{"id":"https://openalex.org/W4403752390","doi":"https://doi.org/10.48550/arxiv.2409.13791","title":"Multi-omics data integration for early diagnosis of hepatocellular carcinoma (HCC) using machine learning","display_name":"Multi-omics data integration for early diagnosis of hepatocellular carcinoma (HCC) using machine learning","publication_year":2024,"publication_date":"2024-09-20","ids":{"openalex":"https://openalex.org/W4403752390","doi":"https://doi.org/10.48550/arxiv.2409.13791"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2409.13791","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2409.13791","pdf_url":"https://arxiv.org/pdf/2409.13791","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2409.13791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023792790","display_name":"Annette Spooner","orcid":"https://orcid.org/0000-0002-5705-0602"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Spooner, Annette","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005208666","display_name":"Mohammad Karimi Moridani","orcid":"https://orcid.org/0000-0003-0793-3797"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moridani, Mohammad Karimi","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001525349","display_name":"Azadeh Safarchi","orcid":"https://orcid.org/0000-0002-9112-939X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Safarchi, Azadeh","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004735573","display_name":"Salim Maher","orcid":"https://orcid.org/0000-0002-2579-5925"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maher, Salim","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090363651","display_name":"Fatemeh Vafaee","orcid":"https://orcid.org/0000-0002-7521-2417"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vafaee, Fatemeh","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045169514","display_name":"Amany Zekry","orcid":"https://orcid.org/0000-0002-5675-1810"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zekry, Amany","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055952724","display_name":"Arcot Sowmya","orcid":"https://orcid.org/0000-0001-9236-5063"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sowmya, Arcot","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023792790"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8906999826431274,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8906999826431274,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8655999898910522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.8338000178337097,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.870322585105896},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.6307817697525024},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4432600736618042},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4149315059185028},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3295040428638458},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32498329877853394},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.30235448479652405},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29101964831352234},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24251121282577515}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.870322585105896},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.6307817697525024},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4432600736618042},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4149315059185028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3295040428638458},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32498329877853394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30235448479652405},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29101964831352234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24251121282577515}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2409.13791","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2409.13791","pdf_url":"https://arxiv.org/pdf/2409.13791","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2409.13791","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2409.13791","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2409.13791","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2409.13791","pdf_url":"https://arxiv.org/pdf/2409.13791","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403752390.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W2404951810","https://openalex.org/W2800415451","https://openalex.org/W2337719538"],"abstract_inverted_index":{"The":[0,84],"complementary":[1],"information":[2],"found":[3],"in":[4,12],"different":[5,82],"modalities":[6,124],"of":[7,16,25,30,36,64,67,75,78,136,139,191,201,229,235,247],"patient":[8],"data":[9,39,80,156],"can":[10],"aid":[11],"more":[13],"accurate":[14],"modelling":[15],"a":[17,22,31,65,93,102,106,111,114,118,133,137,149,189,198,215],"patient's":[18],"disease":[19,178],"state":[20],"and":[21,46,52,87,98,117,132,175,205,212,232],"better":[23],"understanding":[24],"the":[26,34,62,123,129,181,184,219,227,233,236,245],"underlying":[27],"biological":[28],"processes":[29],"disease.":[32],"However,":[33],"analysis":[35],"multi-modal,":[37],"multi-omics":[38],"presents":[40],"many":[41],"challenges,":[42],"including":[43],"high":[44],"dimensionality":[45],"varying":[47],"size,":[48],"statistical":[49],"distribution,":[50],"scale":[51],"signal":[53],"strength":[54],"between":[55],"modalities.":[56,83],"In":[57],"this":[58],"work":[59],"we":[60,193,241],"compare":[61],"performance":[63,192,199],"variety":[66],"ensemble":[68,85],"machine":[69],"learning":[70],"algorithms":[71],"that":[72,196,207],"are":[73],"capable":[74],"late":[76],"integration":[77,246],"multi-class":[79,249],"from":[81,157,172],"methods":[86,154],"their":[88],"variations":[89],"tested":[90],"were":[91,143,218],"i)":[92],"voting":[94],"ensemble,":[95],"with":[96,166,214],"hard":[97,112],"soft":[99,115,216],"vote,":[100,113],"ii)":[101],"meta":[103,119],"learner,":[104],"iii)":[105],"multi-modal":[107,248],"Adaboost":[108,213],"model":[109,131],"using":[110,155],"vote":[116,217],"learner":[120],"to":[121,145,203],"integrate":[122],"on":[125,161,170],"each":[126],"boosting":[127],"round,":[128],"PB-MVBoost":[130,211],"novel":[134],"application":[135],"mixture":[138],"experts":[140],"model.":[141],"These":[142],"compared":[144],"simple":[146],"concatenation":[147],"as":[148,188],"baseline.":[150],"We":[151,224],"examine":[152,226],"these":[153],"an":[158],"in-house":[159],"study":[160],"hepatocellular":[162],"carcinoma":[163],"(HCC),":[164],"along":[165],"four":[167],"validation":[168],"datasets":[169],"studies":[171],"breast":[173],"cancer":[174],"irritable":[176],"bowel":[177],"(IBD).":[179],"Using":[180],"area":[182],"under":[183],"receiver":[185],"operating":[186],"curve":[187],"measure":[190],"develop":[194],"models":[195],"achieve":[197],"value":[200],"up":[202],"0.85":[204],"find":[206],"two":[208],"boosted":[209],"methods,":[210],"overall":[220],"best":[221],"performing":[222],"models.":[223],"also":[225],"stability":[228],"features":[230],"selected,":[231],"size":[234],"clinical":[237],"signature":[238],"determined.":[239],"Finally,":[240],"provide":[242],"recommendations":[243],"for":[244],"data.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}
