{"id":"https://openalex.org/W2945575908","doi":"https://doi.org/10.3390/data4020071","title":"Isolation, Characterization, and Agent-Based Modeling of Mesenchymal Stem Cells in a Bio-construct for Myocardial Regeneration Scaffold Design","display_name":"Isolation, Characterization, and Agent-Based Modeling of Mesenchymal Stem Cells in a Bio-construct for Myocardial Regeneration Scaffold Design","publication_year":2019,"publication_date":"2019-05-19","ids":{"openalex":"https://openalex.org/W2945575908","doi":"https://doi.org/10.3390/data4020071","mag":"2945575908"},"language":"en","primary_location":{"id":"doi:10.3390/data4020071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/data4020071","pdf_url":"https://www.mdpi.com/2306-5729/4/2/71/pdf?version=1558260096","source":{"id":"https://openalex.org/S4210226510","display_name":"Data","issn_l":"2306-5729","issn":["2306-5729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2306-5729/4/2/71/pdf?version=1558260096","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024790917","display_name":"Diana Victoria Ram\u00edrez L\u00f3pez","orcid":"https://orcid.org/0000-0001-5857-5796"},"institutions":[{"id":"https://openalex.org/I47726972","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/02drkkh02","country_code":"CO","type":"education","lineage":["https://openalex.org/I47726972"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Diana Victoria Ram\u00edrez L\u00f3pez","raw_affiliation_strings":["College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia","institution_ids":["https://openalex.org/I47726972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020852607","display_name":"Maria Isabel Melo-Escobar","orcid":"https://orcid.org/0000-0003-3176-9181"},"institutions":[{"id":"https://openalex.org/I47726972","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/02drkkh02","country_code":"CO","type":"education","lineage":["https://openalex.org/I47726972"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Isabel Melo Escobar","raw_affiliation_strings":["College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia","institution_ids":["https://openalex.org/I47726972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050923109","display_name":"Carlos Andr\u00e9s Pe\u00f1a-Reyes","orcid":"https://orcid.org/0000-0002-2113-6498"},"institutions":[{"id":"https://openalex.org/I173439891","display_name":"HES-SO University of Applied Sciences and Arts Western Switzerland","ror":"https://ror.org/01xkakk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I173439891"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Carlos A. Pe\u00f1a-Reyes","raw_affiliation_strings":["School of Business and Engineering Vaud (HEIG-VD), University of Applied Sciences Western of Switzerland (HES-SO), Route de Cheseaux 1, CH-1400 Yverdon-les-Bains, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2113-6498","affiliations":[{"raw_affiliation_string":"School of Business and Engineering Vaud (HEIG-VD), University of Applied Sciences Western of Switzerland (HES-SO), Route de Cheseaux 1, CH-1400 Yverdon-les-Bains, Switzerland","institution_ids":["https://openalex.org/I173439891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024139287","display_name":"\u00c1lvaro J. Rojas Arciniegas","orcid":"https://orcid.org/0000-0001-9242-799X"},"institutions":[{"id":"https://openalex.org/I47726972","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/02drkkh02","country_code":"CO","type":"education","lineage":["https://openalex.org/I47726972"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro J. Rojas Arciniegas","raw_affiliation_strings":["College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia"],"raw_orcid":"https://orcid.org/0000-0001-9242-799X","affiliations":[{"raw_affiliation_string":"College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia","institution_ids":["https://openalex.org/I47726972"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012753350","display_name":"Paola Andrea Neuta Arciniegas","orcid":null},"institutions":[{"id":"https://openalex.org/I47726972","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/02drkkh02","country_code":"CO","type":"education","lineage":["https://openalex.org/I47726972"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Paola Andrea Neuta Arciniegas","raw_affiliation_strings":["College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, Universidad Aut\u00f3noma de Occidente, Calle 25 115-85, Cali 760030, Colombia","institution_ids":["https://openalex.org/I47726972"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020852607","https://openalex.org/A5024790917"],"corresponding_institution_ids":["https://openalex.org/I47726972"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":0.4421,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65650386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"2","first_page":"71","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cell","display_name":"Mesenchymal stem cell","score":0.7916891574859619},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.6958105564117432},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6063894033432007},{"id":"https://openalex.org/keywords/regeneration","display_name":"Regeneration (biology)","score":0.5824319124221802},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.5755905508995056},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5534746646881104},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5527443289756775},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"Regenerative medicine","score":0.5300084352493286},{"id":"https://openalex.org/keywords/biomaterial","display_name":"Biomaterial","score":0.5258398652076721},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5057494640350342},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.48847854137420654},{"id":"https://openalex.org/keywords/viability-assay","display_name":"Viability