{"id":"https://openalex.org/W2137151335","doi":"https://doi.org/10.7551/978-0-262-31050-5-ch014","title":"Adaptation and Divergence during Experimental Evolution of Multicellular Saccharomyces cerevisiae","display_name":"Adaptation and Divergence during Experimental Evolution of Multicellular Saccharomyces cerevisiae","publication_year":2012,"publication_date":"2012-07-02","ids":{"openalex":"https://openalex.org/W2137151335","doi":"https://doi.org/10.7551/978-0-262-31050-5-ch014","mag":"2137151335"},"language":"en","primary_location":{"id":"doi:10.7551/978-0-262-31050-5-ch014","is_oa":false,"landing_page_url":"https://doi.org/10.7551/978-0-262-31050-5-ch014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life 13","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062224310","display_name":"Mar\u00eda Rebolleda\u2010G\u00f3mez","orcid":"https://orcid.org/0000-0002-3592-4479"},"institutions":[{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria Rebolleda-Gomez","raw_affiliation_strings":["University of Minnesota Twin Cities"],"affiliations":[{"raw_affiliation_string":"University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032185000","display_name":"William C. Ratcliff","orcid":"https://orcid.org/0000-0002-6837-8355"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Ratcliff","raw_affiliation_strings":["University of Minnesota Twin Cities"],"affiliations":[{"raw_affiliation_string":"University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060768261","display_name":"Michael Travisano","orcid":"https://orcid.org/0000-0001-8168-0842"},"institutions":[{"id":"https://openalex.org/I4210104899","display_name":"Ecologie & Evolution","ror":"https://ror.org/01ffjs081","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210104899","https://openalex.org/I4210139971","https://openalex.org/I4210161506"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael Travisano","raw_affiliation_strings":["Ecology, Evolution and Behavior"],"affiliations":[{"raw_affiliation_string":"Ecology, Evolution and Behavior","institution_ids":["https://openalex.org/I4210104899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062224310"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210101327"],"apc_list":null,"apc_paid":null,"fwci":0.6211,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74013623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10487","display_name":"Plant and animal studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.7570604085922241},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.7101760506629944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5975673198699951},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5402287244796753},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.5055794715881348},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3934444189071655},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32140052318573},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29753613471984863},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.11661514639854431},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1025192141532898},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.09217092394828796},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.08844751119613647}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.7570604085922241},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.7101760506629944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5975673198699951},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5402287244796753},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.5055794715881348},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3934444189071655},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32140052318573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29753613471984863},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.11661514639854431},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1025192141532898},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09217092394828796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08844751119613647},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7551/978-0-262-31050-5-ch014","is_oa":false,"landing_page_url":"https://doi.org/10.7551/978-0-262-31050-5-ch014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life 13","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.401.6529","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.401.6529","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mitpress.mit.edu/sites/default/files/titles/content/alife13/978-0-262-31050-5-ch014.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1583030352","https://openalex.org/W1982286661","https://openalex.org/W1982943809","https://openalex.org/W1996460711","https://openalex.org/W2035791902","https://openalex.org/W2054926876","https://openalex.org/W2066818550","https://openalex.org/W2088381634","https://openalex.org/W2106453287","https://openalex.org/W2122562915","https://openalex.org/W2130913636","https://openalex.org/W2170755251"],"related_works":["https://openalex.org/W306450906","https://openalex.org/W2614029615","https://openalex.org/W2996680662","https://openalex.org/W2132267912","https://openalex.org/W1547548607","https://openalex.org/W2038227545","https://openalex.org/W2782073194","https://openalex.org/W2952656033","https://openalex.org/W4322576436","https://openalex.org/W2591057174"],"abstract_inverted_index":{"The":[0],"evolution":[1,161],"of":[2,6,13,80,104,122,142,157,162],"multicellularity":[3],"was":[4],"one":[5],"the":[7,11,27,35,50,78,81,105,124,140,147,160],"key":[8],"innovations":[9],"in":[10,23,120,139,146,159],"history":[12],"life":[14],"on":[15],"Earth.":[16],"Virtually":[17],"all":[18,92],"morphological":[19,112,131],"and":[20,119,165],"ecological":[21,38,163],"diversity":[22,39],"macro-organisms":[24],"builds":[25],"upon":[26],"evolutionary":[28],"potential":[29,36],"associated":[30],"with":[31,135],"multicellularity.":[32,46],"We":[33,128],"examined":[34],"for":[37],"to":[40,45,60,62,86,173],"rapidly":[41],"arise":[42],"following":[43],"transitions":[44],"Replicate":[47],"microcosms":[48,93],"containing":[49],"yeast":[51],"Saccharomyces":[52],"cerevisiae":[53,68],"were":[54,84,114,126],"maintained":[55],"under":[56],"serial":[57],"transfer.":[58],"Prior":[59],"transfer":[61],"fresh":[63,87],"media":[64],"each":[65],"day,":[66],"S.":[67],"underwent":[69],"settling":[70],"selection":[71],"via":[72,99],"mild":[73],"centrifugation.":[74],"Those":[75],"individuals":[76,96,144],"reaching":[77],"bottom":[79],"centrifuge":[82],"tube":[83],"transferred":[85],"media.":[88],"After":[89],"sixty":[90,117],"days,":[91,118],"contained":[94],"multicellular":[95,143],"that":[97,166],"develop":[98],"motherdaughter":[100],"adhesion.":[101],"In":[102],"nine":[103],"ten":[106],"microcosms,":[107],"at":[108,116],"least":[109],"two":[110],"distinctive":[111],"genotypes":[113],"evident":[115],"eight":[121],"them,":[123],"variants":[125],"multicellular.":[127],"observed":[129],"substantial":[130],"variation":[132,149],"across":[133],"replicates,":[134],"relatively":[136],"little":[137],"parallelism":[138],"size":[141,148],"or":[145],"within":[150],"microcosms.":[151],"These":[152],"results":[153],"suggest":[154],"surprising":[155],"amounts":[156],"contingency":[158],"diversity,":[164],"\u201creplaying":[167],"life\u2019s":[168],"tape":[169],"\u201d":[170],"would":[171],"lead":[172],"divergent":[174],"outcomes.":[175]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}