{"id":"https://openalex.org/W4393748956","doi":"https://doi.org/10.5281/zenodo.2636981","title":"Synthetic mutational spectra with mixed and correlated mutational signatures SBS1 and SBS5","display_name":"Synthetic mutational spectra with mixed and correlated mutational signatures SBS1 and SBS5","publication_year":2019,"publication_date":"2019-04-11","ids":{"openalex":"https://openalex.org/W4393748956","doi":"https://doi.org/10.5281/zenodo.2636981"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:2636981","is_oa":true,"landing_page_url":"https://zenodo.org/record/2636981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/2636981","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078961996","display_name":"Steve Rozen","orcid":"https://orcid.org/0000-0002-4288-0056"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Rozen, Steven G.","raw_affiliation_strings":["Duke-NUS Medical School"],"affiliations":[{"raw_affiliation_string":"Duke-NUS Medical School","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066935160","display_name":"Yang Wu","orcid":"https://orcid.org/0000-0002-1837-8330"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wu, Yang","raw_affiliation_strings":["Duke-NUS Medical School"],"affiliations":[{"raw_affiliation_string":"Duke-NUS Medical School","institution_ids":["https://openalex.org/I4210126319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078961996"],"corresponding_institution_ids":["https://openalex.org/I4210126319"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6937000155448914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6937000155448914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.6937000155448914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5099204778671265},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3856084942817688},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3404102623462677}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5099204778671265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3856084942817688},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3404102623462677}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:zenodo.org:2636981","is_oa":true,"landing_page_url":"https://zenodo.org/record/2636981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},{"id":"doi:10.5281/zenodo.2636981","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.2636981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"dataset"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:2636981","is_oa":true,"landing_page_url":"https://zenodo.org/record/2636981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933","https://openalex.org/W1641042124"],"abstract_inverted_index":{"Experience":[0],"suggests":[1],"that":[2,9,13,57,77],"it":[3],"harder":[4],"to":[5,52,83,106],"extract":[6],"mutational":[7,30,41,139],"signatures":[8,44,85,140],"always":[10],"co-occur":[11],"and":[12,37,66,118,126,142,148],"generate":[14],"correlated":[15],"numbers":[16,79],"of":[17,27,35,54,60,80,101,104,109,124,129],"mutations.":[18],"Here":[19],"we":[20,75],"provide":[21],"12":[22,91],"data":[23,92,116,136],"sets,":[24],"each":[25],"consisting":[26],"500":[28],"synthetic":[29],"spectra":[31,113,133],"with":[32,87],"varying":[33],"degrees":[34],"mixture":[36],"correlation":[38,120],"between":[39,121],"two":[40,96],"signatures.":[42],"The":[43,90,138],"studied":[45],"were":[46],"SBS1,":[47],"a":[48,68],"\"clock-like\"":[49,71,74],"signature":[50],"due":[51],"deamination":[53],"5-methyl":[55],"cytosine":[56],"consists":[58],"primarily":[59],"mutations":[61,81,111,131],"from":[62],"CG":[63],">":[64],"TG,":[65],"SBS5,":[67],"relatively":[69],"flat":[70],"signature.":[72],"By":[73],"mean":[76],"the":[78,102,107,115,122,127,135],"attributable":[82],"these":[84],"increase":[86],"patients'":[88],"ages.":[89],"sets":[93],"varied":[94],"in":[95,112,114,132,134],"dimensions:":[97],"(i)":[98],"average":[99],"ratio":[100],"number":[103,108,123,128],"SBS1":[105,125,141],"SBS5":[110,130,143],"set":[117],"(ii)":[119],"set.":[137],"are":[144],"described":[145],"at":[146],"https://doi.org/10.7303/syn12025148":[147],"https://doi.org/10.1101/322859.":[149]},"counts_by_year":[],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}