{"id":"https://openalex.org/W4392538656","doi":"https://doi.org/10.48550/arxiv.2403.03018","title":"CRISPR: Ensemble Model","display_name":"CRISPR: Ensemble Model","publication_year":2024,"publication_date":"2024-03-05","ids":{"openalex":"https://openalex.org/W4392538656","doi":"https://doi.org/10.48550/arxiv.2403.03018"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2403.03018","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2403.03018","pdf_url":"https://arxiv.org/pdf/2403.03018","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2403.03018","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101313937","display_name":"Rostami Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Rostami, Mohammad","raw_affiliation_strings":["Department of Mathematics Sharif University of Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics Sharif University of Tech","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094087191","display_name":"Amin Ghariyazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghariyazi, Amin","raw_affiliation_strings":["Department of Computer Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062640830","display_name":"Hamed Dashti","orcid":"https://orcid.org/0000-0003-0399-0524","observed_orcids":["https://orcid.org/0000-0003-0399-0524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dashti, Hamed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041967349","display_name":"Mohammad Hossein Rohban","orcid":"https://orcid.org/0000-0001-6589-850X","observed_orcids":["https://orcid.org/0000-0001-6589-850X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohban, Mohammad Hossein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063512925","display_name":"Hamid Reza Rabiee","orcid":"https://orcid.org/0000-0002-9835-4493","observed_orcids":["https://orcid.org/0000-0002-9835-4493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabiee, Hamid R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.9070000052452087},{"id":"https://openalex.org/keywords/single-guide-rna-design","display_name":"single guide RNA design","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ensemble-learning","display_name":"ensemble learning","score":0.9950000047683716},{"id":"https://openalex.org/keywords/generalizability","display_name":"generalizability","score":0.6919999718666077},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.823022186756134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47459930181503296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24350294470787048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13879680633544922},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2403.03018","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2403.03018","pdf_url":"https://arxiv.org/pdf/2403.03018","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2403.03018","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2403.03018","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2403.03018","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2403.03018","pdf_url":"https://arxiv.org/pdf/2403.03018","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392538656.pdf","grobid_xml":"https://content.openalex.org/works/W4392538656.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4293199045","https://openalex.org/W2405656580","https://openalex.org/W3162049976","https://openalex.org/W2642604616","https://openalex.org/W4381712632","https://openalex.org/W3163009052","https://openalex.org/W4365936098","https://openalex.org/W3029656231","https://openalex.org/W3116547599"],"abstract_inverted_index":{"Clustered":[0],"Regularly":[1],"Interspaced":[2],"Short":[3],"Palindromic":[4],"Repeats":[5],"(CRISPR)":[6],"is":[7,29,42,75],"a":[8,66,91,103,120,187],"gene":[9],"editing":[10],"technology":[11],"that":[12,74,128,143],"has":[13],"revolutionized":[14],"the":[15,24,31,82,110,169],"fields":[16],"of":[17,23,26,37,84,106,112,123,135,172,189],"biology":[18],"and":[19,34,55,77,126,138,155,183],"medicine.":[20],"However,":[21],"one":[22],"challenges":[25],"using":[27],"CRISPR":[28],"predicting":[30],"on-target":[32],"efficacy":[33],"off-target":[35],"sensitivity":[36,154],"single-guide":[38],"RNAs":[39],"(sgRNAs).":[40],"This":[41,96,163],"because":[43],"most":[44],"existing":[45,131],"methods":[46,132],"are":[47],"trained":[48],"on":[49,119],"separate":[50],"datasets":[51],"with":[52,152],"different":[53],"genes":[54,160],"cells,":[56],"which":[57,108],"limits":[58],"their":[59],"generalizability.":[60,139],"In":[61],"this":[62],"paper,":[63],"we":[64],"propose":[65],"novel":[67],"ensemble":[68],"learning":[69,87],"method":[70,80,118,145],"for":[71,158,168,186],"sgRNA":[72,124],"design":[73,150,180],"accurate":[76],"generalizable.":[78],"Our":[79,140],"combines":[81],"predictions":[83],"multiple":[85],"machine":[86],"models":[88],"to":[89,100,149,179],"produce":[90],"single,":[92],"more":[93,181],"robust":[94],"prediction.":[95],"approach":[97],"allows":[98],"us":[99],"learn":[101],"from":[102],"wider":[104],"range":[105],"data,":[107],"improves":[109],"generalizability":[111],"our":[113,117,144],"model.":[114],"We":[115],"evaluated":[116],"benchmark":[121],"dataset":[122],"designs":[125],"found":[127],"it":[129,175],"outperformed":[130],"in":[133],"terms":[134],"both":[136],"accuracy":[137],"results":[141],"suggest":[142],"can":[146],"be":[147],"used":[148],"sgRNAs":[151],"high":[153],"specificity,":[156],"even":[157],"new":[159],"or":[161],"cells.":[162],"could":[164],"have":[165],"important":[166],"implications":[167],"clinical":[170],"use":[171],"CRISPR,":[173],"as":[174],"would":[176],"allow":[177],"researchers":[178],"effective":[182],"safer":[184],"treatments":[185],"variety":[188],"diseases.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-30T09:27:27.532063","created_date":"2025-10-10T00:00:00"}
