{"id":"https://openalex.org/W2966218244","doi":"https://doi.org/10.3390/sym11080980","title":"The Immobilization of ChEMBL474807 Molecules Using Different Classes of Nanostructures","display_name":"The Immobilization of ChEMBL474807 Molecules Using Different Classes of Nanostructures","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2966218244","doi":"https://doi.org/10.3390/sym11080980","mag":"2966218244"},"language":"en","primary_location":{"id":"doi:10.3390/sym11080980","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym11080980","pdf_url":"https://www.mdpi.com/2073-8994/11/8/980/pdf?version=1564728140","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-8994/11/8/980/pdf?version=1564728140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031969122","display_name":"Przemys\u0142aw Czele\u0144","orcid":"https://orcid.org/0000-0001-7268-4956"},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Przemys\u0142aw Czele\u0144","raw_affiliation_strings":["Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpinskiego 5, 85-096 Bydgoszcz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-7268-4956","affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpinskiego 5, 85-096 Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020187585","display_name":"Beata Szefler","orcid":"https://orcid.org/0000-0001-8433-3520"},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Beata Szefler","raw_affiliation_strings":["Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpinskiego 5, 85-096 Bydgoszcz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8433-3520","affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpinskiego 5, 85-096 Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031969122"],"corresponding_institution_ids":["https://openalex.org/I3019271933"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2165},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2165},"fwci":0.4589,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.5769813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"11","issue":"8","first_page":"980","last_page":"980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10074","display_name":"Carbon Nanotubes in Composites","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10074","display_name":"Carbon Nanotubes in Composites","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10083","display_name":"Graphene research and applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanocarriers","display_name":"Nanocarriers","score":0.8286956548690796},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.7078568935394287},{"id":"https://openalex.org/keywords/fullerene","display_name":"Fullerene","score":0.5711736083030701},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.5367122292518616},{"id":"https://openalex.org/keywords/stacking","display_name":"Stacking","score":0.532153308391571},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5294824242591858},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5181300044059753},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4961758553981781},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.48552966117858887},{"id":"https://openalex.org/keywords/nanostructure","display_name":"Nanostructure","score":0.48430314660072327},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3985246419906616},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.18724223971366882},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.13246741890907288},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.11357176303863525},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08439543843269348}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.8286956548690796},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.7078568935394287},{"id":"https://openalex.org/C162862793","wikidata":"https://www.wikidata.org/wiki/Q178026","display_name":"Fullerene","level":2,"score":0.5711736083030701},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5367122292518616},{"id":"https://openalex.org/C33347731","wikidata":"https://www.wikidata.org/wiki/Q285210","display_name":"Stacking","level":2,"score":0.532153308391571},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5294824242591858},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5181300044059753},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4961758553981781},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.48552966117858887},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.48430314660072327},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3985246419906616},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.18724223971366882},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13246741890907288},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11357176303863525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08439543843269348}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/sym11080980","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym11080980","pdf_url":"https://www.mdpi.com/2073-8994/11/8/980/pdf?version=1564728140","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:9a500b127cd645c791712c6fe66696e7","is_oa":true,"landing_page_url":"https://doaj.org/article/9a500b127cd645c791712c6fe66696e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry, Vol 11, Iss 8, p 980 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/sym11080980","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym11080980","pdf_url":"https://www.mdpi.com/2073-8994/11/8/980/pdf?version=1564728140","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2966218244.pdf","grobid_xml":"https://content.openalex.org/works/W2966218244.