205582932"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Timm Weber", "raw_affiliation_strings": ["Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany", "institution_ids": ["https://openalex.org/I205582932"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5009471955", "display_name": "Benedikt Wefers", "orcid": "https://orcid.org/0000-0002-2492-9389"}, "institutions": [{"id": "https://openalex.org/I2801533059", "display_name": "German Center for Neurodegenerative Diseases", "ror": "https://ror.org/043j0f473", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I2801533059", "https://openalex.org/I4405256427"]}, {"id": "https://openalex.org/I3018134672", "display_name": "Helmholtz Zentrum M\u00fcnchen", "ror": "https://ror.org/00cfam450", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I3018134672"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Benedikt Wefers", "raw_affiliation_strings": ["1] Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany. [2] Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen e.V., Munich, Germany", "Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"], "raw_orcid": "https://orcid.org/0000-0002-2492-9389", "affiliations": [{"raw_affiliation_string": "1] Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany. [2] Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen e.V., Munich, Germany", "institution_ids": ["https://openalex.org/I3018134672", "https://openalex.org/I2801533059"]}, {"raw_affiliation_string": "Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany", "institution_ids": ["https://openalex.org/I3018134672"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5027520924", "display_name": "Wolfgang Wurst", "orcid": "https://orcid.org/0000-0003-4422-7410"}, "institutions": [{"id": "https://openalex.org/I3018134672", "display_name": "Helmholtz Zentrum M\u00fcnchen", "ror": "https://ror.org/00cfam450", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I3018134672"]}, {"id": "https://openalex.org/I4210113080", "display_name": "Munich Cluster for Systems Neurology", "ror": "https://ror.org/025z3z560", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I4210113080", "https://openalex.org/I62916508", "https://openalex.org/I8204097"]}, {"id": "https://openalex.org/I8204097", "display_name": "Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen", "ror": "https://ror.org/05591te55", "country_code": "DE", "type": "education", "lineage": ["https://openalex.org/I8204097"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Wolfgang Wurst", "raw_affiliation_strings": ["1] Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany. [2] Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen e.V., Munich, Germany. [3] Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany", "Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany. [2] Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen e.V., Munich, Germany. [3] Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany", "institution_ids": ["https://openalex.org/I4210113080", "https://openalex.org/I8204097", "https://openalex.org/I3018134672"]}, {"raw_affiliation_string": "Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany", "institution_ids": ["https://openalex.org/I3018134672"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5031772520", "display_name": "Sandrine Sander", "orcid": "https://orcid.org/0000-0003-4645-3366"}, "institutions": [{"id": "https://openalex.org/I205582932", "display_name": "Max Delbr\u00fcck Center", "ror": "https://ror.org/04p5ggc03", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I205582932"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Sandrine Sander", "raw_affiliation_strings": ["Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany", "institution_ids": ["https://openalex.org/I205582932"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5012958604", "display_name": "Klaus Rajewsky", "orcid": "https://orcid.org/0000-0002-6633-6370"}, "institutions": [{"id": "https://openalex.org/I205582932", "display_name": "Max Delbr\u00fcck Center", "ror": "https://ror.org/04p5ggc03", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I205582932"]}], "countries": ["DE"], "is_corresponding": false, "raw_author_name": "Klaus Rajewsky", "raw_affiliation_strings": ["Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany", "institution_ids": ["https://openalex.org/I205582932"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5071396382", "display_name": "Ralf K\u00fchn", "orcid": "https://orcid.org/0000-0003-1694-9803"}, "institutions": [{"id": "https://openalex.org/I205582932", "display_name": "Max Delbr\u00fcck Center", "ror": "https://ror.org/04p5ggc03", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I205582932"]}, {"id": "https://openalex.org/I2802821144", "display_name": "Center for Environmental Health", "ror": "https://ror.org/03k84rm07", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I2802821144"]}, {"id": "https://openalex.org/I3018134672", "display_name": "Helmholtz Zentrum M\u00fcnchen", "ror": "https://ror.org/00cfam450", "country_code": "DE", "type": "facility", "lineage": ["https://openalex.org/I1305996414", "https://openalex.org/I3018134672"]}], "countries": ["DE", "US"], "is_corresponding": false, "raw_author_name": "Ralf K\u00fchn", "raw_affiliation_strings": ["1] Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany. [2] Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany. [3] Berlin Institute of Health, Berlin, Germany", "Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "1] Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany. [2] Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany. [3] Berlin Institute of Health, Berlin, Germany", "institution_ids": ["https://openalex.org/I3018134672", "https://openalex.org/I205582932", "https://openalex.org/I2802821144"]}, {"raw_affiliation_string": "Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany", "institution_ids": ["https://openalex.org/I3018134672"]}]}], "institutions": [], "countries_distinct_count": 2, "institutions_distinct_count": 7, "corresponding_author_ids": ["https://openalex.org/A5006227902"], "corresponding_institution_ids": ["https://openalex.org/I205582932"], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 68.3613, "has_fulltext": false, "cited_by_count": 1238, "citation_normalized_percentile": {"value": 0.9996463, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "33", "issue": "5", "first_page": "543", "last_page": "548"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10613", "display_name": "Virus-based gene therapy research", "score": 0.9821000099182129, "subfield": {"id": "https://openalex.org/subfields/1311", "display_name": "Genetics"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12610", "display_name": "RNA regulation and disease", "score": 0.9631999731063843, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8921937942504883}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.819909930229187}, {"id": "https://openalex.org/keywords/homology", "display_name": "Homology (biology)", "score": 0.5642722249031067}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.55618816614151}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5518956780433655}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.5456408262252808}, {"id": "https://openalex.org/keywords/homology-directed-repair", "display_name": "Homology directed repair", "score": 0.49543559551239014}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.46268004179000854}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.45880356431007385}, {"id": "https://openalex.org/keywords/dna-repair", "display_name": "DNA repair", "score": 0.17517772316932678}, {"id": "https://openalex.org/keywords/nucleotide-excision-repair", "display_name": "Nucleotide excision repair", "score": 0.11549586057662964}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8921937942504883}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.819909930229187}, {"id": "https://openalex.org/C165525559", "wikidata": "https://www.wikidata.org/wiki/Q224180", "display_name": "Homology (biology)", "level": 3, "score": 0.5642722249031067}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.55618816614151}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5518956780433655}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.5456408262252808}, {"id": "https://openalex.org/C74054111", "wikidata": "https://www.wikidata.org/wiki/Q5891445", "display_name": "Homology directed repair", "level": 5, "score": 0.49543559551239014}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.46268004179000854}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.45880356431007385}, {"id": "https://openalex.org/C134935766", "wikidata": "https://www.wikidata.org/wiki/Q210538", "display_name": "DNA repair", "level": 3, "score": 0.17517772316932678}, {"id": "https://openalex.org/C104451858", "wikidata": "https://www.wikidata.org/wiki/Q2714458", "display_name": "Nucleotide excision repair", "level": 4, "score": 0.11549586057662964}], "mesh": [{"descriptor_ui": "D000072481", "descriptor_name": "DNA Ligase ATP", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000072481", "descriptor_name": "DNA Ligase ATP", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000072481", "descriptor_name": "DNA Ligase ATP", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000256", "descriptor_name": "Adenoviridae", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000256", "descriptor_name": "Adenoviridae", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000256", "descriptor_name": "Adenoviridae", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002460", "descriptor_name": "Cell Line", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002460", "descriptor_name": "Cell Line", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002460", "descriptor_name": "Cell Line", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005786", "descriptor_name": "Gene Expression Regulation", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011088", "descriptor_name": "DNA Ligases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011088", "descriptor_name": "DNA Ligases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011088", "descriptor_name": "DNA Ligases", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D014764", "descriptor_name": "Viral Proteins", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D014764", "descriptor_name": "Viral Proteins", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D014764", "descriptor_name": "Viral Proteins", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D014764", "descriptor_name": "Viral Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D014764", "descriptor_name": "Viral Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D014764", "descriptor_name": "Viral Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D015894", "descriptor_name": "Genome, Human", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015894", "descriptor_name": "Genome, Human", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015894", "descriptor_name": "Genome, Human", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017504", "descriptor_name": "Adenovirus E4 Proteins", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D017504", "descriptor_name": "Adenovirus E4 Proteins", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D017504", "descriptor_name": "Adenovirus E4 Proteins", "qualifier_ui": "Q000096", "qualifier_name": "biosynthesis", "is_major_topic": false}, {"descriptor_ui": "D017504", "descriptor_name": "Adenovirus E4 Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017504", "descriptor_name": "Adenovirus E4 Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017504", "descriptor_name": "Adenovirus E4 Proteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D053903", "descriptor_name": "DNA Breaks, Double-Stranded", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D053903", "descriptor_name": "DNA Breaks, Double-Stranded", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D053903", "descriptor_name": "DNA Breaks, Double-Stranded", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D059765", "descriptor_name": "Homologous Recombination", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D059765", "descriptor_name": "Homologous Recombination", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D059765", "descriptor_name": "Homologous Recombination", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D059766", "descriptor_name": "DNA End-Joining Repair", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D059766", "descriptor_name": "DNA End-Joining Repair", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D059766", "descriptor_name": "DNA End-Joining Repair", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 7, "locations": [{"id": "doi:10.1038/nbt.3198", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nbt.3198", "pdf_url": null, "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, {"id": "pmid:25803306", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/25803306", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature biotechnology", "raw_type": null}, {"id": "pmid:29406513", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/29406513", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature biotechnology", "raw_type": null}, {"id": "pmh:oai:edoc.mdc-berlin.de:14712", "is_oa": false, "landing_page_url": null, "pdf_url": null, "source": {"id": "https://openalex.org/S4306400224", "display_name": "MDC Repository (Max-Delbrueck-Center for Molecular Medicine)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I149899117", "host_organization_name": "Max Planck Society", "host_organization_lineage": ["https://openalex.org/I149899117"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "acceptedVersion", "is_accepted": true, "is_published": false, "raw_source_name": "", "raw_type": "Article"}, {"id": "pmh:oai:opus-zb.helmholtz-muenchen.de:43965", "is_oa": false, "landing_page_url": "https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=43965", "pdf_url": null, "source": {"id": "https://openalex.org/S4377196115", "display_name": "Site cant be reached", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat. Biotechnol. 33, 543-548 (2015)", "raw_type": "article"}, {"id": "pmh:oai:pub.dzne.de:137925", "is_oa": false, "landing_page_url": "https://pub.dzne.de/search?p=id:%22DZNE-2020-04247%22", "pdf_url": null, "source": {"id": "https://openalex.org/S7407051172", "display_name": "DZNE Pub", "issn_l": null, "issn": [], "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nature biotechnology 33(5), 543-548 (2015). doi:10.1038/nbt.3198", "raw_type": "info:eu-repo/semantics/article"}, {"id": "pmh:oai:push-zb.helmholtz-munich.de:43965", "is_oa": false, "landing_page_url": "https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=43965", "pdf_url": null, "source": {"id": "https://openalex.org/S7407055352", "display_name": "PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat. Biotechnol. 33, 543-548 (2015)", "raw_type": "info:eu-repo/semantics/article"}], "best_oa_location": null, "sustainable_development_goals": [], "awards": [], "funders": [], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 30, "referenced_works": ["https://openalex.org/W1554330891", "https://openalex.org/W1905750137", "https://openalex.org/W1972222169", "https://openalex.org/W1973260880", "https://openalex.org/W1981646999", "https://openalex.org/W1984881284", "https://openalex.org/W2003581594", "https://openalex.org/W2007886976", "https://openalex.org/W2015594699", "https://openalex.org/W2020091112", "https://openalex.org/W2020783477", "https://openalex.org/W2038898265", "https://openalex.org/W2056900440", "https://openalex.org/W2064815984", "https://openalex.org/W2067492027", "https://openalex.org/W2095191866", "https://openalex.org/W2096261947", "https://openalex.org/W2100032211", "https://openalex.org/W2108552490", "https://openalex.org/W2110099382", "https://openalex.org/W2110371268", "https://openalex.org/W2110565227", "https://openalex.org/W2114232807", "https://openalex.org/W2131561597", "https://openalex.org/W2156026149", "https://openalex.org/W2159015766", "https://openalex.org/W2159569892", "https://openalex.org/W2164995160", "https://openalex.org/W2169741450", "https://openalex.org/W4285719527"], "related_works": ["https://openalex.org/W4311501380", "https://openalex.org/W2603161682", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W3052741125", "https://openalex.org/W2466284841", "https://openalex.org/W2357872089"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 24}, {"year": 2025, "cited_by_count": 60}, {"year": 2024, "cited_by_count": 85}, {"year": 2023, "cited_by_count": 103}, {"year": 2022, "cited_by_count": 128}, {"year": 2021, "cited_by_count": 117}, {"year": 2020, "cited_by_count": 142}, {"year": 2019, "cited_by_count": 127}, {"year": 2018, "cited_by_count": 126}, {"year": 2017, "cited_by_count": 138}, {"year": 2016, "cited_by_count": 136}, {"year": 2015, "cited_by_count": 50}, {"year": 2014, "cited_by_count": 1}], "updated_date": "2026-05-19T08:33:51.333923", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W4207050757", "doi": "https://doi.org/10.3389/fgeed.2022.830178", "title": "Advances in Delivery Mechanisms of CRISPR Gene-Editing Reagents in Plants", "display_name": "Advances in Delivery Mechanisms of CRISPR Gene-Editing Reagents in Plants", "relevance_score": 1173.5353, "publication_year": 2022, "publication_date": "2022-01-24", "ids": {"openalex": "https://openalex.org/W4207050757", "doi": "https://doi.org/10.3389/fgeed.2022.830178", "pmid": "https://pubmed.ncbi.nlm.nih.gov/35141701"}, "language": "en", "primary_location": {"id": "doi:10.3389/fgeed.2022.830178", "is_oa": true, "landing_page_url": "https://doi.org/10.3389/fgeed.2022.830178", "pdf_url": "https://www.frontiersin.org/articles/10.3389/fgeed.2022.830178/pdf", "source": {"id": "https://openalex.org/S4210236911", "display_name": "Frontiers in Genome Editing", "issn_l": "2673-3439", "issn": ["2673-3439"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320527", "host_organization_name": "Frontiers Media", "host_organization_lineage": ["https://openalex.org/P4310320527"], "host_organization_lineage_names": ["Frontiers Media"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in Genome Editing", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://www.frontiersin.org/articles/10.3389/fgeed.2022.830178/pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5011700109", "display_name": "Larissa C. Laforest", "orcid": "https://orcid.org/0000-0002-6937-9229"}, "institutions": [{"id": "https://openalex.org/I33213144", "display_name": "University of Florida", "ror": "https://ror.org/02y3ad647", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I33213144"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Larissa C. Laforest", "raw_affiliation_strings": ["Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL, United States", "institution_ids": ["https://openalex.org/I33213144"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5051925982", "display_name": "Satya Swathi Nadakuduti", "orcid": "https://orcid.org/0000-0002-0831-3760"}, "institutions": [{"id": "https://openalex.org/I33213144", "display_name": "University of Florida", "ror": "https://ror.org/02y3ad647", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I33213144"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Satya Swathi Nadakuduti", "raw_affiliation_strings": ["Department of Environmental Horticulture, University of Florida, Gainesville, FL, United States", "Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Environmental Horticulture, University of Florida, Gainesville, FL, United States", "institution_ids": ["https://openalex.org/I33213144"]}, {"raw_affiliation_string": "Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL, United States", "institution_ids": ["https://openalex.org/I33213144"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5051925982"], "corresponding_institution_ids": ["https://openalex.org/I33213144"], "apc_list": {"value": 1900, "currency": "USD", "value_usd": 1900}, "apc_paid": {"value": 1900, "currency": "USD", "value_usd": 1900}, "fwci": 6.67, "has_fulltext": true, "cited_by_count": 90, "citation_normalized_percentile": {"value": 0.9793294, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 97, "max": 100}, "biblio": {"volume": "4", "issue": null, "first_page": "830178", "last_page": "830178"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.9409000277519226, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T12856", "display_name": "Transgenic Plants and Applications", "score": 0.9296000003814697, "subfield": {"id": "https://openalex.org/subfields/1305", "display_name": "Biotechnology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.9084814190864563}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8373680114746094}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.6187475919723511}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.5935388803482056}, {"id": "https://openalex.org/keywords/gene-delivery", "display_name": "Gene delivery", "score": 0.5350778102874756}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.5188844799995422}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.46967917680740356}, {"id": "https://openalex.org/keywords/functional-genomics", "display_name": "Functional genomics", "score": 0.4545820951461792}, {"id": "https://openalex.org/keywords/effector", "display_name": "Effector", "score": 0.43501392006874084}, {"id": "https://openalex.org/keywords/genomics", "display_name": "Genomics", "score": 0.33020055294036865}, {"id": "https://openalex.org/keywords/biotechnology", "display_name": "Biotechnology", "score": 0.32698166370391846}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.2936190664768219}, {"id": "https://openalex.org/keywords/genetic-enhancement", "display_name": "Genetic enhancement", "score": 0.26400429010391235}, {"id": "https://openalex.org/keywords/cell-biology", "display_name": "Cell biology", "score": 0.08653545379638672}], "concepts": [{"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.9084814190864563}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8373680114746094}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.6187475919723511}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.5935388803482056}, {"id": "https://openalex.org/C135983454", "wikidata": "https://www.wikidata.org/wiki/Q2790163", "display_name": "Gene delivery", "level": 4, "score": 0.5350778102874756}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.5188844799995422}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.46967917680740356}, {"id": "https://openalex.org/C161078062", "wikidata": "https://www.wikidata.org/wiki/Q1068690", "display_name": "Functional genomics", "level": 5, "score": 0.4545820951461792}, {"id": "https://openalex.org/C51785407", "wikidata": "https://www.wikidata.org/wiki/Q2627568", "display_name": "Effector", "level": 2, "score": 0.43501392006874084}, {"id": "https://openalex.org/C189206191", "wikidata": "https://www.wikidata.org/wiki/Q222046", "display_name": "Genomics", "level": 4, "score": 0.33020055294036865}, {"id": "https://openalex.org/C150903083", "wikidata": "https://www.wikidata.org/wiki/Q7108", "display_name": "Biotechnology", "level": 1, "score": 0.32698166370391846}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.2936190664768219}, {"id": "https://openalex.org/C111599444", "wikidata": "https://www.wikidata.org/wiki/Q213901", "display_name": "Genetic enhancement", "level": 3, "score": 0.26400429010391235}, {"id": "https://openalex.org/C95444343", "wikidata": "https://www.wikidata.org/wiki/Q7141", "display_name": "Cell biology", "level": 1, "score": 0.08653545379638672}], "mesh": [], "locations_count": 4, "locations": [{"id": "doi:10.3389/fgeed.2022.830178", "is_oa": true, "landing_page_url": "https://doi.org/10.3389/fgeed.2022.830178", "pdf_url": "https://www.frontiersin.org/articles/10.3389/fgeed.2022.830178/pdf", "source": {"id": "https://openalex.org/S4210236911", "display_name": "Frontiers in Genome Editing", "issn_l": "2673-3439", "issn": ["2673-3439"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320527", "host_organization_name": "Frontiers Media", "host_organization_lineage": ["https://openalex.org/P4310320527"], "host_organization_lineage_names": ["Frontiers Media"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in Genome Editing", "raw_type": "journal-article"}, {"id": "pmid:35141701", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/35141701", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in genome editing", "raw_type": null}, {"id": "pmh:oai:doaj.org/article:ed8dbf8f63df4aa485089da1db2bd8bb", "is_oa": true, "landing_page_url": "https://doaj.org/article/ed8dbf8f63df4aa485089da1db2bd8bb", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-sa", "license_id": "https://openalex.org/licenses/cc-by-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Frontiers in Genome Editing, Vol 4 (2022)", "raw_type": "article"}, {"id": "pmh:oai:pubmedcentral.nih.gov:8819002", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/8819002", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Front Genome Ed", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.3389/fgeed.2022.830178", "is_oa": true, "landing_page_url": "https://doi.org/10.3389/fgeed.2022.830178", "pdf_url": "https://www.frontiersin.org/articles/10.3389/fgeed.2022.830178/pdf", "source": {"id": "https://openalex.org/S4210236911", "display_name": "Frontiers in Genome Editing", "issn_l": "2673-3439", "issn": ["2673-3439"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320527", "host_organization_name": "Frontiers Media", "host_organization_lineage": ["https://openalex.org/P4310320527"], "host_organization_lineage_names": ["Frontiers Media"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in Genome Editing", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [], "funders": [{"id": "https://openalex.org/F4320306114", "display_name": "U.S. Department of Agriculture", "ror": "https://ror.org/01na82s61"}, {"id": "https://openalex.org/F4320332299", "display_name": "National Institute of Food and Agriculture", "ror": "https://ror.org/05qx3fv49"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W4207050757.pdf", "grobid_xml": "https://content.openalex.org/works/W4207050757.grobid-xml"}, "referenced_works_count": 108, "referenced_works": ["https://openalex.org/W1835708631", "https://openalex.org/W1937054661", "https://openalex.org/W1965442116", "https://openalex.org/W1991710875", "https://openalex.org/W1995272878", "https://openalex.org/W2014880518", "https://openalex.org/W2016845439", "https://openalex.org/W2045435533", "https://openalex.org/W2068325529", "https://openalex.org/W2082507214", "https://openalex.org/W2116122104", "https://openalex.org/W2136656609", "https://openalex.org/W2137082459", "https://openalex.org/W2142150660", "https://openalex.org/W2146387619", "https://openalex.org/W2148302985", "https://openalex.org/W2149058703", "https://openalex.org/W2150861956", "https://openalex.org/W2168245648", "https://openalex.org/W2170185310", "https://openalex.org/W2196121581", "https://openalex.org/W2196993543", "https://openalex.org/W2292390328", "https://openalex.org/W2401079771", "https://openalex.org/W2518225655", "https://openalex.org/W2519197628", "https://openalex.org/W2531575240", "https://openalex.org/W2551575280", "https://openalex.org/W2560685378", "https://openalex.org/W2572900050", "https://openalex.org/W2581151188", "https://openalex.org/W2594683972", "https://openalex.org/W2595015883", "https://openalex.org/W2598674316", "https://openalex.org/W2616302079", "https://openalex.org/W2728695862", "https://openalex.org/W2752954491", "https://openalex.org/W2759402071", "https://openalex.org/W2759858333", "https://openalex.org/W2768919282", "https://openalex.org/W2771785605", "https://openalex.org/W2786455124", "https://openalex.org/W2791695010", "https://openalex.org/W2793762852", "https://openalex.org/W2804636356", "https://openalex.org/W2805771153", "https://openalex.org/W2889606920", "https://openalex.org/W2901599119", "https://openalex.org/W2914580634", "https://openalex.org/W2915437394", "https://openalex.org/W2916239133", "https://openalex.org/W2921196042", "https://openalex.org/W2936889661", "https://openalex.org/W2950849557", "https://openalex.org/W2960786686", "https://openalex.org/W2981137429", "https://openalex.org/W2991361270", "https://openalex.org/W2995711654", "https://openalex.org/W2997729955", "https://openalex.org/W3000262573", "https://openalex.org/W3002620407", "https://openalex.org/W3003676829", "https://openalex.org/W3009142909", "https://openalex.org/W3009793704", "https://openalex.org/W3011719482", "https://openalex.org/W3011791788", "https://openalex.org/W3012016445", "https://openalex.org/W3013993115", "https://openalex.org/W3016002413", "https://openalex.org/W3025159539", "https://openalex.org/W3030665654", "https://openalex.org/W3036253871", "https://openalex.org/W3037369258", "https://openalex.org/W3037978928", "https://openalex.org/W3039067516", "https://openalex.org/W3040759425", "https://openalex.org/W3043719325", "https://openalex.org/W3048787020", "https://openalex.org/W3067698579", "https://openalex.org/W3087309731", "https://openalex.org/W3089464612", "https://openalex.org/W3091894549", "https://openalex.org/W3094498257", "https://openalex.org/W3096884850", "https://openalex.org/W3101072696", "https://openalex.org/W3110994576", "https://openalex.org/W3121950226", "https://openalex.org/W3126667983", "https://openalex.org/W3128518529", "https://openalex.org/W3132357341", "https://openalex.org/W3135783950", "https://openalex.org/W3137273638", "https://openalex.org/W3138004611", "https://openalex.org/W3148527842", "https://openalex.org/W3153407713", "https://openalex.org/W3157921564", "https://openalex.org/W3164276893", "https://openalex.org/W3169070265", "https://openalex.org/W3181953750", "https://openalex.org/W3201337808", "https://openalex.org/W3202188128", "https://openalex.org/W3214587117", "https://openalex.org/W6654051926", "https://openalex.org/W6654543650", "https://openalex.org/W6667656977", "https://openalex.org/W6684420763", "https://openalex.org/W6744691091", "https://openalex.org/W6781082476"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W3030388918", "https://openalex.org/W4200005163", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W3165203721", "https://openalex.org/W4388296936", "https://openalex.org/W2960163646"], "abstract_inverted_index": {"Gene-editing": [0, 