{"id":"https://openalex.org/W4399210031","doi":"https://doi.org/10.3390/computation12060112","title":"Structure-Based Discovery of Potential HPV E6 and EBNA1 Inhibitors: Implications for Cervical Cancer Treatment","display_name":"Structure-Based Discovery of Potential HPV E6 and EBNA1 Inhibitors: Implications for Cervical Cancer Treatment","publication_year":2024,"publication_date":"2024-05-31","ids":{"openalex":"https://openalex.org/W4399210031","doi":"https://doi.org/10.3390/computation12060112"},"language":"en","primary_location":{"id":"doi:10.3390/computation12060112","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation12060112","pdf_url":"https://www.mdpi.com/2079-3197/12/6/112/pdf?version=1717211759","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/12/6/112/pdf?version=1717211759","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027716268","display_name":"Emmanuel Broni","orcid":"https://orcid.org/0000-0002-6793-7530"},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Broni","raw_affiliation_strings":["Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA"],"raw_orcid":"https://orcid.org/0000-0002-6793-7530","affiliations":[{"raw_affiliation_string":"Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081559484","display_name":"Carolyn N. Ashley","orcid":"https://orcid.org/0009-0007-9704-3822"},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn N. Ashley","raw_affiliation_strings":["Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA"],"raw_orcid":"https://orcid.org/0009-0007-9704-3822","affiliations":[{"raw_affiliation_string":"Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103413297","display_name":"Miriam Velazquez","orcid":null},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Velazquez","raw_affiliation_strings":["Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","Department of Molecular Pharmacology & Neuroscience, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]},{"raw_affiliation_string":"Department of Molecular Pharmacology & Neuroscience, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060730191","display_name":"Patrick O. Sakyi","orcid":"https://orcid.org/0000-0001-7264-8680"},"institutions":[{"id":"https://openalex.org/I138690464","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83","country_code":"GH","type":"education","lineage":["https://openalex.org/I138690464"]},{"id":"https://openalex.org/I291863076","display_name":"University of Energy and Natural Resources","ror":"https://ror.org/05r9rzb75","country_code":"GH","type":"education","lineage":["https://openalex.org/I291863076"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Patrick O. Sakyi","raw_affiliation_strings":["Department of Chemical Sciences, School of Sciences, University of Energy and Natural Resources, Sunyani P.O. Box 214, Ghana","Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana","Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P.O. BOX LG 56 Legon, Accra, Ghana","Department of Chemical Sciences, School of Sciences, University of Energy and Natural Resources, P.O. Box 214 Sunyani, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, School of Sciences, University of Energy and Natural Resources, Sunyani P.O. Box 214, Ghana","institution_ids":["https://openalex.org/I291863076"]},{"raw_affiliation_string":"Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana","institution_ids":["https://openalex.org/I138690464"]},{"raw_affiliation_string":"Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P.O. BOX LG 56 Legon, Accra, Ghana","institution_ids":["https://openalex.org/I138690464"]},{"raw_affiliation_string":"Department of Chemical Sciences, School of Sciences, University of Energy and Natural Resources, P.O. Box 214 Sunyani, Ghana","institution_ids":["https://openalex.org/I291863076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046288545","display_name":"Samuel K. Kwofie","orcid":null},"institutions":[{"id":"https://openalex.org/I138690464","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83","country_code":"GH","type":"education","lineage":["https://openalex.org/I138690464"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Samuel K. Kwofie","raw_affiliation_strings":["Department of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana","Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana"],"raw_orcid":"https://orcid.org/0000-0002-1093-1517","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana","institution_ids":["https://openalex.org/I138690464"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 56, Ghana","institution_ids":["https://openalex.org/I138690464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081692917","display_name":"Whelton A. Miller","orcid":"https://orcid.org/0000-0003-3822-7940"},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Whelton A. Miller","raw_affiliation_strings":["Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","Department of Molecular Pharmacology & Neuroscience, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA"],"raw_orcid":"https://orcid.org/0000-0003-3822-7940","affiliations":[{"raw_affiliation_string":"Department