{"id":"https://openalex.org/W4401207826","doi":"https://doi.org/10.3390/sym16080967","title":"Mathematical Modeling in Bioinformatics: Application of an Alignment-Free Method Combined with Principal Component Analysis","display_name":"Mathematical Modeling in Bioinformatics: Application of an Alignment-Free Method Combined with Principal Component Analysis","publication_year":2024,"publication_date":"2024-07-30","ids":{"openalex":"https://openalex.org/W4401207826","doi":"https://doi.org/10.3390/sym16080967"},"language":"en","primary_location":{"id":"doi:10.3390/sym16080967","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/sym16080967","pdf_url":"https://www.mdpi.com/2073-8994/16/8/967/pdf","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-8994/16/8/967/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001504659","display_name":"Dorota Bieli\u0144ska-W\u0105\u017c","orcid":"https://orcid.org/0000-0003-4674-0576"},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Dorota Bieli\u0144ska-W\u0105\u017c","raw_affiliation_strings":["Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084600169","display_name":"Piotr W\u0105\u017c","orcid":"https://orcid.org/0000-0002-0696-9950"},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr W\u0105\u017c","raw_affiliation_strings":["Department of Nuclear Medicine, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106113480","display_name":"Agata B\u0142aczkowska","orcid":"https://orcid.org/0009-0004-9697-5079"},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agata B\u0142aczkowska","raw_affiliation_strings":["Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"],"raw_orcid":"https://orcid.org/0009-0004-9697-5079","affiliations":[{"raw_affiliation_string":"Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106215260","display_name":"Jan Mandrysz","orcid":null},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jan Mandrysz","raw_affiliation_strings":["Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"],"raw_orcid":"https://orcid.org/0009-0004-6728-4885","affiliations":[{"raw_affiliation_string":"Department of Radiological Informatics and Statistics, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045365447","display_name":"Anna Lass","orcid":"https://orcid.org/0000-0002-5885-9868"},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Lass","raw_affiliation_strings":["Department of Tropical Parasitology, Medical University of Gda\u0144sk, 81-519 Gdynia, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Parasitology, Medical University of Gda\u0144sk, 81-519 Gdynia, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092881140","display_name":"Pawe\u0142 G\u0142adysz","orcid":"https://orcid.org/0000-0002-8450-1421"},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Pawe\u0142 G\u0142adysz","raw_affiliation_strings":["Department of Tropical Parasitology, Medical University of Gda\u0144sk, 81-519 Gdynia, Poland"],"raw_orcid":"https://orcid.org/0000-0002-8450-1421","affiliations":[{"raw_affiliation_string":"Department of Tropical Parasitology, Medical University of Gda\u0144sk, 81-519 Gdynia, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084600939","display_name":"Jacek Karamon","orcid":"https://orcid.org/0000-0002-5830-167X"},"institutions":[{"id":"https://openalex.org/I4210120736","display_name":"National Veterinary Research Institute","ror":"https://ror.org/02k3v9512","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120736"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek Karamon","raw_affiliation_strings":["Department of Parasitology and Invasive Diseases, National Veterinary Research Institute, 24-100 Pu\u0142awy, Poland"],"raw_orcid":"https://orcid.org/0000-0002-5830-167X","affiliations":[{"raw_affiliation_string":"Department of Parasitology and Invasive Diseases, National Veterinary Research Institute, 24-100 Pu\u0142awy, Poland","institution_ids":["https://openalex.org/I4210120736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001504659"],"corresponding_institution_ids":["https://openalex.org/I75124487"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2165},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2165},"fwci":0.7585,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70170547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":"8","first_page":"967","last_page":"967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.6500469446182251},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.6168023943901062},{"id":"https://openalex.org/keywords/distance-matrix","display_name":"Distance