43], "by": [1, 8, 24], "CRISPR/Cas": [2], "systems": [3, 122], "has": [4, 16, 155, 168], "revolutionized": [5], "plant": [6, 19, 98, 108, 139, 164, 216], "biology": [7], "serving": [9], "as": [10], "a": [11, 45, 160, 203], "functional": [12], "genomics": [13], "tool.": [14], "It": [15], "tremendously": [17], "advanced": [18], "breeding": [20], "and": [21, 34, 40, 62, 72, 91, 113, 130, 191, 198, 201, 208, 223, 233], "crop": [22], "improvement": [23], "accelerating": [25], "the": [26, 94, 101, 125, 142], "development": [27, 52], "of": [28, 38, 53, 78, 104, 128, 144, 163, 196], "improved": [29], "cultivars,": [30], "creating": [31], "genetic": [32, 149], "variability,": [33], "aiding": [35], "in": [36, 97, 159, 172, 176, 210, 215], "domestication": [37], "wild": [39], "orphan": [41], "crops.": [42], "is": [44, 218], "rapidly": [46], "evolving": [47], "field.": [48], "Several": [49], "advancements": [50], "include": [51], "different": [54], "Cas": [55], "effectors": [56], "with": [57, 69], "increased": [58], "target": [59], "range,": [60], "efficacy,": [61], "enhanced": [63], "capacity": [64], "for": [65, 206, 228], "precise": [66, 88], "DNA": [67], "modifications": [68], "base": [70, 89], "editing": [71, 229], "prime": [73], "editing.": [74], "The": [75, 212], "existing": [76], "toolbox": [77], "various": [79], "CRISPR": [80, 173], "reagents": [81, 106, 154, 174], "facilitate": [82], "gene": [83, 86], "knockouts,": [84], "targeted": [85], "insertions,": [87], "substitutions,": [90], "multiplexing.": [92], "However,": [93], "major": [95], "challenge": [96], "genome-editing": [99], "remains": [100], "efficient": [102, 222], "delivery": [103, 175, 184, 190, 195, 226], "these": [105, 183], "into": [107, 187], "cells.": [109], "Plants": [110], "have": [111], "larger": [112], "more": [114], "complex": [115], "genome": [116, 132], "structures": [117], "compared": [118], "to": [119, 124, 151, 219], "other": [120, 131], "living": [121], "due": [123], "common": [126], "occurrence": [127], "polyploidy": [129], "re-arrangements.": [133], "Further,": [134], "rigid": [135], "cell": [136], "walls": [137], "surrounding": [138], "cells": [140], "deter": [141], "entry": [143], "any": [145], "foreign": [146], "biomolecules.": [147], "Unfortunately,": [148], "transformation": [150], "deliver": [152], "gene-editing": [153, 207, 217], "been": [156, 169], "established": [157], "only": [158], "limited": [161], "number": [162], "species.": [165], "Recently,": [166], "there": [167], "significant": [170], "progress": [171], "plants.": [177, 211], "This": [178], "review": [179], "focuses": [180], "on": [181], "exploring": [182], "mechanisms": [185, 227], "categorized": [186], "Agrobacterium": [188], "-mediated": [189], "breakthroughs,": [192], "particle": [193], "bombardment-based": [194], "biomolecules": [197], "recent": [199], "improvements,": [200], "protoplasts,": [202], "versatile": [204], "system": [205], "regeneration": [209], "ultimate": [213], "goal": [214], "establish": [220], "highly": [221], "genotype-independent": [224], "reagent": [225], "multiple": [230], "targets": [231], "simultaneously": [232], "achieve": [234], "DNA-free": [235], "gene-edited": [236], "plants": [237], "at": [238], "scale.": [239]}, "counts_by_year": [{"year": 2026, "cited_by_count": 13}, {"year": 2025, "cited_by_count": 29}, {"year": 2024, "cited_by_count": 27}, {"year": 2023, "cited_by_count": 16}, {"year": 2022, "cited_by_count": 5}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3092108629", "doi": "https://doi.org/10.1038/d41586-020-02765-9", "title": "Pioneers of revolutionary CRISPR gene editing win chemistry Nobel", "display_name": "Pioneers of revolutionary CRISPR gene editing win chemistry Nobel", "relevance_score": 1171.829, "publication_year": 2020, "publication_date": "2020-10-07", "ids": {"openalex": "https://openalex.org/W3092108629", "doi": "https://doi.org/10.1038/d41586-020-02765-9", "mag": "3092108629", "pmid": "https://pubmed.ncbi.nlm.nih.gov/33028993"}, "language": "en", "primary_location": {"id": "doi:10.1038/d41586-020-02765-9", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/d41586-020-02765-9", "pdf_url": null, "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, "type": "letter", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5051432932", "display_name": "Heidi Ledford", "orcid": null}, "institutions": [], "countries": [], "is_corresponding": true, "raw_author_name": "Heidi Ledford", "raw_affiliation_strings": [], "raw_orcid": null, "affiliations": []}, {"author_position": "last", "author": {"id": "https://openalex.org/A5080872001", "display_name": "Ewen Callaway", "orcid": null}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Ewen Callaway", "raw_affiliation_strings": [], "raw_orcid": null, "affiliations": []}], "institutions": [], "countries_distinct_count": 0, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5051432932"], "corresponding_institution_ids": [], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 5.7513, "has_fulltext": false, "cited_by_count": 112, "citation_normalized_percentile": {"value": 0.97218539, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 97, "max": 100}, "biblio": {"volume": "586", "issue": "7829", "first_page": "346", "last_page": "347"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.9890000224113464, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T14293", "display_name": "Biotechnology and Related Fields", "score": 0.9060999751091003, "subfield": {"id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.7404513359069824}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.68091881275177}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.4111935496330261}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.3631110191345215}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.24826285243034363}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.24133148789405823}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.7404513359069824}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.68091881275177}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.4111935496330261}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.3631110191345215}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.24826285243034363}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.24133148789405823}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D003850", "descriptor_name": "Deoxyribonuclease I", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D003850", "descriptor_name": "Deoxyribonuclease I", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D003850", "descriptor_name": "Deoxyribonuclease I", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012313", "descriptor_name": "RNA", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012313", "descriptor_name": "RNA", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D012313", "descriptor_name": "RNA", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 3, "locations": [{"id": "doi:10.1038/d41586-020-02765-9", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/d41586-020-02765-9", "pdf_url": null, "source": {"id": "https://openalex.org/S137773608", "display_name": "Nature", "issn_l": "0028-0836", "issn": ["0028-0836", "1476-4687"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": "journal-article"}, {"id": "pmid:33028993", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/33028993", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature", "raw_type": null}, {"id": "pmh:oai:RePEc:nat:nature:v:586:y:2020:i:7829:d:10.1038_d41586-020-02765-9", "is_oa": false, "landing_page_url": "https://www.nature.com/articles/d41586-020-02765-9", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401271", "display_name": "RePEc: Research Papers in Economics", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I77793887", "host_organization_name": "Federal Reserve Bank of St. Louis", "host_organization_lineage": ["https://openalex.org/I77793887"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "article"}], "best_oa_location": null, "sustainable_development_goals": [], "awards": [], "funders": [], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 1, "referenced_works": ["https://openalex.org/W2045435533"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W2960163646"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 4}, {"year": 2025, "cited_by_count": 15}, {"year": 2024, "cited_by_count": 24}, {"year": 2023, "cited_by_count": 21}, {"year": 2022, "cited_by_count": 26}, {"year": 2021, "cited_by_count": 17}, {"year": 2020, "cited_by_count": 5}], "updated_date": "2026-05-20T08:49:12.498775", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3179699043", "doi": "https://doi.org/10.1371/journal.pgen.1009680", "title": "Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in the beet armyworm", "display_name": "Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in the beet armyworm", "relevance_score": 1160.9513, "publication_year": 2021, "publication_date": "2021-07-12", "ids": {"openalex": "https://openalex.org/W3179699043", "doi": "https://doi.org/10.1371/journal.pgen.1009680", "mag": "3179699043", "pmid": "https://pubmed.ncbi.nlm.nih.gov/34252082"}, "language": "en", "primary_location": {"id": "doi:10.1371/journal.pgen.1009680", "is_oa": true, "landing_page_url": "https://doi.org/10.1371/journal.pgen.1009680", "pdf_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009680&type=printable", "source": {"id": "https://openalex.org/S103870658", "display_name": "PLoS Genetics", "issn_l": "1553-7390", "issn": ["1553-7390", "1553-7404"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310315706", "host_organization_name": "Public Library of Science", "host_organization_lineage": ["https://openalex.org/P4310315706"], "host_organization_lineage_names": ["Public Library of Science"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "PLOS Genetics", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009680&type=printable", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5003105554", "display_name": "Yayun Zuo", "orcid": "https://orcid.org/0000-0001-9198-4057"}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}, {"id": "https://openalex.org/I89652312", "display_name": "Northwest A&F University", "ror": "https://ror.org/0051rme32", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I89652312"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yayun Zuo", "raw_affiliation_strings": ["Institute of Pesticide Science, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China", "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": "https://orcid.org/0000-0001-9198-4057", "affiliations": [{"raw_affiliation_string": "Institute of Pesticide Science, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China", "institution_ids": ["https://openalex.org/I89652312"]}, {"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}, {"author_position": "middle", "author": {"id": null, "display_name": "Yu Shi", "orcid": null}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yu Shi", "raw_affiliation_strings": ["The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5046641754", "display_name": "Feng Zhang", "orcid": "https://orcid.org/0000-0002-1371-266X"}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Feng Zhang", "raw_affiliation_strings": ["The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": "https://orcid.org/0000-0002-1371-266X", "affiliations": [{"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5036018905", "display_name": "Fang Guan", "orcid": "https://orcid.org/0000-0003-0758-1672"}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Fang Guan", "raw_affiliation_strings": ["The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": "https://orcid.org/0000-0003-0758-1672", "affiliations": [{"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100658348", "display_name": "Jianpeng Zhang", "orcid": "https://orcid.org/0000-0002-1904-5124"}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Jianpeng Zhang", "raw_affiliation_strings": ["The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": "https://orcid.org/0000-0002-1904-5124", "affiliations": [{"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5068258357", "display_name": "Ren\u00e9 Feyereisen", "orcid": "https://orcid.org/0000-0002-9560-571X"}, "institutions": [{"id": "https://openalex.org/I124055696", "display_name": "University of Copenhagen", "ror": "https://ror.org/035b05819", "country_code": "DK", "type": "education", "lineage": ["https://openalex.org/I124055696"]}], "countries": ["DK"], "is_corresponding": false, "raw_author_name": "Ren\u00e9 Feyereisen", "raw_affiliation_strings": ["Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark"], "raw_orcid": "https://orcid.org/0000-0002-9560-571X", "affiliations": [{"raw_affiliation_string": "Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark", "institution_ids": ["https://openalex.org/I124055696"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5019750445", "display_name": "Jeffrey A. Fabrick", "orcid": "https://orcid.org/0000-0002-3893-9545"}, "institutions": [{"id": "https://openalex.org/I4210144272", "display_name": "U.S. Arid Land Agricultural Research Center", "ror": "https://ror.org/03qx0n513", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1312222531", "https://openalex.org/I1336096307", "https://openalex.org/I4210094889", "https://openalex.org/I4210144272"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Jeffrey A. Fabrick", "raw_affiliation_strings": ["USDA ARS, U.S. Arid Land Agricultural Research Center, Maricopa, Arizona, United States of America"], "raw_orcid": "https://orcid.org/0000-0002-3893-9545", "affiliations": [{"raw_affiliation_string": "USDA ARS, U.S. Arid Land Agricultural Research Center, Maricopa, Arizona, United States of America", "institution_ids": ["https://openalex.org/I4210144272"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5075792943", "display_name": "Yihua Yang", "orcid": "https://orcid.org/0000-0002-5561-1269"}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}], "countries": ["CN"], "is_corresponding": true, "raw_author_name": "Yihua Yang", "raw_affiliation_strings": ["The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5100638142", "display_name": "Yidong Wu", "orcid": "https://orcid.org/0000-0003-3456-3373"}, "institutions": [{"id": "https://openalex.org/I119454577", "display_name": "Nanjing Agricultural University", "ror": "https://ror.org/05td3s095", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I119454577"]}], "countries": ["CN"], "is_corresponding": true, "raw_author_name": "Yidong Wu", "raw_affiliation_strings": ["The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China"], "raw_orcid": "https://orcid.org/0000-0003-3456-3373", "affiliations": [{"raw_affiliation_string": "The Key Laboratory of Plant Immunity and College of Plant Protection, Nanjing Agricultural University, Nanjing, China", "institution_ids": ["https://openalex.org/I119454577"]}]}], "institutions": [], "countries_distinct_count": 3, "institutions_distinct_count": 9, "corresponding_author_ids": ["https://openalex.org/A5075792943", "https://openalex.org/A5100638142"], "corresponding_institution_ids": ["https://openalex.org/I119454577"], "apc_list": {"value": 2655, "currency": "USD", "value_usd": 2655}, "apc_paid": {"value": 2655, "currency": "USD", "value_usd": 2655}, "fwci": 9.6065, "has_fulltext": true, "cited_by_count": 146, "citation_normalized_percentile": {"value": 0.98922752, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 97, "max": 100}, "biblio": {"volume": "17", "issue": "7", "first_page": "e1009680", "last_page": "e1009680"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T11075", "display_name": "Insect Resistance and Genetics", "score": 0.9986000061035156, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T11075", "display_name": "Insect Resistance and Genetics", "score": 0.9986000061035156, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T11074", "display_name": "Helminth infection and control", "score": 0.9902999997138977, "subfield": {"id": "https://openalex.org/subfields/3404", "display_name": "Small Animals"}, "field": {"id": "https://openalex.org/fields/34", "display_name": "Veterinary"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T11436", "display_name": "Entomopathogenic Microorganisms in Pest Control", "score": 0.9865000247955322, "subfield": {"id": "https://openalex.org/subfields/1109", "display_name": "Insect Science"}, "field": {"id": "https://openalex.org/fields/11", "display_name": "Agricultural and Biological Sciences"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.9091571569442749}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8109030723571777}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7489885687828064}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.6978822350502014}, {"id": "https://openalex.org/keywords/beet-armyworm", "display_name": "Beet armyworm", "score": 0.6635286211967468}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.6521371603012085}, {"id": "https://openalex.org/keywords/avermectin", "display_name": "Avermectin", "score": 0.5526724457740784}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.5378555059432983}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.33938488364219666}, {"id": "https://openalex.org/keywords/spodoptera", "display_name": "Spodoptera", "score": 0.14910882711410522}, {"id": "https://openalex.org/keywords/recombinant-dna", "display_name": "Recombinant DNA", "score": 0.0956411361694336}], "concepts": [{"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.9091571569442749}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8109030723571777}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7489885687828064}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.6978822350502014}, {"id": "https://openalex.org/C2777091279", "wikidata": "https://www.wikidata.org/wiki/Q310344", "display_name": "Beet armyworm", "level": 5, "score": 0.6635286211967468}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.6521371603012085}, {"id": "https://openalex.org/C2780535491", "wikidata": "https://www.wikidata.org/wiki/Q416170", "display_name": "Avermectin", "level": 2, "score": 0.5526724457740784}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.5378555059432983}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.33938488364219666}, {"id": "https://openalex.org/C2777773057", "wikidata": "https://www.wikidata.org/wiki/Q2492887", "display_name": "Spodoptera", "level": 4, "score": 0.14910882711410522}, {"id": "https://openalex.org/C40767141", "wikidata": "https://www.wikidata.org/wiki/Q285697", "display_name": "Recombinant DNA", "level": 3, "score": 0.0956411361694336}, {"id": "https://openalex.org/C105702510", "wikidata": "https://www.wikidata.org/wiki/Q514", "display_name": "Anatomy", "level": 1, "score": 0.0}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D002874", "descriptor_name": "Chromosome Mapping", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D002874", "descriptor_name": "Chromosome Mapping", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D002874", "descriptor_name": "Chromosome Mapping", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D003577", "descriptor_name": "Cytochrome P-450 Enzyme System", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D003577", "descriptor_name": "Cytochrome P-450 Enzyme System", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D003577", "descriptor_name": "Cytochrome P-450 Enzyme System", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007305", "descriptor_name": "Insecticide Resistance", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007305", "descriptor_name": "Insecticide Resistance", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007305", "descriptor_name": "Insecticide Resistance", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007306", "descriptor_name": "Insecticides", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D007306", "descriptor_name": "Insecticides", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D007306", "descriptor_name": "Insecticides", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D007559", "descriptor_name": "Ivermectin", "qualifier_ui": "Q000031", "qualifier_name": "analogs & derivatives", "is_major_topic": false}, {"descriptor_ui": "D007559", "descriptor_name": "Ivermectin", "qualifier_ui": "Q000031", "qualifier_name": "analogs & derivatives", "is_major_topic": false}, {"descriptor_ui": "D007559", "descriptor_name": "Ivermectin", "qualifier_ui": "Q000031", "qualifier_name": "analogs & derivatives", "is_major_topic": false}, {"descriptor_ui": "D007559", "descriptor_name": "Ivermectin", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D007559", "descriptor_name": "Ivermectin", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D007559", "descriptor_name": "Ivermectin", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D007814", "descriptor_name": "Larva", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007814", "descriptor_name": "Larva", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D007814", "descriptor_name": "Larva", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D016678", "descriptor_name": "Genome", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D016678", "descriptor_name": "Genome", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D016678", "descriptor_name": "Genome", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018411", "descriptor_name": "Spodoptera", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018411", "descriptor_name": "Spodoptera", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018411", "descriptor_name": "Spodoptera", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018411", "descriptor_name": "Spodoptera", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D018411", "descriptor_name": "Spodoptera", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D018411", "descriptor_name": "Spodoptera", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 5, "locations": [{"id": "doi:10.1371/journal.pgen.1009680", "is_oa": true, "landing_page_url": "https://doi.org/10.1371/journal.pgen.1009680", "pdf_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009680&type=printable", "source": {"id": "https://openalex.org/S103870658", "display_name": "PLoS Genetics", "issn_l": "1553-7390", "issn": ["1553-7390", "1553-7404"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310315706", "host_organization_name": "Public Library of Science", "host_organization_lineage": ["https://openalex.org/P4310315706"], "host_organization_lineage_names": ["Public Library of Science"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "PLOS Genetics", "raw_type": "journal-article"}, {"id": "pmid:34252082", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/34252082", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "PLoS genetics", "raw_type": null}, {"id": "pmh:oai:doaj.org/article:dae85ce50667431bb2945fd486292f62", "is_oa": true, "landing_page_url": "https://doaj.org/article/dae85ce50667431bb2945fd486292f62", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-sa", "license_id": "https://openalex.org/licenses/cc-by-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "PLoS Genetics, Vol 17, Iss 7, p e1009680 (2021)", "raw_type": "article"}, {"id": "pmh:oai:pubmedcentral.nih.gov:8297932", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/8297932", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "public-domain", "license_id": "https://openalex.org/licenses/public-domain", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "PLoS Genet", "raw_type": "Text"}, {"id": "pmh:oai:pure.atira.dk:openaire_cris_publications/dd12872e-b618-445d-873e-e04f24b80abc", "is_oa": true, "landing_page_url": "https://researchprofiles.ku.dk/da/publications/dd12872e-b618-445d-873e-e04f24b80abc", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401983", "display_name": "Research at the University of Copenhagen (University of Copenhagen)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I124055696", "host_organization_name": "University of Copenhagen", "host_organization_lineage": ["https://openalex.org/I124055696"], "host_organization_lineage_names": [], "type": "repository"}, "license": "other-oa", "license_id": "https://openalex.org/licenses/other-oa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Zuo , Y , Shi , Y , Zhang , F , Guan , F , Zhang , J , Feyereisen , R , Fabrick , J A , Yang , Y & Wu , Y 2021 , ' Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in the beet armyworm ' , PLOS Genetics , vol. 17 , no. 7 , 1009680 . https://doi.org/10.1371/journal.pgen.1009680", "raw_type": "article"}], "best_oa_location": {"id": "doi:10.1371/journal.pgen.1009680", "is_oa": true, "landing_page_url": "https://doi.org/10.1371/journal.pgen.1009680", "pdf_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009680&type=printable", "source": {"id": "https://openalex.org/S103870658", "display_name": "PLoS Genetics", "issn_l": "1553-7390", "issn": ["1553-7390", "1553-7404"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310315706", "host_organization_name": "Public Library of Science", "host_organization_lineage": ["https://openalex.org/P4310315706"], "host_organization_lineage_names": ["Public Library of Science"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "PLOS Genetics", "raw_type": "journal-article"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/2", "display_name": "Zero hunger", "score": 0.6200000047683716}], "awards": [{"id": "https://openalex.org/G5316586608", "display_name": null, "funder_award_id": "2018FY101103", "funder_id": "https://openalex.org/F4320321540", "funder_display_name": "Ministry of Science and Technology of the People's Republic of China"}, {"id": "https://openalex.org/G6013962113", "display_name": null, "funder_award_id": "31572030", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}], "funders": [{"id": "https://openalex.org/F4320321001", "display_name": "National Natural Science Foundation of China", "ror": "https://ror.org/01h0zpd94"}, {"id": "https://openalex.org/F4320321540", "display_name": "Ministry of Science and Technology of the People's Republic of China", "ror": "https://ror.org/027s68j25"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W3179699043.pdf", "grobid_xml": "https://content.openalex.org/works/W3179699043.grobid-xml"}, "referenced_works_count": 