{"id":"https://openalex.org/W7162109711","doi":"https://doi.org/10.48550/arxiv.2605.21745","title":"Quantitative coronary calcification analysis for prediction of myocardial ischemia using non-contrast CT calcium scoring","display_name":"Quantitative coronary calcification analysis for prediction of myocardial ischemia using non-contrast CT calcium scoring","publication_year":2026,"publication_date":"2026-05-20","ids":{"openalex":"https://openalex.org/W7162109711","doi":"https://doi.org/10.48550/arxiv.2605.21745"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2605.21745","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.21745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2605.21745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136763870","display_name":"Juhwan Lee","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee, Juhwan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136775691","display_name":"Sadeer Al-Kindi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Al-Kindi, Sadeer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136512870","display_name":"Ammar Hoori","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hoori, Ammar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136754775","display_name":"Tao Hu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hu, Tao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136798615","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0001-7570-190X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wu, Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136774533","display_name":"Justin N. Kim","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, Justin N.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136812271","display_name":"Robert Gilkeson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilkeson, Robert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136774066","display_name":"Sanjay Rajagopalan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajagopalan, Sanjay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5136794448","display_name":"David L. Wilson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilson, David L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agatston-score","display_name":"Agatston score","score":0.7138000130653381},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.5710999965667725},{"id":"https://openalex.org/keywords/myocardial-perfusion-imaging","display_name":"Myocardial perfusion imaging","score":0.527899980545044},{"id":"https://openalex.org/keywords/framingham-risk-score","display_name":"Framingham Risk Score","score":0.3928000032901764},{"id":"https://openalex.org/keywords/predictive-value","display_name":"Predictive value","score":0.36800000071525574},{"id":"https://openalex.org/keywords/predictive-value-of-tests","display_name":"Predictive value of tests","score":0.3555999994277954},{"id":"https://openalex.org/keywords/ischemia","display_name":"Ischemia","score":0.3492000102996826},{"id":"https://openalex.org/keywords/appropriate-use-criteria","display_name":"Appropriate Use Criteria","score":0.33889999985694885},{"id":"https://openalex.org/keywords/regadenoson","display_name":"Regadenoson","score":0.3386000096797943}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8177000284194946},{"id":"https://openalex.org/C2780609585","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Agatston score","level":4,"score":0.7138000130653381},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5710999965667725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5412999987602234},{"id":"https://openalex.org/C2778405248","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial perfusion imaging","level":3,"score":0.527899980545044},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5084999799728394},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40540000796318054},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3492000102996826},{"id":"https://openalex.org/C2777389994","wikidata":"https://www.wikidata.org/wiki/Q17012884","display_name":"Appropriate Use Criteria","level":2,"score":0.33889999985694885},{"id":"https://openalex.org/C2777361974","wikidata":"https://www.wikidata.org/wiki/Q7307897","display_name":"Regadenoson","level":4,"score":0.3386000096797943},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.33230000734329224},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C2994533308","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary artery calcium","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C3017461755","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Myocardial ischemia","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C2775981168","wikidata":"https://www.wikidata.org/wiki/Q239027","display_name":"Calcinosis","level":3,"score":0.2980000078678131},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C2909917808","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary Calcium Score","level":4,"score":0.275299996137619}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2605.21745","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.21745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2605.21745","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.21745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"score":0.43329381942749023,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Non-contrast":[0],"computed":[1],"tomography":[2,57],"calcium":[3,39],"scoring":[4,229],"(CTCS)":[5],"is":[6],"widely":[7],"recognized":[8],"as":[9],"an":[10],"effective":[11],"tool":[12],"for":[13,27,112,207],"cardiovascular":[14,235],"risk":[15,225,236],"stratification.":[16,237],"This":[17,41],"study":[18,42],"aimed":[19],"to":[20],"develop":[21],"a":[22,131,203],"novel":[23],"machine":[24,204],"learning":[25,205],"framework":[26],"predicting":[28,208],"myocardial":[29,58,113,187,209],"ischemia":[30,188,210],"from":[31],"routine":[32],"non-contrast":[33,49,214],"CTCS":[34,50,215],"scans":[35],"using":[36,89,102,155,211],"quantitative":[37],"coronary":[38],"assessment.":[40],"analyzed":[43],"1,375":[44],"patients":[45],"who":[46],"underwent":[47],"both":[48],"and":[51,80,100,125,138,227,230],"regadenoson":[52],"stress":[53],"cardiac":[54],"positron":[55],"emission":[56],"perfusion":[59],"imaging":[60],"within":[61],"one":[62],"year":[63],"at":[64],"University":[65],"Hospitals":[66],"Cleveland":[67],"Medical":[68],"Center.":[69],"A":[70],"total":[71],"of":[72,133,136,141,145,170],"74":[73],"variables,":[74,77],"including":[75],"clinical":[76,156,160],"Agatston":[78,120,164,228],"score,":[79,121],"calcium-omics":[81,123,146],"features,":[82,124],"were":[83,87,98,110],"evaluated.":[84],"Relevant":[85],"features":[86,147,218],"identified":[88],"XGBoost":[90],"with":[91,153,162,186],"Shapley":[92],"Additive":[93],"exPlanations":[94],"(SHAP).":[95],"Predictive":[96],"models":[97,154],"trained":[99],"evaluated":[101],"5-fold":[103],"cross-validation.":[104],"Among":[105],"987":[106],"patients,":[107],"89":[108],"(9%)":[109],"positive":[111],"ischemia.":[114],"The":[115,127,143],"final":[116],"model":[117,129],"incorporated":[118],"the":[119,163,168,175,183],"eight":[122],"age.":[126],"proposed":[128],"achieved":[130],"precision":[132],"98.9+/-3.0%,":[134],"sensitivity":[135],"79.2+/-8.4,":[137],"F1":[139],"score":[140,165],"87.7+/-5.3%.":[142],"addition":[144],"significantly":[148],"improved":[149],"predictive":[150,221],"performance":[151],"compared":[152],"variables":[157,161],"alone":[158],"or":[159],"(p<0.05).":[166],"Interestingly,":[167],"number":[169],"calcified":[171],"arteries,":[172],"despite":[173],"being":[174],"lowest-ranked":[176],"feature":[177],"based":[178],"on":[179],"SHAP":[180],"analysis,":[181],"showed":[182],"strongest":[184],"association":[185],"in":[189],"logistic":[190],"regression":[191],"analysis":[192],"(odds":[193],"ratio:":[194],"3.63,":[195],"95%":[196],"confidence":[197],"interval:":[198],"2.80-4.77,":[199],"p<0.00001).":[200],"We":[201],"developed":[202],"approach":[206],"routinely":[212],"acquired":[213],"scans.":[216],"Calcium-omics":[217],"provided":[219],"incremental":[220],"value":[222],"beyond":[223],"conventional":[224],"factors":[226],"may":[231],"support":[232],"more":[233],"accessible":[234]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2026-05-23T00:00:00"}