{"id":"https://openalex.org/W2474234325","doi":"https://doi.org/10.4338/aci-2015-11-ra-0159","title":"Validation of test performance and clinical time zero for an electronic health record embedded severe sepsis alert","display_name":"Validation of test performance and clinical time zero for an electronic health record embedded severe sepsis alert","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2474234325","doi":"https://doi.org/10.4338/aci-2015-11-ra-0159","mag":"2474234325","pmid":"https://pubmed.ncbi.nlm.nih.gov/27437061"},"language":"en","primary_location":{"id":"doi:10.4338/aci-2015-11-ra-0159","is_oa":true,"landing_page_url":"https://doi.org/10.4338/aci-2015-11-ra-0159","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.4338/ACI-2015-11-RA-0159.pdf","source":{"id":"https://openalex.org/S187139995","display_name":"Applied Clinical Informatics","issn_l":"1869-0327","issn":["1869-0327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Clinical Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.4338/ACI-2015-11-RA-0159.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011452909","display_name":"N. Lance Downing","orcid":"https://orcid.org/0000-0002-2133-9244"},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Downing","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402140","display_name":"John Shepard","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Shepard","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110427784","display_name":"Weihan Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihan Chu","raw_affiliation_strings":["Stanford School of Medicine","Stanford School of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford School of Medicine","institution_ids":["https://openalex.org/I4210137306"]},{"raw_affiliation_string":"Stanford School of Medicine;","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108602258","display_name":"Julia Tam","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Tam","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042781052","display_name":"Alexander J Wessels","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Wessels","raw_affiliation_strings":["Sagacious Consultants"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sagacious Consultants","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066174471","display_name":"Ron Li","orcid":"https://orcid.org/0000-0002-4310-7137"},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Li","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088771303","display_name":"Brian Dietrich","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Dietrich","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021930739","display_name":"M. Rudy","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Rudy","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007384099","display_name":"Leon Castaneda","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leon Castaneda","raw_affiliation_strings":["Stanford Hospital & Clinics","Stanford Hospital & Clinics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics","institution_ids":["https://openalex.org/I4210105015"]},{"raw_affiliation_string":"Stanford Hospital & Clinics;","institution_ids":["https://openalex.org/I4210105015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032125275","display_name":"Lisa Shieh","orcid":"https://orcid.org/0000-0003-2729-315X"},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Shieh","raw_affiliation_strings":["Stanford School of Medicine","Stanford School of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford School of Medicine","institution_ids":["https://openalex.org/I4210137306"]},{"raw_affiliation_string":"Stanford School of Medicine;","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011618952","display_name":"Joshua Rolnick","orcid":"https://orcid.org/0000-0003-1815-6858"},"institutions":[{"id":"https://openalex.org/I2801022843","display_name":"Santa Clara Valley Medical Center","ror":"https://ror.org/02v7qv571","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801022843","https://openalex.org/I4210115301"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua Rolnick","raw_affiliation_strings":["Santa Clara Valley Medical Center","Santa Clara Valley Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Clara Valley Medical Center","institution_ids":["https://openalex.org/I2801022843"]},{"raw_affiliation_string":"Santa Clara Valley Medical Center;","institution_ids":["https://openalex.org/I2801022843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5011618952"],"corresponding_institution_ids":["https://openalex.org/I2801022843"],"apc_list":null,"apc_paid":null,"fwci":2.1466,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.87314862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"07","issue":"02","first_page":"560","last_page":"572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9509999752044678,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9509999752044678,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13248","display_name":"Healthcare Technology and Patient Monitoring","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.8596422672271729},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.812967836856842},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.5351712703704834},{"id":"https://openalex.org/keywords/electronic-health-record","display_name":"Electronic health record","score":0.5322803258895874},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.5224922299385071},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"Organ dysfunction","score":0.5218102931976318},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"Systemic inflammatory response syndrome","score":0.4914175271987915},{"id":"https://openalex.org/keywords/emergency-medicine","display_name":"Emergency medicine","score":0.4410715103149414},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.4370886981487274},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25192224979400635},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.14075967669487}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8596422672271729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.812967836856842},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5351712703704834},{"id":"https://openalex.org/C3020144179","wikidata":"https://www.wikidata.org/wiki/Q10871684","display_name":"Electronic health