{"id":"https://openalex.org/W7128795926","doi":"https://doi.org/10.48550/arxiv.2602.11391","title":"Advancing AI Trustworthiness Through Patient Simulation: Risk Assessment of Conversational Agents for Antidepressant Selection","display_name":"Advancing AI Trustworthiness Through Patient Simulation: Risk Assessment of Conversational Agents for Antidepressant Selection","publication_year":2026,"publication_date":"2026-02-11","ids":{"openalex":"https://openalex.org/W7128795926","doi":"https://doi.org/10.48550/arxiv.2602.11391"},"language":null,"primary_location":{"id":"pmh:doi:10.48550/arxiv.2602.11391","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":null,"any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112899465","display_name":"Tanvir Rouf Shawon","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shawon, Md Tanvir Rouf","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072474310","display_name":"Mohammad Sabik Irbaz","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irbaz, Mohammad Sabik","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117862538","display_name":"Hadeel R A Elyazori","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elyazori, Hadeel R. A.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125985291","display_name":"Keerti Reddy Resapu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Resapu, Keerti Reddy","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125980594","display_name":"Yili Lin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin, Yili","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125888498","display_name":"Vladimir Franzuela Cardenas","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cardenas, Vladimir Franzuela","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121854307","display_name":"Farrokh Alemi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alemi, Farrokh","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060395338","display_name":"Kevin Lybarger","orcid":"https://orcid.org/0000-0001-5798-2664"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lybarger, Kevin","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5112899465"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.33219999074935913,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.33219999074935913,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11519","display_name":"Digital Mental Health Interventions","score":0.2669000029563904,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/health-literacy","display_name":"Health literacy","score":0.5335999727249146},{"id":"https://openalex.org/keywords/literacy","display_name":"Literacy","score":0.48100000619888306},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"Risk assessment","score":0.44519999623298645},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.43149998784065247},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4056999981403351},{"id":"https://openalex.org/keywords/sociotechnical-system","display_name":"Sociotechnical system","score":0.3260999917984009},{"id":"https://openalex.org/keywords/trustworthiness","display_name":"Trustworthiness","score":0.3228999972343445},{"id":"https://openalex.org/keywords/health-records","display_name":"Health records","score":0.3176000118255615},{"id":"https://openalex.org/keywords/decision-aids","display_name":"Decision aids","score":0.3174000084400177}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5435000061988831},{"id":"https://openalex.org/C2778843546","wikidata":"https://www.wikidata.org/wiki/Q3097973","display_name":"Health literacy","level":3,"score":0.5335999727249146},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4828999936580658},{"id":"https://openalex.org/C547764534","wikidata":"https://www.wikidata.org/wiki/Q8236","display_name":"Literacy","level":2,"score":0.48100000619888306},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.44519999623298645},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.43149998784065247},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4302000105381012},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4016999900341034},{"id":"https://openalex.org/C75630572","wikidata":"https://www.wikidata.org/wiki/Q538904","display_name":"Applied psychology","level":1,"score":0.39649999141693115},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.3375999927520752},{"id":"https://openalex.org/C127627568","wikidata":"https://www.wikidata.org/wiki/Q1639361","display_name":"Sociotechnical system","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C153701036","wikidata":"https://www.wikidata.org/wiki/Q659974","display_name":"Trustworthiness","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C2780033181","wikidata":"https://www.wikidata.org/wiki/Q24962805","display_name":"Decision