of Medicine, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]},{"raw_affiliation_string":"Department of Molecular Pharmacology & Neuroscience, Loyola University Medical Center, Loyola University Chicago, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5081692917"],"corresponding_institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1515},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1515},"fwci":1.1009,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.77949019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"12","issue":"6","first_page":"112","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"Cervical cancer","score":0.695151150226593},{"id":"https://openalex.org/keywords/hela","display_name":"HeLa","score":0.6268532276153564},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5732839703559875},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5064233541488647},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.47952723503112793},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46759623289108276},{"id":"https://openalex.org/keywords/hpv-vaccines","display_name":"HPV vaccines","score":0.445875883102417},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.43911212682724},{"id":"https://openalex.org/keywords/oncogene","display_name":"Oncogene","score":0.41324496269226074},{"id":"https://openalex.org/keywords/epstein\u2013barr-virus","display_name":"Epstein\u2013Barr virus","score":0.41088324785232544},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.40163809061050415},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.37323421239852905},{"id":"https://openalex.org/keywords/hpv-infection","display_name":"HPV infection","score":0.3106151223182678},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.28662437200546265},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.26380643248558044},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2109416425228119},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.20777440071105957}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.695151150226593},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6268532276153564},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5732839703559875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5064233541488647},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47952723503112793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46759623289108276},{"id":"https://openalex.org/C2780009117","wikidata":"https://www.wikidata.org/wiki/Q900189","display_name":"HPV vaccines","level":5,"score":0.445875883102417},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.43911212682724},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.41324496269226074},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.41088324785232544},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40163809061050415},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.37323421239852905},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.3106151223182678},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28662437200546265},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26380643248558044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2109416425228119},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.20777440071105957}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/computation12060112","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation12060112","pdf_url":"https://www.mdpi.com/2079-3197/12/6/112/pdf?version=1717211759","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e6dc6a9dce4c441baadd80d8051271bc","is_oa":true,"landing_page_url":"https://doaj.org/article/e6dc6a9dce4c441baadd80d8051271bc","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 12, Iss 6, p 112 (2024)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2079-3197/12/6/112/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/computation12060112","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/computation12060112","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation12060112","pdf_url":"https://www.mdpi.com/2079-3197/12/6/112/pdf?version=1717211759","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4399210031.pdf"},"referenced_works_count":194,"referenced_works":["https://openalex.org/W72407919","https://openalex.org/W1031578623","https://openalex.org/W1482971402","https://openalex.org/W1757990252","https://openalex.org/W1781972052","https://openalex.org/W1887624773","https://openalex.org/W1911328979","https://openalex.org/W1926472300","https://openalex.org/W1964736119","https://openalex.org/W1964837805","https://openalex.org/W1964932776","https://openalex.org/W1971298232","https://openalex.org/W1971849220","https://openalex.org/W1971962325","https://openalex.org/W1973108158","https://openalex.org/W1979915001","https://openalex.org/W1980378174","https://openalex.org/W1997374910","https://openalex.org/W1997872815","https://openalex.org/W2002512110","https://