{"id":"https://openalex.org/W4403364987","doi":"https://doi.org/10.48550/arxiv.2410.07890","title":"Identifying latent disease factors differently expressed in patient subgroups using group factor analysis","display_name":"Identifying latent disease factors differently expressed in patient subgroups using group factor analysis","publication_year":2024,"publication_date":"2024-10-10","ids":{"openalex":"https://openalex.org/W4403364987","doi":"https://doi.org/10.48550/arxiv.2410.07890"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2410.07890","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2410.07890","pdf_url":"https://arxiv.org/pdf/2410.07890","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2410.07890","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023094191","display_name":"F\u00e1bio S. Ferreira","orcid":"https://orcid.org/0000-0002-0977-2539"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ferreira, Fabio S.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029410349","display_name":"John Ashburner","orcid":"https://orcid.org/0000-0001-7605-2518"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashburner, John","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057656507","display_name":"Arabella Bouzigues","orcid":"https://orcid.org/0000-0002-0267-8590"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bouzigues, Arabella","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111396877","display_name":"Chatrin Suksasilp","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suksasilp, Chatrin","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068882196","display_name":"Lucy L. Russell","orcid":"https://orcid.org/0000-0001-5023-5893"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russell, Lucy L.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055260337","display_name":"Phoebe H. Foster","orcid":"https://orcid.org/0000-0001-6300-6598"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Foster, Phoebe H.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040586642","display_name":"Eve Ferry\u2010Bolder","orcid":"https://orcid.org/0009-0006-5083-0901"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferry-Bolder, Eve","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006096323","display_name":"John C. van Swieten","orcid":"https://orcid.org/0000-0001-6278-6844"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"van Swieten, John C.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060633478","display_name":"Lize C. Jiskoot","orcid":"https://orcid.org/0000-0002-1120-1858"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiskoot, Lize C.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049091731","display_name":"Harro Seelaar","orcid":"https://orcid.org/0000-0003-1989-7527"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seelaar, Harro","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047159861","display_name":"Raquel S\u00e1nchez\u2010Valle","orcid":"https://orcid.org/0000-0001-7750-896X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanchez-Valle, Raquel","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086819795","display_name":"Robert Laforce","orcid":"https://orcid.org/0000-0002-2031-490X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laforce, Robert","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012540754","display_name":"Caroline Graff","orcid":"https://orcid.org/0000-0002-9949-2951"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graff, Caroline","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081436063","display_name":"Daniela Galimberti","orcid":"https://orcid.org/0000-0002-9284-5953"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galimberti, Daniela","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071341444","display_name":"Rik Vandenberghe","orcid":"https://orcid.org/0000-0001-6237-2502"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vandenberghe, Rik","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039110327","display_name":"Alexandre de Mendon\u00e7a","orcid":"https://orcid.org/0000-0002-0488-1453"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"de Mendonca, Alexandre","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052325805","display_name":"Pietro Tiraboschi","orcid":"https://orcid.org/0000-0002-2171-1720"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiraboschi, Pietro","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060131002","display_name":"Isabel Santana","orcid":"https://orcid.org/0000-0002-8114-9434"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santana, Isabel","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026422297","display_name":"Alexander Gerhard","orcid":"https://orcid.org/0000-0002-8071-6062"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerhard, Alexander","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035514608","display_name":"Johannes Levin","orcid":"https://orcid.org/0000-0001-5092-4306"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levin, Johannes","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011011071","display_name":"Sandro Sorbi","orcid":"https://orcid.org/0000-0002-0380-6670"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sorbi, Sandro","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071308068","display_name":"Markus Otto","orcid":"https://orcid.org/0000-0003-4273-4267"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Otto, Markus","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055524428","display_name":"Florence Pasquier","orcid":"https://orcid.org/0000-0001-9880-9788"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pasquier, Florence","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108040638","display_name":"Simon Ducharme","orcid":"https://orcid.org/0000-0002-7309-1113"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ducharme, Simon","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028560179","display_name":"Christopher Butler","orcid":"https://orcid.org/0000-0002-7502-9284"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Butler, Chris R.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042566383","display_name":"Isabelle Le Ber","orcid":"https://orcid.org/0000-0002-2508-5181"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ber, Isabelle Le","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072242679","display_name":"Elizabeth Finger","orcid":"https://orcid.org/0000-0003-4461-7427"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Finger, Elizabeth","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015941834","display_name":"Maria Carmela Tartaglia","orcid":"https://orcid.org/0000-0002-5944-8497"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tartaglia, Maria C.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085497748","display_name":"Mario Masellis","orcid":"https://orcid.org/0000-0002-6244-2096"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masellis, Mario","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025003387","display_name":"James B. Rowe","orcid":"https://orcid.org/0000-0001-7216-8679"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rowe, James B.