{"id":"https://openalex.org/W2054332455","doi":"https://doi.org/10.4018/jkdb.2012010102","title":"Insight into Disrupted Spatial Patterns of Human Connectome in Alzheimer\u2019s Disease via Subgraph Mining","display_name":"Insight into Disrupted Spatial Patterns of Human Connectome in Alzheimer\u2019s Disease via Subgraph Mining","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2054332455","doi":"https://doi.org/10.4018/jkdb.2012010102","mag":"2054332455"},"language":"en","primary_location":{"id":"doi:10.4018/jkdb.2012010102","is_oa":false,"landing_page_url":"https://doi.org/10.4018/jkdb.2012010102","pdf_url":null,"source":{"id":"https://openalex.org/S113982356","display_name":"International Journal of Knowledge Discovery in Bioinformatics","issn_l":"1947-9115","issn":["1947-9115","1947-9123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Knowledge Discovery in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088843448","display_name":"Junming Shao","orcid":"https://orcid.org/0000-0002-1183-2991"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Junming Shao","raw_affiliation_strings":["Department of Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany, & Institute for Computer Science, Johannes Gutenberg-Universit\u00e4t Mainz, Mainz, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany, & Institute for Computer Science, Johannes Gutenberg-Universit\u00e4t Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015410049","display_name":"Qinli Yang","orcid":"https://orcid.org/0000-0001-8966-6762"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qinli Yang","raw_affiliation_strings":["Institute for Computer Science, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Computer Science, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113683965","display_name":"Afra M. Wohlschl\u00e4ger","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Afra Wohlschl\u00e4ger","raw_affiliation_strings":["Department of Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073171809","display_name":"Christian Sorg","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Sorg","raw_affiliation_strings":["Department of Neuroradiology and Psychiarty, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology and Psychiarty, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088843448"],"corresponding_institution_ids":["https://openalex.org/I197323543","https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.14132242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"1","first_page":"23","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.9250048398971558},{"id":"https://openalex.org/keywords/human-connectome-project","display_name":"Human Connectome Project","score":0.7706747055053711},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.6263453960418701},{"id":"https://openalex.org/keywords/tractography","display_name":"Tractography","score":0.626238226890564},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5818718671798706},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5633230805397034},{"id":"https://openalex.org/keywords/connectomics","display_name":"Connectomics","score":0.5333703756332397},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5061895251274109},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.43020322918891907},{"id":"https://openalex.org/keywords/grey-matter","display_name":"Grey matter","score":0.43000921607017517},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.4149715304374695},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39954257011413574},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32290226221084595},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32156944274902344},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19516366720199585},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.1280345618724823},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.08512040972709656},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08477771282196045}],"concepts":[{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.9250048398971558},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.7706747055053711},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.6263453960418701},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.626238226890564},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5818718671798706},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5633230805397034},{"id":"https://openalex.org/C2779097318","wikidata":"https://www.wikidata.org/wiki/Q2993446","display_name":"Connectomics","level":4,"score":0.5333703756332397},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5061895251274109},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43020322918891907},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.43000921607017517},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.4149715304374695},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39954257011413574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32290226221084595},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32156944274902344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19516366720199585},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.1280345618724823},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.08512040972709656},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08477771282196045},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4018/jkdb.2012010102","is_oa":false,"landing_page_url":"https://doi.org/10.4018/jkdb.2012010102","pdf_url":null,"source":{"id":"https://openalex.org/S113982356","display_name":"International Journal of Knowledge Discovery in Bioinformatics","issn_l":"1947-9115","issn":["1947-9115","1947-9123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Knowledge Discovery in Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:igg:jkdb00:v:3:y:2012:i:1:p:23-38","is_oa":false,"landing_page_url":"http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/jkdb.2012010102","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1534632902","https://openalex.org/W1967823816","https://openalex.org/W1983537704","https://openalex.org/W1991952617","https://openalex.org/W1999653836","https://openalex.org/W2009036027","https://openalex.org/W2050255138","https://openalex.org/W2052742260","https://openalex.org/W2053133374","https://openalex.org/W2073017605","https://openalex.org/W2075496760","https://openalex.org/W2081825327","https://openalex.org/W2094347446","https://openalex.org/W2104598584","https://openalex.org/W2118323338","https://openalex.org/W2120111102","https://openalex.org/W2123326080","https://openalex.org/W2128106262","https://openalex.org/W2130142990","https://openalex.org/W2146693559","https://openalex.org/W2148601182","https://openalex.org/W2159929956","https://openalex.org/W2162632094","https://openalex.org/W2164661899","https://openalex.org/W2168209541","https://openalex.org/W2171831801","https://openalex.org/W2320779214","https://openalex.org/W2600151521","https://openalex.org/W4211156109"],"related_works":["https://openalex.org/W1480657811","https://openalex.org/W2091910928","https://openalex.org/W2223311443","https://openalex.org/W2611561168","https://openalex.org/W3016416492","https://openalex.org/W2759294325","https://openalex.org/W1934073137","https://openalex.org/W2016096972","https://openalex.org/W4293090388","https://openalex.org/W2004056475"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD)":[2],"is":[3],"the":[4,14,20,24,34,48,70,79,99,109,121,135],"most":[5],"common":[6],"cause":[7],"of":[8,33,108,120,138],"age-related":[9],"dementia,":[10],"which":[11],"prominently":[12],"affects":[13],"human":[15,35,49,110],"connectome.":[16],"In":[17],"this":[18],"paper,":[19],"authors":[21],"focus":[22],"on":[23,40,58],"question":[25],"how":[26,130],"they":[27],"can":[28],"identify":[29,86],"disrupted":[30,87],"spatial":[31,105],"patterns":[32,89],"connectome":[36,111],"in":[37,90,112,143],"AD":[38,113,131],"based":[39,57],"a":[41,144],"data":[42],"mining":[43],"framework.":[44],"Using":[45],"diffusion":[46,60],"tractography,":[47],"connectomes":[50],"for":[51,98],"each":[52],"individual":[53],"subject":[54],"were":[55],"constructed":[56],"two":[59],"derived":[61],"attributes:":[62],"fiber":[63,145],"density":[64],"and":[65,133],"fractional":[66],"anisotropy,":[67],"to":[68,85],"represent":[69],"structural":[71,140],"brain":[72,141],"connectivity":[73],"patterns.":[74],"After":[75],"frequent":[76],"subgraph":[77,88],"mining,":[78],"abnormal":[80],"score":[81],"was":[82],"finally":[83],"defined":[84],"patients.":[91],"Experiments":[92],"demonstrated":[93],"that":[94,114],"our":[95],"data-driven":[96],"approach,":[97],"first":[100],"time,":[101],"allows":[102],"identifying":[103],"selective":[104],"pattern":[106],"changes":[107,119],"perfectly":[115],"matched":[116],"grey":[117],"matter":[118],"disease.":[122],"Their":[123],"findings":[124],"also":[125],"bring":[126],"new":[127],"insights":[128],"into":[129],"propagates":[132],"disrupts":[134],"regional":[136],"integrity":[137],"large-scale":[139],"networks":[142],"connectivity-based":[146],"way.":[147]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}