{"id":"https://openalex.org/W7154565574","doi":"https://doi.org/10.48550/arxiv.2604.13397","title":"A Multimodal Clinically Informed Coarse-to-Fine Framework for Longitudinal CT Registration in Proton Therapy","display_name":"A Multimodal Clinically Informed Coarse-to-Fine Framework for Longitudinal CT Registration in Proton Therapy","publication_year":2026,"publication_date":"2026-04-15","ids":{"openalex":"https://openalex.org/W7154565574","doi":"https://doi.org/10.48550/arxiv.2604.13397"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2604.13397","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.13397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2604.13397","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133735570","display_name":"Caiwen Jiang","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiang, Caiwen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133800521","display_name":"Yuzhen Ding","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ding, Yuzhen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133812026","display_name":"Mi Jia","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia, Mi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133814506","display_name":"Samir H. Patel","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patel, Samir H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032470889","display_name":"Terence T. Sio","orcid":"https://orcid.org/0000-0003-4210-5479"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sio, Terence T.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089819634","display_name":"Jonathan B. Ashman","orcid":"https://orcid.org/0000-0001-7098-9465"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashman, Jonathan B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133777436","display_name":"Lisa A. McGee","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"McGee, Lisa A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133751083","display_name":"Jean-Claude M. Rwigema","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rwigema, Jean-Claude M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033395766","display_name":"William G. Rule","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rule, William G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087495484","display_name":"Sameer R. Keole","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keole, Sameer R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133800534","display_name":"Sujay A. Vora","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vora, Sujay A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133804020","display_name":"William W. Wong","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wong, William W.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039114910","display_name":"Nathan Y. Yu","orcid":"https://orcid.org/0000-0003-4059-650X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu, Nathan Y.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090700846","display_name":"Michele Y. Halyard","orcid":"https://orcid.org/0000-0003-0998-4600"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Halyard, Michele Y.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062848479","display_name":"Steven E. Schild","orcid":"https://orcid.org/0000-0002-2850-4126"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schild, Steven E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133752546","display_name":"Dinggang Shen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shen, Dinggang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5133760199","display_name":"Wei Liu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5133735570"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.4507000148296356,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.4507000148296356,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.39590001106262207,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.6265000104904175},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"Proton therapy","score":0.5496000051498413},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5430999994277954},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.4814999997615814},{"id":"https://openalex.org/keywords/radiation-treatment-planning","display_name":"Radiation treatment planning","score":0.4350999891757965},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.3831000030040741},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"Computed tomography","score":0.3564999997615814}],"concepts":[{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.6265000104904175},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5537999868392944},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.5496000051498413},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5478000044822693},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5430999994277954},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.4814999997615814},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.4350999891757965},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.42480000853538513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3871000111103058},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3831000030040741},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3684000074863434},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32919999957084656},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C9267231","wikidata":"https://www.wikidata.org/wiki/Q15841445","display_name":"Image-guided radiation therapy","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.2648000121116638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2604.13397","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.13397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2604.13397","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2604.13397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4","score":0.45873844623565674}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Proton":[0],"therapy":[1,147],"offers":[2],"superior":[3],"organ-at-risk":[4,109],"sparing":[5],"but":[6],"is":[7],"highly":[8],"sensitive":[9],"to":[10,76,95],"anatomical":[11,160],"changes,":[12],"making":[13],"accurate":[14],"deformable":[15,64],"image":[16],"registration":[17,65],"(DIR)":[18],"across":[19,158],"longitudinal":[20],"CT":[21,101,156],"scans":[22,157],"essential.":[23],"Conventional":[24],"DIR":[25,148],"methods":[26],"are":[27,41,117],"often":[28],"too":[29],"slow":[30],"for":[31,44,87],"emerging":[32],"online":[33],"adaptive":[34],"workflows,":[35],"while":[36],"existing":[37],"deep":[38],"learning-based":[39],"approaches":[40],"primarily":[42],"designed":[43],"generic":[45],"benchmarks":[46],"and":[47,91,108,113,121,127,133,154,162,175],"underutilize":[48],"clinically":[49,61,103,134,177],"relevant":[50],"information":[51,70],"beyond":[52],"images.":[53],"To":[54],"address":[55],"this":[56],"gap,":[57],"we":[58],"propose":[59],"a":[60,92,144],"scalable":[62],"coarse-to-fine":[63],"framework":[66,142],"that":[67],"integrates":[68],"multimodal":[69],"from":[71],"the":[72,140],"proton":[73,146],"radiotherapy":[74],"workflow":[75],"accommodate":[77],"diverse":[78],"clinical":[79],"scenarios.":[80],"The":[81],"model":[82],"employs":[83],"dual":[84],"CNN-based":[85],"encoders":[86],"hierarchical":[88],"feature":[89,125],"extraction":[90],"transformer-based":[93],"decoder":[94],"progressively":[96],"refine":[97],"deformation":[98,136],"fields.":[99],"Beyond":[100],"intensities,":[102],"critical":[104],"priors,":[105],"including":[106],"target":[107],"contours,":[110],"dose":[111],"distributions,":[112],"treatment":[114],"planning":[115,153],"text,":[116],"incorporated":[118],"through":[119],"anatomy-":[120],"risk-guided":[122],"attention,":[123],"text-conditioned":[124],"modulation,":[126],"foreground-aware":[128],"optimization,":[129],"enabling":[130,173],"anatomically":[131],"focused":[132],"informed":[135],"estimation.":[137],"We":[138],"evaluate":[139],"proposed":[141],"on":[143],"large-scale":[145],"dataset":[149],"comprising":[150],"1,222":[151],"paired":[152],"repeat":[155],"multiple":[159],"regions":[161],"disease":[163],"types.":[164],"Extensive":[165],"experiments":[166],"demonstrate":[167],"consistent":[168],"improvements":[169],"over":[170],"state-of-the-art":[171],"methods,":[172],"fast":[174],"robust":[176],"meaningful":[178],"registration.":[179]},"counts_by_year":[],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2026-04-17T00:00:00"}