{"id":"https://openalex.org/W7147622603","doi":"https://doi.org/10.48550/arxiv.2603.27303","title":"Self-evolving AI agents for protein discovery and directed evolution","display_name":"Self-evolving AI agents for protein discovery and directed evolution","publication_year":2026,"publication_date":"2026-03-28","ids":{"openalex":"https://openalex.org/W7147622603","doi":"https://doi.org/10.48550/arxiv.2603.27303"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2603.27303","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.27303","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2603.27303","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132688991","display_name":"Yang Tan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tan, Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111348177","display_name":"Lingrong Zhang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Lingrong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132708765","display_name":"Mingchen Li","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Mingchen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132571489","display_name":"Yuanxi Yu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu, Yuanxi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090728932","display_name":"Bozitao Zhong","orcid":"https://orcid.org/0000-0001-9363-6099"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong, Bozitao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027695625","display_name":"Bingxin Zhou","orcid":"https://orcid.org/0000-0002-3897-9766"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhou, Bingxin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132727902","display_name":"Nanqing Dong","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong, Nanqing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5132641317","display_name":"Liang Hong","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong, Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.32829999923706055,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.32829999923706055,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.10520000010728836,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12784","display_name":"Modular Robots and Swarm Intelligence","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7353000044822693},{"id":"https://openalex.org/keywords/orchestration","display_name":"Orchestration","score":0.646399974822998},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5293999910354614},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4952999949455261},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4749999940395355},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"Directed evolution","score":0.4708999991416931},{"id":"https://openalex.org/keywords/scientific-discovery","display_name":"Scientific discovery","score":0.3553999960422516}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7353000044822693},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6714000105857849},{"id":"https://openalex.org/C199168358","wikidata":"https://www.wikidata.org/wiki/Q3367000","display_name":"Orchestration","level":3,"score":0.646399974822998},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5293999910354614},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4952999949455261},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4749999940395355},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.4708999991416931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4408999979496002},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3824000060558319},{"id":"https://openalex.org/C2984917352","wikidata":"https://www.wikidata.org/wiki/Q12772819","display_name":"Scientific discovery","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.34779998660087585},{"id":"https://openalex.org/C13687954","wikidata":"https://www.wikidata.org/wiki/Q4826847","display_name":"Autonomous agent","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.31949999928474426},{"id":"https://openalex.org/C207685749","wikidata":"https://www.wikidata.org/wiki/Q2088941","display_name":"Domain knowledge","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.2793999910354614}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2603.27303","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.27303","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2603.27303","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.27303","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.624261736869812,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Protein":[0],"scientific":[1],"discovery":[2,61],"is":[3],"bottlenecked":[4],"by":[5],"the":[6,54,60],"manual":[7],"orchestration":[8],"of":[9,50,64],"information":[10],"and":[11,57,62],"algorithms,":[12],"while":[13],"general":[14],"agents":[15,52],"are":[16],"insufficient":[17],"in":[18],"complex":[19],"domain":[20],"projects.":[21],"VenusFactory2":[22],"provides":[23],"an":[24],"autonomous":[25],"framework":[26],"that":[27],"shifts":[28],"from":[29,66],"static":[30],"tool":[31],"usage":[32],"to":[33,42],"dynamic":[34],"workflow":[35],"synthesis":[36],"via":[37],"a":[38,48,67],"self-evolving":[39],"multi-agent":[40],"infrastructure":[41],"address":[43],"protein-related":[44],"demands.":[45],"It":[46],"outperforms":[47],"set":[49],"well-known":[51],"on":[53],"VenusAgentEval":[55],"benchmark,":[56],"autonomously":[58],"organizes":[59],"optimization":[63],"proteins":[65],"single":[68],"natural":[69],"language":[70],"prompt.":[71]},"counts_by_year":[],"updated_date":"2026-07-01T06:00:48.157686","created_date":"2026-04-02T00:00:00"}