assay","score":0.47072306275367737},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.42505043745040894},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.41630643606185913},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.41216227412223816},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27973800897598267},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1529880166053772},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11442115902900696}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7916891574859619},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.6958105564117432},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6063894033432007},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5824319124221802},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5755905508995056},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5534746646881104},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5527443289756775},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5300084352493286},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.5258398652076721},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5057494640350342},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48847854137420654},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.47072306275367737},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42505043745040894},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.41630643606185913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41216227412223816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27973800897598267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1529880166053772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11442115902900696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/data4020071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/data4020071","pdf_url":"https://www.mdpi.com/2306-5729/4/2/71/pdf?version=1558260096","source":{"id":"https://openalex.org/S4210226510","display_name":"Data","issn_l":"2306-5729","issn":["2306-5729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:31783746a1ef400b9e8ee3dcea4021d7","is_oa":true,"landing_page_url":"https://doaj.org/article/31783746a1ef400b9e8ee3dcea4021d7","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Data, Vol 4, Iss 2, p 71 (2019)","raw_type":"article"},{"id":"pmh:oai:hesso.tind.io:4351","is_oa":false,"landing_page_url":"http://arodes.hes-so.ch/record/4351","pdf_url":null,"source":{"id":"https://openalex.org/S4306402432","display_name":"ArODES (HES-SO (https://www.hes-so.ch/))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210088449","host_organization_name":"HES-SO Gen\u00e8ve","host_organization_lineage":["https://openalex.org/I4210088449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://arodes.hes-so.ch/record/4351","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/2306-5729/4/2/71/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/data4020071","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Data","raw_type":"Text"},{"id":"pmh:oai:red.uao.edu.co:10614/11552","is_oa":true,"landing_page_url":"http://hdl.handle.net/10614/11552","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:RED: Repositorio Educativo Digital UAO","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.3390/data4020071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/data4020071","pdf_url":"https://www.mdpi.com/2306-5729/4/2/71/pdf?version=1558260096","source":{"id":"https://openalex.org/S4210226510","display_name":"Data","issn_l":"2306-5729","issn":["2306-5729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2945575908.pdf","grobid_xml":"https://content.openalex.org/works/W2945575908.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W808473155","https://openalex.org/W830547093","https://openalex.org/W1964874228","https://openalex.org/W1974193257","https://openalex.org/W1985226116","https://openalex.org/W2000957726","https://openalex.org/W2009916207","https://openalex.org/W2050744280","https://openalex.org/W2061814847","https://openalex.org/W2081245002","https://openalex.org/W2091395040","https://openalex.org/W2103337096","https://openalex.org/W2112777549","https://openalex.org/W2129227934","https://openalex.org/W2161226422","https://openalex.org/W2167897928","https://openalex.org/W2321682621","https://openalex.org/W2414272954","https://openalex.org/W2485789424","https://openalex.org/W2508710172","https://openalex.org/W2568881151","https://openalex.org/W2605115371","https://openalex.org/W2763881952","https://openalex.org/W2912815827","https://openalex.org/W6699931807"],"related_works":["https://openalex.org/W3003069570","https://openalex.org/W3215530055","https://openalex.org/W2412922490","https://openalex.org/W2626164717","https://openalex.org/W2387757681","https://openalex.org/W2478420051","https://openalex.org/W3196863326","https://openalex.org/W922543731","https://openalex.org/W2435286860","https://openalex.org/W3014163099"],"abstract_inverted_index":{"Regenerative":[0],"medicine":[1],"involves":[2],"methods":[3],"to":[4,19,41,59,69,137,161,182],"control":[5],"and":[6,13,47,55,58,95,98,115,126,171,179,193,199,232,237],"modify":[7],"normal":[8],"tissue":[9,21,29],"repair":[10],"processes.":[11],"Polymer":[12],"cell":[14,108,128,221],"constructs":[15],"are":[16,89,159,210],"under":[17],"research":[18],"create":[20],"that":[22,63,120,168,218],"replaces":[23],"the":[24,37,43,61,70,76,121,131,143,155,165,183,191,196,213,224],"affected":[25],"area":[26],"in":[27,53,56,81,85,100,130,156,164,190,212,235,238],"cardiac":[28],"after":[30],"myocardial":[31],"infarction":[32],"(MI).":[33],"The":[34],"aim":[35],"of":[36,45,73,78,103,145,195,220,226],"present":[38],"study":[39],"is":[40,110,169,216],"evaluate":[42],"behavior":[44,109,144,222],"differentiated":[46,99],"undifferentiated":[48,97],"mesenchymal":[49],"stem":[50],"cells":[51,122],"(MSCs)":[52],"vitro":[54,86,157,236],"silico":[57],"compare":[60],"results":[62,158,184,189],"both":[64],"offer":[65],"when":[66],"it":[67],"comes":[68],"design":[71,192],"process":[72],"biodevices":[74],"for":[75,187,207,244],"treatment":[77],"infarcted":[79],"myocardium":[80],"biomodels.":[82],"To":[83],"assess":[84],"behavior,":[87],"MSCs":[88,147],"isolated":[90],"from":[91],"rat":[92],"bone":[93],"marrow":[94],"seeded":[96],"multiple":[101],"scaffolds":[102,198],"a":[104],"gelled":[105],"biomaterial.":[106,132],"Subsequently,":[107],"evaluated":[111],"by":[112,148],"trypan":[113],"blue":[114],"fluorescence":[116],"microscopy,":[117],"which":[118,172],"showed":[119],"presented":[123,211],"high":[124],"viability":[125],"low":[127],"migration":[129],"An":[133],"agent-based":[134,166,202],"model":[135,167,203],"intended":[136],"reproduce":[138],"as":[139,141],"closely":[140],"possible":[142],"individual":[146],"simulating":[149],"cellular-level":[150,174],"processes":[151],"was":[152],"developed,":[153,170],"where":[154],"used":[160],"identify":[162],"parameters":[163],"simulates":[173],"processes:":[175],"Apoptosis,":[176],"differentiation,":[177],"proliferation,":[178,228],"migration.":[180],"Thanks":[181],"obtained,":[185],"suggestions":[186],"good":[188],"fabrication":[194],"proposed":[197],"how":[200],"an":[201,241],"can":[204],"be":[205],"helpful":[206],"testing":[208],"hypothesis":[209],"discussion.":[214],"It":[215],"concluded":[217],"assessment":[219],"through":[223],"observation":[225],"viability,":[227],"migration,":[229],"inflammation":[230],"reduction,":[231],"spatial":[233],"composition":[234],"silico,":[239],"represents":[240],"appropriate":[242],"strategy":[243],"scaffold":[245],"engineering.":[246]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
