{"id":"https://openalex.org/W4392142128","doi":"https://doi.org/10.5220/0012268800003657","title":"Modeling iPSC-Derived Endothelial Cell Transition in Tumor Angiogenesis Using Petri Nets","display_name":"Modeling iPSC-Derived Endothelial Cell Transition in Tumor Angiogenesis Using Petri Nets","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4392142128","doi":"https://doi.org/10.5220/0012268800003657"},"language":"en","primary_location":{"id":"doi:10.5220/0012268800003657","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0012268800003657","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.5220/0012268800003657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058692403","display_name":"Ad\u00e9la \u0160terberov\u00e1","orcid":null},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ad\u00e9la \u0160terberov\u00e1","raw_affiliation_strings":["Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093998273","display_name":"Andreea Dincu","orcid":null},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Andreea Dincu","raw_affiliation_strings":["Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093998274","display_name":"Stijn Oudshoorn","orcid":null},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stijn Oudshoorn","raw_affiliation_strings":["Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013814940","display_name":"Vincent van Duinen","orcid":"https://orcid.org/0000-0002-8866-9088"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Vincent van Duinen","raw_affiliation_strings":["Leiden University Medical Center, Leiden, The Netherlands, --- Select a Country ---"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Leiden, The Netherlands, --- Select a Country ---","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100393055","display_name":"Lu Cao","orcid":"https://orcid.org/0000-0002-1847-068X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Lu Cao","raw_affiliation_strings":["Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden Insisute of Advanced Computer Science, Leiden University, Leiden, The Netherlands, --- Select a Country ---","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100393055"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":null,"apc_paid":null,"fwci":3.8249,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.91289233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"337","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9681000113487244,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11125","display_name":"Petri Nets in System Modeling","score":0.9646999835968018,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.8524646162986755},{"id":"https://openalex.org/keywords/endothelial-stem-cell","display_name":"Endothelial stem cell","score":0.6203532218933105},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.6198863983154297},{"id":"https://openalex.org/keywords/petri-net","display_name":"Petri net","score":0.6159745454788208},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44439005851745605},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4259181618690491},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39728832244873047},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3231236934661865},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.21386903524398804},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.1459347903728485},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.14132088422775269},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1373034417629242},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07681086659431458}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8524646162986755},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6203532218933105},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6198863983154297},{"id":"https://openalex.org/C38677869","wikidata":"https://www.wikidata.org/wiki/Q724168","display_name":"Petri net","level":2,"score":0.6159745454788208},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44439005851745605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4259181618690491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39728832244873047},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3231236934661865},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.21386903524398804},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.1459347903728485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14132088422775269},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1373034417629242},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07681086659431458}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5220/0012268800003657","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0012268800003657","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:2403.06555","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2403.06555","pdf_url":"https://arxiv.org/pdf/2403.06555","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.5220/0012268800003657","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0012268800003657","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1124044266","https://openalex.org/W1994080277","https://openalex.org/W2011835017","https://openalex.org/W2035363534","https://openalex.org/W2088488298","https://openalex.org/W2109962618","https://openalex.org/W2137358665","https://openalex.org/W2324083334","https://openalex.org/W2551134023","https://openalex.org/W2577441975","https://openalex.org/W2766481824","https://openalex.org/W2809538995","https://openalex.org/W2989121157","https://openalex.org/W3015654211","https://openalex.org/W3034820596","https://openalex.org/W3099878876","https://openalex.org/W4212826693","https://openalex.org/W4231777709","https://openalex.org/W4250428608"],"related_works":["https://openalex.org/W1551257573","https://openalex.org/W4230983483","https://openalex.org/W2132799268","https://openalex.org/W1980200158","https://openalex.org/W2154794415","https://openalex.org/W791317142","https://openalex.org/W2982241419","https://openalex.org/W2109094990","https://openalex.org/W1538101305","https://openalex.org/W3021516290"],"abstract_inverted_index":{"Tumor":[0],"angiogenesis":[1,53,151],"concerns":[2],"the":[3,10,14,27,83,100,109,127,132,143],"development":[4,16],"of":[5,17,31,54,104,135,145],"new":[6],"blood":[7],"vessels":[8],"supplying":[9],"necessary":[11],"nutrients":[12],"for":[13,65,81,107],"further":[15],"existing":[18],"tumor":[19,136,150],"cells.":[20],"The":[21,115],"entire":[22,133],"process":[23,86],"is":[24],"complex,":[25],"involving":[26],"production":[28],"and":[29,42,85,102,112,117],"consumption":[30],"chemicals,":[32],"endothelial":[33,55,90,146],"cell":[34,39,45,91,110,147],"transitions":[35,148],"as":[36,38],"well":[37],"interactions,":[40],"divisions,":[41],"migrations.":[43],"Microfluidic":[44],"culture":[46],"platform":[47],"has":[48],"been":[49],"used":[50],"to":[51,77,141],"study":[52],"cells":[56,63],"derived":[57],"from":[58],"human":[59],"induced":[60],"pluripotent":[61],"stem":[62],"(iPSC-ECs)":[64],"a":[66,79],"physiological":[67],"relevant":[68],"micro-environment.":[69],"In":[70],"this":[71,95,153],"paper,":[72],"we":[73,138],"elaborate":[74],"on":[75],"how":[76],"define":[78],"pipeline":[80,128],"simulating":[82],"transformation":[84,111],"that":[87],"an":[88],"iPSC-derived":[89],"goes":[92],"through":[93],"in":[94,149],"biological":[96],"scenario.":[97],"We":[98],"leverage":[99],"robustness":[101],"simplicity":[103],"Petri":[105],"nets":[106],"modeling":[108],"associated":[113],"constraints.":[114],"environmental":[116],"spacial":[118],"factors":[119],"are":[120,139],"added":[121],"using":[122,152],"custom":[123],"2-dimensional":[124],"grids.":[125],"Although":[126],"does":[129],"not":[130],"capture":[131,142],"complexity":[134],"angiogenesis,":[137],"able":[140],"essence":[144],"conceptually":[154],"simplified":[155],"solution.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2024-02-26T00:00:00"}