{"id":"https://openalex.org/W7133338125","doi":"https://doi.org/10.48550/arxiv.2603.00097","title":"Exploring Drug Safety Through Knowledge Graphs: Protein Kinase Inhibitors as a Case Study","display_name":"Exploring Drug Safety Through Knowledge Graphs: Protein Kinase Inhibitors as a Case Study","publication_year":2026,"publication_date":"2026-02-17","ids":{"openalex":"https://openalex.org/W7133338125","doi":"https://doi.org/10.48550/arxiv.2603.00097"},"language":null,"primary_location":{"id":"doi:10.48550/arxiv.2603.00097","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.00097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2603.00097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5127987300","display_name":"David Jackson","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jackson, David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061021795","display_name":"Michael Gertz","orcid":"https://orcid.org/0000-0003-4530-6110"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gertz, Michael","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083522280","display_name":"J\u00fcrgen Hesser","orcid":"https://orcid.org/0000-0002-4001-1164"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hesser, J\u00fcrgen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5127987300"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.6552000045776367,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.6552000045776367,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.25110000371932983,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5199000239372253},{"id":"https://openalex.org/keywords/metadata","display_name":"Metadata","score":0.4763999879360199},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4708000123500824},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.41909998655319214},{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.37299999594688416},{"id":"https://openalex.org/keywords/tolerability","display_name":"Tolerability","score":0.3407000005245209},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.3393999934196472},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5199000239372253},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4779999852180481},{"id":"https://openalex.org/C93518851","wikidata":"https://www.wikidata.org/wiki/Q180160","display_name":"Metadata","level":2,"score":0.4763999879360199},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4708000123500824},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.435699999332428},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3912000060081482},{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.37299999594688416},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3531000018119812},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3319999873638153},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.3109000027179718},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2603.00097","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.00097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2603.00097","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2603.00097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7448834776878357}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Adverse":[0],"Drug":[1],"Reactions":[2],"(ADRs)":[3],"are":[4,155],"a":[5,41,65,134],"leading":[6],"cause":[7],"of":[8,70,87],"morbidity":[9],"and":[10,59,72,93,96,112,120,129,149,153],"mortality.":[11],"Existing":[12],"prediction":[13,98],"methods":[14],"rely":[15],"mainly":[16],"on":[17,22],"chemical":[18],"similarity,":[19,95],"machine":[20],"learning":[21],"structured":[23],"databases,":[24],"or":[25],"isolated":[26],"target":[27,94,115],"profiles,":[28],"but":[29],"often":[30],"fail":[31],"to":[32,76],"integrate":[33],"heterogeneous,":[34],"partly":[35],"unstructured":[36],"evidence":[37],"effectively.":[38],"We":[39],"present":[40],"knowledge":[42],"graph-based":[43],"framework":[44,140],"that":[45],"unifies":[46],"diverse":[47],"sources,":[48],"drug-target":[49],"data":[50,154],"(ChEMBL),":[51],"clinical":[52],"trial":[53,56],"literature":[54],"(PubMed),":[55],"metadata":[57],"(ClinicalTrials.gov),":[58],"post-marketing":[60],"safety":[61],"reports":[62],"(FAERS)":[63],"into":[64],"single":[66],"evidence-weighted":[67],"bipartite":[68],"network":[69,83],"drugs":[71],"medical":[73],"conditions.":[74],"Applied":[75],"400":[77],"protein":[78],"kinase":[79],"inhibitors,":[80],"the":[81,139],"resulting":[82],"enables":[84],"contextual":[85],"comparison":[86],"efficacy":[88],"(HR,":[89],"PFS,":[90],"OS),":[91],"phenotypic":[92],"ADR":[97],"via":[99],"target-to-adverse-event":[100],"correlations.":[101],"A":[102],"non-small":[103],"cell":[104],"lung":[105],"cancer":[106],"case":[107],"study":[108],"correctly":[109],"highlights":[110],"established":[111],"candidate":[113],"drugs,":[114],"communities":[116],"(ERbB,":[117],"ALK,":[118],"VEGF),":[119],"tolerability":[121],"differences.":[122],"Designed":[123],"as":[124],"an":[125],"orthogonal,":[126],"extensible":[127],"analysis":[128],"search":[130],"tool":[131],"rather":[132],"than":[133],"replacement":[135],"for":[136],"current":[137],"models,":[138],"excels":[141],"at":[142,158],"revealing":[143],"complex":[144],"patterns,":[145],"supporting":[146],"hypothesis":[147],"generation,":[148],"enhancing":[150],"pharmacovigilance.":[151],"Code":[152],"publicly":[156],"available":[157],"https://github.com/davidjackson99/PKI_KG.":[159]},"counts_by_year":[],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2026-03-04T00:00:00"}