{"id":"https://openalex.org/W7137906032","doi":"https://doi.org/10.48550/arxiv.2603.13598","title":"Tau-induced atrophy drives functional connectivity disruption in Alzheimer's disease","display_name":"Tau-induced atrophy drives functional connectivity disruption in Alzheimer's disease","publication_year":2026,"publication_date":"2026-03-13","ids":{"openalex":"https://openalex.org/W7137906032","doi":"https://doi.org/10.48550/arxiv.2603.13598"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2603.13598","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.13598","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2603.13598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5129645217","display_name":"Kun Jiang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang, Kun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129642587","display_name":"Can Liao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liao, Can","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129646155","display_name":"Sujin Jiang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang, Sujin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129675716","display_name":"Haidong Lin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin, Haidong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101503812","display_name":"Jixin Hou","orcid":"https://orcid.org/0000-0002-7425-1510"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hou, Jixin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129659538","display_name":"Tianming Liu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Tianming","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129717471","display_name":"Gang Li","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Gang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122762857","display_name":"Taotao Wu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wu, Taotao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025364441","display_name":"Yiqi Mao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mao, Yiqi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005701510","display_name":"Ellen Kuhl","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuhl, Ellen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122839659","display_name":"Xianqiao Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Xianqiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5129650908","display_name":"Xianyan Chen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Xianyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.08320000022649765,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.8648999929428101},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4790000021457672},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.4025000035762787},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.32670000195503235},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.31450000405311584},{"id":"https://openalex.org/keywords/degenerative-disease","display_name":"Degenerative disease","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.8648999929428101},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6535000205039978},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4790000021457672},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4025000035762787},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38350000977516174},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32269999384880066},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.31450000405311584},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3057999908924103},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26980000734329224},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2603.13598","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.13598","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2603.13598","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.13598","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.47470560669898987}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,176],"involves":[2],"progressive":[3],"tau":[4,20,48],"accumulation":[5],"and":[6,13,22,52,78,91,108,142,151,178],"spread,":[7],"leading":[8],"to":[9,55,116],"regional":[10,88,131,134,155],"brain":[11],"atrophy":[12,30,58,70,89,106,135,161],"disruption":[14],"of":[15,154],"large-scale":[16],"functional":[17,34,79],"networks.":[18],"While":[19],"propagation":[21],"tissue":[23],"degeneration":[24],"have":[25],"been":[26],"widely":[27],"modeled,":[28],"how":[29],"dynamics":[31],"translate":[32],"into":[33,111,162],"connectivity":[35],"(FC)":[36],"degradation":[37,101,146],"remains":[38],"unclear.":[39],"Here,":[40],"we":[41,81],"develop":[42],"a":[43,112,170],"multiphysics":[44],"framework":[45,168],"integrating":[46],"anisotropic":[47],"reaction-diffusion,":[49],"finite-deformation":[50],"biomechanics,":[51],"network":[53,100],"modeling":[54],"link":[56],"tau-driven":[57,160],"with":[59,72],"FC":[60,92,118,140,156,164],"changes.":[61],"Model":[62],"fidelity":[63],"is":[64],"evaluated":[65],"by":[66],"quantitatively":[67],"comparing":[68],"simulated":[69],"patterns":[71],"imaging-derived":[73],"measurements.":[74],"Using":[75],"longitudinal":[76,139],"structural":[77,99],"MRI,":[80],"identify":[82],"an":[83,97],"approximately":[84],"linear":[85],"relationship":[86],"between":[87],"rates":[90,107,136],"change.":[93],"We":[94],"then":[95],"construct":[96],"atrophy-informed":[98,145],"matrix":[102,147],"from":[103],"model-predicted":[104],"region-specific":[105],"embed":[109],"it":[110],"neural":[113],"oscillation":[114],"model":[115,128],"predict":[117,138],"disruption.":[119,157],"Our":[120],"results":[121],"show":[122],"that":[123],"(i)":[124],"the":[125,144,149,166],"coupled":[126],"reaction-diffusion-biomechanical":[127],"reproduces":[129],"observed":[130],"atrophy,":[132],"(ii)":[133],"parsimoniously":[137],"changes,":[141],"(iii)":[143],"captures":[148],"direction":[150],"relative":[152],"magnitude":[153],"By":[158],"converting":[159],"predictive":[163],"trajectories,":[165],"proposed":[167],"offers":[169],"clinically":[171],"interpretable":[172],"avenue":[173],"for":[174],"forecasting":[175],"progression":[177],"informing":[179],"trial":[180],"design.":[181]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2026-03-18T00:00:00"}
