{"id":"https://openalex.org/W2936133164","doi":"https://doi.org/10.3390/sym11040578","title":"Convenient Asymmetric Synthesis of Fmoc-(S)-6,6,6-Trifluoro-Norleucine","display_name":"Convenient Asymmetric Synthesis of Fmoc-(S)-6,6,6-Trifluoro-Norleucine","publication_year":2019,"publication_date":"2019-04-21","ids":{"openalex":"https://openalex.org/W2936133164","doi":"https://doi.org/10.3390/sym11040578","mag":"2936133164"},"language":"en","primary_location":{"id":"doi:10.3390/sym11040578","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym11040578","pdf_url":"https://www.mdpi.com/2073-8994/11/4/578/pdf?version=1556251215","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-8994/11/4/578/pdf?version=1556251215","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081059719","display_name":"Haibo Mei","orcid":"https://orcid.org/0000-0002-2857-1935"},"institutions":[{"id":"https://openalex.org/I167027274","display_name":"Nanjing Forestry University","ror":"https://ror.org/03m96p165","country_code":"CN","type":"education","lineage":["https://openalex.org/I167027274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haibo Mei","raw_affiliation_strings":["Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China"],"affiliations":[{"raw_affiliation_string":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China","institution_ids":["https://openalex.org/I167027274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005471681","display_name":"Zizhen Yin","orcid":"https://orcid.org/0000-0003-1320-3053"},"institutions":[{"id":"https://openalex.org/I167027274","display_name":"Nanjing Forestry University","ror":"https://ror.org/03m96p165","country_code":"CN","type":"education","lineage":["https://openalex.org/I167027274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zizhen Yin","raw_affiliation_strings":["Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China"],"affiliations":[{"raw_affiliation_string":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China","institution_ids":["https://openalex.org/I167027274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112716064","display_name":"Toshio Miwa","orcid":null},"institutions":[{"id":"https://openalex.org/I4210136985","display_name":"Hamari Chemicals (Japan)","ror":"https://ror.org/04941ww55","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210136985"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Miwa","raw_affiliation_strings":["Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan"],"affiliations":[{"raw_affiliation_string":"Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan","institution_ids":["https://openalex.org/I4210136985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035552042","display_name":"Hiroki Moriwaki","orcid":"https://orcid.org/0000-0002-2028-2565"},"institutions":[{"id":"https://openalex.org/I4210136985","display_name":"Hamari Chemicals (Japan)","ror":"https://ror.org/04941ww55","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210136985"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroki Moriwaki","raw_affiliation_strings":["Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan"],"affiliations":[{"raw_affiliation_string":"Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan","institution_ids":["https://openalex.org/I4210136985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026741358","display_name":"Hidenori Abe","orcid":"https://orcid.org/0000-0003-4899-377X"},"institutions":[{"id":"https://openalex.org/I4210136985","display_name":"Hamari Chemicals (Japan)","ror":"https://ror.org/04941ww55","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210136985"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Abe","raw_affiliation_strings":["Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan"],"affiliations":[{"raw_affiliation_string":"Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan","institution_ids":["https://openalex.org/I4210136985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088776829","display_name":"Jianlin Han","orcid":"https://orcid.org/0000-0002-3817-0764"},"institutions":[{"id":"https://openalex.org/I167027274","display_name":"Nanjing Forestry University","ror":"https://ror.org/03m96p165","country_code":"CN","type":"education","lineage":["https://openalex.org/I167027274"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianlin Han","raw_affiliation_strings":["Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China"],"affiliations":[{"raw_affiliation_string":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China","institution_ids":["https://openalex.org/I167027274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036717626","display_name":"Vadim A. Soloshonok","orcid":"https://orcid.org/0000-0003-0681-4526"},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Vadim A. Soloshonok","raw_affiliation_strings":["Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardiz\u00e1bal 3, 20018 San Sebasti\u00e1n, Spain","IKERBASQUE, Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardiz\u00e1bal 3, 20018 San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"IKERBASQUE, Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain","institution_ids":["https://openalex.org/I110594554"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035552042","https://openalex.org/A5036717626","https://openalex.org/A5088776829"],"corresponding_institution_ids":["https://openalex.org/I110594554","https://openalex.org/I167027274","https://openalex.org/I169108374","https://openalex.org/I4210136985"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2165},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2165},"fwci":2.1726,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85995812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"578","last_page":"578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norleucine","display_name":"Norleucine","score":0.9847168326377869},{"id":"https://openalex.org/keywords/alkylation","display_name":"Alkylation","score":0.7228893637657166},{"id":"https://openalex.org/keywords/enantiomer","display_name":"Enantiomer","score":0.6879854798316956},{"id":"https://openalex.org/keywords/yield","display_name":"Yield (engineering)","score":0.6644465327262878},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6497346758842468},{"id":"https://openalex.org/keywords/enantioselective-synthesis","display_name":"Enantioselective synthesis","score":0.6123162508010864},{"id":"https://openalex.org/keywords/glycine","display_name":"Glycine","score":0.5354326963424683},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.4656316637992859},{"id":"https://openalex.org/keywords/enantiomeric-excess","display_name":"Enantiomeric