{"id":"https://openalex.org/W7202364904","doi":"https://doi.org/10.1016/j.xcrm.2026.102988","title":"Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans","display_name":"Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7202364904","doi":"https://doi.org/10.1016/j.xcrm.2026.102988","pmid":"https://pubmed.ncbi.nlm.nih.gov/42594877"},"language":"en","primary_location":{"id":"doi:10.1016/j.xcrm.2026.102988","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.102988","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xcrm.2026.102988","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147076179","display_name":"Luke Olsen","orcid":null},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Olsen","raw_affiliation_strings":["Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014368664","display_name":"Javier Botella","orcid":"https://orcid.org/0000-0001-9722-8519"},"institutions":[{"id":"https://openalex.org/I71270174","display_name":"Victoria University","ror":"https://ror.org/04j757h98","country_code":"AU","type":"education","lineage":["https://openalex.org/I71270174"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Javier Botella","raw_affiliation_strings":["Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I71270174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137357825","display_name":"Douglas Barrows","orcid":null},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Barrows","raw_affiliation_strings":["Bioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134702592","display_name":"Ethan Romero","orcid":null},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Romero","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147108930","display_name":"Kaitlyn Baird","orcid":null},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn Baird","raw_affiliation_strings":["Department of Rehabilitation and Performance, Hospital for Special Surgery, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation and Performance, Hospital for Special Surgery, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076327968","display_name":"Mutsumi Katayama","orcid":null},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mutsumi Katayama","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120113304","display_name":"Ece Kilic","orcid":null},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ece Kilic","raw_affiliation_strings":["Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054190726","display_name":"Christopher Peralta","orcid":"https://orcid.org/0009-0003-1801-3002"},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Peralta","raw_affiliation_strings":["Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003420280","display_name":"Nad\u00e8ge Zanou","orcid":"https://orcid.org/0000-0001-6626-3127"},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nad\u00e8ge Zanou","raw_affiliation_strings":["Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114787139","display_name":"Henry Sanford","orcid":null},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Sanford","raw_affiliation_strings":["Laboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147135289","display_name":"Laurie Farrell","orcid":null},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie Farrell","raw_affiliation_strings":["Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039093132","display_name":"Christopher L. Axelrod","orcid":"https://orcid.org/0000-0002-1444-8557"},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Axelrod","raw_affiliation_strings":["Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019060378","display_name":"Kaja Pluci\u0144ska","orcid":"https://orcid.org/0000-0002-2144-7712"},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaja Pluci\u0144ska","raw_affiliation_strings":["Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147090655","display_name":"Jeanne Walker","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093632","display_name":"Rockefeller University Hospital","ror":"https://ror.org/00jjq6q61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanne Walker","raw_affiliation_strings":["The Rockefeller University Hospital, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University Hospital, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4210093632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147117782","display_name":"Lu Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Yan","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050001519","display_name":"Katie Fredrickson","orcid":null},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Fredrickson","raw_affiliation_strings":["Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072335242","display_name":"Olivier Pourqui\u00e9","orcid":"https://orcid.org/0000-0001-5189-1227"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivier Pourquie","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147071461","display_name":"Jeremy M. Robbins","orcid":null},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy M. Robbins","raw_affiliation_strings":["Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027175067","display_name":"Ekaterina