{"id":"https://openalex.org/W2916384176","doi":"https://doi.org/10.7551/978-0-262-32621-6-ch141","title":"Pre-Template Metabolic Replicators: Genotype-Phenotype Decoupling as a Route to Evolvability","display_name":"Pre-Template Metabolic Replicators: Genotype-Phenotype Decoupling as a Route to Evolvability","publication_year":2014,"publication_date":"2014-07-06","ids":{"openalex":"https://openalex.org/W2916384176","doi":"https://doi.org/10.7551/978-0-262-32621-6-ch141","mag":"2916384176"},"language":"en","primary_location":{"id":"doi:10.7551/978-0-262-32621-6-ch141","is_oa":false,"landing_page_url":"https://doi.org/10.7551/978-0-262-32621-6-ch141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life 14: Proceedings of the Fourteenth International Conference on the Synthesis and Simulation of Living Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049532425","display_name":"William Hurndall","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"William Hurndall","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082699760","display_name":"Richard A. Watson","orcid":"https://orcid.org/0000-0002-2521-8255"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Watson","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000066138","display_name":"Markus Brede","orcid":"https://orcid.org/0000-0002-0197-8612"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Brede","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049532425"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20019883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"856","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolvability","display_name":"Evolvability","score":0.9693633913993835},{"id":"https://openalex.org/keywords/decoupling","display_name":"Decoupling (probability)","score":0.6617107391357422},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.586803138256073},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4919907748699188},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3298007547855377},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25090649724006653},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19905316829681396}],"concepts":[{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.9693633913993835},{"id":"https://openalex.org/C205606062","wikidata":"https://www.wikidata.org/wiki/Q5249645","display_name":"Decoupling (probability)","level":2,"score":0.6617107391357422},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.586803138256073},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4919907748699188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3298007547855377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25090649724006653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19905316829681396},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7551/978-0-262-32621-6-ch141","is_oa":false,"landing_page_url":"https://doi.org/10.7551/978-0-262-32621-6-ch141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life 14: Proceedings of the Fourteenth International Conference on the Synthesis and Simulation of Living Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2105160260","https://openalex.org/W2922935424","https://openalex.org/W2571877704","https://openalex.org/W2122461052","https://openalex.org/W1781524388","https://openalex.org/W2040177850","https://openalex.org/W2783956319","https://openalex.org/W2773108699"],"abstract_inverted_index":{"The":[0],"RNA":[1,31],"World":[2],"is":[3,105,120],"widely":[4],"heralded":[5],"as":[6,22,127],"the":[7,16,24,27,41,48,59,69,72,117,144],"leading":[8],"candidate":[9],"for":[10],"a":[11,75,86,108,125],"template":[12],"first":[13,43],"vision":[14],"of":[15,18,26,30,47,50,54,61,74,111,146,167,172],"origin":[17],"life,":[19],"yet":[20],"doubts":[21],"to":[23,37,96,115],"plausibility":[25],"natural":[28,168],"formation":[29],"with":[32,99],"catalytic":[33],"function":[34],"have":[35,56],"led":[36],"revived":[38],"interest":[39],"in":[40,64,85,135,152,170],"metabolism":[42],"paradigm.":[44],"Recent":[45],"studies":[46],"evolvability":[49],"reflexively":[51],"autocatalytic":[52],"sets":[53],"polymers":[55],"also":[57],"revealed":[58],"nature":[60],"limited":[62,100],"heredity":[63],"compartmentalised":[65],"reaction":[66],"networks.":[67],"In":[68],"algorithmic":[70],"sense,":[71],"lack":[73],"meaningful":[76],"distinction":[77],"between":[78],"data":[79],"storage":[80],"and":[81],"functional":[82],"expression":[83],"results":[84],"protocell":[87,126],"heredity-fitness":[88],"dichotomy":[89],"which":[90,136],"gives":[91],"an":[92,128,153],"intrinsic":[93],"selective":[94],"advantage":[95],"those":[97],"protocells":[98],"heredity.":[101],"An":[102],"idealised":[103],"model":[104],"used":[106],"explore":[107],"minimal":[109],"set":[110],"dynamical":[112],"requirements":[113],"necessary":[114],"weaken":[116],"dichotomy.":[118],"This":[119],"achieved":[121,164],"by":[122],"explicitly":[123],"modelling":[124],"outer":[129],"compartment":[130],"\u2019phenotype\u2019,":[131],"heritable":[132,160],"only":[133],"indirectly,":[134],"competitive":[137],"exponential":[138],"growth":[139,150],"may":[140],"occur":[141],"without":[142],"compromising":[143],"heritability":[145],"previously":[147],"discounted":[148],"non-competitive":[149],"autocatalysts":[151],"inner":[154],"sub-compartment,":[155],"\u2019genotype\u2019.":[156],"Results":[157],"show":[158],"that":[159],"variation":[161],"can":[162],"be":[163],"under":[165],"simulations":[166],"selection":[169],"populations":[171],"such":[173],"metabolic":[174],"replicators.":[175]},"counts_by_year":[],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2019-03-02T00:00:00"}
