{"id":"https://openalex.org/W7154970739","doi":"https://doi.org/10.3390/systems14040444","title":"An Immune-Inspired Dynamic Regulation Framework for Supply Chain Viability","display_name":"An Immune-Inspired Dynamic Regulation Framework for Supply Chain Viability","publication_year":2026,"publication_date":"2026-04-19","ids":{"openalex":"https://openalex.org/W7154970739","doi":"https://doi.org/10.3390/systems14040444"},"language":"en","primary_location":{"id":"doi:10.3390/systems14040444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/systems14040444","pdf_url":"https://www.mdpi.com/2079-8954/14/4/444/pdf?version=1776591536","source":{"id":"https://openalex.org/S4210219410","display_name":"Systems","issn_l":"2079-8954","issn":["2079-8954"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-8954/14/4/444/pdf?version=1776591536","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5129748831","display_name":"Andr\u00e9s Polo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093783","display_name":"Fundaci\u00f3n Universitaria Agraria de Colombia - UNIAGRARIA","ror":"https://ror.org/00kt2hh26","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210093783"]},{"id":"https://openalex.org/I91732220","display_name":"Universidad del Valle","ror":"https://ror.org/00jb9vg53","country_code":"CO","type":"education","lineage":["https://openalex.org/I91732220"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Andr\u00e9s Polo","raw_affiliation_strings":["Department of Industrial Engineering, Fundaci\u00f3n Universitaria Agraria de Colombia, Bogot\u00e1 110110, Colombia","School of Industrial Engineering, Universidad del Valle, Cali 760001, Colombia"],"raw_orcid":"https://orcid.org/0000-0002-9384-053X","affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, Fundaci\u00f3n Universitaria Agraria de Colombia, Bogot\u00e1 110110, Colombia","institution_ids":["https://openalex.org/I4210093783"]},{"raw_affiliation_string":"School of Industrial Engineering, Universidad del Valle, Cali 760001, Colombia","institution_ids":["https://openalex.org/I91732220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065792888","display_name":"Daniel Morillo-Torres","orcid":"https://orcid.org/0000-0001-7731-1104"},"institutions":[{"id":"https://openalex.org/I233745408","display_name":"Pontificia Universidad Javeriana","ror":"https://ror.org/03etyjw28","country_code":"CO","type":"education","lineage":["https://openalex.org/I233745408"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Daniel Morillo-Torres","raw_affiliation_strings":["Department of Civil and Industrial Engineering, Pontificia Universidad Javeriana, Cali 760001, Colombia"],"raw_orcid":"https://orcid.org/0000-0001-7731-1104","affiliations":[{"raw_affiliation_string":"Department of Civil and Industrial Engineering, Pontificia Universidad Javeriana, Cali 760001, Colombia","institution_ids":["https://openalex.org/I233745408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019598153","display_name":"John Willmer Escobar","orcid":"https://orcid.org/0000-0001-6175-9553"},"institutions":[{"id":"https://openalex.org/I91732220","display_name":"Universidad del Valle","ror":"https://ror.org/00jb9vg53","country_code":"CO","type":"education","lineage":["https://openalex.org/I91732220"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"John Willmer Escobar","raw_affiliation_strings":["School of Industrial Engineering, Universidad del Valle, Cali 760001, Colombia"],"raw_orcid":"https://orcid.org/0000-0001-6175-9553","affiliations":[{"raw_affiliation_string":"School of Industrial Engineering, Universidad del Valle, Cali 760001, Colombia","institution_ids":["https://openalex.org/I91732220"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5129748831"],"corresponding_institution_ids":["https://openalex.org/I4210093783","https://openalex.org/I91732220"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1782},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1782},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3059136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"4","first_page":"444","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.30869999527931213,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.30869999527931213,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11864","display_name":"Supply Chain Resilience and Risk Management","score":0.23469999432563782,"subfield":{"id":"https://openalex.org/subfields/1408","display_name":"Strategy and Management"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10328","display_name":"Supply Chain and Inventory Management","score":0.14329999685287476,"subfield":{"id":"https://openalex.org/subfields/1404","display_name":"Management Information Systems"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/supply-chain","display_name":"Supply chain","score":0.7002999782562256},{"id":"https://openalex.org/keywords/resilience","display_name":"Resilience (materials science)","score":0.6082000136375427},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.5159000158309937},{"id":"https://openalex.org/keywords/system-dynamics","display_name":"System dynamics","score":0.4106000065803528},{"id":"https://openalex.org/keywords/psychological-resilience","display_name":"Psychological resilience","score":0.3725000023841858},{"id":"https://openalex.org/keywords/adaptive-system","display_name":"Adaptive system","score":0.3612000048160553},{"id":"https://openalex.org/keywords/chain","display_name":"Chain (unit)","score":0.33629998564720154},{"id":"https://openalex.org/keywords/supply-chain-risk-management","display_name":"Supply chain risk management","score":0.3336000144481659}],"concepts":[{"id":"https://openalex.org/C108713360","wikidata":"https://www.wikidata.org/wiki/Q1824206","display_name":"Supply