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031917279","display_name":"Matthis Synofzik","orcid":"https://orcid.org/0000-0002-2280-7273"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Synofzik, Matthis","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086774103","display_name":"Ferm\u00edn Moreno","orcid":"https://orcid.org/0000-0001-5200-3164"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moreno, Fermin","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090580473","display_name":"Barbara Borroni","orcid":"https://orcid.org/0000-0001-9340-9814"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Borroni, Barbara","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018305257","display_name":"Samuel Kaski","orcid":"https://orcid.org/0000-0003-1925-9154"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaski, Samuel","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070348432","display_name":"Jonathan D. Rohrer","orcid":"https://orcid.org/0000-0002-6155-8417"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohrer, Jonathan D.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036416110","display_name":"Jana\u0131\u0301na Mour\u00e3o-Miranda","orcid":"https://orcid.org/0000-0002-3309-8441"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mourao-Miranda, Janaina","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":36,"corresponding_author_ids":["https://openalex.org/A5023094191"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13748","display_name":"Advanced Statistical Modeling Techniques","score":0.2094999998807907,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13748","display_name":"Advanced Statistical Modeling Techniques","score":0.2094999998807907,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor","display_name":"Factor (programming language)","score":0.549445629119873},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5247806906700134},{"id":"https://openalex.org/keywords/group","display_name":"Group (periodic table)","score":0.5028592944145203},{"id":"https://openalex.org/keywords/latent-class-model","display_name":"Latent class model","score":0.45666366815567017},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3401336669921875},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.336273193359375},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26780965924263},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21633458137512207},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20938414335250854},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.20164966583251953},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08358460664749146}],"concepts":[{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.549445629119873},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5247806906700134},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.5028592944145203},{"id":"https://openalex.org/C70727504","wikidata":"https://www.wikidata.org/wiki/Q1806878","display_name":"Latent class model","level":2,"score":0.45666366815567017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3401336669921875},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.336273193359375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26780965924263},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21633458137512207},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20938414335250854},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.20164966583251953},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08358460664749146},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2410.07890","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2410.07890","pdf_url":"https://arxiv.org/pdf/2410.07890","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"doi:10.48550/arxiv.2410.07890","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2410.07890","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2410.07890","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2410.07890","pdf_url":"https://arxiv.org/pdf/2410.07890","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403364987.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2495310989","https://openalex.org/W2931662336","https://openalex.org/W2077865380","https://openalex.org/W4401768695","https://openalex.org/W2765597752","https://openalex.org/W2134894512","https://openalex.org/W2083375246","https://openalex.org/W2067108088"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3],"propose":[4],"a":[5],"novel":[6],"approach":[7],"to":[8,89,192],"uncover":[9,55],"subgroup-specific":[10,194],"and":[11,24,33,53,84,128,145,152,182,209,220,226],"subgroup-common":[12],"latent":[13,58,82,112,123,131,137,167,212],"factors":[14,83,114,124,132,139,168,214],"addressing":[15],"the":[16,20,73,90,108,118,156,173,189,199,218],"challenges":[17],"posed":[18],"by":[19,79],"heterogeneity":[21],"of":[22,75,201,222],"neurological":[23,225],"mental":[25,227],"disorders,":[26],"which":[27,97],"hinder":[28],"disease":[29,113,138,153,163,213],"understanding,":[30],"treatment":[31],"development,":[32],"outcome":[34],"prediction.":[35],"The":[36,136],"proposed":[37],"approach,":[38],"sparse":[39,77,109,202],"Group":[40],"Factor":[41],"Analysis":[42],"(GFA)":[43],"with":[44,50,100,104,224],"regularised":[45],"horseshoe":[46],"priors,":[47],"was":[48],"implemented":[49],"probabilistic":[51],"programming":[52],"can":[54,216],"associations":[56,141],"(or":[57],"factors)":[59],"among":[60],"multiple":[61,206],"data":[62,70,207],"modalities":[63,208],"differentially":[64,115],"expressed":[65,116],"in":[66,172],"sample":[67],"subgroups.":[68,135],"Synthetic":[69],"experiments":[71],"showed":[72],"robustness":[74],"our":[76],"GFA":[78,110,203],"correctly":[80],"inferring":[81],"model":[85],"parameters.":[86],"When":[87],"applied":[88],"Genetic":[91],"Frontotemporal":[92],"Dementia":[93],"Initiative":[94],"(GENFI)":[95],"dataset,":[96],"comprises":[98],"patients":[99,223],"frontotemporal":[101],"dementia":[102],"(FTD)":[103],"genetically":[105],"defined":[106],"subgroups,":[107,119,159],"identified":[111],"across":[117,134,155],"distinguishing":[120],"between":[121,142],"\"subgroup-specific\"":[122],"within":[125],"homogeneous":[126,176],"groups":[127],"\"subgroup":[129],"common\"":[130],"shared":[133],"captured":[140],"brain":[143],"structure":[144],"non-imaging":[146],"variables":[147],"(i.e.,":[148],"questionnaires":[149],"assessing":[150],"behaviour":[151],"severity)":[154],"different":[157],"genetic":[158],"offering":[160],"insights":[161],"into":[162],"profiles.":[164],"Importantly,":[165],"two":[166,174],"were":[169],"more":[170,175],"pronounced":[171],"FTD":[177],"patient":[178],"subgroups":[179],"(progranulin":[180],"(GRN)":[181],"microtubule-associated":[183],"protein":[184],"tau":[185],"(MAPT)":[186],"mutation),":[187],"showcasing":[188],"method's":[190],"ability":[191],"reveal":[193],"characteristics.":[195],"These":[196],"findings":[197],"underscore":[198],"potential":[200],"for":[204],"integrating":[205],"identifying":[210],"interpretable":[211],"that":[215],"improve":[217],"characterization":[219],"stratification":[221],"health":[228],"disorders.":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2024-10-13T00:00:00"}