91, "referenced_works": ["https://openalex.org/W1482190741", "https://openalex.org/W1498652161", "https://openalex.org/W1512402023", "https://openalex.org/W1557506896", "https://openalex.org/W1595002441", "https://openalex.org/W1630717967", "https://openalex.org/W1848851712", "https://openalex.org/W1892093764", "https://openalex.org/W1920762266", "https://openalex.org/W1951469402", "https://openalex.org/W1961590596", "https://openalex.org/W1968771265", "https://openalex.org/W1976952993", "https://openalex.org/W1982855075", "https://openalex.org/W1990689006", "https://openalex.org/W1997424063", "https://openalex.org/W2003944833", "https://openalex.org/W2005305297", "https://openalex.org/W2012404590", "https://openalex.org/W2013110849", "https://openalex.org/W2024983582", "https://openalex.org/W2034273204", "https://openalex.org/W2035282516", "https://openalex.org/W2045204781", "https://openalex.org/W2045799172", "https://openalex.org/W2046787515", "https://openalex.org/W2068813094", "https://openalex.org/W2068979346", "https://openalex.org/W2081145349", "https://openalex.org/W2081977302", "https://openalex.org/W2091598944", "https://openalex.org/W2091738431", "https://openalex.org/W2091914833", "https://openalex.org/W2095680943", "https://openalex.org/W2099753867", "https://openalex.org/W2102278945", "https://openalex.org/W2104005232", "https://openalex.org/W2107277218", "https://openalex.org/W2108234281", "https://openalex.org/W2110155683", "https://openalex.org/W2110641507", "https://openalex.org/W2111293707", "https://openalex.org/W2114451730", "https://openalex.org/W2118970397", "https://openalex.org/W2119180969", "https://openalex.org/W2124102028", "https://openalex.org/W2128635872", "https://openalex.org/W2131271579", "https://openalex.org/W2142678478", "https://openalex.org/W2164612146", "https://openalex.org/W2169790161", "https://openalex.org/W2216234219", "https://openalex.org/W2226299262", "https://openalex.org/W2265098483", "https://openalex.org/W2343195612", "https://openalex.org/W2396077153", "https://openalex.org/W2479687279", "https://openalex.org/W2481029670", "https://openalex.org/W2538143681", "https://openalex.org/W2557496587", "https://openalex.org/W2567127730", "https://openalex.org/W2618891038", "https://openalex.org/W2738191634", "https://openalex.org/W2741383737", "https://openalex.org/W2752100281", "https://openalex.org/W2754169408", "https://openalex.org/W2757004498", "https://openalex.org/W2759996086", "https://openalex.org/W2773282011", "https://openalex.org/W2784049056", "https://openalex.org/W2788228074", "https://openalex.org/W2789843538", "https://openalex.org/W2795418753", "https://openalex.org/W2803532708", "https://openalex.org/W2900629010", "https://openalex.org/W2901126365", "https://openalex.org/W2903125175", "https://openalex.org/W2916114485", "https://openalex.org/W2949086752", "https://openalex.org/W2949841808", "https://openalex.org/W2951257985", "https://openalex.org/W2968984052", "https://openalex.org/W3011056092", "https://openalex.org/W3021844428", "https://openalex.org/W3036319615", "https://openalex.org/W3102786052", "https://openalex.org/W3103682485", "https://openalex.org/W3135813588", "https://openalex.org/W4293247451", "https://openalex.org/W4394666350", "https://openalex.org/W7075604223"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W4388296936", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W4401335721"], "abstract_inverted_index": {"The": [0, 56], "evolution": [1], "of": [2, 13, 25, 42, 52, 76, 89, 107, 110, 119, 134, 142, 146, 191, 199, 207, 218, 235], "insecticide": [3, 29, 54, 224, 236], "resistance": [4, 44, 94, 220], "represents": [5], "a": [6, 73, 115, 179], "global": [7, 87], "constraint": [8], "to": [9, 35, 95, 130], "agricultural": [10], "production.": [11], "Because": [12], "the": [14, 22, 40, 80, 100, 104, 120, 132, 147, 185, 192, 204, 215], "extreme": [15], "genetic": [16], "diversity": [17], "found": [18, 183], "in": [19, 28, 99, 166, 172, 184, 196], "insects": [20], "and": [21, 38, 50, 61, 124, 171, 201, 232], "large": [23], "numbers": [24], "genes": [26, 45, 221], "involved": [27], "detoxification,": [30], "better": [31], "tools": [32], "are": [33, 63], "needed": [34], "quickly": [36], "identify": [37, 131], "validate": [39], "involvement": [41], "putative": [43], "for": [46, 214, 223, 229], "improved": [47], "monitoring,": [48], "management,": [49], "countering": [51], "field-evolved": [53], "resistance.": [55, 168, 237], "avermectins,": [57], "emamectin": [58], "benzoate": [59], "(EB)": [60], "abamectin": [62], "relatively": [64], "new": [65], "pesticides": [66], "with": [67, 211], "reduced": [68], "environmental": [69], "risk": [70], "that": [71, 150, 178], "target": [72], "wide": [74], "number": [75], "insect": [77], "pests,": [78], "including": [79], "beet": [81, 101, 121], "armyworm,": [82, 102], "Spodoptera": [83], "exigua,": [84], "an": [85], "important": [86], "pest": [88], "many": [90], "crops.": [91], "Unfortunately,": [92], "field": [93], "avermectins": [96], "recently": [97], "evolved": [98], "threatening": [103], "sustainable": [105], "use": [106, 125], "this": [108, 153, 164], "class": [109], "insecticides.": [111], "Here,": [112], "we": [113], "report": [114], "high-quality": [116], "chromosome-level": [117], "assembly": [118], "armyworm": [122], "genome": [123], "bulked": [126], "segregant": [127], "analysis": [128], "(BSA)": [129], "locus": [133], "avermectin": [135, 167], "resistance,": [136, 225], "which": [137, 226], "mapped": [138], "on": [139], "15-16": [140], "Mbp": [141], "chromosome": [143], "17.": [144], "Knockout": [145], "CYP9A186": [148, 193], "gene": [149, 157, 165, 209], "maps": [151], "within": [152], "region": [154], "by": [155], "CRISPR/Cas9": [156], "editing": [158, 210], "fully": [159], "restored": [160], "EB": [161, 200], "susceptibility,": [162], "implicating": [163], "Heterologous": [169], "expression": [170], "vitro": [173], "functional": [174], "assays": [175], "further": [176], "confirm": [177], "natural": [180], "substitution": [181], "(F116V)": [182], "substrate": [186], "recognition": [187], "site": [188], "1": [189], "(SRS1)": [190], "protein": [194], "results": [195], "enhanced": [197], "metabolism": [198], "abamectin.": [202], "Hence,": [203], "combined": [205], "approach": [206], "coupling": [208], "BSA": [212], "allows": [213], "rapid": [216], "identification": [217], "metabolic": [219], "responsible": [222], "is": [227], "critical": [228], "effective": [230], "monitoring": [231], "adaptive": [233], "management": [234]}, "counts_by_year": [{"year": 2026, "cited_by_count": 5}, {"year": 2025, "cited_by_count": 23}, {"year": 2024, "cited_by_count": 24}, {"year": 2023, "cited_by_count": 23}, {"year": 2022, "cited_by_count": 67}, {"year": 2021, "cited_by_count": 4}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2769555213", "doi": "https://doi.org/10.2174/1566523217666171121165935", "title": "First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?", "display_name": "First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?", "relevance_score": 1155.2466, "publication_year": 2017, "publication_date": "2017-11-25", "ids": {"openalex": "https://openalex.org/W2769555213", "doi": "https://doi.org/10.2174/1566523217666171121165935", "mag": "2769555213", "pmid": "https://pubmed.ncbi.nlm.nih.gov/29173170"}, "language": "en", "primary_location": {"id": "doi:10.2174/1566523217666171121165935", "is_oa": false, "landing_page_url": "https://doi.org/10.2174/1566523217666171121165935", "pdf_url": null, "source": {"id": "https://openalex.org/S31345238", "display_name": "Current Gene Therapy", "issn_l": "1566-5232", "issn": ["1566-5232", "1875-5631"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320079", "host_organization_name": "Bentham Science Publishers", "host_organization_lineage": ["https://openalex.org/P4310320079"], "host_organization_lineage_names": ["Bentham Science Publishers"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Current Gene Therapy", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5077679949", "display_name": "Fran\u00e7oise \u0392aylis", "orcid": "https://orcid.org/0000-0003-2961-5802"}, "institutions": [{"id": "https://openalex.org/I129902397", "display_name": "Dalhousie University", "ror": "https://ror.org/01e6qks80", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I129902397"]}], "countries": ["CA"], "is_corresponding": true, "raw_author_name": "Francoise Baylis", "raw_affiliation_strings": ["Novel Tech Ethics, Faculty of Medicine, Dalhousie University, P.O. Box 15000, 1379 Seymour Street Halifax, NS, Canada"], "affiliations": [{"raw_affiliation_string": "Novel Tech Ethics, Faculty of Medicine, Dalhousie University, P.O. Box 15000, 1379 Seymour Street Halifax, NS, Canada", "institution_ids": ["https://openalex.org/I129902397"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5003225159", "display_name": "Marcus McLeod", "orcid": null}, "institutions": [{"id": "https://openalex.org/I129902397", "display_name": "Dalhousie University", "ror": "https://ror.org/01e6qks80", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I129902397"]}], "countries": ["CA"], "is_corresponding": false, "raw_author_name": "Marcus McLeod", "raw_affiliation_strings": ["Novel Tech Ethics, Faculty of Medicine, Dalhousie University, P.O. Box 15000, 1379 Seymour Street Halifax, NS, Canada"], "affiliations": [{"raw_affiliation_string": "Novel Tech Ethics, Faculty of Medicine, Dalhousie University, P.O. Box 15000, 1379 Seymour Street Halifax, NS, Canada", "institution_ids": ["https://openalex.org/I129902397"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5077679949"], "corresponding_institution_ids": ["https://openalex.org/I129902397"], "apc_list": null, "apc_paid": null, "fwci": 7.9766, "has_fulltext": false, "cited_by_count": 95, "citation_normalized_percentile": {"value": 0.98108163, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 97, "max": 100}, "biblio": {"volume": "17", "issue": "4", "first_page": "309", "last_page": "319"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T13417", "display_name": "Biomedical Ethics and Regulation", "score": 0.9973999857902527, "subfield": {"id": "https://openalex.org/subfields/2737", "display_name": "Physiology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, "topics": [{"id": "https://openalex.org/T13417", "display_name": "Biomedical Ethics and Regulation", "score": 0.9973999857902527, "subfield": {"id": "https://openalex.org/subfields/2737", "display_name": "Physiology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9958999752998352, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T13280", "display_name": "Biomedical and Engineering Education", "score": 0.9919999837875366, "subfield": {"id": "https://openalex.org/subfields/2204", "display_name": "Biomedical Engineering"}, "field": {"id": "https://openalex.org/fields/22", "display_name": "Engineering"}, "domain": {"id": "https://openalex.org/domains/3", "display_name": "Physical Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/clinical-trial", "display_name": "Clinical trial", "score": 0.7634730339050293}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.5384379029273987}, {"id": "https://openalex.org/keywords/credibility", "display_name": "Credibility", "score": 0.5020663738250732}, {"id": "https://openalex.org/keywords/medicine", "display_name": "Medicine", "score": 0.4674423933029175}, {"id": "https://openalex.org/keywords/clinical-study-design", "display_name": "Clinical study design", "score": 0.44752442836761475}, {"id": "https://openalex.org/keywords/pathology", "display_name": "Pathology", "score": 0.1612417995929718}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.0991172194480896}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.08833274245262146}], "concepts": [{"id": "https://openalex.org/C535046627", "wikidata": "https://www.wikidata.org/wiki/Q30612", "display_name": "Clinical trial", "level": 2, "score": 0.7634730339050293}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.5384379029273987}, {"id": "https://openalex.org/C2780224610", "wikidata": "https://www.wikidata.org/wiki/Q1530061", "display_name": "Credibility", "level": 2, "score": 0.5020663738250732}, {"id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.4674423933029175}, {"id": "https://openalex.org/C148482608", "wikidata": "https://www.wikidata.org/wiki/Q17007018", "display_name": "Clinical study design", "level": 3, "score": 0.44752442836761475}, {"id": "https://openalex.org/C142724271", "wikidata": "https://www.wikidata.org/wiki/Q7208", "display_name": "Pathology", "level": 1, "score": 0.1612417995929718}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.0991172194480896}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.08833274245262146}, {"id": "https://openalex.org/C17744445", "wikidata": "https://www.wikidata.org/wiki/Q36442", "display_name": "Political science", "level": 0, "score": 0.0}, {"id": "https://openalex.org/C199539241", "wikidata": "https://www.wikidata.org/wiki/Q7748", "display_name": "Law", "level": 1, "score": 0.0}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.0}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D008545", "descriptor_name": "Melanoma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009101", "descriptor_name": "Multiple Myeloma", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D011446", "descriptor_name": "Prospective Studies", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011446", "descriptor_name": "Prospective Studies", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011446", "descriptor_name": "Prospective Studies", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011446", "descriptor_name": "Prospective Studies", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011519", "descriptor_name": "Proto-Oncogenes", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011519", "descriptor_name": "Proto-Oncogenes", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011519", "descriptor_name": "Proto-Oncogenes", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D011519", "descriptor_name": "Proto-Oncogenes", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012107", "descriptor_name": "Research Design", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D012107", "descriptor_name": "Research Design", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D012107", "descriptor_name": "Research Design", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D012107", "descriptor_name": "Research Design", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D013584", "descriptor_name": "Sarcoma, Synovial", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015203", "descriptor_name": "Reproducibility of Results", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015203", "descriptor_name": "Reproducibility of Results", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015203", "descriptor_name": "Reproducibility of Results", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015203", "descriptor_name": "Reproducibility of Results", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D017321", "descriptor_name": "Clinical Trials, Phase I as Topic", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D057170", "descriptor_name": "Translational Research, Biomedical", "qualifier_ui": "Q000941", "qualifier_name": "ethics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 3, "locations": [{"id": "doi:10.2174/1566523217666171121165935", "is_oa": false, "landing_page_url": "https://doi.org/10.2174/1566523217666171121165935", "pdf_url": null, "source": {"id": "https://openalex.org/S31345238", "display_name": "Current Gene Therapy", "issn_l": "1566-5232", "issn": ["1566-5232", "1875-5631"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320079", "host_organization_name": "Bentham Science Publishers", "host_organization_lineage": ["https://openalex.org/P4310320079"], "host_organization_lineage_names": ["Bentham Science Publishers"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Current Gene Therapy", "raw_type": "journal-article"}, {"id": "pmid:29173170", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/29173170", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Current gene therapy", "raw_type": null}, {"id": "pmh:oai:europepmc.org:4701062", "is_oa": false, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/5769084", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400806", "display_name": "Europe PMC (PubMed Central)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1303153112", "host_organization_name": "European Bioinformatics Institute", "host_organization_lineage": ["https://openalex.org/I1303153112"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "Text"}], "best_oa_location": null, "sustainable_development_goals": [], "awards": [], "funders": [{"id": "https://openalex.org/F4320315119", "display_name": "Parker Institute for Cancer Immunotherapy", "ror": "https://ror.org/0184qbg02"}, {"id": "https://openalex.org/F4320321629", "display_name": "Dalhousie University", "ror": "https://ror.org/01e6qks80"}], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 52, "referenced_works": ["https://openalex.org/W71660379", "https://openalex.org/W1877911682", "https://openalex.org/W1975092457", "https://openalex.org/W1977680690", "https://openalex.org/W1983156083", "https://openalex.org/W1985579610", "https://openalex.org/W1985649889", "https://openalex.org/W1987443121", "https://openalex.org/W1987777080", "https://openalex.org/W2007605965", "https://openalex.org/W2009164582", "https://openalex.org/W2014428158", "https://openalex.org/W2016657204", "https://openalex.org/W2021555547", "https://openalex.org/W2023003954", "https://openalex.org/W2029725525", "https://openalex.org/W2030728140", "https://openalex.org/W2034428193", "https://openalex.org/W2049563195", "https://openalex.org/W2052975116", "https://openalex.org/W2058521477", "https://openalex.org/W2061338442", "https://openalex.org/W2064349256", "https://openalex.org/W2067833766", "https://openalex.org/W2078662547", "https://openalex.org/W2083802683", "https://openalex.org/W2096322385", "https://openalex.org/W2097608695", "https://openalex.org/W2098900183", "https://openalex.org/W2103875073", "https://openalex.org/W2105601126", "https://openalex.org/W2109937560", "https://openalex.org/W2113720647", "https://openalex.org/W2118952409", "https://openalex.org/W2130364039", "https://openalex.org/W2147354890", "https://openalex.org/W2150060517", "https://openalex.org/W2153712501", "https://openalex.org/W2155367684", "https://openalex.org/W2161771297", "https://openalex.org/W2162181903", "https://openalex.org/W2252537650", "https://openalex.org/W2311385685", "https://openalex.org/W2315610616", "https://openalex.org/W2345969225", "https://openalex.org/W2460688976", "https://openalex.org/W2513573571", "https://openalex.org/W2556159813", "https://openalex.org/W2559594954", "https://openalex.org/W2560367415", "https://openalex.org/W2564241908", "https://openalex.org/W4243249605"], "related_works": ["https://openalex.org/W2409877361", "https://openalex.org/W2128497441", "https://openalex.org/W2126486918", "https://openalex.org/W2790193975", "https://openalex.org/W1576735944", "https://openalex.org/W2067584555", "https://openalex.org/W2104933030", "https://openalex.org/W3183817480", "https://openalex.org/W4285900245", "https://openalex.org/W2799753303"], "abstract_inverted_index": {"A": [0], "prospective": [1], "first-in-human": [2, 38, 151], "Phase": [3, 39, 114, 152, 226], "1": [4, 40, 115, 153, 227], "CRISPR": [5, 154, 228], "gene": [6, 25, 155, 229], "editing": [7, 26, 156, 230], "trial": [8, 73, 117, 123, 232, 245, 262], "in": [9, 142, 233], "the": [10, 56, 68, 85, 94, 113, 192, 218, 224, 234, 243, 248, 255], "United": [11, 235], "States": [12, 236], "for": [13, 100, 130], "patients": [14], "with": [15, 37, 202], "melanoma,": [16], "synovial": [17], "sarcoma,": [18], "and": [19, 60, 121, 140, 166, 172, 187, 212], "multiple": [20], "myeloma": [21], "offers": [22], "hope": [23], "that": [24, 71, 112, 122, 242], "tools": [27], "may": [28, 103], "usefully": [29], "treat": [30], "human": [31], "disease.": [32], "An": [33], "overarching": [34], "ethical": [35, 95, 249], "challenge": [36], "clinical": [41, 101, 116, 138, 157, 173], "trials,": [42, 158], "however,": [43], "is": [44, 48, 90, 146, 197, 264], "knowing": [45], "when": [46, 144], "it": [47, 145], "ethically": [49, 147], "acceptable": [50, 148], "to": [51, 128, 149, 164, 179, 198, 205, 222, 260], "initiate": [52, 150], "such": [53], "trials": [54], "on": [55], "basis": [57], "of": [58, 83, 87, 97, 182, 194, 210, 251], "safety": [59], "efficacy": [61], "data": [62], "obtained": [63], "from": [64], "pre-clinical": [65, 69, 88, 171, 219, 257], "studies.": [66], "If": [67], "studies": [70], "inform": [72, 261], "design": [74, 263], "are": [75], "themselves": [76], "poorly": [77], "designed": [78], "-": [79, 92], "as": [80], "a": [81], "result": [82], "which": [84], "quality": [86], "evidence": [89, 196, 220, 258], "deficient": [91], "then": [93], "requirement": [96, 250], "scientific": [98, 252], "validity": [99, 253], "research": [102], "not": [104], "be": [105, 119, 126, 199], "satisfied.": [106], "In": [107], "turn,": [108], "this": [109], "could": [110], "mean": [111], "will": [118, 125], "unsafe": [120], "participants": [124], "exposed": [127], "risk": [129], "no": [131], "potential": [132], "benefit.": [133], "To": [134], "assist": [135], "sponsors,": [136], "researchers,": [137], "investigators": [139], "reviewers": [141], "deciding": [143], "structured": [159], "processes": [160, 176], "have": [161], "been": [162], "developed": [163], "assess": [165], "minimize": [167], "translational": [168], "distance": [169], "between": [170], "research.": [174], "These": [175], "draw": [177], "attention": [178, 204], "various": [180], "features": [181], "internal": [183], "validity,": [184, 186], "construct": [185], "external": [188], "validity.": [189], "As": [190], "well,": [191], "credibility": [193], "supporting": [195, 256], "critically": [200, 216], "assessed": [201], "particular": [203], "optimism": [206], "bias,": [207], "financial": [208], "conflicts": [209], "interest": [211], "publication": [213], "bias.": [214], "We": [215, 240], "examine": [217], "used": [221, 259], "justify": [223], "first-inhuman": [225], "cancer": [231], "using": [237], "these": [238], "tools.": [239], "conclude": [241], "proposed": [244], "cannot": [246], "satisfy": [247], "because": [254], "deficient.": [265]}, "counts_by_year": [{"year": 2025, "cited_by_count": 8}, {"year": 2024, "cited_by_count": 7}, {"year": 2023, "cited_by_count": 10}, {"year": 2022, "cited_by_count": 5}, {"year": 2021, "cited_by_count": 12}, {"year": 2020, "cited_by_count": 21}, {"year": 2019, "cited_by_count": 22}, {"year": 2018, "cited_by_count": 10}], "updated_date": "2025-11-06T03:46:38.306776", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2531575240", "doi": "https://doi.org/10.1038/nbt.3680", "title": "Bypassing GMO regulations with CRISPR gene editing", "display_name": "Bypassing GMO regulations with CRISPR gene editing", "relevance_score": 1154.4857, "publication_year": 2016, "publication_date": "2016-10-01", "ids": {"openalex": "https://openalex.org/W2531575240", "doi": "https://doi.org/10.1038/nbt.3680", "mag": "2531575240", "pmid": "https://pubmed.ncbi.nlm.nih.gov/27727209"}, "language": "en", "primary_location": {"id": "doi:10.1038/nbt.3680", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nbt.3680", "pdf_url": null, "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, "type": "letter", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5086513730", "display_name": "Jungeun Kim", "orcid": null}, "institutions": [{"id": "https://openalex.org/I139264467", "display_name": "Seoul National University", "ror": "https://ror.org/04h9pn542", "country_code": "KR", "type": "education", "lineage": ["https://openalex.org/I139264467"]}, {"id": "https://openalex.org/I4210104335", "display_name": "Institute for Basic Science", "ror": "https://ror.org/00y0zf565", "country_code": "KR", "type": "facility", "lineage": ["https://openalex.org/I4210104335"]}], "countries": ["KR"], "is_corresponding": true, "raw_author_name": "Jungeun Kim", "raw_affiliation_strings": ["Center for Genome Engineering, Institute for Basic Science, Seoul, South Korea", "Department of Chemistry, Seoul National University, Seoul, South Korea"], "affiliations": [{"raw_affiliation_string": "Center for Genome Engineering, Institute for Basic Science, Seoul, South Korea", "institution_ids": ["https://openalex.org/I4210104335"]}, {"raw_affiliation_string": "Department of Chemistry, Seoul National University, Seoul, South Korea", "institution_ids": ["https://openalex.org/I139264467"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5100390285", "display_name": "Jin\u2010Soo Kim", "orcid": "https://orcid.org/0000-0003-4847-1306"}, "institutions": [{"id": "https://openalex.org/I139264467", "display_name": "Seoul National University", "ror": "https://ror.org/04h9pn542", "country_code": "KR", "type": "education", "lineage": ["https://openalex.org/I139264467"]}, {"id": "https://openalex.org/I4210104335", "display_name": "Institute for Basic Science", "ror": "https://ror.org/00y0zf565", "country_code": "KR", "type": "facility", "lineage": ["https://openalex.org/I4210104335"]}], "countries": ["KR"], "is_corresponding": false, "raw_author_name": "Jin-Soo Kim", "raw_affiliation_strings": ["Center for Genome Engineering, Institute for Basic Science, Seoul, South Korea", "Department of Chemistry, Seoul National University, Seoul, South Korea"], "affiliations": [{"raw_affiliation_string": "Center for Genome Engineering, Institute for Basic Science, Seoul, South Korea", "institution_ids": ["https://openalex.org/I4210104335"]}, {"raw_affiliation_string": "Department of Chemistry, Seoul National University, Seoul, South Korea", "institution_ids": ["https://openalex.org/I139264467"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 2, "corresponding_author_ids": ["https://openalex.org/A5086513730"], "corresponding_institution_ids": ["https://openalex.org/I139264467", "https://openalex.org/I4210104335"], "apc_list": {"value": 9750, "currency": "EUR", "value_usd": 11690}, "apc_paid": null, "fwci": 4.67980646, "has_fulltext": false, "cited_by_count": 87, "citation_normalized_percentile": {"value": 0.95614925, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 94, "max": 100}, "biblio": {"volume": "34", "issue": "10", "first_page": "1014", "last_page": "1015"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.9905999898910522, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T11426", "display_name": "Genetically Modified Organisms Research", "score": 0.9818999767303467, "subfield": {"id": "https://openalex.org/subfields/1110", "display_name": "Plant Science"}, "field": {"id": "https://openalex.org/fields/11", "display_name": "Agricultural and Biological Sciences"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.9116549491882324}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7304524779319763}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5105773210525513}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.4425663948059082}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.43053242564201355}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.42624136805534363}, {"id": "https://openalex.org/keywords/biotechnology", "display_name": "Biotechnology", "score": 0.37584853172302246}, {"id": "https://openalex.org/keywords/business", "display_name": "Business", "score": 0.33457523584365845}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.9116549491882324}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7304524779319763}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5105773210525513}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.4425663948059082}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.43053242564201355}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.42624136805534363}, {"id": "https://openalex.org/C150903083", "wikidata": "https://www.wikidata.org/wiki/Q7108", "display_name": "Biotechnology", "level": 1, "score": 0.37584853172302246}, {"id": "https://openalex.org/C144133560", "wikidata": "https://www.wikidata.org/wiki/Q4830453", "display_name": "Business", "level": 0, "score": 0.33457523584365845}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": false}, {"descriptor_ui": "D000363", "descriptor_name": "Agaricales", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000363", "descriptor_name": "Agaricales", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000363", "descriptor_name": "Agaricales", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004271", "descriptor_name": "DNA, Fungal", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004271", "descriptor_name": "DNA, Fungal", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D004271", "descriptor_name": "DNA, Fungal", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D005515", "descriptor_name": "Food Labeling", "qualifier_ui": "Q000331", "qualifier_name": "legislation & jurisprudence", "is_major_topic": false}, {"descriptor_ui": "D005515", "descriptor_name": "Food Labeling", "qualifier_ui": "Q000331", "qualifier_name": "legislation & jurisprudence", "is_major_topic": false}, {"descriptor_ui": "D005515", "descriptor_name": "Food Labeling", "qualifier_ui": "Q000331", "qualifier_name": "legislation & jurisprudence", "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D010957", "descriptor_name": "Plasmids", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D010957", "descriptor_name": "Plasmids", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D010957", "descriptor_name": "Plasmids", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014481", "descriptor_name": "United States", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016885", "descriptor_name": "United States Department of Agriculture", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016885", "descriptor_name": "United States Department of Agriculture", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D016885", "descriptor_name": "United States Department of Agriculture", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D017360", "descriptor_name": "Arabidopsis", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017360", "descriptor_name": "Arabidopsis", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D017360", "descriptor_name": "Arabidopsis", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D030821", "descriptor_name": "Plants, Genetically Modified", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D030821", "descriptor_name": "Plants, Genetically Modified", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D030821", "descriptor_name": "Plants, Genetically Modified", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D030841", "descriptor_name": "Food, Genetically Modified", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D030841", "descriptor_name": "Food, Genetically Modified", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D030841", "descriptor_name": "Food, Genetically Modified", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 4, "locations": [{"id": "doi:10.1038/nbt.3680", "is_oa": false, "landing_page_url": "https://doi.org/10.1038/nbt.3680", "pdf_url": null, "source": {"id": "https://openalex.org/S106963461", "display_name": "Nature Biotechnology", "issn_l": "1087-0156", "issn": ["1087-0156", "1546-1696"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Biotechnology", "raw_type": "journal-article"}, {"id": "pmid:27727209", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/27727209", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature biotechnology", "raw_type": null}, {"id": "pmh:oai:s-space.snu.ac.kr:10371/165660", "is_oa": false, "landing_page_url": "https://www.nature.com/articles/nbt.3680", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401345", "display_name": "Seoul National University Open Repository (Seoul National University)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I139264467", "host_organization_name": "Seoul National University", "host_organization_lineage": ["https://openalex.org/I139264467"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "", "raw_type": "Other"}, {"id": "pmh:oai:s-space.snu.ac.kr:10371/189792", "is_oa": false, "landing_page_url": "https://hdl.handle.net/10371/189792", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401345", "display_name": "Seoul National University Open Repository (Seoul National University)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I139264467", "host_organization_name": "Seoul National University", "host_organization_lineage": ["https://openalex.org/I139264467"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "", "raw_type": "Article"}], "best_oa_location": null, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/2", "display_name": "Zero hunger", "score": 0.6200000047683716}], "awards": [], "funders": [{"id": "https://openalex.org/F4320326441", "display_name": "Institute for Basic Science", "ror": "https://ror.org/00y0zf565"}, {"id": "https://openalex.org/F4320332778", "display_name": "Animal and Plant Health Inspection Service", "ror": "https://ror.org/0599wfz09"}], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 6, "referenced_works": ["https://openalex.org/W1787401975", "https://openalex.org/W2085993152", "https://openalex.org/W2116534141", "https://openalex.org/W2337748739", "https://openalex.org/W2410526873", "https://openalex.org/W2412316478"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W4401335721", "https://openalex.org/W4388296936"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 2}, {"year": 2025, "cited_by_count": 8}, {"year": 2024, "cited_by_count": 6}, {"year": 2023, "cited_by_count": 12}, {"year": 2022, "cited_by_count": 10}, {"year": 2021, "cited_by_count": 12}, {"year": 2020, "cited_by_count": 10}, {"year": 2019, "cited_by_count": 8}, {"year": 2018, "cited_by_count": 9}, {"year": 2017, "cited_by_count": 8}, {"year": 2016, "cited_by_count": 2}], "updated_date": "2026-02-09T09:26:11.010843", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W4403749986", "doi": "https://doi.org/10.1038/s41375-024-02444-y", "title": "Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapy", "display_name": "Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapy", "relevance_score": 1081.2672, "publication_year": 2024, "publication_date": "2024-10-25", "ids": {"openalex": "https://openalex.org/W4403749986", "doi": "https://doi.org/10.1038/s41375-024-02444-y", "pmid": "https://pubmed.ncbi.nlm.nih.gov/39455854"}, "language": "en", "primary_location": {"id": "doi:10.1038/s41375-024-02444-y", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41375-024-02444-y", "pdf_url": "https://www.nature.com/articles/s41375-024-02444-y.pdf", "source": {"id": "https://openalex.org/S149476849", "display_name": "Leukemia", "issn_l": "0887-6924", "issn": ["0887-6924", "1476-5551"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319965", "host_organization_name": "Springer Nature", "host_organization_lineage": ["https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Springer Nature"], "type": "journal"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Leukemia", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": true, "oa_status": "hybrid", "oa_url": "https://www.nature.com/articles/s41375-024-02444-y.pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5101614515", "display_name": "Tao Lei", "orcid": "https://orcid.org/0000-0002-7991-3448"}, "institutions": [{"id": "https://openalex.org/I4210120929", "display_name": "Zhujiang Hospital", "ror": "https://ror.org/02mhxa927", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210120929"]}], "countries": ["CN"], "is_corresponding": true, "raw_author_name": "Tao Lei", "raw_affiliation_strings": ["The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I4210120929"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5020404240", "display_name": "Yazhuo Wang", "orcid": "https://orcid.org/0000-0003-3952-9553"}, "institutions": [{"id": "https://openalex.org/I99065089", "display_name": "Tsinghua University", "ror": "https://ror.org/03cve4549", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I99065089"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yazhuo Wang", "raw_affiliation_strings": ["School of Life Sciences, Tsinghua University, Beijing, 100084, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "School of Life Sciences, Tsinghua University, Beijing, 100084, China", "institution_ids": ["https://openalex.org/I99065089"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100424329", "display_name": "Yuchen Zhang", "orcid": "https://orcid.org/0000-0003-4441-0346"}, "institutions": [{"id": "https://openalex.org/I4210120929", "display_name": "Zhujiang Hospital", "ror": "https://ror.org/02mhxa927", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210120929"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yuchen Zhang", "raw_affiliation_strings": ["The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I4210120929"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5112567295", "display_name": "Yufei Yang", "orcid": "https://orcid.org/0000-0002-7297-4491"}, "institutions": [{"id": "https://openalex.org/I4210120929", "display_name": "Zhujiang Hospital", "ror": "https://ror.org/02mhxa927", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210120929"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Yufei Yang", "raw_affiliation_strings": ["The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I4210120929"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5091855110", "display_name": "Jiaying Cao", "orcid": "https://orcid.org/0009-0009-0365-3123"}, "institutions": [{"id": "https://openalex.org/I4210103346", "display_name": "Nanfang Hospital", "ror": "https://ror.org/01eq10738", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210103346"]}, {"id": "https://openalex.org/I58200834", "display_name": "Southern Medical University", "ror": "https://ror.org/01vjw4z39", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I58200834"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Jiaying Cao", "raw_affiliation_strings": ["The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I58200834", "https://openalex.org/I4210103346"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5058815529", "display_name": "Jiansong Huang", "orcid": "https://orcid.org/0000-0003-0821-2801"}, "institutions": [{"id": "https://openalex.org/I4210120929", "display_name": "Zhujiang Hospital", "ror": "https://ror.org/02mhxa927", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210120929"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Jiansong Huang", "raw_affiliation_strings": ["The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I4210120929"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100459752", "display_name": "Jiali Chen", "orcid": null}, "institutions": [{"id": "https://openalex.org/I4210120929", "display_name": "Zhujiang Hospital", "ror": "https://ror.org/02mhxa927", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210120929"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Jiali Chen", "raw_affiliation_strings": ["The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I4210120929"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5104337529", "display_name": "Huajing Chen", "orcid": null}, "institutions": [{"id": "https://openalex.org/I4210103346", "display_name": "Nanfang Hospital", "ror": "https://ror.org/01eq10738", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210103346"]}, {"id": "https://openalex.org/I58200834", "display_name": "Southern Medical University", "ror": "https://ror.org/01vjw4z39", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I58200834"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Huajing Chen", "raw_affiliation_strings": ["The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I58200834", "https://openalex.org/I4210103346"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100357315", "display_name": "Jiayi Zhang", "orcid": "https://orcid.org/0009-0001-0726-0126"}, "institutions": [{"id": "https://openalex.org/I4210103346", "display_name": "Nanfang Hospital", "ror": "https://ror.org/01eq10738", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210103346"]}, {"id": "https://openalex.org/I58200834", "display_name": "Southern Medical University", "ror": "https://ror.org/01vjw4z39", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I58200834"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Jiayi Zhang", "raw_affiliation_strings": ["The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510145, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510145, China", "institution_ids": ["https://openalex.org/I58200834", "https://openalex.org/I4210103346"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5045031971", "display_name": "lingdie wang", "orcid": null}, "institutions": [{"id": "https://openalex.org/I1294606314", "display_name": "Beijing Tongren Hospital", "ror": "https://ror.org/013e4n276", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I1294606314"]}, {"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210146711", "display_name": "Sun Yat-sen University Cancer Center", "ror": "https://ror.org/0400g8r85", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210146711"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Luzheng Wang", "raw_affiliation_strings": ["Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. wangliangtrhos@126.com", "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. wangliangtrhos@126.com", "institution_ids": ["https://openalex.org/I1294606314"]}, {"raw_affiliation_string": "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210146711"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5103868642", "display_name": "Xinjie Xu", "orcid": "https://orcid.org/0000-0002-5679-9750"}, "institutions": [{"id": "https://openalex.org/I200296433", "display_name": "Chinese Academy of Medical Sciences & Peking Union Medical College", "ror": "https://ror.org/02drdmm93", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I200296433"]}, {"id": "https://openalex.org/I4210161896", "display_name": "Fu Wai Hospital", "ror": "https://ror.org/0590dnz19", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210161896"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Xinjie Xu", "raw_affiliation_strings": ["State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. xuxinjiepumc@126.com"], "raw_orcid": "https://orcid.org/0000-0002-5679-9750", "affiliations": [{"raw_affiliation_string": "State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. xuxinjiepumc@126.com", "institution_ids": ["https://openalex.org/I4210161896", "https://openalex.org/I200296433"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5110094570", "display_name": "Robert Peter Gale", "orcid": null}, "institutions": [{"id": "https://openalex.org/I4210151647", "display_name": "Centre for Inflammation Research", "ror": "https://ror.org/05wcr1b38", "country_code": "GB", "type": "facility", "lineage": ["https://openalex.org/I4210087105", "https://openalex.org/I4210151647", "https://openalex.org/I90344618", "https://openalex.org/I98677209"]}], "countries": ["GB"], "is_corresponding": false, "raw_author_name": "Robert Peter Gale", "raw_affiliation_strings": ["Centre for Haematology, Department of Immunology and Inflammation, Imperial College of Science, Technology and Medicine, London, UK. robertpeter@alumni.ucla.edu"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Centre for Haematology, Department of Immunology and Inflammation, Imperial College of Science, Technology and Medicine, London, UK. robertpeter@alumni.ucla.edu", "institution_ids": ["https://openalex.org/I4210151647"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5100456475", "display_name": "Liang Wang", "orcid": "https://orcid.org/0000-0001-6140-914X"}, "institutions": [{"id": "https://openalex.org/I1294606314", "display_name": "Beijing Tongren Hospital", "ror": "https://ror.org/013e4n276", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I1294606314"]}, {"id": "https://openalex.org/I157773358", "display_name": "Sun Yat-sen University", "ror": "https://ror.org/0064kty71", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I157773358"]}, {"id": "https://openalex.org/I4210146711", "display_name": "Sun Yat-sen University Cancer Center", "ror": "https://ror.org/0400g8r85", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210146711"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Liang Wang", "raw_affiliation_strings": ["Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. wangliangtrhos@126.com", "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China"], "raw_orcid": "https://orcid.org/0000-0001-6140-914X", "affiliations": [{"raw_affiliation_string": "Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. wangliangtrhos@126.com", "institution_ids": ["https://openalex.org/I1294606314"]}, {"raw_affiliation_string": "State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China", "institution_ids": ["https://openalex.org/I157773358", "https://openalex.org/I4210146711"]}]}], "institutions": [], "countries_distinct_count": 2, "institutions_distinct_count": 13, "corresponding_author_ids": ["https://openalex.org/A5101614515"], "corresponding_institution_ids": ["https://openalex.org/I4210120929"], "apc_list": {"value": 3890, "currency": "EUR", "value_usd": 4790}, "apc_paid": {"value": 3890, "currency": "EUR", "value_usd": 4790}, "fwci": 24.299, "has_fulltext": true, "cited_by_count": 96, "citation_normalized_percentile": {"value": 0.99726932, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "38", "issue": "12", "first_page": "2517", "last_page": "2543"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T11491", "display_name": "CAR-T cell therapy research", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/2730", "display_name": "Oncology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, "topics": [{"id": "https://openalex.org/T11491", "display_name": "CAR-T cell therapy research", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/2730", "display_name": "Oncology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.998199999332428, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T11663", "display_name": "Viral Infectious Diseases and Gene Expression in Insects", "score": 0.9574000239372253, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8930553793907166}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7772102355957031}, {"id": "https://openalex.org/keywords/genetic-enhancement", "display_name": "Genetic enhancement", "score": 0.6053664684295654}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.4516708552837372}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.4381254017353058}, {"id": "https://openalex.org/keywords/cell-therapy", "display_name": "Cell therapy", "score": 0.4108560085296631}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.353360652923584}, {"id": "https://openalex.org/keywords/computer-science", "display_name": "Computer science", "score": 0.35149842500686646}, {"id": "https://openalex.org/keywords/medicine", "display_name": "Medicine", "score": 0.3338560461997986}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.3315727710723877}, {"id": "https://openalex.org/keywords/stem-cell", "display_name": "Stem cell", "score": 0.3150233328342438}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8930553793907166}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7772102355957031}, {"id": "https://openalex.org/C111599444", "wikidata": "https://www.wikidata.org/wiki/Q213901", "display_name": "Genetic enhancement", "level": 3, "score": 0.6053664684295654}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.4516708552837372}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.4381254017353058}, {"id": "https://openalex.org/C10882517", "wikidata": "https://www.wikidata.org/wiki/Q15268054", "display_name": "Cell therapy", "level": 3, "score": 0.4108560085296631}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.353360652923584}, {"id": "https://openalex.org/C41008148", "wikidata": "https://www.wikidata.org/wiki/Q21198", "display_name": "Computer science", "level": 0, "score": 0.35149842500686646}, {"id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.3338560461997986}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.3315727710723877}, {"id": "https://openalex.org/C28328180", "wikidata": "https://www.wikidata.org/wiki/Q48196", "display_name": "Stem cell", "level": 2, "score": 0.3150233328342438}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000076962", "descriptor_name": "Receptors, Chimeric Antigen", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D009369", "descriptor_name": "Neoplasms", "qualifier_ui": "Q000628", "qualifier_name": "therapy", "is_major_topic": true}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D013601", "descriptor_name": "T-Lymphocytes", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000009", "qualifier_name": "adverse effects", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D016219", "descriptor_name": "Immunotherapy, Adoptive", "qualifier_ui": "Q000379", "qualifier_name": "methods", "is_major_topic": true}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 3, "locations": [{"id": "doi:10.1038/s41375-024-02444-y", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41375-024-02444-y", "pdf_url": "https://www.nature.com/articles/s41375-024-02444-y.pdf", "source": {"id": "https://openalex.org/S149476849", "display_name": "Leukemia", "issn_l": "0887-6924", "issn": ["0887-6924", "1476-5551"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319965", "host_organization_name": "Springer Nature", "host_organization_lineage": ["https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Springer Nature"], "type": "journal"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Leukemia", "raw_type": "journal-article"}, {"id": "pmid:39455854", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/39455854", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Leukemia", "raw_type": null}, {"id": "pmh:oai:pubmedcentral.nih.gov:11588664", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/11588664", "pdf_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11588664/pdf/41375_2024_Article_2444.pdf", "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Leukemia", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1038/s41375-024-02444-y", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41375-024-02444-y", "pdf_url": "https://www.nature.com/articles/s41375-024-02444-y.pdf", "source": {"id": "https://openalex.org/S149476849", "display_name": "Leukemia", "issn_l": "0887-6924", "issn": ["0887-6924", "1476-5551"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310319965", "host_organization_name": "Springer Nature", "host_organization_lineage": ["https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Springer Nature"], "type": "journal"}, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Leukemia", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G2067105946", "display_name": null, "funder_award_id": "82370188", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G5597771340", "display_name": null, "funder_award_id": "82170181", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}], "funders": [{"id": "https://openalex.org/F4320314997", "display_name": "Strong", "ror": "https://ror.org/041vyzr56"}, {"id": "https://openalex.org/F4320321001", "display_name": "National Natural Science Foundation of China", "ror": "https://ror.org/01h0zpd94"}], "has_content": {"pdf": true, "grobid_xml": false}, "content_urls": {"pdf": "https://content.openalex.org/works/W4403749986.pdf"}, "referenced_works_count": 272, "referenced_works": ["https://openalex.org/W1980201684", "https://openalex.org/W2160051211", "https://openalex.org/W2165869860", "https://openalex.org/W2210357377", "https://openalex.org/W2219506342", "https://openalex.org/W2224398381", "https://openalex.org/W2247762492", "https://openalex.org/W2410526873", "https://openalex.org/W2465120080", "https://openalex.org/W2548694234", "https://openalex.org/W2558333564", "https://openalex.org/W2560230043", "https://openalex.org/W2568738534", "https://openalex.org/W2588571054", "https://openalex.org/W2589417329", "https://openalex.org/W2617763104", "https://openalex.org/W2621848900", "https://openalex.org/W2626752341", "https://openalex.org/W2772339799", "https://openalex.org/W2773804840", "https://openalex.org/W2782124401", "https://openalex.org/W2782690022", "https://openalex.org/W2790984880", "https://openalex.org/W2791408070", "https://openalex.org/W2791923357", "https://openalex.org/W2792588868", "https://openalex.org/W2792803089", "https://openalex.org/W2793359586", "https://openalex.org/W2801052048", "https://openalex.org/W2801641802", "https://openalex.org/W2803295557", "https://openalex.org/W2804231581", "https://openalex.org/W2805058565", "https://openalex.org/W2810059222", "https://openalex.org/W2810308581", "https://openalex.org/W2810715813", "https://openalex.org/W2810961119", "https://openalex.org/W2818540548", "https://openalex.org/W2885949612", "https://openalex.org/W2886819502", "https://openalex.org/W2889641854", "https://openalex.org/W2897295193", "https://openalex.org/W2898826636", "https://openalex.org/W2901478468", "https://openalex.org/W2902250833", "https://openalex.org/W2903225254", "https://openalex.org/W2903565415", "https://openalex.org/W2906950793", "https://openalex.org/W2909752178", "https://openalex.org/W2910070214", "https://openalex.org/W2910803005", "https://openalex.org/W2913447577", "https://openalex.org/W2916027162", "https://openalex.org/W2917919793", "https://openalex.org/W2919051790", "https://openalex.org/W2921526118", "https://openalex.org/W2921769581", "https://openalex.org/W2947751606", "https://openalex.org/W2947777875", "https://openalex.org/W2974009848", "https://openalex.org/W2979813221", "https://openalex.org/W2980110583", "https://openalex.org/W2985370419", "https://openalex.org/W2988100850", "https://openalex.org/W2989635394", "https://openalex.org/W2991627551", "https://openalex.org/W2995081665", "https://openalex.org/W2996644149", "https://openalex.org/W2997122742", "https://openalex.org/W2997152681", "https://openalex.org/W2998345757", "https://openalex.org/W2998399996", "https://openalex.org/W3003839508", "https://openalex.org/W3004461655", "https://openalex.org/W3004490498", "https://openalex.org/W3004706073", "https://openalex.org/W3006116138", "https://openalex.org/W3010217167", "https://openalex.org/W3010291540", "https://openalex.org/W3015141182", "https://openalex.org/W3016711432", "https://openalex.org/W3017329354", "https://openalex.org/W3017464623", "https://openalex.org/W3021994425", "https://openalex.org/W3024497436", "https://openalex.org/W3030448313", "https://openalex.org/W3033006672", "https://openalex.org/W3033331291", "https://openalex.org/W3033491714", "https://openalex.org/W3035764705", "https://openalex.org/W3036078444", "https://openalex.org/W3037236323", "https://openalex.org/W3041276616", "https://openalex.org/W3042904924", "https://openalex.org/W3045563299", "https://openalex.org/W3083268149", "https://openalex.org/W3086882763", "https://openalex.org/W3088246260", "https://openalex.org/W3088669664", "https://openalex.org/W3093469725", "https://openalex.org/W3094746469", "https://openalex.org/W3096848745", "https://openalex.org/W3109746568", "https://openalex.org/W3109885192", "https://openalex.org/W3112226569", "https://openalex.org/W3113171896", "https://openalex.org/W3119665747", "https://openalex.org/W3119774682", "https://openalex.org/W3121806651", "https://openalex.org/W3124631812", "https://openalex.org/W3128879876", "https://openalex.org/W3129391675", "https://openalex.org/W3131565677", "https://openalex.org/W3132062361", "https://openalex.org/W3132274017", "https://openalex.org/W3144992645", "https://openalex.org/W3151543485", "https://openalex.org/W3157147797", "https://openalex.org/W3158544805", "https://openalex.org/W3160669634", "https://openalex.org/W3160860896", "https://openalex.org/W3162374648", "https://openalex.org/W3163599487", "https://openalex.org/W3164457455", "https://openalex.org/W3164622970", "https://openalex.org/W3165603599", "https://openalex.org/W3172817466", "https://openalex.org/W3173650989", "https://openalex.org/W3174856194", "https://openalex.org/W3186077712", "https://openalex.org/W3186956177", "https://openalex.org/W3188046629", "https://openalex.org/W3188078179", "https://openalex.org/W3190511250", "https://openalex.org/W3196112346", "https://openalex.org/W3200735940", "https://openalex.org/W3203657967", "https://openalex.org/W3205666663", "https://openalex.org/W3210595403", "https://openalex.org/W3211754161", "https://openalex.org/W3212016889", "https://openalex.org/W3212255992", "https://openalex.org/W3213155546", "https://openalex.org/W3214677002", "https://openalex.org/W3216414181", "https://openalex.org/W3216532486", "https://openalex.org/W3217337235", "https://openalex.org/W4200424290", "https://openalex.org/W4205786643", "https://openalex.org/W4206390074", "https://openalex.org/W4206716689", "https://openalex.org/W4207068215", "https://openalex.org/W4210396037", "https://openalex.org/W4211219428", "https://openalex.org/W4213070361", "https://openalex.org/W4220655611", "https://openalex.org/W4220793272", "https://openalex.org/W4220874827", "https://openalex.org/W4221014433", "https://openalex.org/W4224115060", "https://openalex.org/W4224254421", "https://openalex.org/W4224255508", "https://openalex.org/W4226342186", "https://openalex.org/W4280491484", "https://openalex.org/W4280546227", "https://openalex.org/W4280546371", "https://openalex.org/W4280591645", "https://openalex.org/W4281741939", "https://openalex.org/W4281992440", "https://openalex.org/W4282975663", "https://openalex.org/W4283033607", "https://openalex.org/W4283259772", "https://openalex.org/W4283265905", "https://openalex.org/W4283720903", "https://openalex.org/W4289322051", "https://openalex.org/W4292707809", "https://openalex.org/W4293004820", "https://openalex.org/W4293178266", "https://openalex.org/W4293237445", "https://openalex.org/W4293792836", "https://openalex.org/W4294904375", "https://openalex.org/W4296373959", "https://openalex.org/W4296693026", "https://openalex.org/W4297020650", "https://openalex.org/W4304807853", "https://openalex.org/W4306655745", "https://openalex.org/W4307309183", "https://openalex.org/W4308399396", "https://openalex.org/W4308844502", "https://openalex.org/W4309889967", "https://openalex.org/W4310106398", "https://openalex.org/W4310161875", "https://openalex.org/W4310943805", "https://openalex.org/W4311039296", "https://openalex.org/W4312113766", "https://openalex.org/W4317437864", "https://openalex.org/W4317716331", "https://openalex.org/W4318071581", "https://openalex.org/W4318071647", "https://openalex.org/W4319301889", "https://openalex.org/W4319337688", "https://openalex.org/W4323642908", "https://openalex.org/W4324046169", "https://openalex.org/W4324309777", "https://openalex.org/W4361289318", "https://openalex.org/W4363676877", "https://openalex.org/W4366085943", "https://openalex.org/W4366823157", "https://openalex.org/W4366826630", "https://openalex.org/W4366998803", "https://openalex.org/W4367609975", "https://openalex.org/W4372352552", "https://openalex.org/W4376876442", "https://openalex.org/W4378214164", "https://openalex.org/W4378976404", "https://openalex.org/W4380563796", "https://openalex.org/W4385186095", "https://openalex.org/W4385271103", "https://openalex.org/W4385330042", "https://openalex.org/W4385406685", "https://openalex.org/W4386317087", "https://openalex.org/W4386495872", "https://openalex.org/W4386560010", "https://openalex.org/W4386744896", "https://openalex.org/W4386886473", "https://openalex.org/W4387307597", "https://openalex.org/W4388411540", "https://openalex.org/W4388464258", "https://openalex.org/W4388694182", "https://openalex.org/W4389229161", "https://openalex.org/W4389243495", "https://openalex.org/W4389671974", "https://openalex.org/W4390507384", "https://openalex.org/W4390732271", "https://openalex.org/W4390742484", "https://openalex.org/W4390750892", "https://openalex.org/W4390946758", "https://openalex.org/W4391160815", "https://openalex.org/W4391745500", "https://openalex.org/W4391792333", "https://openalex.org/W4392005435", "https://openalex.org/W4392303996", "https://openalex.org/W4392508479", "https://openalex.org/W4392818398", "https://openalex.org/W4392892866", "https://openalex.org/W4392967953", "https://openalex.org/W4393902863", "https://openalex.org/W4394950908", "https://openalex.org/W4395081799", "https://openalex.org/W4396708194", "https://openalex.org/W4396734291", "https://openalex.org/W4398240063", "https://openalex.org/W4399284143", "https://openalex.org/W4399670534", "https://openalex.org/W4400415576", "https://openalex.org/W4400651835", "https://openalex.org/W4400809661", "https://openalex.org/W4400869843", "https://openalex.org/W6740353148", "https://openalex.org/W6749364406", "https://openalex.org/W6758581624", "https://openalex.org/W6759760999", "https://openalex.org/W6760574476", "https://openalex.org/W6790645595", "https://openalex.org/W6799637380", "https://openalex.org/W6801514578", "https://openalex.org/W6807514860", "https://openalex.org/W6808253099", "https://openalex.org/W6839049752", "https://openalex.org/W6849033462", "https://openalex.org/W6854817861", "https://openalex.org/W6925262497"], "related_works": ["https://openalex.org/W4366822718", "https://openalex.org/W4200005163", "https://openalex.org/W3030388918", "https://openalex.org/W2807464733", "https://openalex.org/W4220766053", "https://openalex.org/W2603161682", "https://openalex.org/W4213248511", "https://openalex.org/W2991257722", "https://openalex.org/W3165203721", "https://openalex.org/W4401335721"], "abstract_inverted_index": {"Chimeric": [0], "Antigen": [1], "Receptor": [2], "(CAR)-T-cell": [3], "therapy": [4, 