{"id":"https://openalex.org/W7160416178","doi":"https://doi.org/10.48550/arxiv.2605.03536","title":"Device-Induced Thrombus Formation in Cerebral Aneurysms: Linking Patient-Specific Clot Modeling and Functional Occlusion to Virtual Angiographic Assessment","display_name":"Device-Induced Thrombus Formation in Cerebral Aneurysms: Linking Patient-Specific Clot Modeling and Functional Occlusion to Virtual Angiographic Assessment","publication_year":2026,"publication_date":"2026-05-05","ids":{"openalex":"https://openalex.org/W7160416178","doi":"https://doi.org/10.48550/arxiv.2605.03536"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2605.03536","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.03536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2605.03536","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093854303","display_name":"Fabian Holzberger","orcid":"https://orcid.org/0000-0003-3577-5466"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holzberger, Fabian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069438019","display_name":"Struan Hume","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hume, Struan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014826338","display_name":"Markus Muhr","orcid":"https://orcid.org/0000-0001-7899-2861"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhr, Markus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135468742","display_name":"Malebogo Ngoepe","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ngoepe, Malebogo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5135501641","display_name":"Barbara Wohlmuth","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wohlmuth, Barbara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9180999994277954,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9180999994277954,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11402","display_name":"Vascular Malformations Diagnosis and Treatment","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombus","display_name":"Thrombus","score":0.7484999895095825},{"id":"https://openalex.org/keywords/occlusion","display_name":"Occlusion","score":0.6485000252723694},{"id":"https://openalex.org/keywords/thrombosis","display_name":"Thrombosis","score":0.5608999729156494},{"id":"https://openalex.org/keywords/digital-subtraction-angiography","display_name":"Digital subtraction angiography","score":0.5595999956130981},{"id":"https://openalex.org/keywords/pulsatile-flow","display_name":"Pulsatile flow","score":0.48089998960494995},{"id":"https://openalex.org/keywords/angiography","display_name":"Angiography","score":0.42579999566078186},{"id":"https://openalex.org/keywords/aneurysm","display_name":"Aneurysm","score":0.4088999927043915}],"concepts":[{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.7484999895095825},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.6485000252723694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.64410001039505},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5608999729156494},{"id":"https://openalex.org/C2778286760","wikidata":"https://www.wikidata.org/wiki/Q1224954","display_name":"Digital subtraction angiography","level":3,"score":0.5595999956130981},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.557200014591217},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5162000060081482},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.48089998960494995},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4156999886035919},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2971000075340271},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C2779786684","wikidata":"https://www.wikidata.org/wiki/Q906156","display_name":"Contrast medium","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2908581485","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clot formation","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C71839028","wikidata":"https://www.wikidata.org/wiki/Q7972627","display_name":"Washout","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2605.03536","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.03536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2605.03536","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2605.03536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"score":0.4686034023761749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Endovascular":[0],"treatment":[1,21,75],"of":[2,12,140,150],"cerebral":[3],"aneurysms":[4],"aims":[5],"to":[6,65,91,121,155],"achieve":[7],"functional":[8],"occlusion":[9,169],"and":[10,35,81,89,111,124,158],"isolation":[11],"the":[13,100,134,151,180],"aneurysm":[14,98],"sac":[15],"from":[16],"bloodflow.":[17],"In":[18],"clinical":[19],"practice,":[20],"success":[22],"is":[23,146],"assessed":[24],"primarily":[25],"through":[26,68],"digital":[27],"subtraction":[28],"angiography":[29],"(DSA),":[30],"which":[31],"visualizes":[32],"contrast-agent":[33],"inflow":[34],"washout":[36,126],"but":[37],"does":[38],"not":[39],"directly":[40],"resolve":[41],"thrombus":[42,56,63,117],"formation":[43,57,118],"driving":[44],"early":[45,62,116],"occlusion.":[46],"We":[47],"present":[48],"a":[49,165,174],"computational":[50],"framework":[51],"that":[52,103],"couples":[53],"acute":[54],"fibrin":[55],"with":[58,115,161,164],"virtual":[59,135],"angiography,":[60],"enabling":[61],"growth":[64],"be":[66],"interpreted":[67],"clinically":[69],"familiar":[70],"DSA-like":[71],"imaging.":[72,137],"Three":[73],"common":[74],"strategies:":[76],"endovascular":[77],"coiling,":[78,83],"flow":[79],"diversion,":[80],"stent-assisted":[82],"are":[84,130],"modeled":[85],"under":[86],"pulsatile":[87],"hemodynamics":[88],"linked":[90],"simulated":[92],"contrast":[93,109],"transport.":[94],"Across":[95],"three":[96],"representative":[97],"morphologies,":[99],"simulations":[101],"demonstrate":[102],"while":[104],"devices":[105],"reduce":[106],"inflow,":[107],"residual":[108],"access":[110],"trapping":[112],"may":[113],"persist,":[114],"contributing":[119],"substantially":[120],"perfusion":[122],"suppression":[123],"altered":[125],"patterns.":[127],"These":[128],"effects":[129],"clearly":[131],"reflected":[132],"in":[133,143,148],"angiographic":[136],"The":[138],"importance":[139],"vortical":[141],"structures":[142],"device-induced":[144],"thrombosis":[145],"highligthed":[147],"one":[149],"cases.":[152],"By":[153],"seeking":[154],"align":[156],"modelling":[157],"simulation":[159],"tools":[160],"clinically-relevant":[162],"metrics,":[163],"particular":[166],"focus":[167],"on":[168],"outcome,":[170],"this":[171],"work":[172],"presents":[173],"good":[175],"starting":[176],"point":[177],"for":[178],"bridging":[179],"gap":[181],"between":[182],"these":[183],"two":[184],"paradigms.":[185]},"counts_by_year":[],"updated_date":"2026-07-01T06:00:48.157686","created_date":"2026-05-07T00:00:00"}