openalex.org/W2005521980","https://openalex.org/W2009313526","https://openalex.org/W2010852905","https://openalex.org/W2016667992","https://openalex.org/W2026934188","https://openalex.org/W2030971064","https://openalex.org/W2038181603","https://openalex.org/W2044172327","https://openalex.org/W2044624955","https://openalex.org/W2044769768","https://openalex.org/W2048526191","https://openalex.org/W2049793020","https://openalex.org/W2050027039","https://openalex.org/W2058743222","https://openalex.org/W2061043015","https://openalex.org/W2062845956","https://openalex.org/W2062918882","https://openalex.org/W2063460304","https://openalex.org/W2066597581","https://openalex.org/W2074473216","https://openalex.org/W2078492140","https://openalex.org/W2078976625","https://openalex.org/W2086874336","https://openalex.org/W2087155047","https://openalex.org/W2088104424","https://openalex.org/W2094206384","https://openalex.org/W2099686861","https://openalex.org/W2111581388","https://openalex.org/W2116623522","https://openalex.org/W2127228110","https://openalex.org/W2127553917","https://openalex.org/W2130541969","https://openalex.org/W2132629607","https://openalex.org/W2134967712","https://openalex.org/W2151056909","https://openalex.org/W2154474046","https://openalex.org/W2162990042","https://openalex.org/W2164825836","https://openalex.org/W2166742830","https://openalex.org/W2168848634","https://openalex.org/W2169678694","https://openalex.org/W2171268876","https://openalex.org/W2176516200","https://openalex.org/W2177551934","https://openalex.org/W2183709168","https://openalex.org/W2230047757","https://openalex.org/W2262285906","https://openalex.org/W2277129408","https://openalex.org/W2292278614","https://openalex.org/W2298793375","https://openalex.org/W2320784348","https://openalex.org/W2346292862","https://openalex.org/W2475045070","https://openalex.org/W2480788528","https://openalex.org/W2550557415","https://openalex.org/W2589236205","https://openalex.org/W2593436234","https://openalex.org/W2606142660","https://openalex.org/W2623334545","https://openalex.org/W2745989620","https://openalex.org/W2752617071","https://openalex.org/W2761751098","https://openalex.org/W2765570325","https://openalex.org/W2767707410","https://openalex.org/W2767891136","https://openalex.org/W2768702618","https://openalex.org/W2784286881","https://openalex.org/W2807949216","https://openalex.org/W2884940901","https://openalex.org/W2888264084","https://openalex.org/W2899070097","https://openalex.org/W2909290882","https://openalex.org/W2914423469","https://openalex.org/W2920649407","https://openalex.org/W2921282474","https://openalex.org/W2923972641","https://openalex.org/W2926651094","https://openalex.org/W2943893168","https://openalex.org/W2944361240","https://openalex.org/W2953154649","https://openalex.org/W2961633759","https://openalex.org/W2965307048","https://openalex.org/W2970756039","https://openalex.org/W2971801381","https://openalex.org/W2975067375","https://openalex.org/W2981437601","https://openalex.org/W2991594699","https://openalex.org/W2991724444","https://openalex.org/W2993403458","https://openalex.org/W3006297435","https://openalex.org/W3014593404","https://openalex.org/W3015400246","https://openalex.org/W3016523338","https://openalex.org/W3028004908","https://openalex.org/W3039476123","https://openalex.org/W3040041453","https://openalex.org/W3042201570","https://openalex.org/W3046915674","https://openalex.org/W3048076557","https://openalex.org/W3081334037","https://openalex.org/W3087664139","https://openalex.org/W3087987920","https://openalex.org/W3090300247","https://openalex.org/W3093933677","https://openalex.org/W3094051077","https://openalex.org/W3099854242","https://openalex.org/W3104537585","https://openalex.org/W3109266655","https://openalex.org/W3110789075","https://openalex.org/W3121484186","https://openalex.org/W3122785142","https://openalex.org/W3126684855","https://openalex.org/W3128646645","https://openalex.org/W3132575808","https://openalex.org/W3135726897","https://openalex.org/W3135926854","https://openalex.org/W3154945997","https://openalex.org/W3165291270","https://openalex.org/W3165618429","https://openalex.org/W3184138602","https://openalex.org/W3189776437","https://openalex.org/W3193543560","https://openalex.org/W3196221953","https://openalex.org/W3212419871","https://openalex.org/W3213713678","https://openalex.org/W3214622423","https://openalex.org/W3217257896","https://openalex.org/W4206509885","https://openalex.org/W4220687226","https://openalex.org/W4221091810","https://openalex.org/W4226116867","https://openalex.org/W4245989495","https://openalex.org/W4248069649","https://openalex.org/W4248078658","https://openalex.org/W4251132141","https://openalex.org/W4281836397","https://openalex.org/W4283363085","https://openalex.org/W4284964336","https://openalex.org/W4285097413","https://openalex.org/W4295570935","https://openalex.org/W4296180398","https://openalex.org/W4297101637","https://openalex.org/W4307468223","https://openalex.org/W4308484237","https://openalex.org/W4308620128","