{"id":"https://openalex.org/W4322619780","doi":"https://doi.org/10.3390/sym15030609","title":"New Schiff Base\u2013TMB Hybrids: Design, Synthesis and Antiproliferative Investigation as Potential Anticancer Agents","display_name":"New Schiff Base\u2013TMB Hybrids: Design, Synthesis and Antiproliferative Investigation as Potential Anticancer Agents","publication_year":2023,"publication_date":"2023-02-28","ids":{"openalex":"https://openalex.org/W4322619780","doi":"https://doi.org/10.3390/sym15030609"},"language":"en","primary_location":{"id":"doi:10.3390/sym15030609","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym15030609","pdf_url":"https://www.mdpi.com/2073-8994/15/3/609/pdf?version=1677564785","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-8994/15/3/609/pdf?version=1677564785","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000013546","display_name":"Najiah M. Alyamani","orcid":null},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"Jeddah University","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Najiah M. Alyamani","raw_affiliation_strings":["Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia","Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]},{"raw_affiliation_string":"Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia;","institution_ids":["https://openalex.org/I4210099699"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000013546"],"corresponding_institution_ids":["https://openalex.org/I4210099699"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2165},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2165},"fwci":1.0127,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7152106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"15","issue":"3","first_page":"609","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schiff-base","display_name":"Schiff base","score":0.8807151317596436},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6350317001342773},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.5325300693511963},{"id":"https://openalex.org/keywords/carbon-13-nmr","display_name":"Carbon-13 NMR","score":0.5164130330085754},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.43428462743759155},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.34865444898605347},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3212376832962036}],"concepts":[{"id":"https://openalex.org/C2776428424","wikidata":"https://www.wikidata.org/wiki/Q2602701","display_name":"Schiff base","level":2,"score":0.8807151317596436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6350317001342773},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5325300693511963},{"id":"https://openalex.org/C163111631","wikidata":"https://www.wikidata.org/wiki/Q1952454","display_name":"Carbon-13 NMR","level":2,"score":0.5164130330085754},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43428462743759155},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34865444898605347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3212376832962036}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/sym15030609","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym15030609","pdf_url":"https://www.mdpi.com/2073-8994/15/3/609/pdf?version=1677564785","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:dafae239094d4b35b263107d20166d73","is_oa":false,"landing_page_url":"https://doaj.org/article/dafae239094d4b35b263107d20166d73","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry, Vol 15, Iss 3, p 609 (2023)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2073-8994/15/3/609/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/sym15030609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/sym15030609","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym15030609","pdf_url":"https://www.mdpi.com/2073-8994/15/3/609/pdf?version=1677564785","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4322619780.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W605289355","https://openalex.org/W1973397395","https://openalex.org/W1997708855","https://openalex.org/W2024613683","https://openalex.org/W2036124984","https://openalex.org/W2148626454","https://openalex.org/W2299729257","https://openalex.org/W2528562900","https://openalex.org/W2619771274","https://openalex.org/W2766023905","https://openalex.org/W2917048769","https://openalex.org/W2921291494","https://openalex.org/W2966449487","https://openalex.org/W2967587576","https://openalex.org/W2996972660","https://openalex.org/W3039854014","https://openalex.org/W3049550150","https://openalex.org/W3049759677","https://openalex.org/W3115817518","https://openalex.org/W3127110282","https://openalex.org/W3144674846","https://openalex.org/W3154950152","https://openalex.org/W3164788443","https://openalex.org/W3166207736","https://openalex.org/W3171810308","https://openalex.org/W3173661158","https://openalex.org/W3187834439","https://openalex.org/W3190602430","https://openalex.org/W3193178112","https://openalex.org/W3193347331","https://openalex.org/W3197331074","https://openalex.org/W3202442635","https://openalex.org/W3217454271","https://openalex.org/W4200608891","https://openalex.org/W4210388093","https://openalex.org/W4214811309","https://openalex.org/W4214918434","https://openalex.org/W4220666790","https://openalex.org/W4220776133","https://openalex.org/W4220971085","https://openalex.org/W4223637031","https://openalex.org/W4281695568","https://openalex.org/W4283264616","https://openalex.org/W4286502386","https://openalex.org/W4290790747","https://openalex.org/W4296627443","https://openalex.org/W4297224587","https://openalex.org/W4309739332","https://openalex.org/W6809727682"],"related_works":["https://openalex.org/W2387618262","https://openalex.org/W1975939164","https://openalex.org/W2393044412","https://openalex.org/W2386436982","https://openalex.org/W2327760630","https://openalex.org/W1786408316","https://openalex.org/W3112025214","https://openalex.org/W755732729","https://openalex.org/W2334203538","https://openalex.org/W3127320341"],"abstract_inverted_index":{"The":[0,63,107],"structural":[1],"symmetry":[2],"or":[3],"asymmetry":[4],"of":[5,10,26,32,68,88,109,166,176],"organic":[6],"compounds":[7],"is":[8,150],"one":[9],"the":[11,44,69,75,84,89,99,104,110,118,137,145,163,167,174,177],"most":[12],"fundamental":[13],"characteristics.":[14],"Z-geometrical":[15],"isomers":[16],"are":[17],"promiscuous":[18],"and":[19,38,52,59,148,169],"kinetically":[20],"preferred":[21],"structures":[22],"with":[23,81],"a":[24,151],"plethora":[25],"biological":[27],"activities.":[28],"A":[29],"new":[30],"series":[31],"hybrid":[33],"molecules":[34],"containing":[35],"Schiff":[36,120,130,159],"base":[37,121,131,160],"3,4,5-trimethoxybenzamide":[39],"moieties":[40],"were":[41],"synthesized":[42,91],"from":[43],"starting":[45],"material":[46],"ethyl":[47],"acrylate":[48],"ester":[49],"derivative":[50],"(Z)-1":[51],"structurally":[53],"confirmed":[54],"by":[55,140],"elemental":[56],"microanalysis,":[57],"1H-NMR,":[58],"13C-NMR":[60],"spectroscopic":[61],"studies.":[62],"in":[64],"vitro":[65],"cytotoxic":[66],"activity":[67,97,114,135],"target":[70],"hybrids":[71,92],"was":[72],"tested":[73],"against":[74,98],"MCF-7":[76,100,138],"breast":[77],"cancer":[78],"line":[79],"compared":[80,102],"colchicine":[82],"as":[83],"reference":[85,105],"compound.":[86],"Most":[87],"newly":[90],"showed":[93,116,157],"good":[94,124],"growth":[95],"inhibition":[96,113,125],"cells":[101,139],"to":[103],"substance.":[106],"results":[108],"\u03b2-tubulin":[111],"polymerization":[112],"assay":[115],"that":[117,158],"p-vanillin":[119,129],"4g":[122,132,161],"displayed":[123],"activity.":[126],"In":[127],"addition,":[128],"exhibited":[133],"antiproliferative":[134],"over":[136],"cellular":[141],"cycle":[142],"blockade":[143],"at":[144],"G2/M":[146],"phase":[147],"it":[149],"potent":[152],"apoptotic":[153],"agent.":[154],"qRT-PCR":[155],"analysis":[156],"boosted":[162],"mRNA":[164],"expression":[165,175],"p53":[168],"Bax":[170],"levels":[171],"while":[172],"lowering":[173],"Bcl-2":[178],"level.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2023-03-01T00:00:00"}
