{"id":"https://openalex.org/W4396957217","doi":"https://doi.org/10.3390/s24103162","title":"The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants: A Narrative Review","display_name":"The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants: A Narrative Review","publication_year":2024,"publication_date":"2024-05-16","ids":{"openalex":"https://openalex.org/W4396957217","doi":"https://doi.org/10.3390/s24103162","pmid":"https://pubmed.ncbi.nlm.nih.gov/38794014"},"language":"en","primary_location":{"id":"doi:10.3390/s24103162","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s24103162","pdf_url":"https://www.mdpi.com/1424-8220/24/10/3162/pdf?version=1715850675","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/24/10/3162/pdf?version=1715850675","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114161505","display_name":"Rimke R. de Kroon","orcid":"https://orcid.org/0000-0002-7971-3120"},"institutions":[{"id":"https://openalex.org/I4210096594","display_name":"Emma Kinderziekenhuis","ror":"https://ror.org/00bmv4102","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210096594"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rimke R. de Kroon","raw_affiliation_strings":["Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364","https://openalex.org/I4210096594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018720133","display_name":"Nina M. Frerichs","orcid":"https://orcid.org/0000-0002-3568-863X"},"institutions":[{"id":"https://openalex.org/I4210096594","display_name":"Emma Kinderziekenhuis","ror":"https://ror.org/00bmv4102","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210096594"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nina M. Frerichs","raw_affiliation_strings":["Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3568-863X","affiliations":[{"raw_affiliation_string":"Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364","https://openalex.org/I4210096594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081248858","display_name":"Eduard A. Struys","orcid":"https://orcid.org/0009-0002-8437-4108"},"institutions":[{"id":"https://openalex.org/I2802849423","display_name":"University Medical Center","ror":"https://ror.org/036pt7h44","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802849423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduard A. Struys","raw_affiliation_strings":["Department of Laboratory Medicine, Amsterdam University Medical Center, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Amsterdam University Medical Center, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802849423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000077620","display_name":"Nanne K.H. de Boer","orcid":"https://orcid.org/0000-0001-8357-9887"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nanne K. de Boer","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050981112","display_name":"Tim G. J. de Meij","orcid":"https://orcid.org/0000-0002-7556-5896"},"institutions":[{"id":"https://openalex.org/I4210096594","display_name":"Emma Kinderziekenhuis","ror":"https://ror.org/00bmv4102","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210096594"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tim G. J. de Meij","raw_affiliation_strings":["Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364","https://openalex.org/I4210096594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051628638","display_name":"Hendrik J. Niemarkt","orcid":"https://orcid.org/0000-0002-0844-7208"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210126394","display_name":"M\u00e1xima Medisch Centrum","ror":"https://ror.org/02x6rcb77","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210126394"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hendrik J. Niemarkt","raw_affiliation_strings":["Department of Electrical Engineering, TU Eindhoven, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands","Department of Neonatology, Maxima Medisch Centrum, De Run 4600, 5504 DB Veldhoven, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-0844-7208","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, TU Eindhoven, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]},{"raw_affiliation_string":"Department of Neonatology, Maxima Medisch Centrum, De Run 4600, 5504 DB Veldhoven, The Netherlands","institution_ids":["https://openalex.org/I4210126394","https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5114161505"],"corresponding_institution_ids":["https://openalex.org/I4210096594","https://openalex.org/I887064364"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.0121,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.72556052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"24","issue":"10","first_page":"3162","last_page":"3162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9524000287055969,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feces","display_name":"Feces","score":0.6186148524284363},{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.5660670399665833},{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.5576479434967041},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.5266615748405457},{"id":"https://openalex.org/keywords/gut-flora","display_name":"Gut flora","score":0.490716814994812},{"id":"https://openalex.org/keywords/diagnostic-biomarker","display_name":"Diagnostic biomarker","score":0.48318997025489807},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.46050167083740234},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"Point-of-care