{"id":"https://openalex.org/W2125875569","doi":"https://doi.org/10.7551/978-0-262-31709-2-ch125","title":"The use of Agent-based Simulation to Discover Extreme Cases in Immune-Interactions with Early-Stage Cancer Scenarios","display_name":"The use of Agent-based Simulation to Discover Extreme Cases in Immune-Interactions with Early-Stage Cancer Scenarios","publication_year":2013,"publication_date":"2013-08-29","ids":{"openalex":"https://openalex.org/W2125875569","doi":"https://doi.org/10.7551/978-0-262-31709-2-ch125","mag":"2125875569"},"language":"en","primary_location":{"id":"doi:10.7551/978-0-262-31709-2-ch125","is_oa":true,"landing_page_url":"https://doi.org/10.7551/978-0-262-31709-2-ch125","pdf_url":"http://www.mitpressjournals.org/doi/pdf/10.1162/978-0-262-31709-2-ch125","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Artificial Life, ECAL 2013","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.mitpressjournals.org/doi/pdf/10.1162/978-0-262-31709-2-ch125","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051446557","display_name":"Grazziela P. Figueredo","orcid":"https://orcid.org/0000-0003-4094-7680"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Grazziela Figueredo","raw_affiliation_strings":["University of Nottingham"],"affiliations":[{"raw_affiliation_string":"University of Nottingham","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047408988","display_name":"Peer\u2010Olaf Siebers","orcid":"https://orcid.org/0000-0002-0603-5904"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peer-Olaf Siebers","raw_affiliation_strings":["University of Nottingham"],"affiliations":[{"raw_affiliation_string":"University of Nottingham","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029199758","display_name":"Douglas A. Augusto","orcid":"https://orcid.org/0000-0001-5719-6786"},"institutions":[{"id":"https://openalex.org/I4210142352","display_name":"Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica","ror":"https://ror.org/0498ekt05","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210142352"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Douglas Augusto","raw_affiliation_strings":["Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica"],"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica","institution_ids":["https://openalex.org/I4210142352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052002490","display_name":"H\u00e9lio J. C. Barbosa","orcid":"https://orcid.org/0000-0001-5810-7554"},"institutions":[{"id":"https://openalex.org/I4210142352","display_name":"Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica","ror":"https://ror.org/0498ekt05","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210142352"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Helio Barbosa","raw_affiliation_strings":["Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica"],"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica","institution_ids":["https://openalex.org/I4210142352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002768704","display_name":"Uwe Aickelin","orcid":"https://orcid.org/0000-0002-2679-2275"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Uwe Aickelin","raw_affiliation_strings":["University of Nottingham"],"affiliations":[{"raw_affiliation_string":"University of Nottingham","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051446557"],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12470374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"854","last_page":"855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9451000094413757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9318000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.6201304197311401},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5730443000793457},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.43068182468414307},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12397199869155884}],"concepts":[{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6201304197311401},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5730443000793457},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43068182468414307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12397199869155884},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.7551/978-0-262-31709-2-ch125","is_oa":true,"landing_page_url":"https://doi.org/10.7551/978-0-262-31709-2-ch125","pdf_url":"http://www.mitpressjournals.org/doi/pdf/10.1162/978-0-262-31709-2-ch125","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Artificial Life, ECAL 2013","raw_type":"proceedings-article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/241183","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/241183","pdf_url":"http://hdl.handle.net/11343/241183","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Artificial Life Conference Proceedings","raw_type":"Conference Paper"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.470.5001","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.470.5001","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ima.ac.uk/papers/Figueredo2013d.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.474.9305","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.474.9305","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mitpress.mit.edu/sites/default/files/titles/content/ecal13/978-0-262-31709-2-ch125.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.nottingham.ac.uk:3335","is_oa":true,"landing_page_url":"http://eprints.nottingham.ac.uk/3335/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402013","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"},{"id":"pmh:oai:nottingham-repository.worktribe.com:1002990","is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/1002990","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Presentation / Conference Contribution"}],"best_oa_location":{"id":"doi:10.7551/978-0-262-31709-2-ch125","is_oa":true,"landing_page_url":"https://doi.org/10.7551/978-0-262-31709-2-ch125","pdf_url":"http://www.mitpressjournals.org/doi/pdf/10.1162/978-0-262-31709-2-ch125","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Artificial Life, ECAL 2013","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5199999809265137,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125875569.pdf","grobid_xml":"https://content.openalex.org/works/W2125875569.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1618745088","https://openalex.org/W1964601264","https://openalex.org/W1992839337","https://openalex.org/W2029159090","https://openalex.org/W2082652742","https://openalex.org/W2138571902","https://openalex.org/W2150704630","https://openalex.org/W2414645854"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2350741829","https://openalex.org/W2130043461","https://openalex.org/W2530322880"],"abstract_inverted_index":{"Early-stage":[0],"cancer":[1],"and":[2,26,52,80,90,99,103],"its":[3],"interactions":[4,86],"with":[5],"the":[6,75,97,108,117],"immune":[7,78,91,109],"system":[8],"are":[9],"still":[10],"not":[11],"fully":[12],"understood.":[13],"In":[14,59],"order":[15],"to":[16,73],"better":[17],"understand":[18],"these":[19],"processes,":[20],"researchers":[21],"employ":[22],"different":[23],"methods.":[24],"Simulation":[25],"in":[27],"particular,":[28],"agent-based":[29],"simu-lation":[30],"(ABS)":[31],"have":[32,68],"been":[33],"found":[34],"useful":[35],"tools":[36],"for":[37],"understand-ing":[38],"it":[39],"(Look":[40],"et":[41,45,56,64],"al.,":[42,46,57,65],"1981;":[43],"Castiglione":[44],"1999,":[47],"2001;":[48],"Bonabeau,":[49],"2002;":[50],"Figueredo":[51,55],"Aickelin,":[53],"2011;":[54],"2013a,b).":[58],"a":[60],"previous":[61],"study":[62,74],"(Figueredo":[63],"2013b)":[66],"we":[67],"built":[69],"an":[70],"ABS":[71],"model":[72,84],"interplay":[76],"of":[77,119],"cells":[79,89],"early-stage":[81],"cancer.":[82],"The":[83],"considers":[85],"be-tween":[87],"tumour":[88,112],"effector":[92],"cells,":[93],"as":[94,96],"well":[95],"immune-stimulatory":[98],"suppressive":[100],"cytokines":[101],"IL-2":[102,105],"TGF-.":[104],"molecules":[106],"mediate":[107],"response":[110],"to-wards":[111],"cells.":[113],"They":[114],"interfere":[115],"on":[116],"proliferation":[118]},"counts_by_year":[],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
