{"id":"https://openalex.org/W4396881541","doi":"https://doi.org/10.48550/arxiv.2405.05980","title":"Overcoming challenges of translating deep-learning models for glioblastoma: the ZGBM consortium","display_name":"Overcoming challenges of translating deep-learning models for glioblastoma: the ZGBM consortium","publication_year":2024,"publication_date":"2024-05-07","ids":{"openalex":"https://openalex.org/W4396881541","doi":"https://doi.org/10.48550/arxiv.2405.05980"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2405.05980","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2405.05980","pdf_url":"https://arxiv.org/pdf/2405.05980","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2405.05980","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090413585","display_name":"Haris Shuaib","orcid":"https://orcid.org/0000-0001-6975-5960"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuaib, Haris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079179983","display_name":"Gareth J. Barker","orcid":"https://orcid.org/0000-0002-5214-7421"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barker, Gareth J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025868896","display_name":"Peter Sasieni","orcid":"https://orcid.org/0000-0003-1509-8744"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sasieni, Peter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036521896","display_name":"Enrico De Vita","orcid":"https://orcid.org/0000-0001-8068-1288"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De Vita, Enrico","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048217578","display_name":"Alysha Chelliah","orcid":"https://orcid.org/0000-0003-0867-1565"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chelliah, Alysha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034620211","display_name":"Andrei Roman","orcid":"https://orcid.org/0000-0001-5340-5325"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrei, Roman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113965941","display_name":"Keyoumars Ashkan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashkan, Keyoumars","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085920118","display_name":"Erica Beaumont","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beaumont, Erica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113052338","display_name":"Lucy Brazil","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brazil, Lucy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034657735","display_name":"Chris Rowland-Hill","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rowland-Hill, Chris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068457058","display_name":"Yue Hui Lau","orcid":"https://orcid.org/0000-0003-0558-4095"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lau, Yue Hui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040046638","display_name":"Aysha Luis","orcid":"https://orcid.org/0000-0001-5493-099X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis, Aysha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005950432","display_name":"James Powell","orcid":"https://orcid.org/0000-0002-3517-7485"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Powell, James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035405270","display_name":"Angela Swampillai","orcid":"https://orcid.org/0000-0003-1984-3633"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swampillai, Angela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084675546","display_name":"Sean Tenant","orcid":"https://orcid.org/0000-0003-4005-4663"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tenant, Sean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001240653","display_name":"Stefanie Thust","orcid":"https://orcid.org/0000-0001-5136-6000"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thust, Stefanie C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069635447","display_name":"Stephen Wastling","orcid":"https://orcid.org/0000-0003-4648-9932"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wastling, Stephen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112881223","display_name":"Tom Young","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young, Tom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003607819","display_name":"Thomas C. Booth","orcid":"https://orcid.org/0000-0003-0984-3998"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Booth, Thomas C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9462000131607056,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9391999840736389,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.7672955393791199},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5513696670532227},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5294777154922485},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4762156903743744},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.34538060426712036},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3221997618675232},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20023909211158752},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.15104982256889343}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7672955393791199},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5513696670532227},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5294777154922485},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4762156903743744},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.34538060426712036},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3221997618675232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20023909211158752},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15104982256889343}