{"id":"https://openalex.org/W6893395475","doi":"https://doi.org/10.5281/zenodo.15711415","title":"Targeting ARPC1B+ Cancer Stem Cells to Sensitize Pancreatic Cancer to Gemcitabine Treatment","display_name":"Targeting ARPC1B+ Cancer Stem Cells to Sensitize Pancreatic Cancer to Gemcitabine Treatment","publication_year":2025,"publication_date":"2025-06-21","ids":{"openalex":"https://openalex.org/W6893395475","doi":"https://doi.org/10.5281/zenodo.15711415"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.15711415","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.15711415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.15711415","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wu, Yang","orcid":"https://orcid.org/0000-0002-0906-9667"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu, Yang","raw_affiliation_strings":["Pancreas Center, The First Affiliated Hospital of  Nanjing Medical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-0906-9667","affiliations":[{"raw_affiliation_string":"Pancreas Center, The First Affiliated Hospital of  Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhang, Jianpeng","orcid":"https://orcid.org/0009-0009-7533-3751"},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang, Jianpeng","raw_affiliation_strings":["First Affiliated Hospital of Guangzhou Medical University"],"raw_orcid":"https://orcid.org/0009-0009-7533-3751","affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Guangzhou Medical University","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"zhu, weixiong","orcid":"https://orcid.org/0009-0009-7247-8111"},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"zhu, weixiong","raw_affiliation_strings":["The Second Clinical Medical College, Lanzhou  University, Lanzhou, China"],"raw_orcid":"https://orcid.org/0009-0009-7247-8111","affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Lanzhou  University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhu, Xinrui","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163176","display_name":"Pancreas Centre (Canada)","ror":"https://ror.org/04s8hyg48","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210163176"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zhu, Xinrui","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital  of Suzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital  of Suzhou University","institution_ids":["https://openalex.org/I4210163176"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liu, Yi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu, Yi","raw_affiliation_strings":["Department of Oncology, The Second Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang, Xin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang, Xin","raw_affiliation_strings":["Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical  University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical  University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhao, Tianyu","orcid":null},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Zhao, Tianyu","raw_affiliation_strings":["Institute of Social Medicine and Epidemiology, Medical University of Graz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Social Medicine and Epidemiology, Medical University of Graz","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhang, Chun","orcid":null},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang, Chun","raw_affiliation_strings":["Department of Gastroenterology, Affiliated Hospital of Nanjing University of  Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Affiliated Hospital of Nanjing University of  Chinese Medicine","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhang, Zili","orcid":null},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang, Zili","raw_affiliation_strings":["State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical  Process Control and Intelligent Manufacture, Nanjing University of Chinese  Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical  Process Control and Intelligent Manufacture, Nanjing University of Chinese  Medicine","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":null,"display_name":"shi, wenjie","orcid":"https://orcid.org/0009-0001-7345-579X"},"institutions":[{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"shi, wenjie","raw_affiliation_strings":["Molecular and Experimental Surgery, Clinic for  General-, Visceral -, Vascular- and Transplantation  Surgery, Medical Faculty and University Hospital  Magdeburg, Otto-von-Guericke University,  Magdeburg, Germany"],"raw_orcid":"https://orcid.org/0009-0001-7345-579X","affiliations":[{"raw_affiliation_string":"Molecular and Experimental Surgery, Clinic for  General-, Visceral -, Vascular- and Transplantation  Surgery, Medical Faculty and University Hospital  Magdeburg, Otto-von-Guericke University,  Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202","https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shi, Run","orcid":"https://orcid.org/0000-0003-4667-4812"},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi, Run","raw_affiliation_strings":["Jiangsu Province Hospital","The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":"https://orcid.org/0000-0003-4667-4812","affiliations":[{"raw_affiliation_string":"Jiangsu Province Hospital","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"zhou, zhaokai","orcid":"https://orcid.org/0000-0001-6628-3750"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"zhou, zhaokai","raw_affiliation_strings":["Department of Urology, The Second Xiangya Hospital  of Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-6628-3750","affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Xiangya Hospital  of Central South University, Changsha, China","institution_ids":["https://openalex.org/I4210153856","https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xu, Shaohui","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu, Shaohui","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":null,"topics":[],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"Gemcitabine","score":0.9765999913215637},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.6966999769210815},{"id":"https://openalex.org/keywords/malignancy","display_name":"Malignancy","score":0.5831999778747559},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5059999823570251},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.5027999877929688},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.44369998574256897}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9765999913215637},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8989999890327454},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6966999769210815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6360999941825867},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6079000234603882},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5831999778747559},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5288000106811523},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5027999877929688},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.44369998574256897},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43479999899864197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42179998755455017},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3614000082015991},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C144369459","wikidata":"https://www.wikidata.org/wiki/Q182517","display_name":"CA19-9","level":4,"score":0.3012999892234802},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.30079999566078186},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.2973000109195709}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5281/zenodo.15711415","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.15711415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.15711415","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.15711415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6633232235908508}],"awards":[{"id":"https://openalex.org/G3135337643","display_name":null,"funder_award_id":"No.82304902","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,57,122],"is":[2],"a":[3,83,132],"highly":[4],"aggressive":[5],"malignancy":[6],"and":[7,51,68,74,92],"poses":[8],"significant":[9],"therapeutic":[10,134],"challenges":[11],"due":[12],"to":[13,15,26,44,111,123],"resistance":[14,28,139],"conventional":[16],"therapies.":[17],"Cancer":[18],"stem":[19],"cells":[20],"(CSCs)":[21],"act":[22],"as":[23,82,131],"key":[24],"contributors":[25],"this":[27,34],"with":[29,70,87,103],"their":[30],"self-renewal":[31],"capacity.":[32],"In":[33],"study,":[35],"we":[36],"identified":[37,80],"the":[38],"ARPC1B+":[39,117,129],"CSC":[40],"subpopulation":[41],"specifically":[42],"resistant":[43],"gemcitabine":[45,101,112,124,138],"through":[46],"integrated":[47],"analysis":[48,79],"of":[49,100],"scRNA-seq":[50],"bulk":[52],"RNA-seq":[53],"data":[54],"from":[55],"pancreatic":[56,121,141],"samples.":[58],"Additionally,":[59],"ARPC1B":[60],"expression":[61],"was":[62],"significantly":[63,106],"elevated":[64],"in":[65,93,140],"gemcitabine-resistant":[66],"CSCs":[67,118,130],"correlated":[69],"higher":[71],"mutation":[72],"burden":[73],"intra-tumor":[75],"heterogeneity.":[76],"Molecular":[77],"docking":[78],"CK-636":[81,104],"potential":[84],"ARPC1B-targeting":[85],"agent":[86],"high":[88],"affinity.":[89],"Ex":[90],"vivo":[91,94],"experiments":[95],"demonstrated":[96],"that":[97,115],"combinational":[98],"therapy":[99],"along":[102],"could":[105],"inhibit":[107],"tumor":[108],"growth":[109],"compared":[110],"alone,":[113],"indicating":[114],"targeting":[116],"can":[119],"sensitize":[120],"treatment.":[125],"These":[126],"findings":[127],"highlight":[128],"promising":[133],"target":[135],"for":[136],"overcoming":[137],"cancer.":[142]},"counts_by_year":[],"updated_date":"2026-07-01T06:00:48.157686","created_date":"2025-10-10T00:00:00"}