testing","score":0.4576219320297241},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.44864022731781006},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.4210633337497711},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41045093536376953},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.3922315835952759},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2724841237068176},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2718844413757324},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.2016538381576538},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17305690050125122}],"concepts":[{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.6186148524284363},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5660670399665833},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.5576479434967041},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5266615748405457},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.490716814994812},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.48318997025489807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46050167083740234},{"id":"https://openalex.org/C64841741","wikidata":"https://www.wikidata.org/wiki/Q491983","display_name":"Point-of-care testing","level":2,"score":0.4576219320297241},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44864022731781006},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4210633337497711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41045093536376953},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3922315835952759},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2724841237068176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2718844413757324},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2016538381576538},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17305690050125122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055549","descriptor_name":"Volatile Organic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055549","descriptor_name":"Volatile Organic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055549","descriptor_name":"Volatile Organic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055549","descriptor_name":"Volatile Organic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055549","descriptor_name":"Volatile Organic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3390/s24103162","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s24103162","pdf_url":"https://www.mdpi.com/1424-8220/24/10/3162/pdf?version=1715850675","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:38794014","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38794014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11124895","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11124895","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11124895/pdf/sensors-24-03162.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/fd32f04a-0fed-4c37-ba81-6fa5df43edbf","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/fd32f04a-0fed-4c37-ba81-6fa5df43edbf","pdf_url":"https://pure.amsterdamumc.nl/files/136897249/The-potential-of-fecal-volatile-organic-compound-analysis-for-the-early-diagnosis-of-late-onset-seps.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Kroon, R R, Frerichs, N M, Struys, E A, de Boer, N K, de Meij, T G J & Niemarkt, H J 2024, 'The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants : A Narrative Review', Sensors (Basel, Switzerland), vol. 24, no. 10, 3162. https://doi.org/10.3390/s24103162","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.tue.nl:publications/78ee0a99-1949-4a87-abab-25f6dc96d47e","is_oa":true,"landing_page_url":"https://research.tue.nl/en/publications/78ee0a99-1949-4a87-abab-25f6dc96d47e","pdf_url":"https://pure.tue.nl/ws/files/354871032/sensors-24-03162.pdf","source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Kroon, R R, Frerichs, N M, Struys, E A, de Boer, N K, de Meij, T G J & Niemarkt, H J 2024, 'The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants : A Narrative Review', Sensors, vol. 24, no. 10, 3162. https://doi.org/10.3390/s24103162","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:2c21b777683e4d098368ff6cb2d8c7d4","is_oa":true,"landing_page_url":"https://doaj.org/article/2c21b777683e4d098368ff6cb2d8c7d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 24, Iss 10, p 3162 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/s24103162","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s24103162","pdf_url":"https://www.mdpi.com/1424-8220/24/10/3162/pdf?version=1715850675","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.6100000143051147}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396957217.pdf"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W72014743","https://openalex.org/W905687799","https://openalex.org/W1445777096","https://openalex.org/W1544737548","https://openalex.org/W1547922007","https://openalex.org/W1569631496","https://openalex.org/W1901666604","https://openalex.org/W1974091107","https://openalex.org/W1975072968","https://openalex.org/W1978213978","https://openalex.org/W2006259329","https://openalex.org/W2007408526","https://openalex.org/W2007760699","https://openalex.org/W2012782636","https://openalex.org/W2014606556","https://openalex.org/W2035467636","https://openalex.org/W2041127220","https://openalex.org/W2047812910","https://openalex.org/W2051765750","https://openalex.org/W2052281365","https://openalex.org/W2069470844","https://openalex.org/W2071116992","https://openalex.org/W2073979833","https://openalex.org/W2078653417","https://openalex.org/W2079499441","https://openalex.org/W2081164775","https://openalex.org/W2081232379","https://openalex.org/W2101166655","https://openalex.org/W2102810061","https://openalex.org/W2103541053","https://openalex.org/W2115980431","https://openalex