107], "has": [5], "revolutionized": [6], "cancer": [7], "immune": [8], "therapy.": [9, 135], "However,": [10], "challenges": [11, 120], "remain": [12], "including": [13, 108], "increasing": [14, 20], "efficacy,": [15], "reducing": [16], "adverse": [17], "events": [18], "and": [19, 43, 78, 86, 111, 125], "accessibility.": [21], "Use": [22], "of": [23, 67, 97, 104], "Clustered": [24], "Regularly": [25], "Interspaced": [26], "Short": [27], "Palindromic": [28], "Repeats": [29], "(CRISPR)": [30], "technology": [31], "can": [32], "effectively": [33], "perform": [34], "various": [35], "functions": [36], "such": [37], "as": [38], "precise": [39], "integration,": [40], "multi-gene": [41], "editing,": [42], "genome-wide": [44], "functional": [45], "regulation.": [46], "Additionally,": [47], "CRISPR": [48, 72, 99, 122], "screening": [49], "using": [50], "large-scale": [51], "guide": [52], "RNA": [53], "(gRNA)": [54], "genetic": [55], "perturbation": [56], "provides": [57], "an": [58], "unbiased": [59], "approach": [60], "to": [61, 82, 101], "understanding": [62], "mechanisms": [63], "underlying": [64], "anti-cancer": [65], "efficacy": [66, 110], "CAR": [68, 84, 105, 116, 133], "T-cells.": [69, 117], "Several": [70], "emerging": [71], "tools": [73], "with": [74], "high": [75], "specificity,": [76], "controllability": [77], "efficiency": [79], "are": [80], "useful": [81], "modify": [83], "T-cells": [85, 106], "identify": [87], "new": [88], "targets.": [89], "In": [90], "this": [91], "review": [92], "we": [93], "summarize": [94], "potential": [95], "uses": [96], "the": [98], "system": [100], "improve": [102], "results": [103], "optimizing": [109], "safety": [112], "and,": [113], "developing": [114], "universal": [115], "We": [118], "discuss": [119], "facing": [121], "gene": [123], "editing": [124], "propose": [126], "solutions": [127], "highlighting": [128], "future": [129], "research": [130], "directions": [131], "in": [132], "T-cell": [134]}, "counts_by_year": [{"year": 2026, "cited_by_count": 32}, {"year": 2025, "cited_by_count": 63}, {"year": 2024, "cited_by_count": 1}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W4323666400", "doi": "https://doi.org/10.3389/fbioe.2023.1143157", "title": "Off-target effects in CRISPR/Cas9 gene editing", "display_name": "Off-target effects in CRISPR/Cas9 gene editing", "relevance_score": 1068.3304, "publication_year": 2023, "publication_date": "2023-03-09", "ids": {"openalex": "https://openalex.org/W4323666400", "doi": "https://doi.org/10.3389/fbioe.2023.1143157", "pmid": "https://pubmed.ncbi.nlm.nih.gov/36970624"}, "language": "en", "primary_location": {"id": "doi:10.3389/fbioe.2023.1143157", "is_oa": true, "landing_page_url": "https://doi.org/10.3389/fbioe.2023.1143157", "pdf_url": "https://www.frontiersin.org/articles/10.3389/fbioe.2023.1143157/pdf", "source": {"id": "https://openalex.org/S2595131146", "display_name": "Frontiers in Bioengineering and Biotechnology", "issn_l": "2296-4185", "issn": ["2296-4185"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320527", "host_organization_name": "Frontiers Media", "host_organization_lineage": ["https://openalex.org/P4310320527"], "host_organization_lineage_names": ["Frontiers Media"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in Bioengineering and Biotechnology", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://www.frontiersin.org/articles/10.3389/fbioe.2023.1143157/pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5061369579", "display_name": "Congting Guo", "orcid": "https://orcid.org/0000-0001-7289-2747"}, "institutions": [{"id": "https://openalex.org/I20231570", "display_name": "Peking University", "ror": "https://ror.org/02v51f717", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I20231570"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Congting Guo", "raw_affiliation_strings": ["Peking University Institute of Cardiovascular Sciences, Beijing, China", "School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Peking University Institute of Cardiovascular Sciences, Beijing, China", "institution_ids": ["https://openalex.org/I20231570"]}, {"raw_affiliation_string": "School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China", "institution_ids": ["https://openalex.org/I20231570"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5008825234", "display_name": "Xiaoteng Ma", "orcid": "https://orcid.org/0000-0003-4806-6458"}, "institutions": [{"id": "https://openalex.org/I183519381", "display_name": "Capital Medical University", "ror": "https://ror.org/013xs5b60", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I183519381"]}, {"id": "https://openalex.org/I4210119028", "display_name": "Beijing Anzhen Hospital", "ror": "https://ror.org/02h2j1586", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210119028"]}], "countries": ["CN"], "is_corresponding": false, "raw_author_name": "Xiaoteng Ma", "raw_affiliation_strings": ["Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China", "institution_ids": ["https://openalex.org/I4210119028", "https://openalex.org/I183519381"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5012061252", "display_name": "Fei Gao", "orcid": "https://orcid.org/0000-0003-3633-3133"}, "institutions": [{"id": "https://openalex.org/I183519381", "display_name": "Capital Medical University", "ror": "https://ror.org/013xs5b60", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I183519381"]}, {"id": "https://openalex.org/I4210119028", "display_name": "Beijing Anzhen Hospital", "ror": "https://ror.org/02h2j1586", "country_code": "CN", "type": "healthcare", "lineage": ["https://openalex.org/I4210119028"]}], "countries": ["CN"], "is_corresponding": true, "raw_author_name": "Fei Gao", "raw_affiliation_strings": ["Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China", "institution_ids": ["https://openalex.org/I4210119028", "https://openalex.org/I183519381"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5084882105", "display_name": "Yuxuan Guo", "orcid": "https://orcid.org/0000-0002-6009-4403"}, "institutions": [{"id": "https://openalex.org/I1327237609", "display_name": "Ministry of Education of the People's Republic of China", "ror": "https://ror.org/01mv9t934", "country_code": "CN", "type": "government", "lineage": ["https://openalex.org/I1327237609", "https://openalex.org/I4210127390"]}, {"id": "https://openalex.org/I20231570", "display_name": "Peking University", "ror": "https://ror.org/02v51f717", "country_code": "CN", "type": "education", "lineage": ["https://openalex.org/I20231570"]}], "countries": ["CN"], "is_corresponding": true, "raw_author_name": "Yuxuan Guo", "raw_affiliation_strings": ["Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China", "Ministry of Education Key Laboratory of Molecular Cardiovascular Science, Beijing, China", "Peking University Institute of Cardiovascular Sciences, Beijing, China", "School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China", "institution_ids": []}, {"raw_affiliation_string": "Ministry of Education Key Laboratory of Molecular Cardiovascular Science, Beijing, China", "institution_ids": ["https://openalex.org/I1327237609"]}, {"raw_affiliation_string": "Peking University Institute of Cardiovascular Sciences, Beijing, China", "institution_ids": ["https://openalex.org/I20231570"]}, {"raw_affiliation_string": "School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China", "institution_ids": ["https://openalex.org/I20231570"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 4, "corresponding_author_ids": ["https://openalex.org/A5012061252", "https://openalex.org/A5084882105"], "corresponding_institution_ids": ["https://openalex.org/I1327237609", "https://openalex.org/I183519381", "https://openalex.org/I20231570", "https://openalex.org/I4210119028"], "apc_list": {"value": 2950, "currency": "USD", "value_usd": 2950}, "apc_paid": {"value": 2950, "currency": "USD", "value_usd": 2950}, "fwci": 76.8056, "has_fulltext": true, "cited_by_count": 527, "citation_normalized_percentile": {"value": 0.99968479, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 99, "max": 100}, "biblio": {"volume": "11", "issue": null, "first_page": "1143157", "last_page": "1143157"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.9603000283241272, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T11112", "display_name": "Viral Infections and Immunology Research", "score": 0.9402999877929688, "subfield": {"id": "https://openalex.org/subfields/2705", "display_name": "Cardiology and Cardiovascular Medicine"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.978553056716919}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.867761492729187}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.7118417024612427}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.5753016471862793}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5106928944587708}, {"id": "https://openalex.org/keywords/palindrome", "display_name": "Palindrome", "score": 0.5062669515609741}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.503253161907196}, {"id": "https://openalex.org/keywords/genetic-enhancement", "display_name": "Genetic enhancement", "score": 0.4368850290775299}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.3994862735271454}, {"id": "https://openalex.org/keywords/computer-science", "display_name": "Computer science", "score": 0.3662319779396057}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.978553056716919}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.867761492729187}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.7118417024612427}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.5753016471862793}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5106928944587708}, {"id": "https://openalex.org/C44667518", "wikidata": "https://www.wikidata.org/wiki/Q12321", "display_name": "Palindrome", "level": 4, "score": 0.5062669515609741}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.503253161907196}, {"id": "https://openalex.org/C111599444", "wikidata": "https://www.wikidata.org/wiki/Q213901", "display_name": "Genetic enhancement", "level": 3, "score": 0.4368850290775299}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.3994862735271454}, {"id": "https://openalex.org/C41008148", "wikidata": "https://www.wikidata.org/wiki/Q21198", "display_name": "Computer science", "level": 0, "score": 0.3662319779396057}], "mesh": [], "locations_count": 4, "locations": [{"id": "doi:10.3389/fbioe.2023.1143157", "is_oa": true, "landing_page_url": "https://doi.org/10.3389/fbioe.2023.1143157", "pdf_url": "https://www.frontiersin.org/articles/10.3389/fbioe.2023.1143157/pdf", "source": {"id": "https://openalex.org/S2595131146", "display_name": "Frontiers in Bioengineering and Biotechnology", "issn_l": "2296-4185", "issn": ["2296-4185"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320527", "host_organization_name": "Frontiers Media", "host_organization_lineage": ["https://openalex.org/P4310320527"], "host_organization_lineage_names": ["Frontiers Media"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in Bioengineering and Biotechnology", "raw_type": "journal-article"}, {"id": "pmid:36970624", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/36970624", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in bioengineering and biotechnology", "raw_type": null}, {"id": "pmh:oai:pubmedcentral.nih.gov:10034092", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/10034092", "pdf_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10034092/pdf/fbioe-11-1143157.pdf", "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Front Bioeng Biotechnol", "raw_type": "Text"}, {"id": "pmh:oai:doaj.org/article:ef24fdada7f846b1afbab64c81655a9b", "is_oa": true, "landing_page_url": "https://doaj.org/article/ef24fdada7f846b1afbab64c81655a9b", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-sa", "license_id": "https://openalex.org/licenses/cc-by-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)", "raw_type": "article"}], "best_oa_location": {"id": "doi:10.3389/fbioe.2023.1143157", "is_oa": true, "landing_page_url": "https://doi.org/10.3389/fbioe.2023.1143157", "pdf_url": "https://www.frontiersin.org/articles/10.3389/fbioe.2023.1143157/pdf", "source": {"id": "https://openalex.org/S2595131146", "display_name": "Frontiers in Bioengineering and Biotechnology", "issn_l": "2296-4185", "issn": ["2296-4185"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320527", "host_organization_name": "Frontiers Media", "host_organization_lineage": ["https://openalex.org/P4310320527"], "host_organization_lineage_names": ["Frontiers Media"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Frontiers in Bioengineering and Biotechnology", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G28090676", "display_name": null, "funder_award_id": "82100349", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G3142969181", "display_name": null, "funder_award_id": "82222006", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G420103313", "display_name": null, "funder_award_id": "32100660", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G5889841656", "display_name": null, "funder_award_id": "82170367", "funder_id": "https://openalex.org/F4320321001", "funder_display_name": "National Natural Science Foundation of China"}, {"id": "https://openalex.org/G7913236818", "display_name": null, "funder_award_id": "Z211100002121003", "funder_id": "https://openalex.org/F4320334978", "funder_display_name": "Beijing Nova Program"}, {"id": "https://openalex.org/G8541455857", "display_name": null, "funder_award_id": "20220484205", "funder_id": "https://openalex.org/F4320334978", "funder_display_name": "Beijing Nova Program"}], "funders": [{"id": "https://openalex.org/F4320321001", "display_name": "National Natural Science Foundation of China", "ror": "https://ror.org/01h0zpd94"}, {"id": "https://openalex.org/F4320334978", "display_name": "Beijing Nova Program", "ror": "https://ror.org/034k14f91"}], "has_content": {"pdf": true, "grobid_xml": false}, "content_urls": {"pdf": "https://content.openalex.org/works/W4323666400.pdf"}, "referenced_works_count": 107, "referenced_works": ["https://openalex.org/W1555684022", "https://openalex.org/W1970617888", "https://openalex.org/W1974343902", "https://openalex.org/W1982969769", "https://openalex.org/W1990149668", "https://openalex.org/W1997281938", "https://openalex.org/W2003797386", "https://openalex.org/W2020138382", "https://openalex.org/W2028030005", "https://openalex.org/W2030994161", "https://openalex.org/W2036176224", "https://openalex.org/W2045435533", "https://openalex.org/W2051255304", "https://openalex.org/W2061184966", "https://openalex.org/W2064815984", "https://openalex.org/W2073217307", "https://openalex.org/W2077381938", "https://openalex.org/W2077659966", "https://openalex.org/W2085993152", "https://openalex.org/W2095950258", "https://openalex.org/W2103609218", "https://openalex.org/W2105464583", "https://openalex.org/W2108038398", "https://openalex.org/W2115189270", "https://openalex.org/W2115603949", "https://openalex.org/W2116534141", "https://openalex.org/W2123746851", "https://openalex.org/W2136139751", "https://openalex.org/W2139314409", "https://openalex.org/W2148050025", "https://openalex.org/W2150690792", "https://openalex.org/W2182456467", "https://openalex.org/W2188223075", "https://openalex.org/W2221514390", "https://openalex.org/W2224398381", "https://openalex.org/W2252568502", "https://openalex.org/W2273244674", "https://openalex.org/W2292390328", "https://openalex.org/W2335547104", "https://openalex.org/W2336828812", "https://openalex.org/W2461013690", "https://openalex.org/W2515083702", "https://openalex.org/W2565555627", "https://openalex.org/W2607273379", "https://openalex.org/W2611134270", "https://openalex.org/W2611661371", "https://openalex.org/W2613056759", "https://openalex.org/W2726053863", "https://openalex.org/W2744615298", "https://openalex.org/W2766599608", "https://openalex.org/W2772587092", "https://openalex.org/W2782551527", "https://openalex.org/W2785793003", "https://openalex.org/W2787206763", "https://openalex.org/W2788997515", "https://openalex.org/W2796961959", "https://openalex.org/W2810756255", "https://openalex.org/W2900054591", "https://openalex.org/W2900885456", "https://openalex.org/W2901407263", "https://openalex.org/W2909458562", "https://openalex.org/W2909752178", "https://openalex.org/W2913645636", "https://openalex.org/W2916364858", "https://openalex.org/W2917855738", "https://openalex.org/W2921769581", "https://openalex.org/W2939749480", "https://openalex.org/W2949080752", "https://openalex.org/W2951233129", "https://openalex.org/W2976425815", "https://openalex.org/W2981504990", "https://openalex.org/W2981514644", "https://openalex.org/W2991605677", "https://openalex.org/W3012327875", "https://openalex.org/W3038956601", "https://openalex.org/W3040633579", "https://openalex.org/W3044710522", "https://openalex.org/W3084546431", "https://openalex.org/W3084890671", "https://openalex.org/W3094156280", "https://openalex.org/W3111011311", "https://openalex.org/W3120704519", "https://openalex.org/W3134798812", "https://openalex.org/W3172701693", "https://openalex.org/W3177445623", "https://openalex.org/W3214328950", "https://openalex.org/W4205237319", "https://openalex.org/W4206225117", "https://openalex.org/W4206915884", "https://openalex.org/W4207004471", "https://openalex.org/W4212945596", "https://openalex.org/W4224922515", "https://openalex.org/W4226215757", "https://openalex.org/W4229012751", "https://openalex.org/W4241813303", "https://openalex.org/W4245053291", "https://openalex.org/W4281741939", "https://openalex.org/W4285088294", "https://openalex.org/W4285132200", "https://openalex.org/W4292641173", "https://openalex.org/W4302363821", "https://openalex.org/W4307725211", "https://openalex.org/W4308060847", "https://openalex.org/W4311579433", "https://openalex.org/W4313947391", "https://openalex.org/W4320502521", "https://openalex.org/W4320921285"], "related_works": ["https://openalex.org/W2603161682", "https://openalex.org/W2960163646", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2667943050", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W3000623258", "https://openalex.org/W2437118042", "https://openalex.org/W2337751047"], "abstract_inverted_index": {"Gene": [0], "editing": [1, 31], "stands": [2], "for": [3, 46, 100, 130], "the": [4, 17, 21, 56, 59, 68, 78, 91, 98, 101, 121, 125], "methods": [5, 83], "to": [6, 10, 39, 77, 87], "precisely": [7], "make": [8], "changes": [9], "a": [11], "specific": [12], "nucleic": [13], "acid": [14], "sequence.": [15], "With": [16], "recent": [18], "development": [19], "of": [20, 58, 70, 94, 104, 127], "clustered": [22], "regularly": [23], "interspaced": [24], "short": [25], "palindromic": [26], "repeats": [27], "(CRISPR)/Cas9": [28], "system,": [29], "gene": [30, 132], "has": [32], "become": [33], "efficient,": [34], "convenient": [35], "and": [36, 43, 49, 118], "programmable,": [37], "leading": [38], "promising": [40], "translational": [41], "studies": [42], "clinical": [44], "trials": [45], "both": [47], "genetic": [48], "non-genetic": [50], "diseases.": [51], "A": [52], "major": [53], "concern": [54], "in": [55, 124], "applications": [57], "CRISPR/Cas9": [60, 105], "system": [61], "is": [62], "about": [63, 120], "its": [64], "off-target": [65, 92, 128], "effects,": [66], "namely": [67], "deposition": [69], "unexpected,": [71], "unwanted,": [72], "or": [73, 89], "even": [74], "adverse": [75], "alterations": [76], "genome.": [79], "To": [80], "date,": [81], "many": [82], "have": [84], "been": [85], "developed": [86], "nominate": [88], "detect": [90], "sites": [93], "CRISPR/Cas9,": [95], "which": [96], "laid": [97], "basis": [99], "successful": [102], "upgrades": [103], "derivatives": [106], "with": [107], "enhanced": [108], "precision.": [109], "In": [110], "this": [111], "review,": [112], "we": [113], "summarize": [114], "these": [115], "technological": [116], "advancements": [117], "discuss": [119], "current": [122], "challenges": [123], "management": [126], "effects": [129], "future": [131], "therapy.": [133]}, "counts_by_year": [{"year": 2026, "cited_by_count": 93}, {"year": 2025, "cited_by_count": 265}, {"year": 2024, "cited_by_count": 140}, {"year": 2023, "cited_by_count": 29}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2755653587", "doi": "https://doi.org/10.1016/j.jconrel.2017.09.012", "title": "Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications", "display_name": "Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications", "relevance_score": 1042.8699, "publication_year": 2017, "publication_date": "2017-09-11", "ids": {"openalex": "https://openalex.org/W2755653587", "doi": "https://doi.org/10.1016/j.jconrel.2017.09.012", "mag": "2755653587", "pmid": "https://pubmed.ncbi.nlm.nih.gov/28911805"}, "language": "en", "primary_location": {"id": "doi:10.1016/j.jconrel.2017.09.012", "is_oa": false, "landing_page_url": "https://doi.org/10.1016/j.jconrel.2017.09.012", "pdf_url": null, "source": {"id": "https://openalex.org/S161954266", "display_name": "Journal of Controlled Release", "issn_l": "0168-3659", "issn": ["0168-3659", "1873-4995"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Journal of Controlled Release", "raw_type": "journal-article"}, "type": "review", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5100353339", "display_name": "Chang Liu", "orcid": "https://orcid.org/0000-0003-1450-4608"}, "institutions": [{"id": "https://openalex.org/I75421653", "display_name": "University of Missouri\u2013Kansas City", "ror": "https://ror.org/01w0d5g70", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I75421653"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Chang Liu", "raw_affiliation_strings": ["Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States", "institution_ids": ["https://openalex.org/I75421653"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100425530", "display_name": "Li Zhang", "orcid": "https://orcid.org/0000-0002-2679-0712"}, "institutions": [{"id": "https://openalex.org/I75421653", "display_name": "University of Missouri\u2013Kansas City", "ror": "https://ror.org/01w0d5g70", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I75421653"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Li Zhang", "raw_affiliation_strings": ["Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States", "institution_ids": ["https://openalex.org/I75421653"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5100458874", "display_name": "Hao Liu", "orcid": "https://orcid.org/0000-0003-0994-6284"}, "institutions": [{"id": "https://openalex.org/I75421653", "display_name": "University of Missouri\u2013Kansas City", "ror": "https://ror.org/01w0d5g70", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I75421653"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Hao Liu", "raw_affiliation_strings": ["Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States", "institution_ids": ["https://openalex.org/I75421653"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5066607484", "display_name": "Kun Cheng", "orcid": "https://orcid.org/0000-0001-9544-4680"}, "institutions": [{"id": "https://openalex.org/I75421653", "display_name": "University of Missouri\u2013Kansas City", "ror": "https://ror.org/01w0d5g70", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I75421653"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Kun Cheng", "raw_affiliation_strings": ["Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States. Electronic address: chengkun@umkc.edu", "Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States. Electronic address: chengkun@umkc.edu", "institution_ids": []}, {"raw_affiliation_string": "Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, United States", "institution_ids": ["https://openalex.org/I75421653"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 4, "corresponding_author_ids": ["https://openalex.org/A5066607484"], "corresponding_institution_ids": ["https://openalex.org/I75421653"], "apc_list": {"value": 4540, "currency": "USD", "value_usd": 4540}, "apc_paid": null, "fwci": 21.9809, "has_fulltext": false, "cited_by_count": 613, "citation_normalized_percentile": {"value": 0.99713774, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 90, "max": 100}, "biblio": {"volume": "266", "issue": null, "first_page": "17", "last_page": "26"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T12786", "display_name": "Innovation and Socioeconomic Development", "score": 0.9520000219345093, "subfield": {"id": "https://openalex.org/subfields/1403", "display_name": "Business and International Management"}, "field": {"id": "https://openalex.org/fields/14", "display_name": "Business, Management and Accounting"}, "domain": {"id": "https://openalex.org/domains/2", "display_name": "Social Sciences"}}, {"id": "https://openalex.org/T10166", "display_name": "Mosquito-borne diseases and control", "score": 0.9336000084877014, "subfield": {"id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.9679906964302063}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.8304091691970825}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8057736158370972}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.5805470943450928}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.5348562002182007}, {"id": "https://openalex.org/keywords/plasmid", "display_name": "Plasmid", "score": 