record","level":3,"score":0.5322803258895874},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5224922299385071},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.5218102931976318},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.4914175271987915},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4410715103149414},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4370886981487274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25192224979400635},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.14075967669487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010820","descriptor_name":"Physicians","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010820","descriptor_name":"Physicians","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010820","descriptor_name":"Physicians","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4338/aci-2015-11-ra-0159","is_oa":true,"landing_page_url":"https://doi.org/10.4338/aci-2015-11-ra-0159","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.4338/ACI-2015-11-RA-0159.pdf","source":{"id":"https://openalex.org/S187139995","display_name":"Applied Clinical Informatics","issn_l":"1869-0327","issn":["1869-0327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Clinical Informatics","raw_type":"journal-article"},{"id":"pmid:27437061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27437061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied clinical informatics","raw_type":null},{"id":"pmh:oai:europepmc.org:4324888","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4941860","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4338/aci-2015-11-ra-0159","is_oa":true,"landing_page_url":"https://doi.org/10.4338/aci-2015-11-ra-0159","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.4338/ACI-2015-11-RA-0159.pdf","source":{"id":"https://openalex.org/S187139995","display_name":"Applied Clinical Informatics","issn_l":"1869-0327","issn":["1869-0327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Clinical Informatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2474234325.pdf","grobid_xml":"https://content.openalex.org/works/W2474234325.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1807259383","https://openalex.org/W1969760843","https://openalex.org/W1974950941","https://openalex.org/W1986836608","https://openalex.org/W1995887867","https://openalex.org/W2002514548","https://openalex.org/W2007420330","https://openalex.org/W2009527638","https://openalex.org/W2034769820","https://openalex.org/W2049231035","https://openalex.org/W2069455115","https://openalex.org/W2083009186","https://openalex.org/W2094915224","https://openalex.org/W2101082552","https://openalex.org/W2102290891","https://openalex.org/W2105161550","https://openalex.org/W2115540308","https://openalex.org/W2125603252","https://openalex.org/W2134689623","https://openalex.org/W2139517484","https://openalex.org/W2140410010","https://openalex.org/W2147002030","https://openalex.org/W2165760729","https://openalex.org/W2170215820","https://openalex.org/W2183670545","https://openalex.org/W2331591468","https://openalex.org/W2442246762","https://openalex.org/W2581605534","https://openalex.org/W3023757607"],"related_works":["https://openalex.org/W2408782992","https://openalex.org/W3030014144","https://openalex.org/W2593799432","https://openalex.org/W4383099252","https://openalex.org/W2034930488","https://openalex.org/W2886808995","https://openalex.org/W2051112422","https://openalex.org/W2950750147","https://openalex.org/W2259586633","https://openalex.org/W2294851047"],"abstract_inverted_index":{"BACHGROUND:":[0],"Increasing":[1],"use":[2,44],"of":[3,11,19,45,58,108,117,127,133,141,208,228,236,239],"EHRs":[4],"has":[5],"generated":[6],"interest":[7],"in":[8,38,87,123,162,226,234,269],"the":[9,33,43,53,67,99,153,160,191,198,250,254,270],"potential":[10,68],"computerized":[12],"clinical":[13,157,223,263],"decision":[14],"support":[15],"to":[16,29,35,69,148,155,252,281],"improve":[17],"treatment":[18],"sepsis.":[20,118,169],"Electronic":[21],"sepsis":[22,37,64,71,84,93,103,258],"alerts":[23,240],"have":[24],"had":[25],"mixed":[26],"results":[27],"due":[28],"poor":[30],"test":[31,150],"characteristics,":[32],"inability":[34],"detect":[36,156],"a":[39,88,106,115,128,165,243,257],"timely":[40,62,82],"fashion":[41],"and":[42,56,61,77,81,139,152,177,197,230,260],"outside":[46],"software":[47],"limiting":[48],"widespread":[49],"adoption.":[50],"We":[51,248],"describe":[52],"development,":[54],"evaluation":[55],"validation":[57],"an":[59,79],"accurate":[60,80],"severe":[63,83,102,168],"alert":[65,85,94,120,219,259,271,283,291],"with":[66,110],"impact":[70],"management.":[72],"OBJECTIVE:":[73],"To":[74],"develop,":[75],"evaluate,":[76],"validate":[78],"embedded":[86],"commercial":[89],"EHR.":[90],"METHODS:":[91],"The":[92,204,218],"was":[95,146,186,189,195,202,211,220],"developed":[96],"by":[97,295],"identifying":[98],"most":[100,205],"common":[101,206],"criteria":[104,122,272],"among":[105],"cohort":[107],"patients":[109],"ICD":[111],"9":[112],"codes":[113],"indicating":[114],"diagnosis":[116],"This":[119],"requires":[121],"three":[124,232],"categories:":[125],"indicators":[126],"systemic":[129],"inflammatory":[130],"response,":[131],"evidence":[132],"suspected":[134],"infection":[135],"from":[136],"physician":[137,261,267],"orders,":[138],"markers":[140],"organ":[142],"dysfunction.":[143],"Chart":[144],"review":[145],"used":[147],"evaluate":[149],"performance":[151],"ability":[154],"time":[158,163,224,255,264],"zero,":[159],"point":[161],"when":[164],"patient":[166],"develops":[167],"RESULTS:":[170],"Two":[171],"physicians":[172],"reviewed":[173],"100":[174],"positive":[175,192],"cases":[176,229],"75":[178],"negative":[179,199],"cases.":[180,237],"Based":[181],"on":[182],"this":[183,290],"review,":[184],"sensitivity":[185],"74.5%,":[187],"specificity":[188,274],"86.0%,":[190],"predictive":[193,200],"value":[194,201],"50.3%,":[196],"94.7%.":[203],"source":[207],"end-organ":[209],"dysfunction":[210],"MAP":[212],"less":[213],"than":[214],"70":[215],"mm/Hg":[216],"(59%).":[217],"triggered":[221,241],"at":[222],"zero":[225],"41%":[227],"within":[231],"hours":[233],"53.6%":[235],"96%":[238],"before":[242],"manual":[244],"nurse":[245],"screen.":[246],"CONCLUSION:":[247],"are":[249],"first":[251],"report":[253],"between":[256],"chart-review":[262],"zero.":[265],"Incorporating":[266],"orders":[268],"improves":[273],"while":[275],"maintaining":[276],"sensitivity,":[277],"which":[278],"is":[279],"important":[280],"reduce":[282],"fatigue.":[284],"By":[285],"leveraging":[286],"standard":[287],"EHR":[288],"functionality,":[289],"could":[292],"be":[293],"implemented":[294],"other":[296],"healthcare":[297],"systems.":[298]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2017,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2016-07-22T00:00:00"}