chain","level":2,"score":0.7002999782562256},{"id":"https://openalex.org/C2779585090","wikidata":"https://www.wikidata.org/wiki/Q3457762","display_name":"Resilience (materials science)","level":2,"score":0.6082000136375427},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5321000218391418},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5159000158309937},{"id":"https://openalex.org/C77405623","wikidata":"https://www.wikidata.org/wiki/Q598451","display_name":"System dynamics","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C137176749","wikidata":"https://www.wikidata.org/wiki/Q4105337","display_name":"Psychological resilience","level":2,"score":0.3725000023841858},{"id":"https://openalex.org/C52970973","wikidata":"https://www.wikidata.org/wiki/Q2497134","display_name":"Adaptive system","level":2,"score":0.3612000048160553},{"id":"https://openalex.org/C199185054","wikidata":"https://www.wikidata.org/wiki/Q552299","display_name":"Chain (unit)","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.33550000190734863},{"id":"https://openalex.org/C192639820","wikidata":"https://www.wikidata.org/wiki/Q1114469","display_name":"Supply chain risk management","level":5,"score":0.3336000144481659},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3319000005722046},{"id":"https://openalex.org/C107464732","wikidata":"https://www.wikidata.org/wiki/Q235781","display_name":"Adaptive control","level":3,"score":0.32510000467300415},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2780504989","wikidata":"https://www.wikidata.org/wiki/Q2742037","display_name":"Dynamic capabilities","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C44104985","wikidata":"https://www.wikidata.org/wiki/Q492886","display_name":"Supply chain management","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C63108463","wikidata":"https://www.wikidata.org/wiki/Q581233","display_name":"Complex adaptive system","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.25429999828338623}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/systems14040444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/systems14040444","pdf_url":"https://www.mdpi.com/2079-8954/14/4/444/pdf?version=1776591536","source":{"id":"https://openalex.org/S4210219410","display_name":"Systems","issn_l":"2079-8954","issn":["2079-8954"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ae2b41d9dbe14c40ae78b9dcb983ab47","is_oa":true,"landing_page_url":"https://doaj.org/article/ae2b41d9dbe14c40ae78b9dcb983ab47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Systems, Vol 14, Iss 4, p 444 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/systems14040444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/systems14040444","pdf_url":"https://www.mdpi.com/2079-8954/14/4/444/pdf?version=1776591536","source":{"id":"https://openalex.org/S4210219410","display_name":"Systems","issn_l":"2079-8954","issn":["2079-8954"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7154970739.pdf","grobid_xml":"https://content.openalex.org/works/W7154970739.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Evidence":[0],"from":[1],"recent":[2],"large-scale":[3],"disruptions":[4],"indicates":[5],"that":[6,37,115,153],"efficiency-centered":[7],"supply":[8,59,107],"chain":[9,108],"designs":[10],"struggle":[11],"to":[12,99,130,133],"sustain":[13],"operation":[14],"under":[15,109,170],"persistent":[16],"and":[17,25,41,49,70,90,104,124,143,148,162],"systemic":[18],"uncertainty.":[19],"This":[20],"study":[21],"introduces":[22,156],"the":[23],"Response":[24],"Adaptive":[26],"Immune-Inspired":[27],"Supply":[28],"Chain":[29],"Immune":[30],"System":[31],"(RAIE\u2013SCIS),":[32],"a":[33,53,100,157],"continuous-time":[34],"dynamic":[35],"framework":[36,57],"extends":[38],"existing":[39],"viability":[40,93],"resilience":[42],"approaches":[43],"by":[44,122,128,175],"explicitly":[45],"modeling":[46],"inter-temporal":[47],"adaptation":[48],"operational":[50],"memory":[51,71,165],"within":[52],"control-theoretic":[54],"structure.":[55],"The":[56,95,150],"represents":[58],"chains":[60],"as":[61],"multi-layer":[62],"control":[63],"systems":[64],"where":[65],"structural":[66],"protection,":[67],"adaptive":[68,154],"regulation,":[69],"mechanisms":[72,166],"jointly":[73],"shape":[74,167],"system":[75],"response":[76],"over":[77],"time.":[78],"Viability":[79],"is":[80,97],"assessed":[81],"using":[82],"time-dependent":[83],"indicators,":[84],"including":[85],"performance":[86,120],"trajectories,":[87],"recovery":[88,126,160,168],"time,":[89],"an":[91],"adaptation-based":[92],"index.":[94],"model":[96],"applied":[98],"carbon":[101],"capture,":[102],"utilization,":[103],"storage":[105],"(CCUS)":[106],"heterogeneous":[110],"disruption":[111],"scenarios.":[112],"Results":[113],"show":[114],"immune-enabled":[116],"configurations":[117],"increase":[118],"minimum":[119],"levels":[121],"15\u201330%":[123],"reduce":[125],"times":[127],"up":[129],"25%":[131],"compared":[132],"non-adaptive":[134],"configurations.":[135],"These":[136],"improvements":[137],"are":[138],"not":[139,173],"uniform":[140],"across":[141],"scenarios":[142],"depend":[144],"on":[145],"disturbance":[146],"structure":[147],"recurrence.":[149],"analysis":[151],"reveals":[152],"regulation":[155],"trade-off":[158],"between":[159],"speed":[161],"variability,":[163],"while":[164],"dynamics":[169],"recurrent":[171],"disruptions\u2014effects":[172],"captured":[174],"static":[176],"or":[177,189],"purely":[178],"reactive":[179],"models.":[180],"Their":[181],"effects":[182],"become":[183],"more":[184],"pronounced":[185],"when":[186],"disturbances":[187],"accumulate":[188],"propagate.":[190]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2026-04-21T00:00:00"}