matrix","score":0.5435994863510132},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4740191102027893},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.46717649698257446},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4400142729282379},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.4395640790462494},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.4330298900604248},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.42293819785118103},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4105806350708008},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.31613481044769287},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15518683195114136},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12932085990905762}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.6500469446182251},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.6168023943901062},{"id":"https://openalex.org/C111208986","wikidata":"https://www.wikidata.org/wiki/Q901698","display_name":"Distance matrix","level":2,"score":0.5435994863510132},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4740191102027893},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.46717649698257446},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4400142729282379},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.4395640790462494},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.4330298900604248},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42293819785118103},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4105806350708008},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.31613481044769287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15518683195114136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12932085990905762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/sym16080967","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/sym16080967","pdf_url":"https://www.mdpi.com/2073-8994/16/8/967/pdf","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:63ddf88201a5473a9ee262f7cce5a770","is_oa":false,"landing_page_url":"https://doaj.org/article/63ddf88201a5473a9ee262f7cce5a770","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry, Vol 16, Iss 8, p 967 (2024)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2073-8994/16/8/967/","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym16080967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/sym16080967","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/sym16080967","pdf_url":"https://www.mdpi.com/2073-8994/16/8/967/pdf","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8393512270","display_name":null,"funder_award_id":"2020/37/B/NZ7/03934","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401207826.pdf","grobid_xml":"https://content.openalex.org/works/W4401207826.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W576482196","https://openalex.org/W1965961979","https://openalex.org/W1971186585","https://openalex.org/W1974757394","https://openalex.org/W1975355749","https://openalex.org/W1988587625","https://openalex.org/W1991340816","https://openalex.org/W1996421807","https://openalex.org/W2007564222","https://openalex.org/W2013036207","https://openalex.org/W2016251735","https://openalex.org/W2030231778","https://openalex.org/W2043124415","https://openalex.org/W2055425683","https://openalex.org/W2077513580","https://openalex.org/W2077759547","https://openalex.org/W2079302202","https://openalex.org/W2079830359","https://openalex.org/W2088538153","https://openalex.org/W2094296386","https://openalex.org/W2110330032","https://openalex.org/W2132069499","https://openalex.org/W2137866800","https://openalex.org/W2152207030","https://openalex.org/W2157323107","https://openalex.org/W2185254985","https://openalex.org/W2189612367","https://openalex.org/W2252278563","https://openalex.org/W2273543050","https://openalex.org/W2322578903","https://openalex.org/W2552647585","https://openalex.org/W2560440601","https://openalex.org/W2593607932","https://openalex.org/W2621314790","https://openalex.org/W2730527311","https://openalex.org/W2774178463","https://openalex.org/W2823132974","https://openalex.org/W2892698694","https://openalex.org/W2897887456","https://openalex.org/W2900399468","https://openalex.org/W2901601633","https://openalex.org/W2916837122","https://openalex.org/W2917579569","https://openalex.org/W2938869514","https://openalex.org/W2963213534","https://openalex.org/W2991539665","https://openalex.org/W3015990691","https://openalex.org/W3119683330","https://openalex.org/W3127988165","https://openalex.org/W3153647524","https://openalex.org/W3165477778","https://openalex.org/W3190803161","https://openalex.org/W4200198176","https://openalex.org/W4206575533","https://openalex.org/W4207065104","https://openalex.org/W4281908559","https://openalex.org/W4318814347","https://openalex.org/W4353065609","https://openalex.org/W4382062672","https://openalex.org/W4386458346","https://openalex.org/W4390539515","https://openalex.org/W4392356375","https://openalex.org/W6652004623","https://openalex.org/W6694083045","https://openalex.org/W6746923518"],"related_works":["https://openalex.org/W1975632186","https://openalex.org/W3027745756","https://openalex.org/W3205213561","https://openalex.org/W2531880140","https://openalex.org/W2036609560","https://openalex.org/W346861917","https://openalex.org/W3024018414","https://openalex.org/W2068608913","https://openalex.org/W2126145365","https://openalex.org/W4380081032"],"abstract_inverted_index":{"In":[0,27],"this":[1,28,246],"paper,":[2],"an":[3],"alignment-free":[4,276],"bioinformatics":[5,277],"technique,":[6],"termed":[7],"the":[8,18,57,77,82,86,89,94,116,146,151,163,169,186,200,215,226,231,242,251,265,269],"20D-Dynamic":[9,152],"Representation":[10,153,271],"of":[11,40,50,56,76,79,81,88,91,93,106,144,154,171,177,179,202,218,233,253,272],"Protein":[12,155],"Sequences,":[13,274],"is":[14,54,61,109,217],"utilized":[15],"to":[16,68,111,250,259],"investigate":[17],"similarity/dissimilarity":[19],"between":[20],"Baculovirus":[21],"and":[22,60,85,108,174,223],"Echinococcus":[23],"multilocularis":[24],"genome":[25],"sequences.":[26],"method,":[29],"amino":[30],"acid":[31],"sequences":[32,212,232],"are":[33,138,160],"depicted":[34],"as":[35,74,97,121,140,182],"20D-dynamic":[36,83,180,203],"graphs,":[37],"comprising":[38],"sets":[39],"\u201cmaterial":[41],"points\u201d":[42],"in":[43,71,189],"a":[44,98,122,128,132,141,190,206],"20-dimensional":[45],"space.":[46],"The":[47,135],"spatial":[48],"distribution":[49],"these":[51],"material":[52],"points":[53],"indicative":[55],"sequence":[58,65],"characteristics":[59],"quantitatively":[62],"described":[63],"by":[64,281],"descriptors":[66],"akin":[67],"those":[69],"employed":[70,110],"dynamics,":[72],"such":[73],"coordinates":[75,173],"center":[78,170],"mass":[80,172],"graph":[84,95],"tensor":[87],"moment":[90],"inertia":[92,178],"(defined":[96],"symmetric":[99,123],"matrix).":[100],"Each":[101],"descriptor":[102],"unveils":[103],"distinct":[104],"features":[105],"similarity":[107,113,147,228,256],"establish":[112],"relations":[114,148,257],"among":[115,230],"examined":[117],"sequences,":[118],"manifested":[119],"either":[120],"distance":[124],"matrix":[125],"(\u201csimilarity":[126],"matrix\u201d),":[127],"classification":[129,136,158],"map,":[130],"or":[131],"phylogenetic":[133],"tree.":[134],"maps":[137,159],"introduced":[139,280],"new":[142,255],"way":[143],"visualizing":[145],"obtained":[149,161],"using":[150,162,268],"Sequences.":[156],"Some":[157],"Principal":[164],"Component":[165],"Analysis":[166],"(PCA)":[167],"for":[168],"normalized":[175],"moments":[176],"graphs":[181,204],"input":[183],"data.":[184],"Although":[185],"method":[187,216,278],"operates":[188],"multidimensional":[191],"space,":[192],"we":[193],"also":[194,279],"apply":[195],"some":[196],"visualization":[197],"techniques,":[198],"including":[199],"projection":[201],"onto":[205],"2D":[207,243],"plane.":[208],"Studies":[209],"on":[210,241],"model":[211],"indicate":[213],"that":[214],"high":[219,227],"quality,":[220],"both":[221],"graphically":[222],"numerically.":[224],"Despite":[225],"observed":[229],"E.":[234],"multilocularis,":[235],"subtle":[236],"discrepancies":[237],"can":[238],"be":[239],"discerned":[240],"graphs.":[244],"Employing":[245],"approach":[247],"has":[248],"led":[249],"discovery":[252],"numerous":[254],"compared":[258],"our":[260],"prior":[261],"study":[262],"conducted":[263],"at":[264],"DNA":[266],"level,":[267],"4D-Dynamic":[270],"DNA/RNA":[273],"another":[275],"us.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}