{"id":"https://openalex.org/W7164364093","doi":"https://doi.org/10.48550/arxiv.2606.11264","title":"OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins","display_name":"OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins","publication_year":2026,"publication_date":"2026-06-09","ids":{"openalex":"https://openalex.org/W7164364093","doi":"https://doi.org/10.48550/arxiv.2606.11264"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13278258","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13278258/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Text"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13278258/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138414253","display_name":"Zhaohui Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Zhaohui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138407308","display_name":"Yu Huang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huang, Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5138482646","display_name":"Jiang Bian","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bian, Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.12389999628067017,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.12389999628067017,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.08049999922513962,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.5706999897956848},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5311999917030334},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.32339999079704285},{"id":"https://openalex.org/keywords/digital-health","display_name":"Digital health","score":0.32100000977516174},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.2761000096797943}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6151999831199646},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5706999897956848},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5311999917030334},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.36149999499320984},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35370001196861267},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.32339999079704285},{"id":"https://openalex.org/C2780433410","wikidata":"https://www.wikidata.org/wiki/Q5276090","display_name":"Digital health","level":3,"score":0.32100000977516174},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.313400000333786},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.2797999978065491},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2549999952316284}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:13278258","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13278258/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Text"},{"id":"doi:10.48550/arxiv.2606.11264","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2606.11264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13278258","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13278258/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6067132353782654,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Health":[0],"digital":[1],"twins":[2,30,103],"(HDTs)":[3],"promise":[4],"patient-specific":[5],"modeling":[6],"and":[7,76,101,107],"decision":[8,78],"support":[9],"but":[10],"current":[11],"approaches":[12],"remain":[13],"structurally":[14],"fragmented:":[15],"monolithic":[16],"models":[17],"that":[18,42],"address":[19],"a":[20,38,55,85,110],"single":[21],"organ":[22],"or":[23],"task":[24],"lack":[25,31],"cross-scale":[26,72],"fidelity,":[27],"while":[28],"system-level":[29],"generalizable":[32],"architectural":[33],"frameworks.":[34],"We":[35,80],"propose":[36],"OmniBioTwin,":[37],"System-of-Twinned-Systems":[39],"(SoTS)":[40],"framework":[41,60],"organizes":[43],"HDTs":[44],"as":[45],"modular":[46],"computational":[47],"entities":[48],"coupled":[49,108],"through":[50],"explicit":[51],"interaction":[52],"operators":[53],"within":[54,109],"multi-layer":[56],"network":[57],"architecture.":[58],"The":[59],"comprises":[61],"seven":[62],"coordinated":[63],"layers":[64],"-":[65],"spanning":[66],"data":[67],"integration,":[68],"autonomous":[69],"twin":[70,87],"modeling,":[71],"coupling,":[73],"temporal":[74],"synchronization,":[75],"human-in-the-loop":[77],"support.":[79],"demonstrate":[81],"OmniBioTwin":[82],"by":[83],"instantiating":[84],"multiscale":[86],"for":[88],"glucagon-like":[89],"peptide-1":[90],"(GLP-1)":[91],"signaling":[92],"pathways":[93],"in":[94],"Alzheimer's":[95],"disease,":[96],"illustrating":[97],"how":[98],"molecular,":[99],"cellular,":[100],"organ-level":[102],"can":[104],"be":[105],"composed":[106],"unified":[111],"system.":[112]},"counts_by_year":[],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2026-06-12T00:00:00"}
