{"id":"https://openalex.org/W4289433359","doi":"https://doi.org/10.48550/arxiv.2207.14294","title":"Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome","display_name":"Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome","publication_year":2022,"publication_date":"2022-07-28","ids":{"openalex":"https://openalex.org/W4289433359","doi":"https://doi.org/10.48550/arxiv.2207.14294"},"language":"en","primary_location":{"id":"doi:10.48550/arxiv.2207.14294","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2207.14294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2207.14294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031147343","display_name":"Tiffany J. Callahan","orcid":"https://orcid.org/0000-0002-8169-9049"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Callahan, Tiffany J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034793798","display_name":"Adrianne L. Stefanski","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanski, Adrianne L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063923711","display_name":"Jin-Dong Kim","orcid":"https://orcid.org/0000-0001-9660-6303"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, Jin-Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030261399","display_name":"William A. Baumgartner","orcid":"https://orcid.org/0000-0001-6717-5313"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baumgartner, William A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035907836","display_name":"Jordan M Wyrwa","orcid":"https://orcid.org/0000-0002-5455-5859"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wyrwa, Jordan M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041860080","display_name":"Lawrence Hunter","orcid":"https://orcid.org/0000-0003-1455-3370"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hunter, Lawrence E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"Preeclampsia","score":0.8856891393661499},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6389048099517822},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5368638038635254},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4599967896938324},{"id":"https://openalex.org/keywords/placenta","display_name":"Placenta","score":0.4521326422691345},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4196321666240692},{"id":"https://openalex.org/keywords/pregnancy","display_name":"Pregnancy","score":0.3800751864910126},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3559987545013428},{"id":"https://openalex.org/keywords/fetus","display_name":"Fetus","score":0.3445735573768616},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3424985408782959},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2108527421951294},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1540636420249939}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.8856891393661499},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6389048099517822},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5368638038635254},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4599967896938324},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.4521326422691345},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4196321666240692},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3800751864910126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3559987545013428},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3445735573768616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3424985408782959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2108527421951294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1540636420249939}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2207.14294","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2207.14294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2207.14294","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2207.14294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1520675682","https://openalex.org/W2167244209","https://openalex.org/W2411259789","https://openalex.org/W2902115400","https://openalex.org/W2090583597","https://openalex.org/W2389974487","https://openalex.org/W2412883775","https://openalex.org/W2364920504","https://openalex.org/W271579791","https://openalex.org/W4296025728"],"abstract_inverted_index":{"Preeclampsia":[0,98],"is":[1,19,25],"a":[2,78,106,141,160],"leading":[3],"cause":[4],"of":[5,17,21,30,35,72,103,109,124,137,151,194,216],"maternal":[6],"and":[7,10,112,147,179,190,219,246],"fetal":[8],"morbidity":[9],"mortality.":[11],"Currently,":[12],"the":[13,22,28,31,88,91,96,192,217,225,231,235],"only":[14,113],"definitive":[15,115],"treatment":[16],"preeclampsia":[18,42,171,204,232],"delivery":[20],"placenta,":[23],"which":[24,74,82,121],"central":[26],"to":[27,47,55,67,87,133,144,168,188,237],"pathogenesis":[29],"disease.":[32,153],"Transcriptional":[33],"profiling":[34,184],"human":[36],"placenta":[37],"from":[38,128,207],"pregnancies":[39],"complicated":[40],"by":[41,61],"has":[43,99],"been":[44],"extensively":[45],"performed":[46],"identify":[48,169,189],"differentially":[49],"expressed":[50],"genes":[51,201],"(DEGs).":[52],"The":[53,213],"decisions":[54],"investigate":[56,238],"DEGs":[57,66,73,228,240],"experimentally":[58],"are":[59,75,93,122],"biased":[60],"many":[62,65,129],"factors,":[63],"causing":[64],"remain":[68],"uninvestigated.":[69],"A":[70],"set":[71],"associated":[76,202],"with":[77,203],"disease":[79,89],"experimentally,":[80],"but":[81],"have":[83],"no":[84],"known":[85,94],"association":[86],"in":[90,131],"literature":[92],"as":[95,224],"ignorome.":[97,233],"an":[100],"extensive":[101],"body":[102],"scientific":[104],"literature,":[105],"large":[107],"pool":[108],"DEG":[110],"data,":[111],"one":[114],"treatment.":[116],"Tools":[117],"facilitating":[118],"knowledge-based":[119],"analyses,":[120],"capable":[123],"combining":[125],"disparate":[126],"data":[127,185],"sources":[130],"order":[132],"suggest":[134],"underlying":[135],"mechanisms":[136],"action,":[138],"may":[139],"be":[140,166],"valuable":[142],"resource":[143],"support":[145],"discovery":[146],"improve":[148],"our":[149],"understanding":[150],"this":[152,155],"In":[154],"work":[156],"we":[157],"demonstrate":[158],"how":[159],"biomedical":[161,177],"knowledge":[162],"graph":[163],"(KG)":[164],"can":[165],"used":[167,187],"novel":[170,243],"molecular":[172],"mechanisms.":[173],"Existing":[174],"open":[175],"source":[176],"resources":[178],"publicly":[180],"available":[181],"high-throughput":[182],"transcriptional":[183],"were":[186,205,222],"annotate":[191],"function":[193],"currently":[195],"uninvestigated":[196,226],"preeclampsia-associated":[197,227],"DEGs.":[198],"Experimentally":[199],"investigated":[200],"identified":[206,223],"PubMed":[208],"abstracts":[209],"using":[210],"text-mining":[211],"methodologies.":[212],"relative":[214],"complement":[215],"text-mined-":[218],"meta-analysis-derived":[220],"lists":[221],"(n=445),":[229],"i.e.,":[230],"Using":[234],"KG":[236],"relevant":[239,245],"revealed":[241],"53":[242],"clinically":[244],"biologically":[247],"actionable":[248],"mechanistic":[249],"associations.":[250]},"counts_by_year":[],"updated_date":"2025-11-06T06:51:31.235846","created_date":"2025-10-10T00:00:00"}