0.5257566571235657}, {"id": "https://openalex.org/keywords/guide-rna", "display_name": "Guide RNA", "score": 0.4940202832221985}, {"id": "https://openalex.org/keywords/genome-engineering", "display_name": "Genome engineering", "score": 0.45225149393081665}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.44103413820266724}, {"id": "https://openalex.org/keywords/genome", "display_name": "Genome", "score": 0.43199506402015686}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.2928115129470825}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.9679906964302063}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.8304091691970825}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8057736158370972}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.5805470943450928}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.5348562002182007}, {"id": "https://openalex.org/C22744801", "wikidata": "https://www.wikidata.org/wiki/Q172778", "display_name": "Plasmid", "level": 3, "score": 0.5257566571235657}, {"id": "https://openalex.org/C97702854", "wikidata": "https://www.wikidata.org/wiki/Q4039747", "display_name": "Guide RNA", "level": 5, "score": 0.4940202832221985}, {"id": "https://openalex.org/C145290725", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome engineering", "level": 5, "score": 0.45225149393081665}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.44103413820266724}, {"id": "https://openalex.org/C141231307", "wikidata": "https://www.wikidata.org/wiki/Q7020", "display_name": "Genome", "level": 3, "score": 0.43199506402015686}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.2928115129470825}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014780", "descriptor_name": "Viruses", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014780", "descriptor_name": "Viruses", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D014780", "descriptor_name": "Viruses", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015316", "descriptor_name": "Genetic Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}], "locations_count": 3, "locations": [{"id": "doi:10.1016/j.jconrel.2017.09.012", "is_oa": false, "landing_page_url": "https://doi.org/10.1016/j.jconrel.2017.09.012", "pdf_url": null, "source": {"id": "https://openalex.org/S161954266", "display_name": "Journal of Controlled Release", "issn_l": "0168-3659", "issn": ["0168-3659", "1873-4995"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": ["https://openalex.org/P4310320990"], "host_organization_lineage_names": ["Elsevier BV"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Journal of Controlled Release", "raw_type": "journal-article"}, {"id": "pmid:28911805", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/28911805", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Journal of controlled release : official journal of the Controlled Release Society", "raw_type": null}, {"id": "pmh:oai:europepmc.org:5215607", "is_oa": false, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/5723556", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400806", "display_name": "Europe PMC (PubMed Central)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1303153112", "host_organization_name": "European Bioinformatics Institute", "host_organization_lineage": ["https://openalex.org/I1303153112"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "Text"}], "best_oa_location": null, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/3", "display_name": "Good health and well-being", "score": 0.6899999976158142}], "awards": [{"id": "https://openalex.org/G5403247677", "display_name": null, "funder_award_id": "1R01GM121798", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G8028393616", "display_name": null, "funder_award_id": "1R01AA021510", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}], "funders": [{"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 124, "referenced_works": ["https://openalex.org/W333206344", "https://openalex.org/W1495583714", "https://openalex.org/W1507470692", "https://openalex.org/W1916572066", "https://openalex.org/W1967046461", "https://openalex.org/W1971191097", "https://openalex.org/W1972476556", "https://openalex.org/W1973260880", "https://openalex.org/W1974343902", "https://openalex.org/W1975188039", "https://openalex.org/W1977709885", "https://openalex.org/W1978094899", "https://openalex.org/W1979659851", "https://openalex.org/W1982831423", "https://openalex.org/W1982846895", "https://openalex.org/W1982873976", "https://openalex.org/W1990487336", "https://openalex.org/W1990675552", "https://openalex.org/W2001314633", "https://openalex.org/W2001497035", "https://openalex.org/W2003171404", "https://openalex.org/W2007164914", "https://openalex.org/W2008719138", "https://openalex.org/W2009880400", "https://openalex.org/W2010666698", "https://openalex.org/W2010986636", "https://openalex.org/W2025045053", "https://openalex.org/W2026520402", "https://openalex.org/W2032141669", "https://openalex.org/W2033184417", "https://openalex.org/W2034629713", "https://openalex.org/W2036226488", "https://openalex.org/W2037197093", "https://openalex.org/W2038985472", "https://openalex.org/W2040195110", "https://openalex.org/W2041217592", "https://openalex.org/W2045435533", "https://openalex.org/W2046992485", "https://openalex.org/W2050480410", "https://openalex.org/W2051255304", "https://openalex.org/W2056111824", "https://openalex.org/W2056512830", "https://openalex.org/W2056833586", "https://openalex.org/W2057921063", "https://openalex.org/W2060837465", "https://openalex.org/W2064815984", "https://openalex.org/W2067036696", "https://openalex.org/W2067119305", "https://openalex.org/W2067220993", "https://openalex.org/W2070614858", "https://openalex.org/W2071404720", "https://openalex.org/W2073217307", "https://openalex.org/W2075595517", "https://openalex.org/W2077190448", "https://openalex.org/W2077379243", "https://openalex.org/W2077659966", "https://openalex.org/W2079084782", "https://openalex.org/W2080718344", "https://openalex.org/W2084747588", "https://openalex.org/W2088474579", "https://openalex.org/W2088555526", "https://openalex.org/W2094649139", "https://openalex.org/W2096261947", "https://openalex.org/W2099040837", "https://openalex.org/W2103609218", "https://openalex.org/W2104654654", "https://openalex.org/W2112424756", "https://openalex.org/W2116534141", "https://openalex.org/W2118746294", "https://openalex.org/W2119771879", "https://openalex.org/W2120503144", "https://openalex.org/W2125524975", "https://openalex.org/W2126259097", "https://openalex.org/W2127749855", "https://openalex.org/W2131395804", "https://openalex.org/W2132401721", "https://openalex.org/W2133067859", "https://openalex.org/W2133702185", "https://openalex.org/W2140022328", "https://openalex.org/W2140754284", "https://openalex.org/W2141570423", "https://openalex.org/W2142159826", "https://openalex.org/W2147193337", "https://openalex.org/W2147256573", "https://openalex.org/W2147511377", "https://openalex.org/W2149480270", "https://openalex.org/W2153552126", "https://openalex.org/W2163241233", "https://openalex.org/W2163445749", "https://openalex.org/W2164934988", "https://openalex.org/W2167523976", "https://openalex.org/W2172425918", "https://openalex.org/W2191052299", "https://openalex.org/W2199695484", "https://openalex.org/W2226427965", "https://openalex.org/W2253584908", "https://openalex.org/W2260024370", "https://openalex.org/W2286872394", "https://openalex.org/W2291052616", "https://openalex.org/W2292390328", "https://openalex.org/W2293216017", "https://openalex.org/W2299381044", "https://openalex.org/W2320147764", "https://openalex.org/W2335235649", "https://openalex.org/W2337595379", "https://openalex.org/W2337931919", "https://openalex.org/W2414377768", "https://openalex.org/W2415583513", "https://openalex.org/W2555666209", "https://openalex.org/W2556159813", "https://openalex.org/W2581151188", "https://openalex.org/W2588152092", "https://openalex.org/W2589897652", "https://openalex.org/W2593151357", "https://openalex.org/W2750015318", "https://openalex.org/W2750081038", "https://openalex.org/W3045133514", "https://openalex.org/W4211072988", "https://openalex.org/W4230140422", "https://openalex.org/W4230212633", "https://openalex.org/W6660596324", "https://openalex.org/W6678500610", "https://openalex.org/W6697116867", "https://openalex.org/W6716460655"], "related_works": ["https://openalex.org/W4311501380", "https://openalex.org/W2603161682", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W3052741125", "https://openalex.org/W2466284841", "https://openalex.org/W4320033130"], "abstract_inverted_index": null, "counts_by_year": [{"year": 2026, "cited_by_count": 19}, {"year": 2025, "cited_by_count": 73}, {"year": 2024, "cited_by_count": 82}, {"year": 2023, "cited_by_count": 62}, {"year": 2022, "cited_by_count": 86}, {"year": 2021, "cited_by_count": 98}, {"year": 2020, "cited_by_count": 115}, {"year": 2019, "cited_by_count": 54}, {"year": 2018, "cited_by_count": 23}, {"year": 2017, "cited_by_count": 1}], "updated_date": "2026-05-12T08:28:47.272897", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W3040803176", "doi": "https://doi.org/10.1038/s41467-020-17154-z", "title": "A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing", "display_name": "A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing", "relevance_score": 1041.1711, "publication_year": 2020, "publication_date": "2020-07-10", "ids": {"openalex": "https://openalex.org/W3040803176", "doi": "https://doi.org/10.1038/s41467-020-17154-z", "mag": "3040803176", "pmid": "https://pubmed.ncbi.nlm.nih.gov/32651371"}, "language": "en", "primary_location": {"id": "doi:10.1038/s41467-020-17154-z", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41467-020-17154-z", "pdf_url": "https://www.nature.com/articles/s41467-020-17154-z.pdf", "source": {"id": "https://openalex.org/S64187185", "display_name": "Nature Communications", "issn_l": "2041-1723", "issn": ["2041-1723"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Communications", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://www.nature.com/articles/s41467-020-17154-z.pdf", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5082082356", "display_name": "Wen\u2010Wei Zhang", "orcid": "https://orcid.org/0000-0003-1996-876X"}, "institutions": [{"id": "https://openalex.org/I5023651", "display_name": "McGill University", "ror": "https://ror.org/01pxwe438", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I5023651"]}], "countries": ["CA"], "is_corresponding": true, "raw_author_name": "Wen-Wei Zhang", "raw_affiliation_strings": ["Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada"], "raw_orcid": "https://orcid.org/0000-0003-1996-876X", "affiliations": [{"raw_affiliation_string": "Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada", "institution_ids": ["https://openalex.org/I5023651"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5012389752", "display_name": "Subir Karmakar", "orcid": "https://orcid.org/0000-0002-6288-7335"}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Subir Karmakar", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5089647417", "display_name": "Sreenivas Gannavaram", "orcid": "https://orcid.org/0000-0002-6557-8220"}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Sreenivas Gannavaram", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5060893561", "display_name": "Ranadhir Dey", "orcid": "https://orcid.org/0000-0003-0069-7867"}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Ranadhir Dey", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5083487513", "display_name": "Patrick Lypaczewski", "orcid": "https://orcid.org/0000-0002-5550-712X"}, "institutions": [{"id": "https://openalex.org/I5023651", "display_name": "McGill University", "ror": "https://ror.org/01pxwe438", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I5023651"]}], "countries": ["CA"], "is_corresponding": false, "raw_author_name": "Patrick Lypaczewski", "raw_affiliation_strings": ["Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada"], "raw_orcid": "https://orcid.org/0000-0002-5550-712X", "affiliations": [{"raw_affiliation_string": "Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada", "institution_ids": ["https://openalex.org/I5023651"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5077207677", "display_name": "Nevien Ismail", "orcid": "https://orcid.org/0000-0003-0294-8834"}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Nevien Ismail", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5076381322", "display_name": "Abid Siddiqui", "orcid": null}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Abid Siddiqui", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5035615708", "display_name": "Vahan Simonyan", "orcid": "https://orcid.org/0000-0002-4868-4785"}, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Vahan Simonyan", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": "https://orcid.org/0000-0002-4868-4785", "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5042149580", "display_name": "Fabiano Oliveira", "orcid": "https://orcid.org/0000-0002-7924-8038"}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Fabiano Oliveira", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": "https://orcid.org/0000-0002-7924-8038", "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5043476870", "display_name": "Iliano V. Coutinho-Abreu", "orcid": "https://orcid.org/0000-0002-1389-1071"}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Iliano V. Coutinho-Abreu", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": "https://orcid.org/0000-0002-1389-1071", "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5085695243", "display_name": "Thiago DeSouza\u2010Vieira", "orcid": "https://orcid.org/0000-0002-6051-8608"}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Thiago DeSouza-Vieira", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5112511662", "display_name": "Claudio Meneses", "orcid": null}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Claudio Meneses", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5006698309", "display_name": "James Oristian", "orcid": null}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "James Oristian", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5049098669", "display_name": "Tiago D. Serafim", "orcid": "https://orcid.org/0000-0003-1606-559X"}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Tiago D. Serafim", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5110696836", "display_name": "Abu Musa", "orcid": null}, "institutions": [{"id": "https://openalex.org/I43777268", "display_name": "Nagasaki University", "ror": "https://ror.org/058h74p94", "country_code": "JP", "type": "education", "lineage": ["https://openalex.org/I43777268"]}], "countries": ["JP"], "is_corresponding": false, "raw_author_name": "Abu Musa", "raw_affiliation_strings": ["Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki, Japan and Nagasaki University Graduate School of Biomedical Sciences Doctoral Leadership Program, Nagasaki, Japan"], "raw_orcid": "https://orcid.org/0000-0003-0662-0078", "affiliations": [{"raw_affiliation_string": "Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki, Japan and Nagasaki University Graduate School of Biomedical Sciences Doctoral Leadership Program, Nagasaki, Japan", "institution_ids": ["https://openalex.org/I43777268"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5110572236", "display_name": "Risa Nakamura", "orcid": null}, "institutions": [{"id": "https://openalex.org/I43777268", "display_name": "Nagasaki University", "ror": "https://ror.org/058h74p94", "country_code": "JP", "type": "education", "lineage": ["https://openalex.org/I43777268"]}], "countries": ["JP"], "is_corresponding": false, "raw_author_name": "Risa Nakamura", "raw_affiliation_strings": ["Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki, Japan and Nagasaki University Graduate School of Biomedical Sciences Doctoral Leadership Program, Nagasaki, Japan"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki, Japan and Nagasaki University Graduate School of Biomedical Sciences Doctoral Leadership Program, Nagasaki, Japan", "institution_ids": ["https://openalex.org/I43777268"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5020155400", "display_name": "Noushin Saljoughian", "orcid": "https://orcid.org/0000-0003-2776-3430"}, "institutions": [{"id": "https://openalex.org/I52357470", "display_name": "The Ohio State University", "ror": "https://ror.org/00rs6vg23", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I52357470"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Noushin Saljoughian", "raw_affiliation_strings": ["Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA", "institution_ids": ["https://openalex.org/I52357470"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5036913900", "display_name": "Greta Volpedo", "orcid": "https://orcid.org/0000-0002-1112-7715"}, "institutions": [{"id": "https://openalex.org/I52357470", "display_name": "The Ohio State University", "ror": "https://ror.org/00rs6vg23", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I52357470"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Greta Volpedo", "raw_affiliation_strings": ["Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA", "institution_ids": ["https://openalex.org/I52357470"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5026230851", "display_name": "Monika Satoskar", "orcid": null}, "institutions": [{"id": "https://openalex.org/I95240055", "display_name": "Northeast Ohio Medical University", "ror": "https://ror.org/04q9qf557", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I95240055"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Monika Satoskar", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "Northeast Ohio Medical University, Rootstown, Ohio, 44272, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}, {"raw_affiliation_string": "Northeast Ohio Medical University, Rootstown, Ohio, 44272, USA", "institution_ids": ["https://openalex.org/I95240055"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5012797030", "display_name": "Sanika Satoskar", "orcid": "https://orcid.org/0000-0002-2937-7384"}, "institutions": [{"id": "https://openalex.org/I95240055", "display_name": "Northeast Ohio Medical University", "ror": "https://ror.org/04q9qf557", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I95240055"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Sanika Satoskar", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "Northeast Ohio Medical University, Rootstown, Ohio, 44272, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}, {"raw_affiliation_string": "Northeast Ohio Medical University, Rootstown, Ohio, 44272, USA", "institution_ids": ["https://openalex.org/I95240055"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5045110601", "display_name": "Pradeep K. Dagur", "orcid": "https://orcid.org/0000-0002-4491-0853"}, "institutions": [{"id": "https://openalex.org/I4210106489", "display_name": "National Heart Lung and Blood Institute", "ror": "https://ror.org/012pb6c26", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210106489"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Pradeep K. Dagur", "raw_affiliation_strings": ["National Institute of Heart, Lung and Blood Institute, NIH, Bethesda, MD, 20852, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "National Institute of Heart, Lung and Blood Institute, NIH, Bethesda, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210106489"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5102771781", "display_name": "J. Philip McCoy", "orcid": "https://orcid.org/0000-0002-8118-5275"}, "institutions": [{"id": "https://openalex.org/I4210106489", "display_name": "National Heart Lung and Blood Institute", "ror": "https://ror.org/012pb6c26", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210106489"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "J. Philip McCoy", "raw_affiliation_strings": ["National Institute of Heart, Lung and Blood Institute, NIH, Bethesda, MD, 20852, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "National Institute of Heart, Lung and Blood Institute, NIH, Bethesda, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210106489"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5064339957", "display_name": "Shaden Kamhawi", "orcid": "https://orcid.org/0000-0003-4304-636X"}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Shaden Kamhawi", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": "https://orcid.org/0000-0003-4304-636X", "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5049600371", "display_name": "Jes\u00fas G. Valenzuela", "orcid": "https://orcid.org/0000-0002-5589-9450"}, "institutions": [{"id": "https://openalex.org/I1299303238", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88", "country_code": "US", "type": "government", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238"]}, {"id": "https://openalex.org/I4210128683", "display_name": "Vector (United States)", "ror": "https://ror.org/036y4q615", "country_code": "US", "type": "company", "lineage": ["https://openalex.org/I4210128683"]}, {"id": "https://openalex.org/I4210134534", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1299303238", "https://openalex.org/I4210134534"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Jesus G. Valenzuela", "raw_affiliation_strings": ["Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA"], "raw_orcid": "https://orcid.org/0000-0002-5589-9450", "affiliations": [{"raw_affiliation_string": "Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA", "institution_ids": ["https://openalex.org/I4210134534", "https://openalex.org/I4210128683", "https://openalex.org/I1299303238"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5041385852", "display_name": "Shinjiro Hamano", "orcid": "https://orcid.org/0000-0003-3881-8337"}, "institutions": [{"id": "https://openalex.org/I43777268", "display_name": "Nagasaki University", "ror": "https://ror.org/058h74p94", "country_code": "JP", "type": "education", "lineage": ["https://openalex.org/I43777268"]}], "countries": ["JP"], "is_corresponding": false, "raw_author_name": "Shinjiro Hamano", "raw_affiliation_strings": ["Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki, Japan and Nagasaki University Graduate School of Biomedical Sciences Doctoral Leadership Program, Nagasaki, Japan"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki, Japan and Nagasaki University Graduate School of Biomedical Sciences Doctoral Leadership Program, Nagasaki, Japan", "institution_ids": ["https://openalex.org/I43777268"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5027775199", "display_name": "Abhay R. Satoskar", "orcid": null}, "institutions": [{"id": "https://openalex.org/I52357470", "display_name": "The Ohio State University", "ror": "https://ror.org/00rs6vg23", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I52357470"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Abhay R. Satoskar", "raw_affiliation_strings": ["Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA. Abhay.Satoskar@osumc.edu", "Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA"], "raw_orcid": "https://orcid.org/0000-0001-5989-1520", "affiliations": [{"raw_affiliation_string": "Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA. Abhay.Satoskar@osumc.edu", "institution_ids": ["https://openalex.org/I52357470"]}, {"raw_affiliation_string": "Department of Pathology and Microbiology, Ohio State University, Columbus, OH, 43210, USA", "institution_ids": ["https://openalex.org/I52357470"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5089387183", "display_name": "Greg Matlashewski", "orcid": "https://orcid.org/0000-0002-8971-5525"}, "institutions": [{"id": "https://openalex.org/I5023651", "display_name": "McGill University", "ror": "https://ror.org/01pxwe438", "country_code": "CA", "type": "education", "lineage": ["https://openalex.org/I5023651"]}], "countries": ["CA"], "is_corresponding": false, "raw_author_name": "Greg Matlashewski", "raw_affiliation_strings": ["Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada. greg.matlashewski@mcgill.ca", "Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada"], "raw_orcid": "https://orcid.org/0000-0002-8971-5525", "affiliations": [{"raw_affiliation_string": "Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada. greg.matlashewski@mcgill.ca", "institution_ids": ["https://openalex.org/I5023651"]}, {"raw_affiliation_string": "Department of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada", "institution_ids": ["https://openalex.org/I5023651"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5000479943", "display_name": "Hira L. Nakhasi", "orcid": "https://orcid.org/0000-0003-4941-1620"}, "institutions": [{"id": "https://openalex.org/I1318287680", "display_name": "Center for Biologics Evaluation and Research", "ror": "https://ror.org/02nr3fr97", "country_code": "US", "type": "facility", "lineage": ["https://openalex.org/I1299022934", "https://openalex.org/I1318287680", "https://openalex.org/I1320320070"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Hira L. Nakhasi", "raw_affiliation_strings": ["Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA. Hira.Nakhasi@fda.hhs.gov", "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA"], "raw_orcid": "https://orcid.org/0000-0003-4941-1620", "affiliations": [{"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA. Hira.Nakhasi@fda.hhs.gov", "institution_ids": ["https://openalex.org/I1318287680"]}, {"raw_affiliation_string": "Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA", "institution_ids": []}]}], "institutions": [], "countries_distinct_count": 3, "institutions_distinct_count": 28, "corresponding_author_ids": ["https://openalex.org/A5082082356"], "corresponding_institution_ids": ["https://openalex.org/I5023651"], "apc_list": {"value": 3920, "currency": "GBP", "value_usd": 4808}, "apc_paid": {"value": 3920, "currency": "GBP", "value_usd": 4808}, "fwci": 14.3829, "has_fulltext": true, "cited_by_count": 115, "citation_normalized_percentile": {"value": 0.99204551, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 97, "max": 100}, "biblio": {"volume": "11", "issue": "1", "first_page": "3461", "last_page": "3461"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10823", "display_name": "Research on Leishmaniasis Studies", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, "topics": [{"id": "https://openalex.org/T10823", "display_name": "Research on Leishmaniasis Studies", "score": 0.9998999834060669, "subfield": {"id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}, {"id": "https://openalex.org/T10890", "display_name": "Trypanosoma species research and implications", "score": 0.9711999893188477, "subfield": {"id": "https://openalex.org/subfields/2713", "display_name": "Epidemiology"}, "field": {"id": "https://openalex.org/fields/27", "display_name": "Medicine"}, "domain": {"id": "https://openalex.org/domains/4", "display_name": "Health Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.6683980822563171}, {"id": "https://openalex.org/keywords/leishmania", "display_name": "Leishmania", "score": 0.6588966846466064}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.6474752426147461}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.6002293229103088}, {"id": "https://openalex.org/keywords/attenuated-vaccine", "display_name": "Attenuated vaccine", "score": 0.578967809677124}, {"id": "https://openalex.org/keywords/immune-system", "display_name": "Immune system", "score": 0.5649446249008179}, {"id": "https://openalex.org/keywords/virology", "display_name": "Virology", "score": 0.5446556806564331}, {"id": "https://openalex.org/keywords/leishmania-major", "display_name": "Leishmania major", "score": 0.5383881330490112}, {"id": "https://openalex.org/keywords/cutaneous-leishmaniasis", "display_name": "Cutaneous leishmaniasis", "score": 0.5258172750473022}, {"id": "https://openalex.org/keywords/vaccination", "display_name": "Vaccination", "score": 0.5159912109375}, {"id": "https://openalex.org/keywords/leishmaniasis", "display_name": "Leishmaniasis", "score": 0.5031797289848328}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.452130526304245}, {"id": "https://openalex.org/keywords/vector", "display_name": "Vector (molecular biology)", "score": 0.44947829842567444}, {"id": "https://openalex.org/keywords/strain", "display_name": "Strain (injury)", "score": 0.4279256761074066}, {"id": "https://openalex.org/keywords/microbiology", "display_name": "Microbiology", "score": 0.3924328088760376}, {"id": "https://openalex.org/keywords/parasite-hosting", "display_name": "Parasite