V. Vinogradova","orcid":"https://orcid.org/0000-0003-3512-5375"},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekaterina V. Vinogradova","raw_affiliation_strings":["Laboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026244741","display_name":"Henrik Molina","orcid":"https://orcid.org/0000-0001-8950-4990"},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henrik Molina","raw_affiliation_strings":["Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087511039","display_name":"Nicolas Place","orcid":"https://orcid.org/0000-0001-9044-0621"},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicolas Place","raw_affiliation_strings":["Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138009484","display_name":"JOHN P. KIRWAN","orcid":null},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Kirwan","raw_affiliation_strings":["Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137081926","display_name":"Juleen R. Zierath","orcid":null},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Juleen R. Zierath","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068081328","display_name":"Anna Krook","orcid":"https://orcid.org/0000-0002-0891-0258"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Krook","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147084851","display_name":"Robert E. Gerszten","orcid":null},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Gerszten","raw_affiliation_strings":["Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147069070","display_name":"David J. Bishop","orcid":null},"institutions":[{"id":"https://openalex.org/I71270174","display_name":"Victoria University","ror":"https://ror.org/04j757h98","country_code":"AU","type":"education","lineage":["https://openalex.org/I71270174"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David J. Bishop","raw_affiliation_strings":["Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I71270174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047214685","display_name":"Paul Cohen","orcid":"https://orcid.org/0000-0002-2786-8585"},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Cohen","raw_affiliation_strings":["Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA. Electronic address: pcohen@rockefeller.edu"],"raw_orcid":"https://orcid.org/0000-0002-2786-8585","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA. Electronic address: pcohen@rockefeller.edu","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5047214685"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.90862542,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"102988","last_page":"102988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.26489999890327454,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.26489999890327454,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.10790000110864639,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intensity","display_name":"Intensity (physics)","score":0.42309999465942383},{"id":"https://openalex.org/keywords/physical-activity","display_name":"Physical activity","score":0.42010000348091125},{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.4023999869823456},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3160000145435333},{"id":"https://openalex.org/keywords/exercise-intensity","display_name":"Exercise intensity","score":0.3118000030517578},{"id":"https://openalex.org/keywords/physical-exercise","display_name":"Physical exercise","score":0.296099990606308},{"id":"https://openalex.org/keywords/medline","display_name":"MEDLINE","score":0.28439998626708984}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7404999732971191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4593000113964081},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.42309999465942383},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.42010000348091125},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4023999869823456},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3555000126361847},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C2776811442","wikidata":"https://www.wikidata.org/wiki/Q5420058","display_name":"Exercise intensity","level":4,"score":0.3118000030517578},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.28049999475479126},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.25209999084472656},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.25119999051094055},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.xcrm.2026.102988","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.102988","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},{"id":"pmid:42594877","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42594877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports. Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/284157","is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/284157","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1016/j.xcrm.2026.102988","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.102988","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320309126","display_name":"Dr. Robert C. and Veronica Atkins Foundation","ror":"https://ror.org/02tjrkg92"},{"id":"https://openalex.org/F4320311634","display_name":"Achelis and Bodman Foundation","ror":"https://ror.org/011xj1a65"},{"id":"https://openalex.org/F4320314691","display_name":"Robertson Foundation","ror":"https://ror.org/04h2x1077"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320322565","display_name":"Stavros Niarchos Foundation","ror":"https://ror.org/0210rze73"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1561325491","https://openalex.org/W1878155485","https://openalex.org/W1969554900","https://openalex.org/W1974559463","https://openalex.org/W2010084870","https://openalex.org/W2012034410","https://openalex.org/W2035618305","https://openalex.org/W2078366210","https://openalex.org/W2102638759","https://openalex.org/W2103488083","https://openalex.org/W2104827888","https://openalex.org/W2130410032","https://openalex.org/W2149164423","https://openalex.org/W2157162286","https://openalex.org/W2161109797","https://openalex.org/W2171506157","https://openalex.org/W2179438025","https://openalex.org/W2193288511","https://openalex.org/W2197124664","https://openalex.org/W2344342871","https://openalex.org/W2517568305","https://openalex.org/W2520784563","https://openalex.org/W2592811885","https://openalex.org/W2785540442","https://openalex.org/W2788552254","https://openalex.org/W2800024870","https://openalex.org/W2886225009","https://openalex.org/W2898027765","https://openalex.org/W3004354477","https://openalex.org/W3008261843","https://openalex.org/W3024249113","https://openalex.org/W3040071858","https://openalex.org/W3094645479","https://openalex.org/W3117184333","https://openalex.org/W3133859624","https://openalex.org/W3155558295","https://openalex.org/W3159120273","https://openalex.org/W4200434404","https://openalex.org/W4200553428","https://openalex.org/W4220729385","https://openalex.org/W4220828826","https://openalex.org/W4223623765","https://openalex.org/W4224097730","https://openalex.org/W4225911871","https://openalex.org/W4282972916","https://openalex.org/W4293102181","https://openalex.org/W4307435157","https://openalex.org/W4308548725","https://openalex.org/W4311312678","https://openalex.org/W4312129908","https://openalex.org/W4317545566","https://openalex.org/W4365445714","https://openalex.org/W4367839701","https://openalex.org/W4382893967","https://openalex.org/W4384560001","https://openalex.org/W4386258244","https://openalex.org/W4389391124","https://openalex.org/W4402415809","https://openalex.org/W4403980232","https://openalex.org/W4404628441","https://openalex.org/W4405229946","https://openalex.org/W4405988692","https://openalex.org/W4407010992","https://openalex.org/W4409252512","https://openalex.org/W4410153656","https://openalex.org/W4410412321","https://openalex.org/W4412535471","https://openalex.org/W4413138710","https://openalex.org/W4415093835","https://openalex.org/W4416869624","https://openalex.org/W7125686611"],"related_works":[],"abstract_inverted_index":{"Exercise":[0],"is":[1],"an":[2],"integral":[3],"therapy":[4],"for":[5],"many":[6],"cardiometabolic":[7,138],"diseases,":[8],"including":[9],"obesity,":[10],"type":[11],"2":[12],"diabetes,":[13],"and":[14,50,71,75,82,89,104,108,116,122,140,150],"hypertension.":[15],"Despite":[16],"its":[17],"broad":[18,120],"health":[19,139],"benefits,":[20],"the":[21,68],"circulating":[22],"factors":[23],"that":[24,63],"mediate":[25],"exercise":[26,36,44,48,52,64,114,144],"adaptations":[27],"in":[28,73,87,90],"humans":[29],"remain":[30],"incompletely":[31],"defined,":[32],"particularly":[33,111],"across":[34],"different":[35],"intensities.":[37],"Here,":[38],"we":[39,94,126],"conducted":[40],"a":[41,128],"multi-cohort":[42],"human":[43],"intervention":[45],"incorporating":[46],"sprint-interval":[47],"(SIE)":[49],"moderate-intensity":[51],"(MIE)":[53],"to":[54,98,113,118,132],"analyze":[55],"intensity-dependent":[56,134],"regulation":[57],"of":[58,102],"interorgan":[59,148],"crosstalk.":[60],"We":[61],"found":[62],"intensity":[65,115,145],"distinctly":[66],"influenced":[67],"plasma":[69],"proteome":[70],"metabolome":[72],"untrained":[74],"trained":[76],"participants.":[77],"By":[78],"integrating":[79],"multi-organ":[80],"gene":[81],"protein":[83],"expression":[84],"datasets":[85],"with":[86,137],"vitro":[88],"vivo":[91],"tissue":[92],"sampling,":[93],"mapped":[95],"regulated":[96],"proteins":[97,135],"their":[99],"predicted":[100],"tissues":[101],"origin":[103],"destination.":[105],"Muscle":[106],"fibers":[107],"adipocytes":[109],"were":[110],"sensitive":[112],"observed":[117],"undergo":[119],"secretory":[121],"transcriptomic":[123],"changes.":[124],"Moreover,":[125],"leveraged":[127],"large-scale":[129],"plasma-phenome":[130],"database":[131],"identify":[133],"associated":[136],"disease,":[141],"highlighting":[142],"how":[143],"differentially":[146],"shapes":[147],"communication":[149],"organismal":[151],"health.":[152]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-08-14T00:00:00"}