{"id":"https://openalex.org/W2517823850","doi":"https://doi.org/10.5220/0005959500710074","title":"Molecular Dynamics Use in Personalized Cancer Medicine - Example of MET Y501C Mutation","display_name":"Molecular Dynamics Use in Personalized Cancer Medicine - Example of MET Y501C Mutation","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2517823850","doi":"https://doi.org/10.5220/0005959500710074","mag":"2517823850"},"language":"en","primary_location":{"id":"doi:10.5220/0005959500710074","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0005959500710074","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 6th International Conference on Simulation and Modeling Methodologies, Technologies and Applications","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.5220/0005959500710074","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047059421","display_name":"Igor F. Tsigelny","orcid":"https://orcid.org/0000-0002-7155-8947"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor F. Tsigelny","raw_affiliation_strings":["University of California at San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["University of California at San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081209855","display_name":"\u00c5ge A. Skjevik","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00c5ge Aleksander Skjevik","raw_affiliation_strings":["University of California at San Diego and University of Bergen, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego and University of Bergen, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050071283","display_name":"Valentina L. Kouznetsova","orcid":"https://orcid.org/0000-0001-9457-7027"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina L. Kouznetsova","raw_affiliation_strings":["University of California at San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018352586","display_name":"Sadakatsu Ikeda","orcid":"https://orcid.org/0000-0003-1629-7171"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadakatsu Ikeda","raw_affiliation_strings":["University of California at San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5847,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92156863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"71","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.916100025177002,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.916100025177002,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.909500002861023,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.6872631907463074},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5823804140090942},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5429860949516296},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.4489986002445221},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44147852063179016},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3885018229484558},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3197649419307709},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3077293038368225},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.257060170173645},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17080655694007874},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1441836953163147},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10875961184501648},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.10099256038665771}],"concepts":[{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.6872631907463074},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5823804140090942},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5429860949516296},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4489986002445221},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44147852063179016},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3885018229484558},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3197649419307709},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3077293038368225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.257060170173645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17080655694007874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1441836953163147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10875961184501648},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10099256038665771},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5220/0005959500710074","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0005959500710074","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 6th International Conference on Simulation and Modeling Methodologies, Technologies and Applications","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.5220/0005959500710074","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0005959500710074","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 6th International Conference on Simulation and Modeling Methodologies, Technologies and Applications","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2531653299","https://openalex.org/W4232007288","https://openalex.org/W2755856286","https://openalex.org/W2192968700","https://openalex.org/W4246843226","https://openalex.org/W343696274","https://openalex.org/W4233865630","https://openalex.org/W2896996832","https://openalex.org/W2333657843","https://openalex.org/W256255033"],"abstract_inverted_index":{"We":[0],"explored":[1],"a":[2,91,97,105],"possible":[3,56],"new":[4],"method":[5,15],"for":[6],"prediction":[7],"of":[8,20,22,32,47,55,63,67],"activating":[9,26],"mutations":[10],"in":[11,25,81],"cancer-related":[12],"proteins.":[13],"This":[14],"is":[16,39],"based":[17],"on":[18,29,108],"elucidation":[19],"flexibility":[21],"proteins":[23],"associated":[24,69],"complexes.":[27],"Based":[28],"the":[30,36,44,52,60,64,68,82,109],"theory":[31],"intermediate":[33],"binding":[34,37],"complexes,":[35],"process":[38],"not":[40],"only":[41],"related":[42],"to":[43,51],"three-dimensional":[45],"structure":[46],"proteins,":[48],"but":[49],"also":[50],"four-dimensional":[53],"set":[54],"conformations":[57],"allowed":[58],"by":[59],"flexible":[61],"regions":[62],"involved":[65],"members":[66],"complex.":[70],"Using":[71,88],"molecular":[72],"dynamics":[73],"simulations,":[74],"we":[75],"found":[76],"that":[77,94],"an":[78],"Y501C":[79],"mutation":[80],"MET":[83,99],"gene":[84],"might":[85],"activate":[86],"it.":[87],"this":[89],"information,":[90],"specific":[92],"drug":[93],"functioned":[95],"as":[96],"potent":[98],"inhibitor":[100],"was":[101],"prescribed":[102],"and":[103],"had":[104],"salutary":[106],"impact":[107],"tumor.":[110]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}