{"id":"https://openalex.org/W4285009906","doi":"https://doi.org/10.3390/sym14071403","title":"Identification of Novel Drugs Targeting Cell Cycle Regulators for the Treatment of High-Grade Serous Ovarian Cancer via Integrated Bioinformatics Analysis","display_name":"Identification of Novel Drugs Targeting Cell Cycle Regulators for the Treatment of High-Grade Serous Ovarian Cancer via Integrated Bioinformatics Analysis","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4285009906","doi":"https://doi.org/10.3390/sym14071403"},"language":"en","primary_location":{"id":"doi:10.3390/sym14071403","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym14071403","pdf_url":"https://www.mdpi.com/2073-8994/14/7/1403/pdf?version=1657700548","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-8994/14/7/1403/pdf?version=1657700548","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021086012","display_name":"Yuanchun Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanchun Zhao","raw_affiliation_strings":["School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111007306","display_name":"Jiachen Zuo","orcid":null},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachen Zuo","raw_affiliation_strings":["School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052859737","display_name":"Yiming Shen","orcid":"https://orcid.org/0000-0002-2558-815X"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Shen","raw_affiliation_strings":["School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China"],"raw_orcid":"https://orcid.org/0000-0002-2558-815X","affiliations":[{"raw_affiliation_string":"School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060954578","display_name":"Donghui Yan","orcid":"https://orcid.org/0000-0002-5131-1509"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donghui Yan","raw_affiliation_strings":["School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401009","display_name":"Jiajia Chen","orcid":"https://orcid.org/0000-0003-3659-0658"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Chen","raw_affiliation_strings":["School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087999294","display_name":"Xin Qi","orcid":"https://orcid.org/0000-0003-2637-3289"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Qi","raw_affiliation_strings":["School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215011, China","institution_ids":["https://openalex.org/I308837"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087999294"],"corresponding_institution_ids":["https://openalex.org/I308837"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2227},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2227},"fwci":0.1362,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4267593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"7","first_page":"1403","last_page":"1403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-1","display_name":"Cyclin-dependent kinase 1","score":0.5576006174087524},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.5118917226791382},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.49554336071014404},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4905208945274353},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4413701295852661},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.41885316371917725},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4050368666648865},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.399189829826355},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34492361545562744},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3389759957790375},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2617231011390686},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13222232460975647}],"concepts":[{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.5576006174087524},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5118917226791382},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.49554336071014404},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4905208945274353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4413701295852661},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41885316371917725},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4050368666648865},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.399189829826355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34492361545562744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3389759957790375},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2617231011390686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13222232460975647}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/sym14071403","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym14071403","pdf_url":"https://www.mdpi.com/2073-8994/14/7/1403/pdf?version=1657700548","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:739415d1469e4445bd6dd420feded9aa","is_oa":true,"landing_page_url":"https://doaj.org/article/739415d1469e4445bd6dd420feded9aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry, Vol 14, Iss 7, p 1403 (2022)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2073-8994/14/7/1403/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/sym14071403","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/sym14071403","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym14071403","pdf_url":"https://www.mdpi.com/2073-8994/14/7/1403/pdf?version=1657700548","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4077210181","display_name":null,"funder_award_id":"31900490","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285009906.pdf"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1270834676","https://openalex.org/W1600604896","https://openalex.org/W1968898725","https://openalex.org/W1971291234","https://openalex.org/W1974614755","https://openalex.org/W1988050012","https://openalex.org/W1995919174","https://openalex.org/W2006617902","https://openalex.org/W2006866162","https://openalex.org/W2012034410","https://openalex.org/W2022208219","https://openalex.org/W2026155624","https://openalex.org/W2058445799","https://openalex.org/W2058680863","https://openalex.org/W2068834223","https://openalex.org/W2079849392","https://openalex.org/W2093191347","https://openalex.org/W2101242266","https://openalex.org/W2116145684","https://openalex.org/W2120343162","https://openalex.org/W2121604817","https://openalex.org/W2146512944","https://openalex.org/W2151357092","https://openalex.org/W2155184582","https://openalex.org/W2169244518","https://openalex.org/W2189238890","https://openalex.org/W2582372140","https://openalex.org/W2607129810","https://openalex.org/W2612467560","https://openalex.org/W2767122952","https://openalex.org/W2894373400","https://openalex.org/W2901086483","https://openalex.org/W3005530540","https://openalex.org/W3021118559","https://openalex.org/W3081592360","https://openalex.org/W3093532012","https://openalex.org/W3107527779","https://openalex.org/W3110536952","https://openalex.org/W3123995258","https://openalex.org/W3128646645","https://openalex.org/W3131432784","https://openalex.org/W3133136432","https://openalex.org/W3145748790","https://openalex.org/W3162350134","https://openalex.org/W3173744242","https://openalex.org/W3175752499","https://openalex.org/W3206873354","https://openalex.org/W4200591918","https://openalex.org/W4225258286","https://openalex.org/W4240150408","https://openalex.org/W4247513463","https://openalex.org/W6674141976","https://openalex.org/W6732085513","https://openalex.org/W6797786779","https://openalex.org/W7075630220"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2028462563","https://openalex.org/W2982720988","https://openalex.org/W4388725868","https://openalex.org/W2346183813","https://openalex.org/W3123797028","https://openalex.org/W2889677605","https://openalex.org/W2347624711","https://openalex.org/W2366424044"],"abstract_inverted_index":{"High-grade":[0],"serous":[1],"ovarian":[2,13],"carcinoma":[3],"(HGSC),":[4],"the":[5,16,33,47,52,57,74,125,147,160,183,190,237],"most":[6,48],"common":[7],"and":[8,79,93,113,130,169,176,185,200,210,219],"aggressive":[9],"histological":[10],"type":[11],"of":[12,19,36,46,51,59,76,159,192],"cancer,":[14],"remains":[15],"leading":[17],"cause":[18],"cancer-related":[20],"deaths":[21],"among":[22],"females.":[23],"It":[24],"is":[25,44,67],"important":[26,49],"to":[27,31,88,235],"develop":[28],"novel":[29,139,228],"drugs":[30,92,141],"improve":[32],"therapeutic":[34,238],"outcomes":[35],"HGSC":[37,98,107,143,231],"patients,":[38],"thereby":[39,233],"reducing":[40],"their":[41,95,177],"mortality.":[42],"Symmetry":[43],"one":[45],"properties":[50],"biological":[53,61,77],"network,":[54,163],"which":[55,132,221],"determines":[56],"stability":[58,75],"a":[60,68,156,203],"system.":[62],"As":[63],"aberrant":[64],"gene":[65],"expression":[66,178,187],"critical":[69],"symmetry-breaking":[70],"event":[71],"that":[72,197],"perturbs":[73],"networks":[78],"triggers":[80],"tumor":[81],"progression,":[82],"we":[83],"aim":[84],"in":[85,106],"this":[86],"study":[87,215],"discover":[89],"new":[90],"candidate":[91,140],"predict":[94],"targets":[96],"for":[97,142,207,230,240],"therapy":[99],"based":[100],"on":[101],"differentially":[102],"expressed":[103],"genes":[104,112,116],"involved":[105],"pathogenesis.":[108],"Firstly,":[109],"98":[110],"up-regulated":[111],"108":[114],"down-regulated":[115],"were":[117,136,171,180],"identified":[118,137,172],"from":[119],"three":[120],"independent":[121],"transcriptome":[122],"datasets.":[123],"Then,":[124],"small-molecule":[126],"compounds":[127],"PHA-793887,":[128,198,217],"pidorubicine":[129,199,218],"lestaurtinib,":[131,220],"target":[133],"cell-cycle-related":[134],"processes,":[135],"as":[138,173,227],"treatment":[144],"by":[145],"adopting":[146],"connectivity":[148],"map":[149],"(CMap)-based":[150],"drug":[151],"repositioning":[152],"approach.":[153],"Furthermore,":[154],"through":[155],"topological":[157],"analysis":[158,195],"protein\u2013protein":[161],"interaction":[162],"cell":[164,224],"cycle":[165,225],"regulators":[166],"CDK1,":[167,208],"TOP2A":[168,209],"AURKA":[170],"bottleneck":[174],"nodes,":[175],"patterns":[179],"validated":[181],"at":[182],"mRNA":[184],"protein":[186],"levels.":[188],"Moreover,":[189],"results":[191],"molecular":[193],"docking":[194],"showed":[196],"lestaurtinib":[201],"had":[202],"strong":[204],"binding":[205],"affinity":[206],"AURKA,":[211],"respectively.":[212],"Therefore,":[213],"our":[214],"repositioned":[216],"can":[222],"inhibit":[223],"regulators,":[226],"agents":[229],"treatment,":[232],"helping":[234],"optimize":[236],"strategy":[239],"HGSC.":[241]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}