{"id":"https://openalex.org/W7158534804","doi":"https://doi.org/10.48550/arxiv.2604.26147","title":"A Data-Centric Framework for Intraoperative Fluorescence Lifetime Imaging for Glioma Surgical Guidance","display_name":"A Data-Centric Framework for Intraoperative Fluorescence Lifetime Imaging for Glioma Surgical Guidance","publication_year":2026,"publication_date":"2026-04-28","ids":{"openalex":"https://openalex.org/W7158534804","doi":"https://doi.org/10.48550/arxiv.2604.26147"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2604.26147","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.26147","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2604.26147","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124701956","display_name":"Silvia Noble Anbunesan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anbunesan, Silvia Noble","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078851910","display_name":"Mohamed Abul Hassan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan, Mohamed Abul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010514255","display_name":"Jinyi Qi","orcid":"https://orcid.org/0000-0002-5428-0322"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi, Jinyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134924413","display_name":"Lisanne Kraft","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kraft, Lisanne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134880152","display_name":"Han Sung Lee","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee, Han Sung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134903267","display_name":"Orin Bloch","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bloch, Orin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5134884404","display_name":"Laura Marcu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcu, Laura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3691999912261963,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3691999912261963,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.10909999907016754,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.7092000246047974},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.5902000069618225},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.5123999714851379},{"id":"https://openalex.org/keywords/margin","display_name":"Margin (machine learning)","score":0.4740999937057495},{"id":"https://openalex.org/keywords/infiltration","display_name":"Infiltration (HVAC)","score":0.444599986076355},{"id":"https://openalex.org/keywords/resection","display_name":"Resection","score":0.37369999289512634},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.3578000068664551},{"id":"https://openalex.org/keywords/resection-margin","display_name":"Resection margin","score":0.35030001401901245}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7092000246047974},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.5902000069618225},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5123999714851379},{"id":"https://openalex.org/C774472","wikidata":"https://www.wikidata.org/wiki/Q6760393","display_name":"Margin (machine learning)","level":2,"score":0.4740999937057495},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40070000290870667},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3986999988555908},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3709000051021576},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C2778132481","wikidata":"https://www.wikidata.org/wiki/Q7646216","display_name":"Resection margin","level":3,"score":0.35030001401901245},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.34310001134872437},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C13460635","wikidata":"https://www.wikidata.org/wiki/Q85753676","display_name":"Classification scheme","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2939999997615814},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2778913397","wikidata":"https://www.wikidata.org/wiki/Q7646216","display_name":"Surgical margin","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C3020205268","wikidata":"https://www.wikidata.org/wiki/Q1038886","display_name":"Imaging technique","level":2,"score":0.2630999982357025},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.2583000063896179}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2604.26147","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.26147","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2604.26147","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.26147","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Accurate":[0],"intraoperative":[1],"assessment":[2],"of":[3,174,185,212,218],"glioma":[4,225],"infiltration":[5,151],"is":[6,30],"essential":[7],"for":[8,67,223],"maximizing":[9],"tumor":[10,92],"resection":[11,70],"while":[12],"preserving":[13],"functional":[14],"brain":[15],"tissue.":[16],"Fluorescence":[17],"lifetime":[18],"imaging":[19],"(FLIm)":[20],"offers":[21],"real-time,":[22],"label-free":[23],"biochemical":[24],"contrast,":[25],"but":[26],"its":[27],"clinical":[28],"utility":[29],"challenged":[31],"by":[32,95,177],"biological":[33,158,210],"heterogeneity,":[34],"class":[35,54,113],"imbalance,":[36],"and":[37,56,87,110,163,208],"variability":[38],"in":[39,134],"histopathological":[40],"labeling.":[41],"We":[42],"present":[43],"a":[44,62,116,128,197],"data-centric":[45],"AI":[46],"(DC-AI)":[47],"framework":[48,199],"that":[49,130,196],"integrates":[50],"confident":[51],"learning":[52],"(CL),":[53],"refinement,":[55],"targeted":[57],"label":[58,108],"evaluation":[59],"to":[60,102,169],"develop":[61],"robust":[63],"multi-class":[64],"FLIm":[65,72,104,142,154,213],"classifier":[66],"glioblastoma":[68],"(GBM)":[69],"margins.":[71],"data":[73,203],"were":[74],"collected":[75],"from":[76],"192":[77],"tissue":[78],"margins":[79,175],"across":[80,149],"31":[81],"newly":[82],"diagnosed":[83],"IDH-wildtype":[84],"GBM":[85],"patients":[86],"initially":[88],"labeled":[89],"into":[90,115],"seven":[91],"cellularity":[93],"classes":[94],"an":[96],"expert":[97],"neuropathologist.":[98],"CL":[99,178],"was":[100],"applied":[101],"quantify":[103],"point-level":[105],"confidence,":[106],"identify":[107],"inconsistencies,":[109],"guide":[111],"iterative":[112],"merging":[114],"three-class":[117,136],"scheme":[118],"(\"low\",":[119],"\"moderate\",":[120],"\"high\").":[121],"The":[122],"resulting":[123],"high-fidelity":[124],"dataset":[125],"enabled":[126],"training":[127],"model":[129,206],"achieved":[131],"96%":[132],"accuracy":[133],"the":[135,150,183,216],"task.":[137],"SHAP":[138],"analysis":[139,155],"revealed":[140],"class-specific":[141],"feature":[143],"importance,":[144],"highlighting":[145],"distinct":[146],"optical":[147,221],"signatures":[148],"spectrum.":[152],"Targeted":[153],"further":[156],"identified":[157],"(e.g.,":[159,165],"gray":[160],"matter":[161],"composition)":[162],"acquisition-related":[164],"blood":[166],"contamination)":[167],"contributors":[168],"low-confidence":[170],"predictions.":[171],"Blinded":[172],"re-evaluation":[173],"flagged":[176],"demonstrated":[179],"intra-pathologist":[180],"variability,":[181],"underscoring":[182],"value":[184],"selective":[186],"relabeling":[187],"rather":[188],"than":[189],"exhaustive":[190],"review.":[191],"Together,":[192],"these":[193],"findings":[194],"demonstrate":[195],"DC-AI":[198],"can":[200],"systematically":[201],"improve":[202],"reliability,":[204],"enhance":[205],"robustness,":[207],"refine":[209],"interpretation":[211],"signals,":[214],"supporting":[215],"development":[217],"clinically":[219],"actionable":[220],"tools":[222],"real-time":[224],"margin":[226],"assessment.":[227]},"counts_by_year":[],"updated_date":"2026-07-01T06:00:48.157686","created_date":"2026-05-01T00:00:00"}