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:arXiv.org:2405.05980","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2405.05980","pdf_url":"https://arxiv.org/pdf/2405.05980","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:nottingham-repository.worktribe.com:48976455","is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/48976455","pdf_url":"https://nottingham-repository.worktribe.com/file/48976455/1/2405.05980v1","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"submittedVersion"},{"id":"doi:10.48550/arxiv.2405.05980","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2405.05980","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2405.05980","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2405.05980","pdf_url":"https://arxiv.org/pdf/2405.05980","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1938145382","display_name":null,"funder_award_id":"WT 203148/Z/16/Z","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5296857752","display_name":null,"funder_award_id":"203148/Z/16/Z","funder_id":"https://openalex.org/F4320337314","funder_display_name":"Centre For Medical Engineering, King\u2019s College London"},{"id":"https://openalex.org/G8215791725","display_name":null,"funder_award_id":"WT 203148/Z/16/Z","funder_id":"https://openalex.org/F4320320285","funder_display_name":"King's College London"},{"id":"https://openalex.org/G8303168876","display_name":null,"funder_award_id":"WT 203148/Z/16/","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8775246936","display_name":null,"funder_award_id":"203148/Z/16/Z","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8787748348","display_name":null,"funder_award_id":"203148/Z/16/Z","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G961285871","display_name":null,"funder_award_id":"WT 203148/Z/16/Z","funder_id":"https://openalex.org/F4320337314","funder_display_name":"Centre For Medical Engineering, King\u2019s College London"}],"funders":[{"id":"https://openalex.org/F4320312714","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794"},{"id":"https://openalex.org/F4320313309","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48"},{"id":"https://openalex.org/F4320314693","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03"},{"id":"https://openalex.org/F4320315882","display_name":"University Hospitals Plymouth NHS Trust","ror":"https://ror.org/05x3jck08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320284","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320320298","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33"},{"id":"https://openalex.org/F4320320324","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58"},{"id":"https://openalex.org/F4320320325","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656"},{"id":"https://openalex.org/F4320330053","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":null},{"id":"https://openalex.org/F4320330329","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320337314","display_name":"Centre For Medical Engineering, King\u2019s College London","ror":"https://ror.org/04s9kfd63"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396881541.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W3215138031","https://openalex.org/W3009238340","https://openalex.org/W4321369474","https://openalex.org/W4360585206","https://openalex.org/W4285208911","https://openalex.org/W3082895349","https://openalex.org/W4213079790","https://openalex.org/W2248239756","https://openalex.org/W4323565446"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"report":[2],"imaging":[3,33,49,87,95,114,124,132,155,178,190],"protocol":[4,133],"and":[5,35,74,134,192],"scheduling":[6,135],"variance":[7],"in":[8,14,23,99,108,164],"routine":[9],"care":[10,25],"of":[11,19,42,57,68,168],"glioblastoma":[12,24],"patients":[13,59],"order":[15],"to":[16,28,38,83,143,185],"demonstrate":[17],"challenges":[18],"integrating":[20],"deep-learning":[21,45,169],"models":[22,146,170],"pathways.":[26],"Additionally,":[27],"understand":[29,84],"the":[30,40,61,69,100,104,120,138],"most":[31,121,158],"common":[32,122],"studies":[34],"image":[36],"contrasts":[37],"inform":[39],"development":[41],"potentially":[43],"robust":[44],"models.":[46],"Methods:":[47],"MR":[48],"data":[50,76],"were":[51,81],"analysed":[52,82],"from":[53,60],"a":[54],"random":[55],"sample":[56],"five":[58,65],"prospective":[62],"cohort":[63],"across":[64,137,160],"participating":[66],"sites":[67,91,110],"ZGBM":[70],"consortium.":[71],"Reported":[72],"clinical":[73],"treatment":[75,85],"alongside":[77],"DICOM":[78],"header":[79],"information":[80],"pathway":[86,101],"schedules.":[88,193],"Results:":[89],"All":[90],"perform":[92,149],"all":[93,161],"structural":[94,176],"at":[96,127,151],"every":[97,128],"stage":[98],"except":[102],"for":[103],"presurgical":[105],"study,":[106],"where":[107],"some":[109],"only":[111],"contrast-enhanced":[112],"T1-weighted":[113],"is":[115,119,156,181],"performed.":[116],"Diffusion":[117],"MRI":[118],"non-structural":[123,187],"type,":[125],"performed":[126,157],"site.":[129],"Conclusion:":[130],"The":[131],"varies":[136],"UK,":[139],"making":[140],"it":[141],"challenging":[142],"develop":[144],"machine-learning":[145],"that":[147],"could":[148],"robustly":[150],"other":[152],"centres.":[153,162],"Structural":[154],"consistently":[159],"Advances":[163],"knowledge:":[165],"Successful":[166],"translation":[167],"will":[171],"likely":[172],"be":[173],"based":[174],"on":[175],"post-treatment":[177],"unless":[179],"there":[180],"significant":[182],"effort":[183],"made":[184],"standardise":[186],"or":[188],"peri-operative":[189],"protocols":[191]},"counts_by_year":[],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2024-05-14T00:00:00"}