{"id":"https://openalex.org/W2395021790","doi":"https://doi.org/10.5220/0004731400050016","title":"A Qualitative Framework for Analysing Homeostasis in Gene Networks","display_name":"A Qualitative Framework for Analysing Homeostasis in Gene Networks","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2395021790","doi":"https://doi.org/10.5220/0004731400050016","mag":"2395021790"},"language":"en","primary_location":{"id":"doi:10.5220/0004731400050016","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0004731400050016","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.5220/0004731400050016","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086778134","display_name":"Sohei Ito","orcid":"https://orcid.org/0000-0002-7029-664X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sohei Ito","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088859890","display_name":"Shigeki Hagihara","orcid":"https://orcid.org/0000-0002-9094-6398"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeki Hagihara","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058739699","display_name":"Naoki Yonezaki","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Yonezaki","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086778134"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1434604,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56248419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"5","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47402551770210266},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4688217341899872},{"id":"https://openalex.org/keywords/homeostasis","display_name":"Homeostasis","score":0.46746090054512024},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25352102518081665},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.1546224057674408}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47402551770210266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4688217341899872},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.46746090054512024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25352102518081665},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1546224057674408}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5220/0004731400050016","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0004731400050016","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.5220/0004731400050016","is_oa":true,"landing_page_url":"https://doi.org/10.5220/0004731400050016","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2350741829","https://openalex.org/W2130043461","https://openalex.org/W2530322880"],"abstract_inverted_index":{"Toward":[0],"the":[1,6,64,139],"system":[2,17],"level":[3],"understanding":[4],"of":[5,26,61,66,70,78,122,134,141,148],"mechanisms":[7],"contributing":[8],"homeostasis":[9,62,71,77,84],"in":[10,144],"organisms,":[11],"a":[12,16,31,47,132,146],"computational\r\n\r\nframework":[13],"to":[14,75,111],"model":[15],"and":[18,36],"analyse":[19,76],"its":[20],"properties":[21,39],"is":[22,29,85,109,131],"indispensable.":[23],"The":[24],"purpose":[25],"this":[27,82],"work":[28],"to\r\n\r\nprovide":[30],"framework":[32,50,143],"which":[33,108],"enables":[34],"testing":[35],"validating":[37],"homeostatic":[38],"on":[40,46],"gene":[41,52,79],"regulatory":[42],"networks\r\n\r\nin":[43],"silico.":[44],"Based":[45],"qualitative":[48],"analysis":[49],"for":[51,90,100],"networks":[53],"using":[54],"temporal":[55],"logic,":[56],"we":[57],"proposed\r\n\r\na":[58],"novel":[59],"formulation":[60,69],"by":[63,114],"notion":[65],"realisability.":[67],"This":[68],"yields":[72],"a\r\n\r\nqualitative":[73],"method":[74],"networks.":[80,151],"In":[81],"formulation,":[83],"captured":[86,113],"by\r\n\r\na":[87],"response":[88],"not":[89],"just":[91],"an":[92,125],"instantaneous":[93],"stimulation":[94],"such":[95],"as":[96],"dose-response":[97],"relationships":[98],"but":[99],"any":[101,120],"input":[102],"scenario\r\n\r\ne.g.":[103],"oscillating":[104],"or":[105],"continuous":[106],"inputs,":[107],"difficult":[110],"be":[112],"quantitative":[115],"models.":[116],"Moreover,\r\n\r\nwe":[117],"can":[118],"consider":[119],"number":[121,147],"inputs":[123],"from":[124],"environment":[126],"without":[127],"difficulty.":[128],"Such":[129],"flexibility":[130],"notable\r\n\r\nadvantage":[133],"our":[135,142],"framework.":[136],"We":[137],"demonstrate":[138],"usefulness":[140],"analysing":[145],"small\r\n\r\nbut":[149],"tricky":[150]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}