{"id":"https://openalex.org/W4417174022","doi":"https://doi.org/10.48550/arxiv.2503.18583","title":"Adapting Video Diffusion Models for Time-Lapse Microscopy","display_name":"Adapting Video Diffusion Models for Time-Lapse Microscopy","publication_year":2025,"publication_date":"2025-03-24","ids":{"openalex":"https://openalex.org/W4417174022","doi":"https://doi.org/10.48550/arxiv.2503.18583"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2503.18583","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2503.18583","pdf_url":"https://arxiv.org/pdf/2503.18583","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2503.18583","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120023516","display_name":"Alexander Holmberg","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holmberg, Alexander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120758944","display_name":"Nils Mechtel","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mechtel, Nils","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047613167","display_name":"Wei Ouyang","orcid":"https://orcid.org/0000-0003-4279-661X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ouyang, Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9388999938964844,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9388999938964844,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10775","display_name":"Generative Adversarial Networks and Image Synthesis","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/video-microscopy","display_name":"Video microscopy","score":0.7483000159263611},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5357999801635742},{"id":"https://openalex.org/keywords/frame","display_name":"Frame (networking)","score":0.47749999165534973},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.45649999380111694},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.4512999951839447},{"id":"https://openalex.org/keywords/domain-adaptation","display_name":"Domain adaptation","score":0.4018999934196472},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.3824999928474426},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.36980000138282776}],"concepts":[{"id":"https://openalex.org/C2993775838","wikidata":"https://www.wikidata.org/wiki/Q14943002","display_name":"Video microscopy","level":2,"score":0.7483000159263611},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5860000252723694},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5357999801635742},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49639999866485596},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.45649999380111694},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.4512999951839447},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.43140000104904175},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4180999994277954},{"id":"https://openalex.org/C2776434776","wikidata":"https://www.wikidata.org/wiki/Q19246213","display_name":"Domain adaptation","level":3,"score":0.4018999934196472},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.36980000138282776},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C35527583","wikidata":"https://www.wikidata.org/wiki/Q189156","display_name":"Cellular automaton","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C76969082","wikidata":"https://www.wikidata.org/wiki/Q486902","display_name":"Mathematical model","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.25380000472068787}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2503.18583","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2503.18583","pdf_url":"https://arxiv.org/pdf/2503.18583","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2503.18583","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2503.18583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2503.18583","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2503.18583","pdf_url":"https://arxiv.org/pdf/2503.18583","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"We":[0],"present":[1],"a":[2,45,91],"domain":[3],"adaptation":[4],"of":[5,16,76,164],"video":[6,25,47,93,166],"diffusion":[7,48],"models":[8,26,167],"to":[9,152,168],"generate":[10],"highly":[11],"realistic":[12],"time-lapse":[13],"microscopy":[14,37,86,173],"videos":[15],"cell":[17,133],"division":[18],"in":[19,36,136],"HeLa":[20],"cells.":[21],"Although":[22],"state-of-the-art":[23],"generative":[24,165],"have":[27],"advanced":[28],"significantly":[29],"for":[30,149,161],"natural":[31],"videos,":[32],"they":[33],"remain":[34],"underexplored":[35],"domains.":[38],"To":[39],"address":[40],"this":[41],"gap,":[42],"we":[43],"fine-tune":[44],"pretrained":[46],"model":[49,124],"on":[50],"microscopy-specific":[51],"sequences,":[52],"exploring":[53],"three":[54],"conditioning":[55,154],"strategies:":[56],"(1)":[57],"text":[58],"prompts":[59],"derived":[60],"from":[61],"numeric":[62,74],"phenotypic":[63,143],"measurements":[64],"(e.g.,":[65],"proliferation":[66],"rates,":[67],"migration":[68,102],"speeds,":[69],"cell-death":[70],"frequencies),":[71],"(2)":[72],"direct":[73],"embeddings":[75],"phenotype":[77],"scores,":[78],"and":[79,101,110,119,182],"(3)":[80],"image-conditioned":[81],"generation,":[82],"where":[83],"an":[84],"initial":[85],"frame":[87],"is":[88],"extended":[89,137],"into":[90],"complete":[92],"sequence.":[94],"Evaluation":[95],"using":[96],"biologically":[97,170],"meaningful":[98],"morphological,":[99],"proliferation,":[100],"metrics":[103],"demonstrates":[104],"that":[105],"fine-tuning":[106,163],"substantially":[107],"improves":[108],"realism":[109],"accurately":[111],"captures":[112],"critical":[113],"cellular":[114],"behaviors":[115],"such":[116,177],"as":[117,178],"mitosis":[118],"migration.":[120],"Notably,":[121],"the":[122,128,159],"fine-tuned":[123],"also":[125],"generalizes":[126],"beyond":[127],"training":[129],"horizon,":[130],"generating":[131],"coherent":[132],"dynamics":[134],"even":[135],"sequences.":[138],"However,":[139],"precisely":[140],"controlling":[141],"specific":[142],"characteristics":[144],"remains":[145],"challenging,":[146],"highlighting":[147],"opportunities":[148],"future":[150],"work":[151],"enhance":[153],"methods.":[155],"Our":[156],"results":[157],"demonstrate":[158],"potential":[160],"domain-specific":[162],"produce":[169],"plausible":[171],"synthetic":[172],"data,":[174],"supporting":[175],"applications":[176],"in-silico":[179],"hypothesis":[180],"testing":[181],"data":[183],"augmentation.":[184]},"counts_by_year":[],"updated_date":"2026-07-01T06:00:48.157686","created_date":"2025-10-10T00:00:00"}