{"id":"https://openalex.org/W7155390085","doi":"https://doi.org/10.48550/arxiv.2604.20594","title":"Physics-Informed Conditional Diffusion for Motion-Robust Retinal Temporal Laser Speckle Contrast Imaging","display_name":"Physics-Informed Conditional Diffusion for Motion-Robust Retinal Temporal Laser Speckle Contrast Imaging","publication_year":2026,"publication_date":"2026-04-22","ids":{"openalex":"https://openalex.org/W7155390085","doi":"https://doi.org/10.48550/arxiv.2604.20594"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2604.20594","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.20594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2604.20594","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104167300","display_name":"Qian Chen","orcid":"https://orcid.org/0009-0003-4609-3599"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Qian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134463234","display_name":"Yuehao Chen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Yuehao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134393604","display_name":"Qiang Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Qiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134433968","display_name":"Lei Zhu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhu, Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082320568","display_name":"Yanye Lu","orcid":"https://orcid.org/0000-0002-3063-8051"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu, Yanye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5134457791","display_name":"Qiushi Ren","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ren, Qiushi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.30169999599456787,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/speckle-pattern","display_name":"Speckle pattern","score":0.7585999965667725},{"id":"https://openalex.org/keywords/adaptive-optics","display_name":"Adaptive optics","score":0.5085999965667725},{"id":"https://openalex.org/keywords/speckle-noise","display_name":"Speckle noise","score":0.43950000405311584},{"id":"https://openalex.org/keywords/speckle-imaging","display_name":"Speckle imaging","score":0.42289999127388},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.4221999943256378},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.4165000021457672},{"id":"https://openalex.org/keywords/temporal-resolution","display_name":"Temporal resolution","score":0.39399999380111694},{"id":"https://openalex.org/keywords/optical-flow","display_name":"Optical flow","score":0.34869998693466187},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.33329999446868896}],"concepts":[{"id":"https://openalex.org/C102290492","wikidata":"https://www.wikidata.org/wiki/Q7575045","display_name":"Speckle pattern","level":2,"score":0.7585999965667725},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6132000088691711},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6068000197410583},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5945000052452087},{"id":"https://openalex.org/C132771110","wikidata":"https://www.wikidata.org/wiki/Q506922","display_name":"Adaptive optics","level":2,"score":0.5085999965667725},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.45190000534057617},{"id":"https://openalex.org/C180940675","wikidata":"https://www.wikidata.org/wiki/Q7575045","display_name":"Speckle noise","level":3,"score":0.43950000405311584},{"id":"https://openalex.org/C99507719","wikidata":"https://www.wikidata.org/wiki/Q1504755","display_name":"Speckle imaging","level":3,"score":0.42289999127388},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.4221999943256378},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C119666444","wikidata":"https://www.wikidata.org/wiki/Q5977280","display_name":"Temporal resolution","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C155542232","wikidata":"https://www.wikidata.org/wiki/Q736111","display_name":"Optical flow","level":3,"score":0.34869998693466187},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.3303999900817871},{"id":"https://openalex.org/C55020928","wikidata":"https://www.wikidata.org/wiki/Q3813865","display_name":"Image quality","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29319998621940613},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C39394851","wikidata":"https://www.wikidata.org/wiki/Q921594","display_name":"Inter frame","level":4,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2604.20594","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.20594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2604.20594","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.20594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Retinal":[0],"laser":[1],"speckle":[2,27,86,140],"contrast":[3,89],"imaging":[4],"(LSCI)":[5],"is":[6,56,62,79],"a":[7,69,108,115,127,151,181,206],"noninvasive":[8],"optical":[9],"modality":[10],"for":[11,58,112,212],"monitoring":[12],"retinal":[13,59,152,214],"blood":[14],"flow":[15,103],"dynamics.":[16,104],"However,":[17],"conventional":[18,196],"temporal":[19,32,44],"LSCI":[20,153],"(tLSCI)":[21],"reconstruction":[22,49,133,168,198,216],"relies":[23],"on":[24,76,137,147],"sufficiently":[25],"long":[26],"sequences":[28],"to":[29,38,64,82],"obtain":[30],"stable":[31],"statistics,":[33],"which":[34],"makes":[35],"it":[36],"vulnerable":[37],"acquisition":[39],"disturbances":[40],"and":[41,66,114,142,162,172,194,208,224],"limits":[42],"effective":[43,179],"resolution.":[45],"A":[46],"physically":[47,209],"informed":[48],"framework,":[50],"termed":[51],"RetinaDiff":[52],"(Retinal":[53],"Diffusion":[54],"Model),":[55],"proposed":[57],"tLSCI":[60,119,215],"that":[61,95],"robust":[63],"motion":[65,113],"requires":[67],"only":[68],"few":[70,170],"frames.":[71,220],"In":[72],"RetinaDiff,":[73],"registration":[74],"based":[75],"phase":[77],"correlation":[78],"first":[80],"applied":[81],"stabilize":[83],"the":[84,124,138,143,190,195],"raw":[85],"sequence":[87,141],"before":[88],"computation,":[90],"reducing":[91],"interframe":[92],"misalignment":[93],"so":[94],"fluctuations":[96],"at":[97,231],"each":[98],"pixel":[99],"primarily":[100],"reflect":[101],"true":[102],"This":[105],"step":[106],"provides":[107,205],"physics":[109,125],"prior":[110],"corrected":[111,144],"high":[116],"quality":[117],"multiframe":[118,197],"reference.":[120],"Next,":[121],"guided":[122],"by":[123,134],"prior,":[126],"conditional":[128],"diffusion":[129],"model":[130,225],"performs":[131],"inverse":[132],"jointly":[135],"conditioning":[136],"registered":[139],"prior.":[145],"Experiments":[146],"data":[148],"acquired":[149],"with":[150,166],"system":[154],"developed":[155],"in":[156,180],"house":[157],"show":[158],"improved":[159],"structural":[160],"continuity":[161],"statistical":[163],"stability":[164],"compared":[165],"direct":[167,191],"from":[169,217],"frames":[171],"representative":[173],"baselines.":[174],"The":[175,221],"framework":[176],"also":[177],"remains":[178],"small":[182],"number":[183],"of":[184],"extremely":[185,218],"challenging":[186],"cases,":[187],"where":[188],"both":[189],"5-frame":[192],"input":[193],"are":[199],"severely":[200],"degraded.":[201],"Overall,":[202],"this":[203],"work":[204],"practical":[207],"grounded":[210],"route":[211],"reliable":[213],"limited":[219],"source":[222],"code":[223],"weights":[226],"will":[227],"be":[228],"publicly":[229],"available":[230],"https://github.com/QianChen113/RetinaDiff.":[232]},"counts_by_year":[],"updated_date":"2026-07-01T06:00:48.157686","created_date":"2026-04-24T00:00:00"}
