{"id":"https://openalex.org/W2128486920","doi":"https://doi.org/10.3390/s91210356","title":"Aptamer-Functionalized Nano-Biosensors","display_name":"Aptamer-Functionalized Nano-Biosensors","publication_year":2009,"publication_date":"2009-12-21","ids":{"openalex":"https://openalex.org/W2128486920","doi":"https://doi.org/10.3390/s91210356","mag":"2128486920","pmid":"https://pubmed.ncbi.nlm.nih.gov/22303178"},"language":"en","primary_location":{"id":"doi:10.3390/s91210356","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s91210356","pdf_url":"https://www.mdpi.com/1424-8220/9/12/10356/pdf?version=1403311971","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/9/12/10356/pdf?version=1403311971","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014463350","display_name":"Tai\u2010Chia Chiu","orcid":"https://orcid.org/0000-0002-6297-7883"},"institutions":[{"id":"https://openalex.org/I178613991","display_name":"National Taitung University","ror":"https://ror.org/05j9d8v51","country_code":"TW","type":"education","lineage":["https://openalex.org/I178613991"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tai-Chia Chiu","raw_affiliation_strings":["Department of Applied Science, National Taitung University, 684, Section 1, Chunghua Road, Taitung, 95002, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-6297-7883","affiliations":[{"raw_affiliation_string":"Department of Applied Science, National Taitung University, 684, Section 1, Chunghua Road, Taitung, 95002, Taiwan","institution_ids":["https://openalex.org/I178613991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040369687","display_name":"Chih\u2010Ching Huang","orcid":"https://orcid.org/0000-0002-0363-1129"},"institutions":[{"id":"https://openalex.org/I153512688","display_name":"National Taiwan Ocean University","ror":"https://ror.org/03bvvnt49","country_code":"TW","type":"education","lineage":["https://openalex.org/I153512688"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih-Ching Huang","raw_affiliation_strings":["Institute of Bioscience and Biotechnology, National Taiwan Ocean University, 2 Beining Road, Keelung, 20224, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University, 2 Beining Road, Keelung, 20224, Taiwan","institution_ids":["https://openalex.org/I153512688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014463350","https://openalex.org/A5040369687"],"corresponding_institution_ids":["https://openalex.org/I153512688","https://openalex.org/I178613991"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":4.3818,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.95218591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"12","first_page":"10356","last_page":"10388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.9688743948936462},{"id":"https://openalex.org/keywords/nanomaterials","display_name":"Nanomaterials","score":0.8543037176132202},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.7761510610580444},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.7372372150421143},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"Surface plasmon resonance","score":0.6529775857925415},{"id":"https://openalex.org/keywords/nanosensor","display_name":"Nanosensor","score":0.5770783424377441},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5292864441871643},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.5009739398956299},{"id":"https://openalex.org/keywords/analyte","display_name":"Analyte","score":0.4849588871002197},{"id":"https://openalex.org/keywords/colloidal-gold","display_name":"Colloidal gold","score":0.4707651138305664},{"id":"https://openalex.org/keywords/quantum-dot","display_name":"Quantum dot","score":0.4208483099937439},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3732186257839203}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9688743948936462},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.8543037176132202},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.7761510610580444},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.7372372150421143},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.6529775857925415},{"id":"https://openalex.org/C41858301","wikidata":"https://www.wikidata.org/wiki/Q2327870","display_name":"Nanosensor","level":2,"score":0.5770783424377441},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5292864441871643},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5009739398956299},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.4849588871002197},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.4707651138305664},{"id":"https://openalex.org/C124657808","wikidata":"https://www.wikidata.org/wiki/Q1133068","display_name":"Quantum