{"id":"https://openalex.org/W7154724194","doi":"https://doi.org/10.48550/arxiv.2604.14216","title":"Neuro-Oracle: A Trajectory-Aware Agentic RAG Framework for Interpretable Epilepsy Surgical Prognosis","display_name":"Neuro-Oracle: A Trajectory-Aware Agentic RAG Framework for Interpretable Epilepsy Surgical Prognosis","publication_year":2026,"publication_date":"2026-04-10","ids":{"openalex":"https://openalex.org/W7154724194","doi":"https://doi.org/10.48550/arxiv.2604.14216"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2604.14216","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.14216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2604.14216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133840144","display_name":"Aizierjiang Aiersilan","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aiersilan, Aizierjiang","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5124304781","display_name":"Mohamad Koubeissi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koubeissi, Mohamad","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5133840144"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.4681999981403351,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.4681999981403351,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.16840000450611115,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.7177000045776367},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.531000018119812},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.4871000051498413},{"id":"https://openalex.org/keywords/resection","display_name":"Resection","score":0.4447999894618988},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.43309998512268066},{"id":"https://openalex.org/keywords/longitudinal-data","display_name":"Longitudinal data","score":0.4041999876499176}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.7177000045776367},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5774000287055969},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.531000018119812},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.4447999894618988},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43309998512268066},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4162999987602234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4140999913215637},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36250001192092896},{"id":"https://openalex.org/C2780148112","wikidata":"https://www.wikidata.org/wiki/Q1432581","display_name":"Proxy (statistics)","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3154999911785126},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.27639999985694885},{"id":"https://openalex.org/C2780803581","wikidata":"https://www.wikidata.org/wiki/Q1347108","display_name":"Epilepsy surgery","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2587999999523163}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2604.14216","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.14216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2604.14216","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.14216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7194684743881226,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Predicting":[0],"post-surgical":[1],"seizure":[2],"outcomes":[3],"in":[4,68],"pharmacoresistant":[5],"epilepsy":[6],"is":[7],"a":[8,27,37,43,55,64,73,102,144,164],"clinical":[9,103],"challenge.":[10],"Conventional":[11],"deep-learning":[12],"approaches":[13],"operate":[14],"on":[15,81,107],"static,":[16],"single-timepoint":[17,165],"pre-operative":[18],"scans,":[19],"omitting":[20],"longitudinal":[21],"morphological":[22],"changes.":[23],"We":[24,111],"propose":[25],"\\emph{Neuro-Oracle},":[26],"three-stage":[28],"framework":[29],"that:":[30],"(i)":[31],"distils":[32],"pre-to-post-operative":[33],"MRI":[34],"changes":[35],"into":[36],"compact":[38],"512-dimensional":[39],"trajectory":[40,178],"vector":[41],"using":[42,72,90],"3D":[44],"Siamese":[45,194],"contrastive":[46],"encoder;":[47],"(ii)":[48],"retrieves":[49],"historically":[50],"similar":[51],"surgical":[52],"trajectories":[53],"from":[54],"population":[56],"archive":[57],"via":[58],"nearest-neighbour":[59],"search;":[60],"and":[61,158],"(iii)":[62],"synthesises":[63],"natural-language":[65],"prognosis":[66],"grounded":[67],"the":[69,82,108,114,120,124,147,173],"retrieved":[70],"evidence":[71],"quantized":[74],"Llama-3-8B":[75],"reasoning":[76],"agent.":[77],"Evaluations":[78],"are":[79,98],"conducted":[80],"public":[83],"EPISURG":[84],"dataset":[85],"($N{=}268$":[86],"longitudinally":[87],"paired":[88],"cases)":[89],"five-fold":[91],"stratified":[92],"cross-validation.":[93],"Since":[94],"ground-truth":[95],"seizure-freedom":[96],"scores":[97],"unavailable,":[99],"we":[100],"utilize":[101],"proxy":[104],"label":[105],"based":[106],"resection":[109,125],"type.":[110],"acknowledge":[112],"that":[113],"network":[115],"representations":[116],"may":[117],"potentially":[118],"learn":[119],"anatomical":[121],"features":[122],"of":[123,175,198,204],"cavities":[126],"(i.e.,":[127],"temporal":[128],"versus":[129],"non-temporal":[130],"locations)":[131],"rather":[132],"than":[133],"true":[134],"prognostic":[135],"morphometry.":[136],"Our":[137],"current":[138],"evaluation":[139],"thus":[140],"serves":[141],"mainly":[142],"as":[143],"proof-of-concept":[145],"for":[146,163],"trajectory-aware":[148],"retrieval":[149],"architecture.":[150],"Trajectory-based":[151],"classifiers":[152,179,200],"achieve":[153],"AUC":[154,174,203],"values":[155],"between":[156],"0.834":[157],"0.905,":[159],"compared":[160],"with":[161,185],"0.793":[162],"ResNet-50":[166],"baseline.":[167],"The":[168],"Neuro-Oracle":[169],"agent":[170],"(M5)":[171],"matches":[172],"purely":[176],"discriminative":[177],"(0.867)":[180],"while":[181],"producing":[182],"structured":[183],"justifications":[184],"zero":[186],"observed":[187],"hallucinations":[188],"under":[189],"our":[190],"audit":[191],"protocol.":[192],"A":[193],"Diversity":[195],"Ensemble":[196],"(M6)":[197],"trajectory-space":[199],"attains":[201],"an":[202],"0.905":[205],"without":[206],"language-model":[207],"overhead.":[208]},"counts_by_year":[],"updated_date":"2026-04-18T06:05:20.339008","created_date":"2026-04-18T00:00:00"}