hosting", "score": 0.293651282787323}, {"id": "https://openalex.org/keywords/immunology", "display_name": "Immunology", "score": 0.28229624032974243}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.20496484637260437}, {"id": "https://openalex.org/keywords/virulence", "display_name": "Virulence", "score": 0.14818495512008667}, {"id": "https://openalex.org/keywords/recombinant-dna", "display_name": "Recombinant DNA", "score": 0.07514673471450806}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.6683980822563171}, {"id": "https://openalex.org/C2781092759", "wikidata": "https://www.wikidata.org/wiki/Q524818", "display_name": "Leishmania", "level": 3, "score": 0.6588966846466064}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.6474752426147461}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.6002293229103088}, {"id": "https://openalex.org/C54602769", "wikidata": "https://www.wikidata.org/wiki/Q1810913", "display_name": "Attenuated vaccine", "level": 4, "score": 0.578967809677124}, {"id": "https://openalex.org/C8891405", "wikidata": "https://www.wikidata.org/wiki/Q1059", "display_name": "Immune system", "level": 2, "score": 0.5649446249008179}, {"id": "https://openalex.org/C159047783", "wikidata": "https://www.wikidata.org/wiki/Q7215", "display_name": "Virology", "level": 1, "score": 0.5446556806564331}, {"id": "https://openalex.org/C2780599195", "wikidata": "https://www.wikidata.org/wiki/Q1950715", "display_name": "Leishmania major", "level": 4, "score": 0.5383881330490112}, {"id": "https://openalex.org/C2778702967", "wikidata": "https://www.wikidata.org/wiki/Q2590966", "display_name": "Cutaneous leishmaniasis", "level": 3, "score": 0.5258172750473022}, {"id": "https://openalex.org/C22070199", "wikidata": "https://www.wikidata.org/wiki/Q192995", "display_name": "Vaccination", "level": 2, "score": 0.5159912109375}, {"id": "https://openalex.org/C2776555147", "wikidata": "https://www.wikidata.org/wiki/Q331283", "display_name": "Leishmaniasis", "level": 2, "score": 0.5031797289848328}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.452130526304245}, {"id": "https://openalex.org/C92087593", "wikidata": "https://www.wikidata.org/wiki/Q427389", "display_name": "Vector (molecular biology)", "level": 4, "score": 0.44947829842567444}, {"id": "https://openalex.org/C2778022156", "wikidata": "https://www.wikidata.org/wiki/Q576145", "display_name": "Strain (injury)", "level": 2, "score": 0.4279256761074066}, {"id": "https://openalex.org/C89423630", "wikidata": "https://www.wikidata.org/wiki/Q7193", "display_name": "Microbiology", "level": 1, "score": 0.3924328088760376}, {"id": "https://openalex.org/C71928629", "wikidata": "https://www.wikidata.org/wiki/Q804206", "display_name": "Parasite hosting", "level": 2, "score": 0.293651282787323}, {"id": "https://openalex.org/C203014093", "wikidata": "https://www.wikidata.org/wiki/Q101929", "display_name": "Immunology", "level": 1, "score": 0.28229624032974243}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.20496484637260437}, {"id": "https://openalex.org/C60987743", "wikidata": "https://www.wikidata.org/wiki/Q1460232", "display_name": "Virulence", "level": 3, "score": 0.14818495512008667}, {"id": "https://openalex.org/C40767141", "wikidata": "https://www.wikidata.org/wiki/Q285697", "display_name": "Recombinant DNA", "level": 3, "score": 0.07514673471450806}, {"id": "https://openalex.org/C41008148", "wikidata": "https://www.wikidata.org/wiki/Q21198", "display_name": "Computer science", "level": 0, "score": 0.0}, {"id": "https://openalex.org/C105702510", "wikidata": "https://www.wikidata.org/wiki/Q514", "display_name": "Anatomy", "level": 1, "score": 0.0}, {"id": "https://openalex.org/C136764020", "wikidata": "https://www.wikidata.org/wiki/Q466", "display_name": "World Wide Web", "level": 1, "score": 0.0}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D003907", "descriptor_name": "Dexamethasone", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D003907", "descriptor_name": "Dexamethasone", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D003907", "descriptor_name": "Dexamethasone", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005260", "descriptor_name": "Female", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005434", "descriptor_name": "Flow Cytometry", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005434", "descriptor_name": "Flow Cytometry", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005434", "descriptor_name": "Flow Cytometry", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D005818", "descriptor_name": "Genetic Engineering", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D006801", "descriptor_name": "Humans", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007165", "descriptor_name": "Immunosuppression Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007165", "descriptor_name": "Immunosuppression Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D007165", "descriptor_name": "Immunosuppression Therapy", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008264", "descriptor_name": "Macrophages", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D008264", "descriptor_name": "Macrophages", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D008264", "descriptor_name": "Macrophages", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D008807", "descriptor_name": "Mice, Inbred BALB C", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008807", "descriptor_name": "Mice, Inbred BALB C", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008807", "descriptor_name": "Mice, Inbred BALB C", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008810", "descriptor_name": "Mice, Inbred C57BL", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008810", "descriptor_name": "Mice, Inbred C57BL", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D008810", "descriptor_name": "Mice, Inbred C57BL", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D011576", "descriptor_name": "Psychodidae", "qualifier_ui": "Q000469", "qualifier_name": "parasitology", "is_major_topic": false}, {"descriptor_ui": "D011576", "descriptor_name": "Psychodidae", "qualifier_ui": "Q000469", "qualifier_name": "parasitology", "is_major_topic": false}, {"descriptor_ui": "D011576", "descriptor_name": "Psychodidae", "qualifier_ui": "Q000469", "qualifier_name": "parasitology", "is_major_topic": false}, {"descriptor_ui": "D014613", "descriptor_name": "Vaccines, Attenuated", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D014613", "descriptor_name": "Vaccines, Attenuated", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D014613", "descriptor_name": "Vaccines, Attenuated", "qualifier_ui": "Q000627", "qualifier_name": "therapeutic use", "is_major_topic": false}, {"descriptor_ui": "D015496", "descriptor_name": "CD4-Positive T-Lymphocytes", "qualifier_ui": "Q000187", "qualifier_name": "drug effects", "is_major_topic": false}, {"descriptor_ui": "D015496", "descriptor_name": "CD4-Positive T-Lymphocytes", "qualifier_ui": "Q000187", "qualifier_name": "drug effects", "is_major_topic": false}, {"descriptor_ui": "D015496", "descriptor_name": "CD4-Positive T-Lymphocytes", "qualifier_ui": "Q000187", "qualifier_name": "drug effects", "is_major_topic": false}, {"descriptor_ui": "D015496", "descriptor_name": "CD4-Positive T-Lymphocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D015496", "descriptor_name": "CD4-Positive T-Lymphocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D015496", "descriptor_name": "CD4-Positive T-Lymphocytes", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D018320", "descriptor_name": "Leishmania major", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018320", "descriptor_name": "Leishmania major", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018320", "descriptor_name": "Leishmania major", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D018320", "descriptor_name": "Leishmania major", "qualifier_ui": "Q000472", "qualifier_name": "pathogenicity", "is_major_topic": false}, {"descriptor_ui": "D018320", "descriptor_name": "Leishmania major", "qualifier_ui": "Q000472", "qualifier_name": "pathogenicity", "is_major_topic": false}, {"descriptor_ui": "D018320", "descriptor_name": "Leishmania major", "qualifier_ui": "Q000472", "qualifier_name": "pathogenicity", "is_major_topic": false}, {"descriptor_ui": "D020133", "descriptor_name": "Reverse Transcriptase Polymerase Chain Reaction", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D020133", "descriptor_name": "Reverse Transcriptase Polymerase Chain Reaction", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D020133", "descriptor_name": "Reverse Transcriptase Polymerase Chain Reaction", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D051379", "descriptor_name": "Mice", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064112", "descriptor_name": "Clustered Regularly Interspaced Short Palindromic Repeats", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 5, "locations": [{"id": "doi:10.1038/s41467-020-17154-z", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41467-020-17154-z", "pdf_url": "https://www.nature.com/articles/s41467-020-17154-z.pdf", "source": {"id": "https://openalex.org/S64187185", "display_name": "Nature Communications", "issn_l": "2041-1723", "issn": ["2041-1723"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Communications", "raw_type": "journal-article"}, {"id": "pmid:32651371", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/32651371", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature communications", "raw_type": null}, {"id": "pmh:oai:RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17154-z", "is_oa": false, "landing_page_url": "https://www.nature.com/articles/s41467-020-17154-z", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401271", "display_name": "RePEc: Research Papers in Economics", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I77793887", "host_organization_name": "Federal Reserve Bank of St. Louis", "host_organization_lineage": ["https://openalex.org/I77793887"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "article"}, {"id": "pmh:oai:doaj.org/article:a50605a064c049859dfcd1fb76a10dad", "is_oa": true, "landing_page_url": "https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-sa", "license_id": "https://openalex.org/licenses/cc-by-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)", "raw_type": "article"}, {"id": "pmh:oai:pubmedcentral.nih.gov:7351751", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/7351751", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "Nat Commun", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1038/s41467-020-17154-z", "is_oa": true, "landing_page_url": "https://doi.org/10.1038/s41467-020-17154-z", "pdf_url": "https://www.nature.com/articles/s41467-020-17154-z.pdf", "source": {"id": "https://openalex.org/S64187185", "display_name": "Nature Communications", "issn_l": "2041-1723", "issn": ["2041-1723"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310319908", "host_organization_name": "Nature Portfolio", "host_organization_lineage": ["https://openalex.org/P4310319908", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["Nature Portfolio", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "Nature Communications", "raw_type": "journal-article"}, "sustainable_development_goals": [{"id": "https://metadata.un.org/sdg/3", "display_name": "Good health and well-being", "score": 0.5899999737739563}], "awards": [], "funders": [{"id": "https://openalex.org/F4320328248", "display_name": "Global Health Innovative Technology Fund", "ror": "https://ror.org/02yfqyv95"}, {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}, {"id": "https://openalex.org/F4320334506", "display_name": "Canadian Institutes of Health Research", "ror": "https://ror.org/01gavpb45"}, {"id": "https://openalex.org/F4320337355", "display_name": "National Institute of Allergy and Infectious Diseases", "ror": "https://ror.org/043z4tv69"}, {"id": "https://openalex.org/F4320338101", "display_name": "CIHR Skin Research Training Centre", "ror": null}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W3040803176.pdf", "grobid_xml": "https://content.openalex.org/works/W3040803176.grobid-xml"}, "referenced_works_count": 57, "referenced_works": ["https://openalex.org/W1638612717", "https://openalex.org/W1894320934", "https://openalex.org/W1967058514", "https://openalex.org/W1972076096", "https://openalex.org/W1973142062", "https://openalex.org/W1976218763", "https://openalex.org/W1985095111", "https://openalex.org/W1986493915", "https://openalex.org/W1990748978", "https://openalex.org/W1995543014", "https://openalex.org/W1995884950", "https://openalex.org/W2002678042", "https://openalex.org/W2003948064", "https://openalex.org/W2004411700", "https://openalex.org/W2007253465", "https://openalex.org/W2013548206", "https://openalex.org/W2019296702", "https://openalex.org/W2027114230", "https://openalex.org/W2035474364", "https://openalex.org/W2038533031", "https://openalex.org/W2040985683", "https://openalex.org/W2042777705", "https://openalex.org/W2058261647", "https://openalex.org/W2063680727", "https://openalex.org/W2066738380", "https://openalex.org/W2095504500", "https://openalex.org/W2095680943", "https://openalex.org/W2102619694", "https://openalex.org/W2102667591", "https://openalex.org/W2105403778", "https://openalex.org/W2107915297", "https://openalex.org/W2108234281", "https://openalex.org/W2112560211", "https://openalex.org/W2112878014", "https://openalex.org/W2113632542", "https://openalex.org/W2122413738", "https://openalex.org/W2123139638", "https://openalex.org/W2123825848", "https://openalex.org/W2132956923", "https://openalex.org/W2161130214", "https://openalex.org/W2162538566", "https://openalex.org/W2239354855", "https://openalex.org/W2293820371", "https://openalex.org/W2412366568", "https://openalex.org/W2475849143", "https://openalex.org/W2523210038", "https://openalex.org/W2577803396", "https://openalex.org/W2729683236", "https://openalex.org/W2767557511", "https://openalex.org/W2774127248", "https://openalex.org/W2944556830", "https://openalex.org/W2982623010", "https://openalex.org/W3007748498", "https://openalex.org/W3013975168", "https://openalex.org/W4211073781", "https://openalex.org/W4298085732", "https://openalex.org/W6600291067"], "related_works": ["https://openalex.org/W3042515694", "https://openalex.org/W1983935024", "https://openalex.org/W2970243300", "https://openalex.org/W2078789060", "https://openalex.org/W2078526653", "https://openalex.org/W4390885843", "https://openalex.org/W2626102211", "https://openalex.org/W3170551269", "https://openalex.org/W2102985321", "https://openalex.org/W2186152422"], "abstract_inverted_index": {"Abstract": [0], "Leishmaniasis": [1], "is": [2, 28, 43, 61, 71, 130, 134, 154], "a": [3, 47, 62, 109], "neglected": [4], "tropical": [5], "disease": [6, 138], "caused": [7], "by": [8, 12], "Leishmania": [9, 21], "protozoa": [10], "transmitted": [11], "infected": [13], "sand": [14, 98, 148], "flies.": [15], "Vaccination": [16], "through": [17], "leishmanization": [18, 42], "with": [19, 85, 94, 108], "live": [20], "major": [22, 52, 96], "has": [23], "been": [24], "used": [25], "successfully": [26], "but": [27], "no": [29, 89], "longer": [30], "practiced": [31], "because": [32, 152], "it": [33, 133, 153], "resulted": [34], "in": [35, 119, 139], "occasional": [36], "skin": [37], "lesions.": [38], "A": [39], "second": [40], "generation": [41], "described": [44], "here": [45], "using": [46], "CRISPR": [48], "genome": [49], "edited": [50], "L.": [51, 95], "strain": [53, 69], "(": [54], "LmCen": [55, 59, 86, 115, 128], "\u2212/\u2212": [56, 60, 87, 116, 129], ").": [57], "Notably,": [58], "genetically": [63], "engineered": [64], "centrin": [65], "gene": [66], "knock-out": [67], "mutant": [68], "that": [70], "antibiotic": [72], "resistant": [73], "marker": [74, 155], "free": [75], "and": [76, 105, 121, 151], "does": [77], "not": [78], "have": [79, 88], "detectable": [80], "off-target": [81], "mutations.": [82], "Mice": [83], "immunized": [84], "visible": [90], "lesions": [91, 107], "following": [92], "challenge": [93, 150], "-infected": [97], "flies,": [99], "while": [100], "non-immunized": [101], "animals": [102], "develop": [103], "large": [104], "progressive": [106], "2-log": [110], "fold": [111], "higher": [112], "parasite": [113], "burden.": [114], "immunization": [117], "results": [118], "protection": [120, 145], "an": [122], "immune": [123], "response": [124], "comparable": [125], "to": [126, 136, 160], "leishmanization.": [127], "safe": [131], "since": [132], "unable": [135], "cause": [137], "immunocompromised": [140], "mice,": [141], "induces": [142], "robust": [143], "host": [144], "against": [146], "vector": [147], "fly": [149], "free,": [156], "can": [157], "be": [158], "advanced": [159], "human": [161], "vaccine": [162], "trials.": [163]}, "counts_by_year": [{"year": 2026, "cited_by_count": 3}, {"year": 2025, "cited_by_count": 13}, {"year": 2024, "cited_by_count": 19}, {"year": 2023, "cited_by_count": 21}, {"year": 2022, "cited_by_count": 29}, {"year": 2021, "cited_by_count": 25}, {"year": 2020, "cited_by_count": 5}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W2581151188", "doi": "https://doi.org/10.1021/acsnano.6b07600", "title": "Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing", "display_name": "Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing", "relevance_score": 971.28253, "publication_year": 2017, "publication_date": "2017-01-27", "ids": {"openalex": "https://openalex.org/W2581151188", "doi": "https://doi.org/10.1021/acsnano.6b07600", "mag": "2581151188", "pmid": "https://pubmed.ncbi.nlm.nih.gov/28129503"}, "language": "en", "primary_location": {"id": "doi:10.1021/acsnano.6b07600", "is_oa": false, "landing_page_url": "https://doi.org/10.1021/acsnano.6b07600", "pdf_url": null, "source": {"id": "https://openalex.org/S145476921", "display_name": "ACS Nano", "issn_l": "1936-0851", "issn": ["1936-0851", "1936-086X"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320006", "host_organization_name": "American Chemical Society", "host_organization_lineage": ["https://openalex.org/P4310320006"], "host_organization_lineage_names": ["American Chemical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "ACS Nano", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "pubmed"], "open_access": {"is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5018650807", "display_name": "Rubul Mout", "orcid": "https://orcid.org/0000-0001-6125-5873"}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Rubul Mout", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": "https://orcid.org/0000-0001-6125-5873", "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5037734999", "display_name": "Moumita Ray", "orcid": "https://orcid.org/0000-0003-0012-1198"}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Moumita Ray", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5079250720", "display_name": "G\u00fclen Yesilbag Tonga", "orcid": null}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Gulen Yesilbag Tonga", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5102886949", "display_name": "Yi-Wei Lee", "orcid": "https://orcid.org/0000-0003-4346-4254"}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Yi-Wei Lee", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5043738890", "display_name": "Tristan Tay", "orcid": "https://orcid.org/0000-0003-2134-995X"}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Tristan Tay", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5068272958", "display_name": "Kanae Sasaki", "orcid": "https://orcid.org/0000-0002-6630-3552"}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Kanae Sasaki", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5076949431", "display_name": "Vincent M. Rotello", "orcid": "https://orcid.org/0000-0002-5184-5439"}, "institutions": [{"id": "https://openalex.org/I24603500", "display_name": "University of Massachusetts Amherst", "ror": "https://ror.org/0072zz521", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I24603500"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Vincent M. Rotello", "raw_affiliation_strings": ["Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States"], "raw_orcid": "https://orcid.org/0000-0002-5184-5439", "affiliations": [{"raw_affiliation_string": "Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States", "institution_ids": ["https://openalex.org/I24603500"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 7, "corresponding_author_ids": ["https://openalex.org/A5018650807"], "corresponding_institution_ids": ["https://openalex.org/I24603500"], "apc_list": null, "apc_paid": null, "fwci": 25.0047, "has_fulltext": false, "cited_by_count": 560, "citation_normalized_percentile": {"value": 0.99765375, "is_in_top_1_percent": true, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 99, "max": 100}, "biblio": {"volume": "11", "issue": "3", "first_page": "2452", "last_page": "2458"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 1.0, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10725", "display_name": "RNA Interference and Gene Delivery", "score": 0.9972000122070312, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10207", "display_name": "Advanced biosensing and bioanalysis techniques", "score": 0.9947999715805054, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.9191818833351135}, {"id": "https://openalex.org/keywords/ribonucleoprotein", "display_name": "Ribonucleoprotein", "score": 0.8852936625480652}, {"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.8609812259674072}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.8510268926620483}, {"id": "https://openalex.org/keywords/guide-rna", "display_name": "Guide RNA", "score": 0.5967420935630798}, {"id": "https://openalex.org/keywords/gene-delivery", "display_name": "Gene delivery", "score": 0.5562658905982971}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.5423086881637573}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.530799925327301}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.5065335035324097}, {"id": "https://openalex.org/keywords/mutagenesis", "display_name": "Mutagenesis", "score": 0.4952193796634674}, {"id": "https://openalex.org/keywords/rna", "display_name": "RNA", "score": 0.4682057499885559}, {"id": "https://openalex.org/keywords/subgenomic-mrna", "display_name": "Subgenomic mRNA", "score": 0.46539247035980225}, {"id": "https://openalex.org/keywords/cytosol", "display_name": "Cytosol", "score": 0.44275790452957153}, {"id": "https://openalex.org/keywords/cell-biology", "display_name": "Cell biology", "score": 0.4262329638004303}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.3655681610107422}, {"id": "https://openalex.org/keywords/genetic-enhancement", "display_name": "Genetic enhancement", "score": 0.18367886543273926}, {"id": "https://openalex.org/keywords/mutation", "display_name": "Mutation", "score": 0.11449426412582397}, {"id": "https://openalex.org/keywords/biochemistry", "display_name": "Biochemistry", "score": 0.09626144170761108}], "concepts": [{"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.9191818833351135}, {"id": "https://openalex.org/C75934600", "wikidata": "https://www.wikidata.org/wiki/Q419245", "display_name": "Ribonucleoprotein", "level": 4, "score": 0.8852936625480652}, {"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.8609812259674072}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.8510268926620483}, {"id": "https://openalex.org/C97702854", "wikidata": "https://www.wikidata.org/wiki/Q4039747", "display_name": "Guide RNA", "level": 5, "score": 0.5967420935630798}, {"id": "https://openalex.org/C135983454", "wikidata": "https://www.wikidata.org/wiki/Q2790163", "display_name": "Gene delivery", "level": 4, "score": 0.5562658905982971}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.5423086881637573}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.530799925327301}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.5065335035324097}, {"id": "https://openalex.org/C16318435", "wikidata": "https://www.wikidata.org/wiki/Q149299", "display_name": "Mutagenesis", "level": 4, "score": 0.4952193796634674}, {"id": "https://openalex.org/C67705224", "wikidata": "https://www.wikidata.org/wiki/Q11053", "display_name": "RNA", "level": 3, "score": 0.4682057499885559}, {"id": "https://openalex.org/C189819185", "wikidata": "https://www.wikidata.org/wiki/Q384283", "display_name": "Subgenomic mRNA", "level": 4, "score": 0.46539247035980225}, {"id": "https://openalex.org/C98539663", "wikidata": "https://www.wikidata.org/wiki/Q220599", "display_name": "Cytosol", "level": 3, "score": 0.44275790452957153}, {"id": "https://openalex.org/C95444343", "wikidata": "https://www.wikidata.org/wiki/Q7141", "display_name": "Cell biology", "level": 1, "score": 0.4262329638004303}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.3655681610107422}, {"id": "https://openalex.org/C111599444", "wikidata": "https://www.wikidata.org/wiki/Q213901", "display_name": "Genetic enhancement", "level": 3, "score": 0.18367886543273926}, {"id": "https://openalex.org/C501734568", "wikidata": "https://www.wikidata.org/wiki/Q42918", "display_name": "Mutation", "level": 3, "score": 0.11449426412582397}, {"id": "https://openalex.org/C55493867", "wikidata": "https://www.wikidata.org/wiki/Q7094", "display_name": "Biochemistry", "level": 1, "score": 0.09626144170761108}, {"id": "https://openalex.org/C181199279", "wikidata": "https://www.wikidata.org/wiki/Q8047", "display_name": "Enzyme", "level": 2, "score": 0.0}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D003600", "descriptor_name": "Cytosol", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D003600", "descriptor_name": "Cytosol", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D003600", "descriptor_name": "Cytosol", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false}, {"descriptor_ui": "D003600", "descriptor_name": "Cytosol", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D003600", "descriptor_name": "Cytosol", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D003600", "descriptor_name": "Cytosol", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D012261", "descriptor_name": "Ribonucleoproteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012261", "descriptor_name": "Ribonucleoproteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012261", "descriptor_name": "Ribonucleoproteins", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D012261", "descriptor_name": "Ribonucleoproteins", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D012261", "descriptor_name": "Ribonucleoproteins", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D012261", "descriptor_name": "Ribonucleoproteins", "qualifier_ui": "Q000737", "qualifier_name": "chemistry", "is_major_topic": false}, {"descriptor_ui": "D015202", "descriptor_name": "Protein Engineering", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015202", "descriptor_name": "Protein Engineering", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015202", "descriptor_name": "Protein Engineering", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D018014", "descriptor_name": "Gene Transfer Techniques", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 3, "locations": [{"id": "doi:10.1021/acsnano.6b07600", "is_oa": false, "landing_page_url": "https://doi.org/10.1021/acsnano.6b07600", "pdf_url": null, "source": {"id": "https://openalex.org/S145476921", "display_name": "ACS Nano", "issn_l": "1936-0851", "issn": ["1936-0851", "1936-086X"], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320006", "host_organization_name": "American Chemical Society", "host_organization_lineage": ["https://openalex.org/P4310320006"], "host_organization_lineage_names": ["American Chemical Society"], "type": "journal"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "ACS Nano", "raw_type": "journal-article"}, {"id": "pmid:28129503", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/28129503", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "ACS nano", "raw_type": null}, {"id": "pmh:oai:europepmc.org:4773635", "is_oa": false, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/5848212", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400806", "display_name": "Europe PMC (PubMed Central)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1303153112", "host_organization_name": "European Bioinformatics Institute", "host_organization_lineage": ["https://openalex.org/I1303153112"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": null, "raw_type": "Text"}], "best_oa_location": null, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G2127317011", "display_name": null, "funder_award_id": "CHE-1307021", "funder_id": "https://openalex.org/F4320337393", "funder_display_name": "Division of