dot","level":2,"score":0.4208483099937439},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3732186257839203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/s91210356","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s91210356","pdf_url":"https://www.mdpi.com/1424-8220/9/12/10356/pdf?version=1403311971","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:22303178","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22303178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:d7063f48d2164f2bad94bd9061598b37","is_oa":true,"landing_page_url":"https://doaj.org/article/d7063f48d2164f2bad94bd9061598b37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 9, Iss 12, Pp 10356-10388 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2278924","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3267226","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/9/12/10356/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s91210356","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 9; Issue 12; Pages: 10356-10388","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s91210356","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s91210356","pdf_url":"https://www.mdpi.com/1424-8220/9/12/10356/pdf?version=1403311971","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W1479859897","https://openalex.org/W1494900315","https://openalex.org/W1589156173","https://openalex.org/W1963582373","https://openalex.org/W1963659626","https://openalex.org/W1963982129","https://openalex.org/W1964858690","https://openalex.org/W1974053573","https://openalex.org/W1974486085","https://openalex.org/W1975816344","https://openalex.org/W1975860847","https://openalex.org/W1976330752","https://openalex.org/W1977827380","https://openalex.org/W1980451925","https://openalex.org/W1980495221","https://openalex.org/W1981855264","https://openalex.org/W1983056085","https://openalex.org/W1983841175","https://openalex.org/W1984687418","https://openalex.org/W1985027409","https://openalex.org/W1986000353","https://openalex.org/W1987355057","https://openalex.org/W1987565198","https://openalex.org/W1987793310","https://openalex.org/W1987821867","https://openalex.org/W1988214044","https://openalex.org/W1989134865","https://openalex.org/W1990679039","https://openalex.org/W1992945717","https://openalex.org/W1994265576","https://openalex.org/W1994372330","https://openalex.org/W1995756508","https://openalex.org/W1997686479","https://openalex.org/W1999091059","https://openalex.org/W1999951470","https://openalex.org/W2001264237","https://openalex.org/W2003097416","https://openalex.org/W2003429108","https://openalex.org/W2006957308","https://openalex.org/W2007858871","https://openalex.org/W2007883129","https://openalex.org/W2011120776","https://openalex.org/W2011833640","https://openalex.org/W2012112777","https://openalex.org/W2012286453","https://openalex.org/W2013753213","https://openalex.org/W2013779288","https://openalex.org/W2016431195","https://openalex.org/W2017031026","https://openalex.org/W2018648960","https://openalex.org/W2019044115","https://openalex.org/W2020777766","https://openalex.org/W2020909844","https://openalex.org/W2021110283","https://openalex.org/W2023264624","https://openalex.org/W2027260822","https://openalex.org/W2029303494","https://openalex.org/W2030205465","https://openalex.org/W2031859764","https://openalex.org/W2031868713","https://openalex.org/W2033043994","https://openalex.org/W2035196676","https://openalex.org/W2035319832","https://openalex.org/W2037468526","https://openalex.org/W2039411384","https://openalex.org/W2040345323","https://openalex.org/W2041525509","https://openalex.org/W2042610830","https://openalex.org/W2045251691","https://openalex.org/W2045334963","https://openalex.org/W2045698533","https://openalex.org/W2046133147","https://openalex.org/W2046448273","https://openalex.org/W2047516358","https://openalex.org/W2047924722","https://openalex.org/W2051443885","https://openalex.org/W2052032121","https://openalex.org/W2053662322","https://openalex.org/W2054273170","https://openalex.org/W2055310046","https://openalex.org/W2055721693","https://openalex.org/W2058604643","https://openalex.org/W2059281433","https://openalex.org/W2061530854","https://openalex.org/W2064560092","https://openalex.org/W2065344170","https://openalex.org/W2065925882","https://openalex.org/W2067885827","https://openalex.org/W2068834028","https://openalex.org/W2072013830","https://openalex.org/W2072262967","https://openalex.org/W2072461007","https://openalex.org/W2073323729","https://openalex.org/W2074210762","https://openalex.org/W2074967571","https://openalex.org/W2075471778","https://openalex.org/W