{"id":"https://openalex.org/W2018249368","doi":"https://doi.org/10.4018/jkdb.2010070102","title":"Mining Protein Interactome Networks to Measure Interaction Reliability and Select Hub Proteins","display_name":"Mining Protein Interactome Networks to Measure Interaction Reliability and Select Hub Proteins","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2018249368","doi":"https://doi.org/10.4018/jkdb.2010070102","mag":"2018249368"},"language":"en","primary_location":{"id":"doi:10.4018/jkdb.2010070102","is_oa":false,"landing_page_url":"https://doi.org/10.4018/jkdb.2010070102","pdf_url":null,"source":{"id":"https://openalex.org/S113982356","display_name":"International Journal of Knowledge Discovery in Bioinformatics","issn_l":"1947-9115","issn":["1947-9115","1947-9123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Knowledge Discovery in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013149893","display_name":"Young\u2010Rae Cho","orcid":"https://orcid.org/0000-0002-4645-2542"},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Young-Rae Cho","raw_affiliation_strings":["Baylor University, USA"],"affiliations":[{"raw_affiliation_string":"Baylor University, USA","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013588572","display_name":"Aidong Zhang","orcid":"https://orcid.org/0000-0001-9723-3246"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aidong Zhang","raw_affiliation_strings":["State University of New York, Buffalo, USA"],"affiliations":[{"raw_affiliation_string":"State University of New York, Buffalo, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013149893"],"corresponding_institution_ids":["https://openalex.org/I157394403"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08189127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"3","first_page":"20","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9786999821662903,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9599000215530396,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.9649468660354614},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7165485620498657},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.5537072420120239},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.44794726371765137},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.42665937542915344},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3612573742866516},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3384024500846863},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3372459411621094},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17018842697143555},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08011677861213684},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07564893364906311}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.9649468660354614},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7165485620498657},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.5537072420120239},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.44794726371765137},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.42665937542915344},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3612573742866516},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3384024500846863},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3372459411621094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17018842697143555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08011677861213684},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07564893364906311},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4018/jkdb.2010070102","is_oa":false,"landing_page_url":"https://doi.org/10.4018/jkdb.2010070102","pdf_url":null,"source":{"id":"https://openalex.org/S113982356","display_name":"International Journal of Knowledge Discovery in Bioinformatics","issn_l":"1947-9115","issn":["1947-9115","1947-9123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Knowledge Discovery in Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:igg:jkdb00:v:1:y:2010:i:3:p:20-35","is_oa":false,"landing_page_url":"http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/jkdb.2010070102","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309644","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08"},{"id":"https://openalex.org/F4320309840","display_name":"Baylor University","ror":"https://ror.org/005781934"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1644749979","https://openalex.org/W2005077027","https://openalex.org/W2008620264","https://openalex.org/W2012852001","https://openalex.org/W2018045523","https://openalex.org/W2023096047","https://openalex.org/W2026353653","https://openalex.org/W2037036397","https://openalex.org/W2037442572","https://openalex.org/W2065304353","https://openalex.org/W2065769502","https://openalex.org/W2071502814","https://openalex.org/W2084619201","https://openalex.org/W2104315543","https://openalex.org/W2112090702","https://openalex.org/W2113019448","https://openalex.org/W2113654464","https://openalex.org/W2121507105","https://openalex.org/W2122863289","https://openalex.org/W2123318061","https://openalex.org/W2128049108","https://openalex.org/W2130687290","https://openalex.org/W2152495216","https://openalex.org/W2163480486","https://openalex.org/W2166468869","https://openalex.org/W2167869241","https://openalex.org/W2172049947","https://openalex.org/W2604823638","https://openalex.org/W2770983033","https://openalex.org/W2917375902","https://openalex.org/W2917431650","https://openalex.org/W3103071483"],"related_works":["https://openalex.org/W2101998831","https://openalex.org/W1922372990","https://openalex.org/W2153577994","https://openalex.org/W2032694615","https://openalex.org/W2086904135","https://openalex.org/W2162117109","https://openalex.org/W3016389020","https://openalex.org/W2157795344","https://openalex.org/W1970306486","https://openalex.org/W4310418333"],"abstract_inverted_index":{"High-throughput":[0],"techniques":[1],"involve":[2],"large-scale":[3],"detection":[4],"of":[5,67,86,102,117,144,164,172],"protein-protein":[6],"interactions.":[7],"This":[8,90,158],"interaction":[9,24,81,168],"data":[10,45],"set":[11],"from":[12,83],"the":[13,23,37,50,62,87,100,111,115,131,139,155,179,183],"genome-scale":[14],"perspective":[15],"is":[16,46],"structured":[17],"into":[18],"an":[19,127],"interactome":[20,38,53,69,88,133,156],"network.":[21],"Since":[22],"evidence":[25],"represents":[26],"functional":[27,41,94,176,188],"linkage,":[28],"various":[29],"graph-theoretic":[30],"computational":[31],"approaches":[32],"have":[33,55],"been":[34],"applied":[35],"to":[36,79],"networks":[39,54],"for":[40,120,129],"characterization.":[42],"However,":[43],"this":[44,60,109,147],"generally":[47],"unreliable,":[48],"and":[49,71,146,175],"typical":[51],"genome-wide":[52],"a":[56,73],"complex":[57,106,132],"connectivity.":[58],"In":[59,108],"paper,":[61],"authors":[63,124,180],"explore":[64],"systematic":[65],"analysis":[66],"protein":[68],"networks,":[70],"propose":[72],"$k$-round":[74],"signal":[75],"flow":[76],"simulation":[77,165],"algorithm":[78,91,112,128,137],"measure":[80],"reliability":[82,169],"connection":[84],"patterns":[85],"networks.":[89,157],"quantitatively":[92],"characterizes":[93],"links":[95],"between":[96],"proteins":[97,153],"by":[98,141],"simulating":[99],"propagation":[101],"information":[103],"signals":[104],"through":[105],"connections.":[107],"regard,":[110],"efficiently":[113],"estimates":[114],"strength":[116],"alternative":[118],"paths":[119],"each":[121],"interaction.":[122],"The":[123,136],"also":[125],"present":[126],"mining":[130],"network":[134,140],"structure.":[135],"restructures":[138],"hierarchical":[142],"ordering":[143],"nodes,":[145],"structure":[148],"re-formatting":[149],"process":[150],"reveals":[151],"hub":[152],"in":[154,170],"paper":[159],"demonstrates":[160],"that":[161,182],"two":[162],"rounds":[163],"accurately":[166],"scores":[167],"terms":[171],"ontological":[173],"correlation":[174],"consistency.":[177],"Finally,":[178],"validate":[181],"selected":[184],"structural":[185],"hubs":[186],"represent":[187],"core":[189],"proteins.":[190]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}