{"id":"https://openalex.org/W4386185362","doi":"https://doi.org/10.48550/arxiv.2308.12736","title":"FastSurfer-HypVINN: Automated sub-segmentation of the hypothalamus and adjacent structures on high-resolutional brain MRI","display_name":"FastSurfer-HypVINN: Automated sub-segmentation of the hypothalamus and adjacent structures on high-resolutional brain MRI","publication_year":2023,"publication_date":"2023-08-24","ids":{"openalex":"https://openalex.org/W4386185362","doi":"https://doi.org/10.48550/arxiv.2308.12736"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2308.12736","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2308.12736","pdf_url":"https://arxiv.org/pdf/2308.12736","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2308.12736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042469943","display_name":"Santiago Estrada","orcid":"https://orcid.org/0000-0003-0339-8870"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Estrada, Santiago","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088046686","display_name":"David K\u00fcgler","orcid":"https://orcid.org/0000-0002-4101-819X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K\u00fcgler, David","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034523504","display_name":"Emad Bahrami","orcid":"https://orcid.org/0000-0003-1694-4199"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bahrami, Emad","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101773658","display_name":"Peng Xu","orcid":"https://orcid.org/0000-0001-6205-2808"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu, Peng","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092698840","display_name":"Dilshad Mousa","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mousa, Dilshad","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070946697","display_name":"Monique M.B. Breteler","orcid":"https://orcid.org/0000-0002-0626-9305"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Breteler, Monique M. B.","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054125078","display_name":"N. Ahmad Aziz","orcid":"https://orcid.org/0000-0001-6184-458X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aziz, N. Ahmad","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045017963","display_name":"Martin Reuter","orcid":"https://orcid.org/0000-0002-2665-9693"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reuter, Martin","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5042469943"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10699","display_name":"Primate Behavior and Ecology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10699","display_name":"Primate Behavior and Ecology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9472000002861023,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generalizability-theory","display_name":"Generalizability theory","score":0.8708475828170776},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7757294178009033},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6427025198936462},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5866775512695312},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5446656346321106},{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.48680636286735535},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4755532443523407},{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.44107386469841003},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4050676226615906},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.33921152353286743},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.18827718496322632},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1458563506603241},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11409103870391846}],"concepts":[{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.8708475828170776},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7757294178009033},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6427025198936462},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5866775512695312},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5446656346321106},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.48680636286735535},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4755532443523407},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.44107386469841003},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4050676226615906},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33921152353286743},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18827718496322632},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1458563506603241},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11409103870391846},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2308.12736","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2308.12736","pdf_url":"https://arxiv.org/pdf/2308.12736","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"doi:10.48550/arxiv.2308.12736","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2308.12736","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2308.12736","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2308.12736","pdf_url":"https://arxiv.org/pdf/2308.12736","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386185362.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4254851101","https://openalex.org/W3171007296","https://openalex.org/W22115721","https://openalex.org/W2118717649","https://openalex.org/W2413243053","https://openalex.org/W410723623","https://openalex.org/W2015341305","https://openalex.org/W2211931904","https://openalex.org/W2035068594","https://openalex.org/W4225593417"],"abstract_inverted_index":{"The":[0,165],"hypothalamus":[1,61,122],"plays":[2],"a":[3,10,24,63,77,107,239,255],"crucial":[4],"role":[5],"in":[6,214,236,246],"the":[7,36,53,60,121,186,198,209,223,227,234,247,266],"regulation":[8],"of":[9,13,38,49,120,200,211,265],"broad":[11],"range":[12],"physiological,":[14],"behavioural,":[15],"and":[16,46,96,110,123,131,156,226,242,258],"cognitive":[17],"functions.":[18],"However,":[19],"despite":[20],"its":[21,31],"importance,":[22],"only":[23,54],"few":[25],"small-scale":[26],"neuroimaging":[27,251],"studies":[28],"have":[29],"investigated":[30],"substructures,":[32],"likely":[33],"due":[34],"to":[35,43,57,83,139,149,158,189],"lack":[37],"fully":[39,111],"automated":[40,81,112],"segmentation":[41,150,170,235],"tools":[42],"address":[44],"scalability":[45],"reproducibility":[47],"issues":[48],"manual":[50],"segmentation.":[51],"While":[52],"previous":[55],"attempt":[56],"automatically":[58],"sub-segment":[59,84],"with":[62,147,185,203,216],"neural":[64],"network":[65],"showed":[66],"promise":[67],"for":[68,79,118,173,180,261],"1.0":[69,217],"mm":[70,128,218],"isotropic":[71,129],"T1-weighted":[72],"(T1w)":[73],"MRI,":[74],"there":[75],"is":[76,137],"need":[78],"an":[80],"tool":[82],"also":[85,100],"high-resolutional":[86],"(HiRes)":[87],"MR":[88,134,219],"scans,":[89],"as":[90,177,179],"they":[91],"are":[92],"becoming":[93],"widely":[94],"available,":[95],"include":[97],"structural":[98],"detail":[99],"from":[101,221],"multi-modal":[102],"MRI.":[103],"We,":[104,206],"therefore,":[105],"introduce":[106],"novel,":[108],"fast,":[109],"deep":[113],"learning":[114],"method":[115,167,213],"named":[116],"HypVINN":[117,231],"sub-segmentation":[119],"adjacent":[124],"structures":[125],"on":[126],"0.8":[127],"T1w":[130,175],"T2w":[132],"brain":[133],"images":[135,176],"that":[136],"robust":[138],"missing":[140],"modalities.":[141],"We":[142],"extensively":[143],"validate":[144],"our":[145,193,212],"model":[146,194],"respect":[148],"accuracy,":[151],"generalizability,":[152],"in-session":[153],"test-retest":[154],"reliability,":[155],"sensitivity":[157],"replicate":[159],"hypothalamic":[160],"volume":[161],"effects":[162],"(e.g.":[163],"sex-differences).":[164],"proposed":[166],"exhibits":[168],"high":[169],"performance":[171,199],"both":[172,222],"standalone":[174],"well":[178],"T1w/T2w":[181],"image":[182],"pairs.":[183],"Even":[184],"additional":[187],"capability":[188],"accept":[190],"flexible":[191],"inputs,":[192],"matches":[195],"or":[196],"exceeds":[197],"state-of-the-art":[201],"methods":[202],"fixed":[204],"inputs.":[205],"further,":[207],"demonstrate":[208],"generalizability":[210],"experiments":[215],"scans":[220],"Rhineland":[224],"Study":[225],"UK":[228],"Biobank.":[229],"Finally,":[230],"can":[232],"perform":[233],"less":[237],"than":[238],"minute":[240],"(GPU)":[241],"will":[243],"be":[244],"available":[245],"open":[248],"source":[249],"FastSurfer":[250],"software":[252],"suite,":[253],"offering":[254],"validated,":[256],"efficient,":[257],"scalable":[259],"solution":[260],"evaluating":[262],"imaging-derived":[263],"phenotypes":[264],"hypothalamus.":[267]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-02-09T09:26:11.010843","created_date":"2025-10-10T00:00:00"}