{"id":"https://openalex.org/W7162447043","doi":"https://doi.org/10.48550/arxiv.2605.24012","title":"Deep Learning-Based Automated Quantification of TIMI Myocardial Perfusion Frame Count (DL-TMPFC) from Coronary Angiography: A Novel Framework for Rapid Assessment of Microvascular Dysfunction","display_name":"Deep Learning-Based Automated Quantification of TIMI Myocardial Perfusion Frame Count (DL-TMPFC) from Coronary Angiography: A Novel Framework for Rapid Assessment of Microvascular Dysfunction","publication_year":2026,"publication_date":"2026-05-20","ids":{"openalex":"https://openalex.org/W7162447043","doi":"https://doi.org/10.48550/arxiv.2605.24012"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2605.24012","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.24012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2605.24012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137020966","display_name":"Si Li","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Si","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136996887","display_name":"Yuanqing He","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"He, Yuanqing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073944287","display_name":"Chenkai Hu","orcid":"https://orcid.org/0000-0001-6136-8712"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hu, Chenkai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137072330","display_name":"Xiaogang Guo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo, Xiaogang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137034166","display_name":"Huay-Cheem Tan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tan, Huay-Cheem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128059870","display_name":"Chieh Yang Koo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koo, Chieh Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137083150","display_name":"Xuan Zhang","orcid":"https://orcid.org/0009-0001-9176-3403"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Xuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137007553","display_name":"Lei He","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"He, Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137069794","display_name":"Jingyuan Zeng","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeng, Jingyuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101605392","display_name":"Shan Xiao","orcid":"https://orcid.org/0009-0005-5855-8618"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao, Shan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.4546000063419342,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.4546000063419342,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.4530999958515167,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/timi","display_name":"TIMI","score":0.8828999996185303},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.5565000176429749},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"Coronary artery disease","score":0.5275999903678894},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.5205000042915344},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"Thrombolysis","score":0.4203999936580658},{"id":"https://openalex.org/keywords/clinical-practice","display_name":"Clinical Practice","score":0.2946000099182129},{"id":"https://openalex.org/keywords/occlusion","display_name":"Occlusion","score":0.290800005197525},{"id":"https://openalex.org/keywords/stenosis","display_name":"Stenosis","score":0.2892000079154968}],"concepts":[{"id":"https://openalex.org/C2777995511","wikidata":"https://www.wikidata.org/wiki/Q2897649","display_name":"TIMI","level":4,"score":0.8828999996185303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8634999990463257},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6097999811172485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5720999836921692},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5565000176429749},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5275999903678894},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5205000042915344},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.4203999936580658},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.35839998722076416},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C2780393670","wikidata":"https://www.wikidata.org/wiki/Q5172192","display_name":"Coronary occlusion","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C2778050738","wikidata":"https://www.wikidata.org/wiki/Q17157161","display_name":"Myocardial infarction diagnosis","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C2778405248","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial perfusion imaging","level":3,"score":0.25209999084472656},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.25099998712539673},{"id":"https://openalex.org/C3017461755","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Myocardial ischemia","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2605.24012","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.24012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2605.24012","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.24012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4448530375957489,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Aims:":[0],"Coronary":[1],"microvascular":[2],"dysfunction":[3],"(CMVD)":[4],"affects":[5],"approximately":[6],"40%-60%":[7],"of":[8,49,130,134,138,142,189,197,214,238],"patients":[9,132],"with":[10,153],"ischemia":[11],"and":[12,61,69,83,109,117,176,192,211,224,236],"non-obstructive":[13],"coronary":[14,97,190],"arteries,":[15],"yet":[16],"diagnosis":[17],"remains":[18],"challenging":[19],"due":[20],"to":[21,67,163],"reliance":[22],"on":[23],"invasive":[24],"functional":[25],"testing":[26],"or":[27],"subjective":[28],"Thrombolysis":[29],"In":[30],"Myocardial":[31,38],"Infarction":[32],"(TIMI)":[33],"flow":[34],"grade.":[35],"The":[36,123],"TIMI":[37],"Perfusion":[39],"Frame":[40],"Count":[41],"(TMPFC)":[42],"offers":[43],"an":[44,222],"objective,":[45],"angiography-based":[46],"quantitative":[47,203],"measure":[48],"CMVD,":[50,140],"but":[51],"its":[52],"clinical":[53,80,170,241],"translation":[54],"is":[55],"hindered":[56],"by":[57,172],"cumbersome":[58],"manual":[59,155],"calculation":[60,75,111],"insufficient":[62],"validation.":[63],"This":[64],"study":[65],"aims":[66],"develop":[68],"validate":[70],"a":[71,128,186],"deep":[72],"learning-powered":[73],"TMPFC":[74,110,175],"(DL-TMPFC),":[76],"enabling":[77,202],"integration":[78],"into":[79],"workflows.":[81],"Methods":[82],"results:":[84],"DL-TMPFC":[85,149,167,181,207],"framework":[86,124],"comprised":[87],"two":[88],"components.":[89],"A":[90,101],"stenosis":[91],"detection":[92],"network":[93,104],"first":[94,116],"excluded":[95],"obstructive":[96,135],"artery":[98],"disease":[99],"(CAD).":[100],"territory-aware":[102],"segmentation":[103],"then":[105],"identified":[106,183],"perfusion":[107],"territories":[108],"module":[112],"automatically":[113],"determined":[114],"the":[115,194],"last":[118],"frames":[119],"from":[120,145,217],"angiographic":[121],"sequences.":[122],"was":[125],"validated":[126],"in":[127,240],"cohort":[129],"655":[131],"(445":[133],"CAD,":[136],"100":[137],"confirmed":[139],"110":[141],"control":[143],"group)":[144],"three":[146],"independent":[147],"institutions.":[148],"showed":[150],"excellent":[151],"agreement":[152],"expert":[154],"measurements":[156],"(bias:":[157],"-0.93":[158],"frames;":[159],"95%":[160],"LoA:":[161],"-5.33":[162],"+3.47;":[164],"r":[165],"=0.98).":[166],"markedly":[168],"enhanced":[169],"feasibility":[171],"fully":[173],"automating":[174],"removing":[177],"observer":[178],"dependence.":[179],"Clinically,":[180],"accurately":[182],"CMVD":[184,198,215,239],"across":[185],"full":[187],"spectrum":[188],"pathologies":[191],"captured":[193],"continuous":[195],"severity":[196],"beyond":[199],"binary":[200],"classification,":[201],"risk":[204],"stratification.":[205],"Conclusion:":[206],"enabled":[208],"automatic,":[209],"standardized,":[210],"accurate":[212],"quantification":[213],"directly":[216],"routine":[218],"angiography.":[219],"By":[220],"providing":[221],"automatic":[223],"objective":[225],"measure,":[226],"this":[227],"tool":[228],"provided":[229],"immediate":[230],"diagnostic":[231],"information":[232],"for":[233],"timely":[234],"recognition":[235],"management":[237],"practice.":[242]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2026-05-27T00:00:00"}