{"id":"https://openalex.org/W4393659941","doi":"https://doi.org/10.5281/zenodo.6851220","title":"Integration of an event-driven Timepix3 hybrid pixel detector into a cryo-EM workflow","display_name":"Integration of an event-driven Timepix3 hybrid pixel detector into a cryo-EM workflow","publication_year":2022,"publication_date":"2022-07-17","ids":{"openalex":"https://openalex.org/W4393659941","doi":"https://doi.org/10.5281/zenodo.6851220"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:6851220","is_oa":true,"landing_page_url":"https://zenodo.org/record/6851220","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/6851220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065638633","display_name":"J. Paul van Schayck","orcid":"https://orcid.org/0000-0001-6591-4637"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"van Schayck, J. Paul","raw_affiliation_strings":["Maastricht MultiModal Molecular Imaging Institute (M4i), FHML, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6591-4637","affiliations":[{"raw_affiliation_string":"Maastricht MultiModal Molecular Imaging Institute (M4i), FHML, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011638743","display_name":"Yue Zhang","orcid":"https://orcid.org/0000-0003-4482-1866"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zhang, Yue","raw_affiliation_strings":["Maastricht MultiModal Molecular Imaging Institute (M4i), FHML, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4482-1866","affiliations":[{"raw_affiliation_string":"Maastricht MultiModal Molecular Imaging Institute (M4i), FHML, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046097263","display_name":"K\u00e8vin Knoops","orcid":"https://orcid.org/0000-0002-7539-1160"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Knoops, K\u00e8vin","raw_affiliation_strings":["Maastricht MultiModal Molecular Imaging Institute (M4i), FHML, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7539-1160","affiliations":[{"raw_affiliation_string":"Maastricht MultiModal Molecular Imaging Institute (M4i), FHML, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111160493","display_name":"Peters","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":", Peters","raw_affiliation_strings":["Peter J"],"raw_orcid":"https://orcid.org/0000-0002-2964-5684","affiliations":[{"raw_affiliation_string":"Peter J","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111159907","display_name":"Ravelli","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":", Ravelli","raw_affiliation_strings":["Raimond B.G>"],"raw_orcid":"https://orcid.org/0000-0001-6056-5888","affiliations":[{"raw_affiliation_string":"Raimond B.G>","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11044","display_name":"Particle Detector Development and Performance","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11044","display_name":"Particle Detector Development and Performance","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11216","display_name":"Radiation Detection and Scintillator Technologies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7215943336486816},{"id":"https://openalex.org/keywords/event","display_name":"Event (particle physics)","score":0.6297051906585693},{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.5958361625671387},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.5479701161384583},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5241820216178894},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27955472469329834},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1982763111591339},{"id":"https://openalex.org/keywords/astrophysics","display_name":"Astrophysics","score":0.12285268306732178},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.11827027797698975},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.0789569616317749}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7215943336486816},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.6297051906585693},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.5958361625671387},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.5479701161384583},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5241820216178894},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27955472469329834},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1982763111591339},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.12285268306732178},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.11827027797698975},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0789569616317749}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:zenodo.org:6851220","