.org/W2140631876","https://openalex.org/W2142757124","https://openalex.org/W2149181253","https://openalex.org/W2169063504","https://openalex.org/W2170556506","https://openalex.org/W2170599153","https://openalex.org/W2223012991","https://openalex.org/W2239108612","https://openalex.org/W2276576131","https://openalex.org/W2280013794","https://openalex.org/W2291770574","https://openalex.org/W2333905278","https://openalex.org/W2508125540","https://openalex.org/W2521042841","https://openalex.org/W2549951486","https://openalex.org/W2555611312","https://openalex.org/W2557181458","https://openalex.org/W2558920480","https://openalex.org/W2576468158","https://openalex.org/W2584698034","https://openalex.org/W2588681363","https://openalex.org/W2597381291","https://openalex.org/W2608844040","https://openalex.org/W2612658510","https://openalex.org/W2734475592","https://openalex.org/W2737461083","https://openalex.org/W2756746526","https://openalex.org/W2766485313","https://openalex.org/W2783716508","https://openalex.org/W2809515090","https://openalex.org/W2886224838","https://openalex.org/W2889427252","https://openalex.org/W2890302151","https://openalex.org/W2890750731","https://openalex.org/W2896304951","https://openalex.org/W2915538561","https://openalex.org/W2925937832","https://openalex.org/W2939895799","https://openalex.org/W2949966008","https://openalex.org/W2955254647","https://openalex.org/W2972690629","https://openalex.org/W2973030962","https://openalex.org/W2978688180","https://openalex.org/W2993825162","https://openalex.org/W2996486822","https://openalex.org/W3005142794","https://openalex.org/W3005949538","https://openalex.org/W3014081259","https://openalex.org/W3023405601","https://openalex.org/W3023823951","https://openalex.org/W3035088603","https://openalex.org/W3044171914","https://openalex.org/W3047979331","https://openalex.org/W3091814494","https://openalex.org/W3093878794","https://openalex.org/W3126234341","https://openalex.org/W3132851859","https://openalex.org/W3133503587","https://openalex.org/W3137742641","https://openalex.org/W3169074803","https://openalex.org/W3195211852","https://openalex.org/W3199592576","https://openalex.org/W4225124967","https://openalex.org/W4292551099","https://openalex.org/W4294670402","https://openalex.org/W4306759366","https://openalex.org/W4307771069","https://openalex.org/W4310261132","https://openalex.org/W4313361279","https://openalex.org/W4320494230","https://openalex.org/W4321786860","https://openalex.org/W4366609205","https://openalex.org/W4367554797","https://openalex.org/W4367839785","https://openalex.org/W4378573874","https://openalex.org/W4383224773","https://openalex.org/W4387447879","https://openalex.org/W4388007003","https://openalex.org/W4388724680","https://openalex.org/W4388973449","https://openalex.org/W4389101467","https://openalex.org/W4390666279","https://openalex.org/W6681102490"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W2916376502","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2777729175","https://openalex.org/W2260452057","https://openalex.org/W4295779760"],"abstract_inverted_index":{"Early":[0],"diagnosis":[1,161],"and":[2,16,25,45,63,172,175,194],"treatment":[3,174],"of":[4,23,34,74,82,118,153,162,182,189,196,205],"late-onset":[5],"sepsis":[6],"(LOS)":[7],"is":[8,29],"crucial":[9],"for":[10,79,87,94,141,159,169,202],"survival,":[11],"but":[12],"challenging.":[13],"Intestinal":[14],"microbiota":[15],"metabolome":[17],"alterations":[18],"precede":[19],"the":[20,26,50,58,61,80,116,137,147,151,203,210],"clinical":[21,178],"onset":[22],"LOS,":[24,163],"preterm":[27,51],"gut":[28],"considered":[30],"an":[31,72,190],"important":[32],"source":[33],"bacterial":[35],"pathogens.":[36,143],"Fecal":[37],"volatile":[38],"organic":[39],"compounds":[40],"(VOCs),":[41],"formed":[42],"by":[43],"physiologic":[44],"pathophysiologic":[46],"metabolic":[47,113],"processes":[48],"in":[49,112,150,209],"gut,":[52],"reflect":[53],"a":[54,83,154,206],"complex":[55],"interplay":[56],"between":[57],"human":[59],"host,":[60],"environment,":[62],"microbiota.":[64],"Disease-associated":[65],"fecal":[66,133,156],"VOCs":[67,93],"can":[68],"be":[69],"detected":[70],"with":[71,76,106,136],"array":[73],"devices":[75],"various":[77],"potential":[78],"development":[81,152,195,204],"point-of-care":[84],"test":[85],"(POCT)":[86],"preclinical":[88],"LOS":[89,96,127],"detection.":[90],"While":[91],"characteristic":[92],"common":[95],"pathogens":[97,108],"have":[98],"been":[99],"described,":[100],"their":[101],"VOC":[102,134,186],"profiles":[103],"often":[104],"overlap":[105],"other":[107],"due":[109],"to":[110],"similarities":[111],"pathways,":[114],"hampering":[115],"construction":[117],"species-specific":[119],"profiles.":[120],"Clinical":[121],"studies":[122],"have,":[123],"however,":[124],"successfully":[125],"discriminated":[126],"patients":[128],"from":[129],"healthy":[130],"individuals":[131],"using":[132],"analysis":[135],"highest":[138],"predictive":[139],"value":[140],"Gram-negative":[142],"This":[144],"review":[145],"discusses":[146],"current":[148],"advancements":[149],"non-invasive":[155],"VOC-based":[157],"POCT":[158,208],"early":[160,170],"which":[164],"may":[165],"potentially":[166],"provide":[167],"opportunities":[168],"intervention":[171],"targeted":[173],"could":[176],"improve":[177],"neonatal":[179],"outcomes.":[180],"Identification":[181],"confounding":[183],"variables":[184],"impacting":[185],"synthesis,":[187],"selection":[188],"optimal":[191],"detection":[192],"device,":[193],"standardized":[197],"sampling":[198],"protocols":[199],"will":[200],"allow":[201],"novel":[207],"near":[211],"future.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}