aids","level":3,"score":0.3174000084400177},{"id":"https://openalex.org/C3020452639","wikidata":"https://www.wikidata.org/wiki/Q454812","display_name":"Clinical judgment","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C84525736","wikidata":"https://www.wikidata.org/wiki/Q831366","display_name":"Decision tree","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C94124525","wikidata":"https://www.wikidata.org/wiki/Q912550","display_name":"Categorization","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.30090001225471497},{"id":"https://openalex.org/C63527458","wikidata":"https://www.wikidata.org/wiki/Q5133829","display_name":"Clinical decision support system","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C2777868144","wikidata":"https://www.wikidata.org/wiki/Q7239817","display_name":"Preference elicitation","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C111219384","wikidata":"https://www.wikidata.org/wiki/Q6954384","display_name":"NIST","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C5570062","wikidata":"https://www.wikidata.org/wiki/Q3919817","display_name":"Behavioural sciences","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C59594135","wikidata":"https://www.wikidata.org/wiki/Q5249242","display_name":"Decision model","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C2778080475","wikidata":"https://www.wikidata.org/wiki/Q4353774","display_name":"Health communication","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C3018396927","wikidata":"https://www.wikidata.org/wiki/Q275969","display_name":"Crowd sourcing","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:doi:10.48550/arxiv.2602.11391","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.48550/arxiv.2602.11391","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2602.11391","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:doi:10.48550/arxiv.2602.11391","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Quality Education","score":0.8898311257362366,"id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Objective:":[0],"This":[1],"paper":[2],"introduces":[3],"a":[4,188],"patient":[5],"simulator":[6,44,107,175],"for":[7,98,195],"scalable,":[8],"automated":[9],"evaluation":[10],"of":[11,55],"healthcare":[12,182],"conversational":[13,181],"agents,":[14],"generating":[15],"realistic,":[16],"controllable":[17],"interactions":[18],"that":[19],"systematically":[20],"vary":[21],"across":[22,32,116,140],"medical,":[23],"linguistic,":[24],"and":[25,69,72,79,91,149,165],"behavioral":[26,74],"dimensions":[27],"to":[28,127],"support":[29],"risk":[30,190],"assessment":[31],"populations.":[33],"Methods:":[34],"Grounded":[35],"in":[36,111,180],"the":[37,43,106],"NIST":[38,86],"AI":[39,87,95,112,197],"Risk":[40],"Management":[41],"Framework,":[42],"integrates":[45],"three":[46],"profile":[47],"components:":[48],"(1)":[49],"medical":[50],"profiles":[51,65,75,159,167],"constructed":[52],"from":[53,124],"All":[54],"Us":[56],"electronic":[57],"health":[58,67,117],"records":[59],"using":[60],"risk-ratio":[61],"gating;":[62],"(2)":[63],"linguistic":[64,166],"modeling":[66],"literacy":[68,118,185],"condition-specific":[70],"communication;":[71],"(3)":[73],"representing":[76],"cooperative,":[77],"distracted,":[78],"adversarial":[80],"engagement.":[81],"Profiles":[82],"were":[83,160],"evaluated":[84],"against":[85,93],"RMF":[88],"trustworthiness":[89],"requirements":[90],"assessed":[92],"an":[94,150],"Decision":[96,113],"Aid":[97,114],"antidepressant":[99],"selection.":[100],"Results:":[101],"Across":[102],"500":[103],"simulated":[104],"conversations,":[105],"revealed":[108],"monotonic":[109],"degradation":[110],"performance":[115,178],"levels:":[119],"Rank-1":[120],"concept":[121,135],"retrieval":[122],"ranged":[123],"47.6%":[125],"(limited)":[126],"81.9%":[128],"(proficient),":[129],"with":[130,153,192],"corresponding":[131],"recommendation":[132],"degradation.":[133],"Medical":[134],"fidelity":[136],"was":[137],"high":[138],"(96.6%":[139],"8,210":[141],"concepts),":[142],"validated":[143],"by":[144],"human":[145],"annotators":[146],"(0.73":[147],"kappa)":[148],"LLM":[151],"judge":[152],"comparable":[154],"agreement":[155,170],"(0.78":[156],"kappa).":[157,172],"Behavioral":[158],"reliably":[161],"distinguished":[162],"(0.93":[163],"kappa),":[164],"showed":[168],"moderate":[169],"(0.61":[171],"Conclusions:":[173],"The":[174],"exposes":[176],"measurable":[177],"risks":[179],"AI.":[183],"Health":[184],"emerged":[186],"as":[187],"primary":[189],"factor":[191],"direct":[193],"implications":[194],"equitable":[196],"deployment.":[198]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2026-02-14T00:00:00"}