{"id":"https://openalex.org/W7171633788","doi":"https://doi.org/10.48550/arxiv.2607.25175","title":"Agentic AI-enabled discovery across large-scale sleep physiology","display_name":"Agentic AI-enabled discovery across large-scale sleep physiology","publication_year":2026,"publication_date":"2026-07-28","ids":{"openalex":"https://openalex.org/W7171633788","doi":"https://doi.org/10.48550/arxiv.2607.25175"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2607.25175","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2607.25175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2607.25175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026274141","display_name":"Rahul Thapa","orcid":"https://orcid.org/0000-0002-1137-955X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thapa, Rahul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143944708","display_name":"Umaer Hanif","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanif, Umaer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081144217","display_name":"Robin Guillard","orcid":"https://orcid.org/0000-0002-7557-5066"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guillard, Robin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143908386","display_name":"Andreas Brink-Kjaer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brink-Kjaer, Andreas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012367368","display_name":"A. Specht","orcid":"https://orcid.org/0000-0001-7301-0419"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Specht, Adrien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075540068","display_name":"Matteo Saibene","orcid":"https://orcid.org/0009-0008-9355-3486"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saibene, Matteo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104284265","display_name":"Magnus Ruud Kj\u00e6r","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kjaer, Magnus Ruud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014149768","display_name":"Harrison G. Zhang","orcid":"https://orcid.org/0000-0001-6679-1464"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Harrison G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144162097","display_name":"Federico Bianchi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bianchi, Federico","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143889044","display_name":"Elisabeth Roxane M. Heremans","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heremans, Elisabeth Roxane M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143966406","display_name":"Eric C. Landsness","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Landsness, Eric C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144168669","display_name":"Emmanuel Mignot","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mignot, Emmanuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5144118107","display_name":"James Zou","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zou, James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.6694999933242798,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.6694999933242798,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep","display_name":"Sleep (system call)","score":0.7289000153541565},{"id":"https://openalex.org/keywords/polysomnography","display_name":"Polysomnography","score":0.6840000152587891},{"id":"https://openalex.org/keywords/narcolepsy","display_name":"Narcolepsy","score":0.6438999772071838},{"id":"https://openalex.org/keywords/arousal","display_name":"Arousal","score":0.5771999955177307},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5539000034332275},{"id":"https://openalex.org/keywords/non-rapid-eye-movement-sleep","display_name":"Non-rapid eye movement sleep","score":0.43309998512268066},{"id":"https://openalex.org/keywords/wakefulness","display_name":"Wakefulness","score":0.4212999939918518},{"id":"https://openalex.org/keywords/actigraphy","display_name":"Actigraphy","score":0.39570000767707825}],"concepts":[{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.7289000153541565},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.6840000152587891},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.6438999772071838},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.5771999955177307},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5539000034332275},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46889999508857727},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.43309998512268066},{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.4212999939918518},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39890000224113464},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.39570000767707825},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3601999878883362},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C2910364982","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep Stages","level":4,"score":0.3156999945640564},{"id":"https://openalex.org/C2992644362","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle disease","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.28130000829696655},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.2799000144004822},{"id":"https://openalex.org/C3019903994","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep patterns","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2607.25175","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2607.25175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2607.25175","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2607.25175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sleep":[0,51],"occupies":[1],"roughly":[2],"one-third":[3],"of":[4,10,89,99],"human":[5,58],"life,":[6],"yet":[7],"many":[8],"aspects":[9],"its":[11,27,158,233],"physiology":[12,110],"remain":[13],"poorly":[14],"understood.":[15],"Large":[16],"polysomnography":[17],"(PSG)":[18],"datasets":[19],"offer":[20],"new":[21],"opportunities":[22],"to":[23,29,79,112,227],"study":[24],"sleep":[25,109,122,132,176,185,201,226],"and":[26,41,68,94,120,125,141,157,175,213,232,236],"links":[28],"disease,":[30,114],"but":[31],"extracting":[32],"insight":[33],"from":[34],"these":[35,223],"recordings":[36,93],"requires":[37],"substantial":[38],"expert":[39],"effort":[40],"remains":[42],"difficult":[43],"for":[44,63],"general-purpose":[45],"AI":[46,50,240],"systems.":[47,169],"We":[48],"developed":[49],"Co-Scientist,":[52],"an":[53,153,179],"expert-guided":[54],"environment":[55],"in":[56,218],"which":[57],"scientists":[59],"direct":[60],"specialist":[61],"agents":[62],"hypothesis":[64],"development,":[65],"signal":[66],"preprocessing,":[67],"statistical":[69],"analysis,":[70],"reviewing":[71],"intermediate":[72,180],"outputs.":[73],"Each":[74],"reported":[75],"result":[76],"is":[77,123],"linked":[78],"the":[80],"executable":[81],"code":[82],"that":[83],"produced":[84],"it.":[85],"Across":[86],"four":[87],"cohorts":[88],"approximately":[90],"124,000":[91],"PSG":[92],"more":[95,202],"than":[96,204],"50":[97],"TB":[98],"raw":[100],"signals,":[101],"we":[102],"conducted":[103],"five":[104],"case":[105],"studies":[106],"spanning":[107],"how":[108,115,121,238],"relates":[111],"future":[113],"it":[116],"distinguishes":[117],"clinical":[118,230],"phenotypes,":[119],"organized":[124],"regulated.":[126],"Diminished":[127],"network-level":[128],"physiological":[129],"coupling":[130],"during":[131],"was":[133,161],"associated":[134,162],"with":[135,163],"incident":[136,164],"Parkinson's":[137],"disease":[138,143,165,228],"(HR":[139,144],"1.48)":[140],"Alzheimer's":[142],"1.38).":[145],"A":[146],"physiologically":[147],"structured":[148],"late-fusion":[149],"sleep-age":[150],"model":[151],"outperformed":[152],"unconstrained":[154],"early-fusion":[155],"approach,":[156],"age":[159],"residual":[160],"across":[166],"multiple":[167],"organ":[168],"Arousal":[170],"dynamics":[171],"characterized":[172],"comorbid":[173],"insomnia":[174],"apnoea":[177],"as":[178],"phenotype":[181],"skewed":[182],"towards":[183],"obstructive":[184],"apnoea,":[186],"distinguished":[187],"by":[188],"prolonged":[189],"post-arousal":[190],"wakefulness.":[191,206],"Rapid":[192],"eye":[193],"movement":[194],"(REM)":[195],"bout":[196],"duration":[197],"tracked":[198],"preceding":[199],"non-REM":[200],"closely":[203],"intervening":[205],"Transient-oscillation":[207],"analysis":[208],"identified":[209],"a":[210],"fast-sigma":[211],"deficit":[212],"excess":[214],"centrofrontal":[215],"theta":[216],"activity":[217],"narcolepsy":[219],"type":[220],"1.":[221],"Together,":[222],"findings":[224],"connect":[225],"risk,":[229],"classification,":[231],"own":[234],"regulation,":[235],"show":[237],"agentic":[239],"can":[241],"support":[242],"large-scale,":[243],"multimodal":[244],"discovery.":[245]},"counts_by_year":[],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2026-07-30T00:00:00"}