is_oa":true,"landing_page_url":"https://zenodo.org/record/6851220","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},{"id":"doi:10.5281/zenodo.6851220","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.6851220","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"dataset"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:6851220","is_oa":true,"landing_page_url":"https://zenodo.org/record/6851220","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W1981780420","https://openalex.org/W2182707996","https://openalex.org/W45233828","https://openalex.org/W2964988449","https://openalex.org/W2397952901","https://openalex.org/W2029380707","https://openalex.org/W4255934811","https://openalex.org/W2465382974","https://openalex.org/W2010229520"],"abstract_inverted_index":{"<strong>Abstract</strong>":[0],"The":[1,141,308,319],"development":[2],"of":[3,119,143,148,162,171,305],"direct":[4],"electron":[5,14,29],"detectors":[6,22,52],"has":[7,152,200,275,315],"played":[8],"a":[9,60,121,124,167,227,256],"key":[10],"role":[11],"in":[12,47,74,146,204,287],"low-dose":[13,87,194],"microscopy":[15,30],"imaging":[16,48,76],"applications.":[17],"Monolithic":[18],"active-pixel":[19],"sensor":[20],"(MAPS)":[21],"are":[23],"currently":[24],"widely":[25],"applied":[26],"for":[27,85,134,236,265,299,311],"cryogenic":[28],"(cryo-EM);":[31],"however,":[32],"they":[33],"have":[34,39,59,66,233,262,327],"best":[35],"performance":[36,142],"at":[37,56,63,155,223,252],"300~kV,":[38],"relatively":[40],"low":[41],"read-out":[42],"speed":[43],"and":[44,71,77,94,105,127,150,157,174,221,241,250,323],"only":[45],"work":[46],"mode.":[49],"Hybrid":[50],"pixel":[51],"(HPDs)":[53],"can":[54,72,106,131],"operate":[55,73],"any":[57],"energy,":[58],"higher":[61],"DQE":[62,151],"lower":[64],"voltage,":[65],"unprecedented":[67],"high":[68],"time":[69,112],"resolution,":[70],"both":[75,219,248],"diffraction":[78],"modes.":[79],"This":[80,272],"could":[81,187],"make":[82],"them":[83],"well-suited":[84],"novel":[86],"life-science":[88],"applications,":[89],"such":[90,120],"as":[91,329],"cryo-ptychography,":[92],"iDPC,":[93],"liquid":[95],"cell":[96],"imaging.":[97],"Timepix3":[98,282],"is":[99],"not":[100],"frame-based,":[101],"but":[102],"truly":[103],"event-based,":[104],"record":[107],"individual":[108,213],"hits":[109],"with":[110,177],"1.56~ns":[111],"resolution.":[113],"Here,":[114],"we":[115,158],"present":[116],"the":[117,144,160,182,189,306,313,324],"integration":[118],"detector":[122,145],"into":[123],"cryo-EM":[125],"workflow":[126],"demonstrate":[128],"that":[129],"it":[130,176],"be":[132],"used":[133,235,264,277],"automated":[135],"data":[136,179,232,261,298],"collection":[137],"on":[138,218,247],"biological":[139],"specimens.":[140],"terms":[147],"MTF":[149],"been":[153,201,234,263,276,316],"investigated":[154],"200~kV":[156],"studied":[159],"effect":[161],"deterministic":[163],"blur.":[164],"We":[165],"describe":[166],"single-particle":[168,195],"analysis":[169],"structure":[170],"\\SI{3}{\\angstrom}":[172],"resolution":[173],"compare":[175],"Falcon3":[178,222,251],"collected":[180],"under":[181],"same":[183],"microscope.":[184,230,259],"These":[185,231,260],"studies":[186],"pave":[188],"way":[190],"toward":[191],"more":[192],"efficient":[193],"techniques.":[196],"<strong>Data":[197],"description</strong>":[198],"Data":[199],"split":[202],"up":[203],"several":[205,300],"different":[206,301],"directories.":[207],"In":[208],"general:":[209],"each":[210],"directory":[211],"contains":[212],"READMEs":[214],"<strong>Flat":[215],"fields</strong>":[216],"Collected":[217,246],"TImepix3":[220,249],"200":[224,253],"kV":[225,254],"using":[226,255],"Tecnai":[228,257],"Arctica":[229,258],"calculating":[237,266,312],"NPS,":[238],"ToT":[239],"correction":[240,269,292],"gain":[242,314],"correction.":[243],"<strong>Knife":[244],"edge</strong>":[245],"MTF.":[267],"<strong>ToT":[268],"calibration":[270,273],"file</strong>":[271],"file":[274],"to":[278,332],"correct":[279],"all":[280],"raw":[281],"data.":[283],"Including":[284],"micrographs":[285],"deposited":[286],"EMPIAR.":[288],"<strong>Gain":[289],"correction</strong>":[290],"Gain":[291],"files":[293],"calculated":[294],"from":[295],"flat":[296],"field":[297],"image":[302],"formation":[303],"methods":[304],"Timepix3.":[307],"Python":[309],"script":[310],"included.":[317],"<strong>Software</strong>":[318],"software":[320],"tpx3HitParser,":[321],"tpx3EventViewer":[322],"MTF-NPS-DQE":[325],"scripts":[326],"listed":[328],"related":[330],"identifiers":[331],"this":[333],"entry.":[334]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}