excess","score":0.44213446974754333},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.39035579562187195},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3638245761394501},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.3407951593399048},{"id":"https://openalex.org/keywords/catalysis","display_name":"Catalysis","score":0.1621689796447754},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.11772358417510986},{"id":"https://openalex.org/keywords/leucine","display_name":"Leucine","score":0.09127023816108704},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.05984565615653992}],"concepts":[{"id":"https://openalex.org/C2780327651","wikidata":"https://www.wikidata.org/wiki/Q27116817","display_name":"Norleucine","level":4,"score":0.9847168326377869},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.7228893637657166},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.6879854798316956},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.6644465327262878},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6497346758842468},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.6123162508010864},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5354326963424683},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4656316637992859},{"id":"https://openalex.org/C3141732","wikidata":"https://www.wikidata.org/wiki/Q568761","display_name":"Enantiomeric excess","level":4,"score":0.44213446974754333},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.39035579562187195},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3638245761394501},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3407951593399048},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1621689796447754},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11772358417510986},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.09127023816108704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05984565615653992},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/sym11040578","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym11040578","pdf_url":"https://www.mdpi.com/2073-8994/11/4/578/pdf?version=1556251215","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d29b0d9ca44f484996d247efce57e037","is_oa":true,"landing_page_url":"https://doaj.org/article/d29b0d9ca44f484996d247efce57e037","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symmetry, Vol 11, Iss 4, p 578 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/sym11040578","is_oa":true,"landing_page_url":"https://doi.org/10.3390/sym11040578","pdf_url":"https://www.mdpi.com/2073-8994/11/4/578/pdf?version=1556251215","source":{"id":"https://openalex.org/S190787756","display_name":"Symmetry","issn_l":"2073-8994","issn":["2073-8994"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Symmetry","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7034487035","display_name":null,"funder_award_id":"21761132021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2936133164.pdf","grobid_xml":"https://content.openalex.org/works/W2936133164.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1946660660","https://openalex.org/W1963841187","https://openalex.org/W1969545648","https://openalex.org/W1972004713","https://openalex.org/W1972773940","https://openalex.org/W1973106952","https://openalex.org/W1975921269","https://openalex.org/W1980638592","https://openalex.org/W1982205639","https://openalex.org/W2007861461","https://openalex.org/W2018602881","https://openalex.org/W2021358299","https://openalex.org/W2024213882","https://openalex.org/W2026706201","https://openalex.org/W2028976764","https://openalex.org/W2033246337","https://openalex.org/W2035442432","https://openalex.org/W2035612795","https://openalex.org/W2039338458","https://openalex.org/W2044729774","https://openalex.org/W2054274084","https://openalex.org/W2054527547","https://openalex.org/W2065729232","https://openalex.org/W2066061833","https://openalex.org/W2068431087","https://openalex.org/W2076009569","https://openalex.org/W2076353988","https://openalex.org/W2076421876","https://openalex.org/W2082251547","https://openalex.org/W2084077558","https://openalex.org/W2088201518","https://openalex.org/W2091439125","https://openalex.org/W2097117086","https://openalex.org/W2098745751","https://openalex.org/W2106505086","https://openalex.org/W2120335933","https://openalex.org/W2128101147","https://openalex.org/W2145123696","https://openalex.org/W2148587511","https://openalex.org/W2151963937","https://openalex.org/W2158438506","https://openalex.org/W2160259511","https://openalex.org/W2164515791","https://openalex.org/W2237872262","https://openalex.org/W2283777186","https://openalex.org/W2313414217","https://openalex.org/W2327138840","https://openalex.org/W2330105514","https://openalex.org/W2333129245","https://openalex.org/W2334566440","https://openalex.org/W2334691491","https://openalex.org/W2334914140","https://openalex.org/W2335396054","https://openalex.org/W2427809417","https://openalex.org/W2516283850","https://openalex.org/W2593924484","https://openalex.org/W2607170952","https://openalex.org/W2731779568","https://openalex.org/W2739354616","https://openalex.org/W2784286141","https://openalex.org/W2890413816","https://openalex.org/W2902475539","https://openalex.org/W2910604955","https://openalex.org/W2915523134","https://openalex.org/W2916316324","https://openalex.org/W2939305935","https://openalex.org/W2949150905","https://openalex.org/W2949996275","https://openalex.org/W2951091152","https://openalex.org/W2951105903","https://openalex.org/W2951395851","https://openalex.org/W2951397293","https://openalex.org/W2951859501","https://openalex.org/W2952699951","https://openalex.org/W4285719527","https://openalex.org/W4323284728","https://openalex.org/W6752090385"],"related_works":["https://openalex.org/W1980122052","https://openalex.org/W2047493107","https://openalex.org/W1969581331","https://openalex.org/W2069924568","https://openalex.org/W2071761581","https://openalex.org/W2022936125","https://openalex.org/W45084373","https://openalex.org/W2418807787","https://openalex.org/W2042049058","https://openalex.org/W2320147830"],"abstract_inverted_index":{"In":[0],"this":[1],"work":[2],"we":[3],"report":[4],"a":[5],"convenient":[6],"asymmetric":[7],"synthesis":[8],"of":[9,14,22],"Fmoc-(S)-6,6,6-trifluoro-norleucine":[10],"via":[11],"alkylation":[12],"reaction":[13],"chiral":[15],"glycine":[16],"equivalent.":[17],"The":[18],"target":[19],"amino":[20],"acid":[21],"99%":[23],"enantiomeric":[24],"purity":[25],"was":[26],"prepared":[27],"with":[28],"82.4%":[29],"total":[30],"yield":[31],"(three":[32],"steps).":[33]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2019-04-25T00:00:00"}