2077028663","https://openalex.org/W2077151519","https://openalex.org/W2079321730","https://openalex.org/W2082580426","https://openalex.org/W2083904368","https://openalex.org/W2086047273","https://openalex.org/W2087569555","https://openalex.org/W2087685496","https://openalex.org/W2088202442","https://openalex.org/W2090247088","https://openalex.org/W2090945062","https://openalex.org/W2091632168","https://openalex.org/W2093945871","https://openalex.org/W2094336200","https://openalex.org/W2094549377","https://openalex.org/W2095469093","https://openalex.org/W2096388691","https://openalex.org/W2098286922","https://openalex.org/W2100606738","https://openalex.org/W2108942037","https://openalex.org/W2109783713","https://openalex.org/W2113406784","https://openalex.org/W2114783261","https://openalex.org/W2119138200","https://openalex.org/W2122836075","https://openalex.org/W2124904019","https://openalex.org/W2126178560","https://openalex.org/W2126875692","https://openalex.org/W2128590183","https://openalex.org/W2131508884","https://openalex.org/W2133282256","https://openalex.org/W2133873308","https://openalex.org/W2140588566","https://openalex.org/W2142316283","https://openalex.org/W2145460471","https://openalex.org/W2146777848","https://openalex.org/W2151014321","https://openalex.org/W2152392158","https://openalex.org/W2153798482","https://openalex.org/W2154321074","https://openalex.org/W2155214429","https://openalex.org/W2157647977","https://openalex.org/W2158180922","https://openalex.org/W2161313073","https://openalex.org/W2163334026","https://openalex.org/W2164403735","https://openalex.org/W2165116615","https://openalex.org/W2165299361","https://openalex.org/W2166926604","https://openalex.org/W2167069898","https://openalex.org/W2167875539","https://openalex.org/W2167926173","https://openalex.org/W2168041418","https://openalex.org/W2170363909","https://openalex.org/W2323429134","https://openalex.org/W2404511958","https://openalex.org/W4211160326"],"related_works":["https://openalex.org/W2416394875","https://openalex.org/W2909245544","https://openalex.org/W2074278683","https://openalex.org/W2166937817","https://openalex.org/W2795349037","https://openalex.org/W2305188194","https://openalex.org/W2171006927","https://openalex.org/W2994973877","https://openalex.org/W2744015724","https://openalex.org/W4205291412"],"abstract_inverted_index":{"Nanomaterials":[0],"have":[1],"become":[2],"one":[3],"of":[4,11,43,55,78,87,121,144,151,164,172],"the":[5,76,136,140,146,154,160,165,173],"most":[6],"interesting":[7],"sensing":[8],"materials":[9],"because":[10],"their":[12,35],"unique":[13],"size-":[14],"and":[15,22,25,52,64,97,109,126,142,149,153,162,170],"shape-dependent":[16],"optical":[17],"properties,":[18],"high":[19,39,124],"surface":[20,27,103],"energy":[21],"surface-to-volume":[23],"ratio,":[24],"tunable":[26],"properties.":[28],"Aptamers":[29],"are":[30,46,113,177],"oligonucleotides":[31],"that":[32,45,139],"can":[33],"bind":[34],"target":[36],"ligands":[37],"with":[38,48,84,123],"affinity.":[40],"The":[41],"use":[42],"nanomaterials":[44,132],"bioconjugated":[47,131],"aptamers":[49,83],"for":[50,117,175],"selective":[51],"sensitive":[53],"detection":[54,115],"analytes":[56,122],"such":[57],"as":[58],"small":[59],"molecules,":[60],"metal":[61],"ions,":[62],"proteins,":[63],"cells":[65],"has":[66],"been":[67],"demonstrated.":[68],"This":[69],"review":[70],"focuses":[71],"on":[72],"recent":[73],"progress":[74],"in":[75,158],"development":[77],"biosensors":[79],"by":[80],"integrating":[81],"functional":[82],"different":[85],"types":[86],"nanomaterials,":[88,145],"including":[89],"quantum":[90],"dots,":[91],"magnetic":[92,110],"nanoparticles":[93],"(NPs),":[94],"metallic":[95],"NPs,":[96],"carbon":[98],"nanotubes.":[99],"Colorimetry,":[100],"fluorescence,":[101],"electrochemistry,":[102],"plasmon":[104],"resonance,":[105],"surface-enhanced":[106],"Raman":[107],"scattering,":[108],"resonance":[111],"imaging":[112],"common":[114],"modes":[116],"a":[118],"broad":[119],"range":[120],"sensitivity":[125,163],"selectivity":[127],"when":[128],"using":[129],"aptamer":[130],"(Apt-NMs).":[133],"We":[134],"highlight":[135],"important":[137],"roles":[138],"size":[141],"concentration":[143],"secondary":[147],"structure":[148],"density":[150],"aptamers,":[152],"multivalent":[155],"interactions":[156],"play":[157],"determining":[159],"specificity":[161],"nanosensors":[166],"towards":[167],"analytes.":[168],"Advantages":[169],"disadvantages":[171],"Apt-NMs":[174],"bioapplications":[176],"focused.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":15}],"updated_date":"2026-06-13T07:54:00.901334","created_date":"2025-10-10T00:00:00"}