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W7882052","https://openalex.org/W1545201063","https://openalex.org/W1564553363","https://openalex.org/W1967900006","https://openalex.org/W1975685724","https://openalex.org/W1981612755","https://openalex.org/W1983691502","https://openalex.org/W1985039245","https://openalex.org/W2002222580","https://openalex.org/W2003700884","https://openalex.org/W2021427002","https://openalex.org/W2021722888","https://openalex.org/W2029071448","https://openalex.org/W2029667189","https://openalex.org/W2034143104","https://openalex.org/W2034973961","https://openalex.org/W2036968634","https://openalex.org/W2044590084","https://openalex.org/W2059654016","https://openalex.org/W2061579734","https://openalex.org/W2071744525","https://openalex.org/W2079464363","https://openalex.org/W2103056710","https://openalex.org/W2134967712","https://openalex.org/W2136673858","https://openalex.org/W2161772005","https://openalex.org/W2163625534","https://openalex.org/W2171195405","https://openalex.org/W2327337848","https://openalex.org/W2345111582","https://openalex.org/W2503754709","https://openalex.org/W2738247636","https://openalex.org/W2885605641","https://openalex.org/W2894910016","https://openalex.org/W2916935765","https://openalex.org/W2954637356","https://openalex.org/W2959638630","https://openalex.org/W3135765194","https://openalex.org/W6753796330","https://openalex.org/W7073624714"],"related_works":["https://openalex.org/W4366721369","https://openalex.org/W3126369458","https://openalex.org/W2895282589","https://openalex.org/W4386456777","https://openalex.org/W4311202961","https://openalex.org/W4387534949","https://openalex.org/W4306391223","https://openalex.org/W3032807122","https://openalex.org/W4205459909","https://openalex.org/W2903956246"],"abstract_inverted_index":{"Indirubin":[0],"derivatives":[1,85],"and":[2,13,34,87,186],"analogues":[3],"are":[4,11],"a":[5,102,114],"large":[6],"group":[7,115],"of":[8,18,45,50,59,65,68,75,94,113,116,141,146,153,160,166,179,194,206],"compounds":[9,117],"which":[10,27],"widely":[12],"successfully":[14],"used":[15,55],"in":[16,40,57,150,177],"treatment":[17],"many":[19],"cancer":[20],"diseases.":[21],"In":[22],"particular,":[23],"the":[24,48,66,92,125,139,174,200,204],"ChEMBL474807":[25,201],"molecule,":[26,202],"has":[28],"confirmed":[29],"inhibiting":[30],"abilities":[31],"against":[32],"CDK2":[33],"GSK3B":[35],"enzymes,":[36],"can":[37,156],"be":[38],"included":[39],"this":[41],"group.":[42],"The":[43,108,164,189],"immobilization":[44],"inhibitors":[46],"with":[47,101,199],"use":[49,93],"nanocarriers":[51],"is":[52,182],"an":[53],"often":[54],"strategy":[56],"creation":[58,205],"targeted":[60,207],"therapies.":[61],"Evaluations":[62],"were":[63,99],"made":[64],"possibility":[67],"immobilizing":[69],"ligand":[70,126],"molecules":[71],"on":[72],"different":[73],"types":[74,152],"nanocarrier,":[76],"such":[77,134,180],"as":[78,135],"carbon":[79],"nanotubes":[80],"(CNT),":[81],"functionalized":[82,88],"fullerene":[83],"C60":[84,106],"(FF_X),":[86],"cube":[89],"rhombellanes,":[90],"via":[91],"docking":[95],"methods.":[96],"All":[97],"results":[98],"compared":[100],"reference":[103],"system,":[104],"namely":[105],"fullerene.":[107],"realized":[109,149,190],"calculations":[110],"allowed":[111,192],"indication":[112],"that":[118,131,173],"exhibited":[119],"significant":[120],"binding":[121,162],"affinity":[122],"relative":[123],"to":[124,138,158],"molecule.":[127],"Obtained":[128],"data":[129],"shows":[130,172],"structural":[132],"modifications,":[133],"those":[136],"related":[137],"addition":[140],"functional":[142],"groups":[143],"or":[144],"changes":[145],"structure":[147],"symmetry,":[148],"particular":[151],"considered":[154],"nanostructures,":[155],"contribute":[157],"increases":[159],"their":[161],"capabilities.":[163],"analysis":[165],"all":[167],"obtained":[168],"nano":[169],"complexes":[170],"clearly":[171],"dominant":[175],"role":[176],"stabilization":[178],"systems":[181],"played":[183],"by":[184],"stacking":[185],"hydrophobic":[187],"interactions.":[188],"research":[191],"identification":[193],"potential":[195],"nanostructures":[196],"that,":[197],"together":[198],"enable":[203],"therapy.":[208]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