Chemistry"}], "funders": [{"id": "https://openalex.org/F4320337354", "display_name": "National Institute of General Medical Sciences", "ror": "https://ror.org/04q48ey07"}, {"id": "https://openalex.org/F4320337393", "display_name": "Division of Chemistry", "ror": "https://ror.org/01ar8dr59"}], "has_content": {"pdf": false, "grobid_xml": false}, "content_urls": null, "referenced_works_count": 29, "referenced_works": ["https://openalex.org/W1710257910", "https://openalex.org/W1751510803", "https://openalex.org/W1977709885", "https://openalex.org/W1977955083", "https://openalex.org/W1986316308", "https://openalex.org/W1996788258", "https://openalex.org/W2045435533", "https://openalex.org/W2050480410", "https://openalex.org/W2056833586", "https://openalex.org/W2059837762", "https://openalex.org/W2068427957", "https://openalex.org/W2073217307", "https://openalex.org/W2096261947", "https://openalex.org/W2103609218", "https://openalex.org/W2116534141", "https://openalex.org/W2119265369", "https://openalex.org/W2119771879", "https://openalex.org/W2121102974", "https://openalex.org/W2124544335", "https://openalex.org/W2127862779", "https://openalex.org/W2140022328", "https://openalex.org/W2164695230", "https://openalex.org/W2164934988", "https://openalex.org/W2173968248", "https://openalex.org/W2191052299", "https://openalex.org/W2219286889", "https://openalex.org/W2496774497", "https://openalex.org/W2589818318", "https://openalex.org/W4230212633"], "related_works": ["https://openalex.org/W4311501380", "https://openalex.org/W4393183656", "https://openalex.org/W2581151188", "https://openalex.org/W4288777264", "https://openalex.org/W2590355459", "https://openalex.org/W2770127492", "https://openalex.org/W3138713572", "https://openalex.org/W2979204485", "https://openalex.org/W2667943050", "https://openalex.org/W3047419816"], "abstract_inverted_index": {"Genome": [0], "editing": [1, 76], "through": [2, 19, 61], "the": [3, 30, 36, 62], "delivery": [4, 21, 26, 51], "of": [5, 27, 52, 64], "CRISPR/Cas9-ribonucleoprotein": [6], "(Cas9-RNP)": [7], "reduces": [8], "unwanted": [9], "gene": [10, 20, 75], "targeting": [11], "and": [12, 24, 67, 78], "avoids": [13], "integrational": [14], "mutagenesis": [15], "that": [16], "can": [17], "occur": [18], "strategies.": [22], "Direct": [23], "efficient": [25, 47], "Cas9-RNP": [28], "into": [29], "cytosol": [31], "followed": [32], "by": [33], "translocation": [34], "to": [35], "nucleus": [37], "remains": [38], "a": [39, 44, 57], "challenge.": [40], "Here,": [41], "we": [42], "report": [43], "remarkably": [45], "highly": [46], "(\u223c90%)": [48], "direct": [49], "cytoplasmic/nuclear": [50], "Cas9": [53, 65], "protein": [54, 66], "complexed": [55], "with": [56], "guide": [58], "RNA": [59], "(sgRNA)": [60], "coengineering": [63], "carrier": [68], "nanoparticles.": [69], "This": [70], "construct": [71], "provides": [72], "effective": [73], "(\u223c30%)": [74], "efficiency": [77], "opens": [79], "up": [80], "opportunities": [81], "in": [82], "studying": [83], "genome": [84], "dynamics.": [85]}, "counts_by_year": [{"year": 2026, "cited_by_count": 15}, {"year": 2025, "cited_by_count": 62}, {"year": 2024, "cited_by_count": 57}, {"year": 2023, "cited_by_count": 52}, {"year": 2022, "cited_by_count": 76}, {"year": 2021, "cited_by_count": 74}, {"year": 2020, "cited_by_count": 80}, {"year": 2019, "cited_by_count": 66}, {"year": 2018, "cited_by_count": 52}, {"year": 2017, "cited_by_count": 25}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}, {"id": "https://openalex.org/W4206626119", "doi": "https://doi.org/10.1186/s12864-021-08238-1", "title": "Evaluation of CRISPR gene-editing tools in zebrafish", "display_name": "Evaluation of CRISPR gene-editing tools in zebrafish", "relevance_score": 964.82605, "publication_year": 2022, "publication_date": "2022-01-05", "ids": {"openalex": "https://openalex.org/W4206626119", "doi": "https://doi.org/10.1186/s12864-021-08238-1", "pmid": "https://pubmed.ncbi.nlm.nih.gov/34986794"}, "language": "en", "primary_location": {"id": "doi:10.1186/s12864-021-08238-1", "is_oa": true, "landing_page_url": "https://doi.org/10.1186/s12864-021-08238-1", "pdf_url": "https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-021-08238-1", "source": {"id": "https://openalex.org/S28614077", "display_name": "BMC Genomics", "issn_l": "1471-2164", "issn": ["1471-2164"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320256", "host_organization_name": "BioMed Central", "host_organization_lineage": ["https://openalex.org/P4310320256", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["BioMed Central", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "BMC Genomics", "raw_type": "journal-article"}, "type": "article", "indexed_in": ["crossref", "doaj", "pubmed"], "open_access": {"is_oa": true, "oa_status": "gold", "oa_url": "https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-021-08238-1", "any_repository_has_fulltext": true}, "authorships": [{"author_position": "first", "author": {"id": "https://openalex.org/A5011005586", "display_name": "Jos\u00e9 M. Uribe\u2010Salazar", "orcid": "https://orcid.org/0000-0003-4875-818X"}, "institutions": [{"id": "https://openalex.org/I84218800", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I84218800"]}], "countries": ["US"], "is_corresponding": true, "raw_author_name": "Jos\u00e9 M. Uribe-Salazar", "raw_affiliation_strings": ["Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA", "Integrative Genetics and Genomics Graduate Group, University of California, Davis, Davis, CA, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}, {"raw_affiliation_string": "Integrative Genetics and Genomics Graduate Group, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5009295217", "display_name": "Gulhan Kaya", "orcid": "https://orcid.org/0000-0003-3142-7886"}, "institutions": [{"id": "https://openalex.org/I84218800", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I84218800"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Gulhan Kaya", "raw_affiliation_strings": ["Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5059426994", "display_name": "Aadithya Sekar", "orcid": "https://orcid.org/0000-0002-1503-2529"}, "institutions": [{"id": "https://openalex.org/I84218800", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I84218800"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Aadithya Sekar", "raw_affiliation_strings": ["Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5022460769", "display_name": "KaeChandra Weyenberg", "orcid": "https://orcid.org/0000-0003-3354-6280"}, "institutions": [{"id": "https://openalex.org/I84218800", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I84218800"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "KaeChandra Weyenberg", "raw_affiliation_strings": ["Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}]}, {"author_position": "middle", "author": {"id": "https://openalex.org/A5056409439", "display_name": "Cole Ingamells", "orcid": "https://orcid.org/0000-0003-4706-2666"}, "institutions": [{"id": "https://openalex.org/I84218800", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I84218800"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Cole Ingamells", "raw_affiliation_strings": ["Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}]}, {"author_position": "last", "author": {"id": "https://openalex.org/A5074379383", "display_name": "Megan Y. Dennis", "orcid": "https://orcid.org/0000-0002-8502-5420"}, "institutions": [{"id": "https://openalex.org/I2803209242", "display_name": "University of California System", "ror": "https://ror.org/00pjdza24", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I2803209242"]}, {"id": "https://openalex.org/I84218800", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69", "country_code": "US", "type": "education", "lineage": ["https://openalex.org/I84218800"]}], "countries": ["US"], "is_corresponding": false, "raw_author_name": "Megan Y. Dennis", "raw_affiliation_strings": ["Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA. mydennis@ucdavis.edu", "Integrative Genetics and Genomics Graduate Group, University of California, Davis, Davis, CA, USA. mydennis@ucdavis.edu", "Integrative Genetics and Genomics Graduate Group, University of California, Davis, Davis, CA, USA"], "raw_orcid": null, "affiliations": [{"raw_affiliation_string": "Genome Center, MIND Institute, and Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA. mydennis@ucdavis.edu", "institution_ids": ["https://openalex.org/I84218800"]}, {"raw_affiliation_string": "Integrative Genetics and Genomics Graduate Group, University of California, Davis, Davis, CA, USA. mydennis@ucdavis.edu", "institution_ids": ["https://openalex.org/I84218800", "https://openalex.org/I2803209242"]}, {"raw_affiliation_string": "Integrative Genetics and Genomics Graduate Group, University of California, Davis, Davis, CA, USA", "institution_ids": ["https://openalex.org/I84218800"]}]}], "institutions": [], "countries_distinct_count": 1, "institutions_distinct_count": 6, "corresponding_author_ids": ["https://openalex.org/A5011005586"], "corresponding_institution_ids": ["https://openalex.org/I84218800"], "apc_list": {"value": 1570, "currency": "GBP", "value_usd": 1925}, "apc_paid": {"value": 1570, "currency": "GBP", "value_usd": 1925}, "fwci": 3.898, "has_fulltext": true, "cited_by_count": 49, "citation_normalized_percentile": {"value": 0.94860746, "is_in_top_1_percent": false, "is_in_top_10_percent": true}, "cited_by_percentile_year": {"min": 94, "max": 100}, "biblio": {"volume": "23", "issue": "1", "first_page": "12", "last_page": "12"}, "is_retracted": false, "is_paratext": false, "is_xpac": false, "primary_topic": {"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9869999885559082, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, "topics": [{"id": "https://openalex.org/T10878", "display_name": "CRISPR and Genetic Engineering", "score": 0.9869999885559082, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T11685", "display_name": "Zebrafish Biomedical Research Applications", "score": 0.003800000064074993, "subfield": {"id": "https://openalex.org/subfields/1307", "display_name": "Cell Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}, {"id": "https://openalex.org/T10691", "display_name": "Retinal Development and Disorders", "score": 0.002400000113993883, "subfield": {"id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology"}, "field": {"id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology"}, "domain": {"id": "https://openalex.org/domains/1", "display_name": "Life Sciences"}}], "keywords": [{"id": "https://openalex.org/keywords/crispr", "display_name": "CRISPR", "score": 0.9511091709136963}, {"id": "https://openalex.org/keywords/biology", "display_name": "Biology", "score": 0.7975969910621643}, {"id": "https://openalex.org/keywords/genome-editing", "display_name": "Genome editing", "score": 0.7500172853469849}, {"id": "https://openalex.org/keywords/guide-rna", "display_name": "Guide RNA", "score": 0.684395432472229}, {"id": "https://openalex.org/keywords/cas9", "display_name": "Cas9", "score": 0.660355269908905}, {"id": "https://openalex.org/keywords/zebrafish", "display_name": "Zebrafish", "score": 0.6423367261886597}, {"id": "https://openalex.org/keywords/computational-biology", "display_name": "Computational biology", "score": 0.6377542018890381}, {"id": "https://openalex.org/keywords/in-silico", "display_name": "In silico", "score": 0.618890643119812}, {"id": "https://openalex.org/keywords/genetics", "display_name": "Genetics", "score": 0.5356060862541199}, {"id": "https://openalex.org/keywords/gene", "display_name": "Gene", "score": 0.4710374176502228}, {"id": "https://openalex.org/keywords/gene-knockout", "display_name": "Gene knockout", "score": 0.42457810044288635}], "concepts": [{"id": "https://openalex.org/C98108389", "wikidata": "https://www.wikidata.org/wiki/Q412563", "display_name": "CRISPR", "level": 3, "score": 0.9511091709136963}, {"id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.7975969910621643}, {"id": "https://openalex.org/C144501496", "wikidata": "https://www.wikidata.org/wiki/Q5533489", "display_name": "Genome editing", "level": 4, "score": 0.7500172853469849}, {"id": "https://openalex.org/C97702854", "wikidata": "https://www.wikidata.org/wiki/Q4039747", "display_name": "Guide RNA", "level": 5, "score": 0.684395432472229}, {"id": "https://openalex.org/C132455925", "wikidata": "https://www.wikidata.org/wiki/Q16965677", "display_name": "Cas9", "level": 4, "score": 0.660355269908905}, {"id": "https://openalex.org/C2776878037", "wikidata": "https://www.wikidata.org/wiki/Q169444", "display_name": "Zebrafish", "level": 3, "score": 0.6423367261886597}, {"id": "https://openalex.org/C70721500", "wikidata": "https://www.wikidata.org/wiki/Q177005", "display_name": "Computational biology", "level": 1, "score": 0.6377542018890381}, {"id": "https://openalex.org/C2775905019", "wikidata": "https://www.wikidata.org/wiki/Q192572", "display_name": "In silico", "level": 3, "score": 0.618890643119812}, {"id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.5356060862541199}, {"id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.4710374176502228}, {"id": "https://openalex.org/C77957584", "wikidata": "https://www.wikidata.org/wiki/Q1133550", "display_name": "Gene knockout", "level": 3, "score": 0.42457810044288635}], "mesh": [{"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000072669", "descriptor_name": "Gene Editing", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": true}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000076987", "descriptor_name": "CRISPR-Associated Protein 9", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000094704", "descriptor_name": "RNA, Guide, CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": null, "qualifier_name": null, "is_major_topic": false}, {"descriptor_ui": "D015027", "descriptor_name": "Zebrafish", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D015027", "descriptor_name": "Zebrafish", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D015027", "descriptor_name": "Zebrafish", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D015027", "descriptor_name": "Zebrafish", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D015027", "descriptor_name": "Zebrafish", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": true}, {"descriptor_ui": "D017394", "descriptor_name": "RNA, Guide, Kinetoplastida", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}, {"descriptor_ui": "D064113", "descriptor_name": "CRISPR-Cas Systems", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false}], "locations_count": 5, "locations": [{"id": "doi:10.1186/s12864-021-08238-1", "is_oa": true, "landing_page_url": "https://doi.org/10.1186/s12864-021-08238-1", "pdf_url": "https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-021-08238-1", "source": {"id": "https://openalex.org/S28614077", "display_name": "BMC Genomics", "issn_l": "1471-2164", "issn": ["1471-2164"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320256", "host_organization_name": "BioMed Central", "host_organization_lineage": ["https://openalex.org/P4310320256", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["BioMed Central", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "BMC Genomics", "raw_type": "journal-article"}, {"id": "pmid:34986794", "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/34986794", "pdf_url": null, "source": {"id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": null, "license_id": null, "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "BMC genomics", "raw_type": null}, {"id": "pmh:oai:doaj.org/article:01505a27b08a458698903f9fad3ca26a", "is_oa": true, "landing_page_url": "https://doaj.org/article/01505a27b08a458698903f9fad3ca26a", "pdf_url": null, "source": {"id": "https://openalex.org/S4306401280", "display_name": "DOAJ (DOAJ: Directory of Open Access Journals)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": null, "host_organization_name": null, "host_organization_lineage": [], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by-sa", "license_id": "https://openalex.org/licenses/cc-by-sa", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "BMC Genomics, Vol 23, Iss 1, Pp 1-16 (2022)", "raw_type": "article"}, {"id": "pmh:oai:escholarship.org:ark:/13030/qt69n9v73k", "is_oa": true, "landing_page_url": "https://escholarship.org/uc/item/69n9v73k", "pdf_url": null, "source": {"id": "https://openalex.org/S4306400115", "display_name": "eScholarship (California Digital Library)", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I2801248553", "host_organization_name": "California Digital Library", "host_organization_lineage": ["https://openalex.org/I2801248553"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "BMC Genomics, vol 23, iss 1", "raw_type": "article"}, {"id": "pmh:oai:pubmedcentral.nih.gov:8734261", "is_oa": true, "landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/8734261", "pdf_url": null, "source": {"id": "https://openalex.org/S2764455111", "display_name": "PubMed Central", "issn_l": null, "issn": null, "is_oa": true, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": ["https://openalex.org/I1299303238"], "host_organization_lineage_names": [], "type": "repository"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "submittedVersion", "is_accepted": false, "is_published": false, "raw_source_name": "BMC Genomics", "raw_type": "Text"}], "best_oa_location": {"id": "doi:10.1186/s12864-021-08238-1", "is_oa": true, "landing_page_url": "https://doi.org/10.1186/s12864-021-08238-1", "pdf_url": "https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-021-08238-1", "source": {"id": "https://openalex.org/S28614077", "display_name": "BMC Genomics", "issn_l": "1471-2164", "issn": ["1471-2164"], "is_oa": true, "is_in_doaj": true, "is_core": true, "host_organization": "https://openalex.org/P4310320256", "host_organization_name": "BioMed Central", "host_organization_lineage": ["https://openalex.org/P4310320256", "https://openalex.org/P4310319965"], "host_organization_lineage_names": ["BioMed Central", "Springer Nature"], "type": "journal"}, "license": "cc-by", "license_id": "https://openalex.org/licenses/cc-by", "version": "publishedVersion", "is_accepted": true, "is_published": true, "raw_source_name": "BMC Genomics", "raw_type": "journal-article"}, "sustainable_development_goals": [], "awards": [{"id": "https://openalex.org/G2161041910", "display_name": null, "funder_award_id": "DP2 OD025824", "funder_id": "https://openalex.org/F4320337346", "funder_display_name": "National Institute of Mental Health"}, {"id": "https://openalex.org/G2213785365", "display_name": null, "funder_award_id": "U54 HD079125", "funder_id": "https://openalex.org/F4320332161", "funder_display_name": "National Institutes of Health"}, {"id": "https://openalex.org/G223681915", "display_name": null, "funder_award_id": "DP2 OD025824", "funder_id": "https://openalex.org/F4320337349", "funder_display_name": "NIH Office of the Director"}, {"id": "https://openalex.org/G353256192", "display_name": null, "funder_award_id": "HD079125", "funder_id": "https://openalex.org/F4320312146", "funder_display_name": "MIND Institute, University of California, Davis"}, {"id": "https://openalex.org/G5144221652", "display_name": null, "funder_award_id": "U54 HD079125", "funder_id": "https://openalex.org/F4320332564", "funder_display_name": "University of California, Davis"}, {"id": "https://openalex.org/G5741677391", "display_name": null, "funder_award_id": "U54 HD079125", "funder_id": "https://openalex.org/F4320332591", "funder_display_name": "Intellectual and Developmental Disabilities Research Center"}, {"id": "https://openalex.org/G8652110378", "display_name": null, "funder_award_id": "U54 HD079125", "funder_id": "https://openalex.org/F4320312146", "funder_display_name": "MIND Institute, University of California, Davis"}, {"id": "https://openalex.org/G8869559357", "display_name": null, "funder_award_id": "U54 HD079125", "funder_id": "https://openalex.org/F4320337346", "funder_display_name": "National Institute of Mental Health"}], "funders": [{"id": "https://openalex.org/F4320312146", "display_name": "MIND Institute, University of California, Davis", "ror": "https://ror.org/05rrcem69"}, {"id": "https://openalex.org/F4320332161", "display_name": "National Institutes of Health", "ror": "https://ror.org/01cwqze88"}, {"id": "https://openalex.org/F4320332564", "display_name": "University of California, Davis", "ror": "https://ror.org/05rrcem69"}, {"id": "https://openalex.org/F4320332591", "display_name": "Intellectual and Developmental Disabilities Research Center", "ror": "https://ror.org/02pttbw34"}, {"id": "https://openalex.org/F4320337346", "display_name": "National Institute of Mental Health", "ror": "https://ror.org/04xeg9z08"}, {"id": "https://openalex.org/F4320337349", "display_name": "NIH Office of the Director", "ror": "https://ror.org/00fj8a872"}], "has_content": {"pdf": true, "grobid_xml": true}, "content_urls": {"pdf": "https://content.openalex.org/works/W4206626119.pdf", "grobid_xml": "https://content.openalex.org/works/W4206626119.grobid-xml"}, "referenced_works_count": 75, "referenced_works": ["https://openalex.org/W1556198965", "https://openalex.org/W1566831845", "https://openalex.org/W1879165674", "https://openalex.org/W1912701812", "https://openalex.org/W1915704240", "https://openalex.org/W1919257374", "https://openalex.org/W1976391205", "https://openalex.org/W1981239255", "https://openalex.org/W1990149668", "https://openalex.org/W1994424017", "https://openalex.org/W2001497035", "https://openalex.org/W2003797386", "https://openalex.org/W2006373538", "https://openalex.org/W2008205228", "https://openalex.org/W2017224987", "https://openalex.org/W2029193852", "https://openalex.org/W2035618305", "https://openalex.org/W2043369680", "https://openalex.org/W2050546910", "https://openalex.org/W2093767301", "https://openalex.org/W2103441770", "https://openalex.org/W2106070783", "https://openalex.org/W2127497550", "https://openalex.org/W2131271579", "https://openalex.org/W2134268326", "https://openalex.org/W2136170412", "https://openalex.org/W2136430672", "https://openalex.org/W2157205823", "https://openalex.org/W2159482845", "https://openalex.org/W2164695230", "https://openalex.org/W2167279371", "https://openalex.org/W2167536144", "https://openalex.org/W2179438025", "https://openalex.org/W2252568502", "https://openalex.org/W2305674065", "https://openalex.org/W2343277111", "https://openalex.org/W2402498701", "https://openalex.org/W2417483443", "https://openalex.org/W2469053820", "https://openalex.org/W2470282799", "https://openalex.org/W2529441459", "https://openalex.org/W2540583032", "https://openalex.org/W2546906832", "https://openalex.org/W2565555627", "https://openalex.org/W2582743722", "https://openalex.org/W2592811885", "https://openalex.org/W2611661371", "https://openalex.org/W2625522207", "https://openalex.org/W2780450926", "https://openalex.org/W2783501849", "https://openalex.org/W2787448102", "https://openalex.org/W2801491597", "https://openalex.org/W2810058136", "https://openalex.org/W2897559392", "https://openalex.org/W2918368935", "https://openalex.org/W2935024989", "https://openalex.org/W2945567049", "https://openalex.org/W2950773377", "https://openalex.org/W2952439736", "https://openalex.org/W2953101207", "https://openalex.org/W2971587210", "https://openalex.org/W2972211029", "https://openalex.org/W2980978771", "https://openalex.org/W2984059576", "https://openalex.org/W2987688991", "https://openalex.org/W2991600264", "https://openalex.org/W2993286292", "https://openalex.org/W3011516138", "https://openalex.org/W3047879827", "https://openalex.org/W3111011311", "https://openalex.org/W3120305566", "https://openalex.org/W3194399644", "https://openalex.org/W4210762403", "https://openalex.org/W4236357753", "https://openalex.org/W4294216483"], "related_works": ["https://openalex.org/W2603161682", "https://openalex.org/W2960163646", "https://openalex.org/W2807464733", "https://openalex.org/W2516842346", "https://openalex.org/W2134268326", "https://openalex.org/W2903635918", "https://openalex.org/W2437118042", "https://openalex.org/W2337751047", "https://openalex.org/W3052741125", "https://openalex.org/W2667943050"], "abstract_inverted_index": {"Abstract": [0], "Background": [1], "Zebrafish": [2], "have": [3], "practical": [4], "features": [5, 210], "that": [6, 176, 211, 303], "make": [7], "them": [8], "a": [9, 55, 273, 295, 312], "useful": [10], "model": [11], "for": [12, 82, 129, 315, 319], "higher-throughput": [13], "tests": [14], "of": [15, 29, 39, 49, 58, 90, 93, 119, 179, 215, 227, 241, 245, 263, 275, 278, 324], "gene": [16, 97, 134], "function": [17], "using": [18], "CRISPR/Cas9": [19, 104, 325], "editing": [20, 143], "to": [21, 36, 64, 103, 289], "create": [22], "\u2018knockout\u2019": [23], "models.": [24], "In": [25], "particular,": [26], "the": [27, 177, 268, 300, 316, 320], "use": [28], "G": [30, 120, 147, 216], "0": [31, 121, 148, 217], "mosaic": [32, 146, 218], "mutants": [33], "has": [34], "potential": [35, 117], "increase": [37], "throughput": [38], "functional": [40], "studies": [41, 214], "significantly": [42], "but": [43, 68], "may": [44], "suffer": [45], "from": [46, 299], "transient": [47], "effects": [48], "introducing": [50], "Cas9": [51, 200], "via": [52], "microinjection.": [53], "Further,": [54], "large": [56, 162], "number": [57, 274], "computational": [59], "and": [60, 95, 132, 160, 172, 282, 291, 322], "empirical": [61], "tools": [62, 159], "exist": [63], "design": [65, 158, 321], "CRISPR": [66, 123, 195, 219], "assays": [67], "often": [69], "produce": [70], "varied": [71], "predictions": [72, 92], "across": [73], "methods": [74], "leaving": [75], "uncertainty": [76], "in": [77, 141, 145, 170, 173, 184, 267], "choosing": [78], "an": [79, 224], "optimal": [80], "approach": [81], "zebrafish": [83, 101, 317], "studies.": [84], "Methods": [85], "To": [86, 189], "systematically": [87], "assess": [88], "accuracy": [89], "tool": [91], "on-": [94], "off-target": [96, 167], "editing,": [98], "we": [99, 222, 237, 248], "subjected": [100], "embryos": [102, 128, 149], "with": [105, 150, 199, 204, 255, 287], "50": [106], "different": [107], "guide": [108], "RNAs": [109], "(gRNAs)": [110], "targeting": [111], "14": [112], "genes.": [113], "We": [114, 137], "also": [115], "investigate": [116], "confounders": [118], "-based": [122], "screens": [124], "by": [125, 153], "assaying": [126], "control": [127, 229], "spurious": [130, 208], "mutations": [131, 168, 244], "altered": [133], "expression.": [135], "Results": [136], "compared": [138], "our": [139, 309], "experimental": [140], "vivo": [142, 185], "efficiencies": [144], "those": [151], "predicted": [152], "eight": [154], "commonly": [155, 192], "used": [156, 193], "gRNA": [157], "found": [161, 175, 238], "discrepancies": [163], "between": [164, 258], "methods.": [165], "Assessing": [166], "(predicted": [169], "silico": [171], "vitro)": [174], "majority": [178], "tested": [180], "loci": [181], "had": [182], "low": [183], "frequencies": [186], "(&lt;": [187], "1%).": [188], "characterize": [190], "if": [191], "\u2018mock\u2019": [194, 269], "controls": [196], "(larvae": [197], "injected": [198, 246, 270], "enzyme": [201], "or": [202], "mRNA": [203], "no": [205, 239], "gRNA)": [206], "exhibited": [207], "molecular": [209], "might": [212], "exacerbate": [213], "knockout": [220], "fish,": [221], "generated": [223], "RNA-seq": [225], "dataset": [226], "various": [228], "larvae": [230, 271], "at": [231], "5": [232], "days": [233], "post": [234], "fertilization.": [235], "While": [236], "evidence": [240], "spontaneous": [242], "somatic": [243], "larvae,": [247], "did": [249], "identify": [250], "several": [251], "hundred": [252], "differentially-expressed": [253, 265], "genes": [254, 266], "high": [256], "variability": [257], "injection": [259], "types.": [260], "Network": [261], "analyses": [262], "shared": [264], "implicated": [272], "key": [276], "regulators": [277], "common": [279], "metabolic": [280], "pathways,": [281], "gene-ontology": [283], "analysis": [284], "revealed": [285], "connections": [286], "response": [288], "wounding": [290], "cytoskeleton": [292], "organization,": [293], "highlighting": [294], "potentially": [296], "lasting": [297], "effect": [298], "microinjection": [301], "process": [302], "requires": [304], "further": [305], "investigation.": [306], "Conclusion": [307], "Overall,": [308], "results": [310], "provide": [311], "valuable": [313], "resource": [314], "community": [318], "execution": [323], "experiments.": [326]}, "counts_by_year": [{"year": 2026, "cited_by_count": 4}, {"year": 2025, "cited_by_count": 22}, {"year": 2024, "cited_by_count": 11}, {"year": 2023, "cited_by_count": 10}, {"year": 2022, "cited_by_count": 2}], "updated_date": "2026-05-21T09:19:25.381259", "created_date": "2025-10-10T00:00:00"}], "group_by": []}