https://openalex.org/W4311738236","https://openalex.org/W4313890802","https://openalex.org/W4315650551","https://openalex.org/W4321003276","https://openalex.org/W4321100313","https://openalex.org/W4323348505","https://openalex.org/W4361765572","https://openalex.org/W4367182451","https://openalex.org/W4375820693","https://openalex.org/W4375856094","https://openalex.org/W4379509242","https://openalex.org/W4382864915","https://openalex.org/W4385471594","https://openalex.org/W4385693450","https://openalex.org/W4386878224","https://openalex.org/W4392982905","https://openalex.org/W6661604429","https://openalex.org/W6686604366","https://openalex.org/W6715277830","https://openalex.org/W6747633488","https://openalex.org/W6765742794","https://openalex.org/W6771069544","https://openalex.org/W6771178045","https://openalex.org/W6781443996","https://openalex.org/W6785824004","https://openalex.org/W6811265776","https://openalex.org/W6854866072","https://openalex.org/W6857352062","https://openalex.org/W7075630220"],"related_works":["https://openalex.org/W3100975367","https://openalex.org/W3206509028","https://openalex.org/W3044185776","https://openalex.org/W2911790415","https://openalex.org/W1645539021","https://openalex.org/W2163792541","https://openalex.org/W1120554102","https://openalex.org/W1566958759","https://openalex.org/W4360825362","https://openalex.org/W2522331541"],"abstract_inverted_index":{"Cervical":[0],"cancer":[1,7,14,49,72,150,170],"is":[2,41,64,122,294],"the":[3,9,37,81,97,110,115,140,155,239,264,298,301,306],"fourth":[4,10],"most":[5],"diagnosed":[6],"and":[8,21,34,62,73,89,112,128,135,152,157,162,194,211,230,246,255,271,275,287,312],"leading":[11],"cause":[12],"of":[13,84,114,160,221,268,300,309],"death":[15],"in":[16,69,109,118,139,315],"women":[17],"globally.":[18],"Its":[19],"onset":[20,151],"progression":[22],"have":[23],"been":[24],"attributed":[25],"to":[26,43,47,80,124,185,201,238,252,296,304],"high-risk":[27,56],"human":[28],"papillomavirus":[29],"(HPV)":[30],"types,":[31],"especially":[32,94],"16":[33],"18,":[35],"while":[36],"Epstein\u2013Barr":[38],"virus":[39],"(EBV)":[40],"believed":[42,123],"also":[44,280],"significantly":[45],"contribute":[46,79],"cervical":[48,71,149,169,316],"growth.":[50,153],"The":[51,196],"E6":[52,77,127,156,273,311],"protein":[53],"associated":[54],"with":[55,181],"HPV":[57,126,161,272,310],"strains,":[58],"such":[59],"as":[60,131,133],"HPV16":[61,190,244],"HPV18,":[63],"known":[65],"for":[66,168,177],"its":[67],"role":[68,108],"promoting":[70],"other":[74,98],"anogenital":[75],"cancers.":[76,317],"proteins":[78,242,314],"malignant":[82],"transformation":[83],"infected":[85,119],"cells":[86],"by":[87],"targeting":[88],"degrading":[90],"tumor":[91],"suppressor":[92],"proteins,":[93,189],"p53.":[95],"On":[96],"hand,":[99],"EBV":[100,116],"nuclear":[101],"antigen":[102],"1":[103],"(EBNA1)":[104],"plays":[105],"a":[106],"crucial":[107],"maintenance":[111],"replication":[113],"genome":[117],"cells.":[120],"EBNA1":[121,158,269,313],"increase":[125],"E7":[129],"levels,":[130],"well":[132],"c-MYC,":[134],"BIRC5":[136],"cellular":[137],"genes":[138],"HeLa":[141],"cell":[142],"line,":[143],"implying":[144],"that":[145],"HPV/EBV":[146],"co-infection":[147],"accelerates":[148],"Thus,":[154],"antigens":[159],"EBV,":[163],"respectively,":[164],"are":[165],"attractive":[166],"targets":[167],"immunotherapy.":[171],"This":[172],"study,":[173],"therefore,":[174],"virtually":[175],"screened":[176],"potential":[178],"drug":[179],"candidates":[180],"good":[182],"binding":[183,262],"affinity":[184,235],"all":[186],"three":[187,240],"oncoviral":[188,241],"E6,":[191,193,245],"HPV18":[192,247],"EBNA1.":[195],"compounds":[197,223,258,303],"were":[198],"further":[199],"subjected":[200,251],"ADMET":[202],"profiling,":[203],"biological":[204],"activity":[205,278],"predictions,":[206],"molecular":[207,212],"dynamics":[208],"(MD)":[209],"simulations,":[210],"mechanics":[213],"Poisson\u2013Boltzmann":[214],"surface":[215],"area":[216],"(MM/PBSA)":[217],"calculations.":[218],"A":[219],"total":[220],"six":[222],"comprising":[224],"ZINC000013380012,":[225],"ZINC000070454124,":[226],"ZINC000014588133,":[227],"ZINC000085568136,":[228],"ZINC000095909247,":[229],"ZINC000085597263":[231],"demonstrated":[232,259],"very":[233],"strong":[234],"(\u2264\u221260":[236],"kJ/mol)":[237],"(EBNA1,":[243],"E6)":[248],"after":[249],"being":[250],"docking,":[253],"MD,":[254],"MM/PBSA.":[256],"These":[257],"relatively":[260],"stronger":[261],"than":[263],"controls":[265],"used,":[266],"inhibitors":[267],"(VK-1727)":[270],"(baicalein":[274],"gossypetin).":[276],"Biological":[277],"predictions":[279],"corroborated":[281],"their":[282],"antineoplastic,":[283],"p53-enhancing,":[284],"Pin1":[285],"inhibitory,":[286],"JAK2":[288],"inhibitory":[289],"activities.":[290],"Further":[291],"experimental":[292],"testing":[293],"required":[295],"validate":[297],"ability":[299],"shortlisted":[302],"silence":[305],"insidious":[307],"effects":[308]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}
