{"id":"https://openalex.org/W2400773095","doi":"https://doi.org/10.5220/0004915002590264","title":"The Possibilities of Filtering Pairs of SNPs in GWAS Studies - Exploratory Study on Public Protein-interaction and Pathway Data","display_name":"The Possibilities of Filtering Pairs of SNPs in GWAS Studies - Exploratory Study on Public Protein-interaction and Pathway Data","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2400773095","doi":"https://doi.org/10.5220/0004915002590264","mag":"2400773095"},"language":"en","primary_location":{"id":"doi:10.5220/0004915002590264","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0004915002590264","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.5220/0004915002590264","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082104022","display_name":"Matej Lexa","orcid":"https://orcid.org/0000-0002-4213-5259"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matej Lexa","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006753836","display_name":"Stanislav \u0160tefani\u010d","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanislav Stefanic","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082104022"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21863691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"259","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.6998162865638733},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5533061027526855},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5352725386619568},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5233368277549744},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5187154412269592},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.49693945050239563},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.4575762450695038},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.44259393215179443},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.43713727593421936},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42339983582496643},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37832653522491455},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12558013200759888},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1212119460105896}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.6998162865638733},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5533061027526855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5352725386619568},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5233368277549744},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5187154412269592},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49693945050239563},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.4575762450695038},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.44259393215179443},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.43713727593421936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42339983582496643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37832653522491455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12558013200759888},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1212119460105896},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5220/0004915002590264","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0004915002590264","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.5220/0004915002590264","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0004915002590264","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2378369506","https://openalex.org/W1547817677","https://openalex.org/W2615678788","https://openalex.org/W2023460495","https://openalex.org/W2109954095","https://openalex.org/W1967902778","https://openalex.org/W1981509636","https://openalex.org/W2140249224","https://openalex.org/W1993755972","https://openalex.org/W4283582241"],"abstract_inverted_index":{"Genome-wide":[0],"association":[1,64],"studies":[2],"have":[3,68],"become":[4],"a":[5,37,142],"standard":[6],"way":[7],"of":[8,94,108,117,130,166,174],"discovering":[9],"novel":[10],"causative":[11],"alleles":[12],"by":[13,132],"looking":[14],"for":[15,26,57,177],"statisticaly":[16],"significant":[17],"associations":[18,32],"in":[19,40,53,63,135,152,163],"patient":[20],"genotyping":[21],"data.":[22],"The":[23,46],"present":[24],"challenge":[25],"these":[27,160],"methods":[28],"is":[29,49],"to":[30,44,71,78,85,103,113],"discover":[31],"involving":[33],"multiple":[34],"interacting":[35,60,79],"loci,":[36],"common":[38,136],"phenomenon":[39],"diseases":[41],"often":[42],"related":[43],"epistasis.":[45],"main":[47],"problem":[48],"the":[50,92,122,149,164,167,172],"exponential":[51],"increase":[52],"necessary":[54],"computational":[55,153],"power":[56],"every":[58],"additional":[59],"locus":[61],"considered":[62],"tests.":[65],"Several":[66],"approaches":[67],"been":[69],"proposed":[70],"manage":[72],"this":[73,175],"problem,":[74],"including":[75],"limiting":[76],"analysis":[77],"pairs":[80,107,129],"and":[81,100,171],"filtering":[82,126],"SNPs":[83,109,131],"according":[84],"external":[86],"biological":[87],"knowledge.":[88],"Here":[89],"we":[90,147],"explore":[91],"possibilities":[93],"using":[95],"public":[96],"protein":[97,123],"interaction":[98],"data":[99],"pathway":[101],"maps":[102],"filter":[104],"out":[105],"only":[106],"that":[110],"are":[111],"likely":[112],"interact,":[114],"perhaps":[115],"because":[116],"epistatic":[118],"mechanisms":[119],"working":[120],"at":[121],"level.":[124],"After":[125],"all":[127],"possible":[128,150],"their":[133],"presence":[134],"protein-protein":[137],"interactions":[138],"or":[139,144],"proteins":[140],"sharing":[141],"metabolic":[143],"signalling":[145],"pathway,":[146],"calculate":[148],"reduction":[151],"requirements":[154],"under":[155],"different":[156],"scenarios.":[157,179],"We":[158],"discuss":[159],"exploratory":[161],"results":[162],"context":[165],"so-called":[168],"lost":[169],"heredity":[170],"usefulness":[173],"approach":[176],"similar":[178]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}
