{"id":"https://openalex.org/W4384341546","doi":"https://doi.org/10.3390/s23146376","title":"Creation of Artificial Luciferase 60s from Sequential Insights and Their Applications to Bioassays","display_name":"Creation of Artificial Luciferase 60s from Sequential Insights and Their Applications to Bioassays","publication_year":2023,"publication_date":"2023-07-13","ids":{"openalex":"https://openalex.org/W4384341546","doi":"https://doi.org/10.3390/s23146376","pmid":"https://pubmed.ncbi.nlm.nih.gov/37514669"},"language":"en","primary_location":{"id":"doi:10.3390/s23146376","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23146376","pdf_url":"https://www.mdpi.com/1424-8220/23/14/6376/pdf?version=1689248642","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/23/14/6376/pdf?version=1689248642","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101578519","display_name":"Sung Bae Kim","orcid":"https://orcid.org/0000-0002-7033-9056"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sung-Bae Kim","raw_affiliation_strings":["Research Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8569, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7033-9056","affiliations":[{"raw_affiliation_string":"Research Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8569, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025091647","display_name":"Tadaomi Furuta","orcid":"https://orcid.org/0000-0003-4568-9043"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadaomi Furuta","raw_affiliation_strings":["School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4568-9043","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062576227","display_name":"Nobuo Kitada","orcid":"https://orcid.org/0000-0002-3104-6963"},"institutions":[{"id":"https://openalex.org/I20529979","display_name":"University of Electro-Communications","ror":"https://ror.org/02x73b849","country_code":"JP","type":"education","lineage":["https://openalex.org/I20529979"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Kitada","raw_affiliation_strings":["Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, Chofu 182-8585, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3104-6963","affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, Chofu 182-8585, Japan","institution_ids":["https://openalex.org/I20529979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036421525","display_name":"Sh\u00f4jir\u00f4 Maki","orcid":"https://orcid.org/0000-0002-9741-0166"},"institutions":[{"id":"https://openalex.org/I20529979","display_name":"University of Electro-Communications","ror":"https://ror.org/02x73b849","country_code":"JP","type":"education","lineage":["https://openalex.org/I20529979"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shojiro A. Maki","raw_affiliation_strings":["Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, Chofu 182-8585, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9741-0166","affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, Chofu 182-8585, Japan","institution_ids":["https://openalex.org/I20529979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101578519"],"corresponding_institution_ids":["https://openalex.org/I73613424"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.5637,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69077282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"23","issue":"14","first_page":"6376","last_page":"6376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luciferase","display_name":"Luciferase","score":0.7433022856712341},{"id":"https://openalex.org/keywords/bioassay","display_name":"Bioassay","score":0.6763041019439697},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43337786197662354},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4210851788520813},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38097867369651794},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3371724486351013},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3289387822151184},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14837682247161865},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12208771705627441},{"id":"https://openalex.org/keywords/transfection","display_name":"Transfection","score":0.0800519585609436}],"concepts":[{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.7433022856712341},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.6763041019439697},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43337786197662354},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4210851788520813},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38097867369651794},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3371724486351013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3289387822151184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14837682247161865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12208771705627441},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0800519585609436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/s23146376","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23146376","pdf_url":"https://www.mdpi.com/1424-8220/23/14/6376/pdf?version=1689248642","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:37514669","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37514669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10384629","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10384629","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10384629/pdf/sensors-23-06376.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1d1fce81f73c4d4fbd6ca1da9b236cc5","is_oa":true,"landing_page_url":"https://doaj.org/article/1d1fce81f73c4d4fbd6ca1da9b236cc5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 23, Iss 14, p 6376 (2023)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/23/14/6376/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s23146376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 23; Issue 14; Pages: 6376","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s23146376","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23146376","pdf_url":"https://www.mdpi.com/1424-8220/23/14/6376/pdf?version=1689248642","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G3320964292","display_name":"Creation of a hospital and environmental diagnosis platform based on bioluminescent C. elegans","funder_award_id":"21H04948","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5380680530","display_name":null,"funder_award_id":"and 17H01215","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6126579488","display_name":"Development of a high-speed luminescence assay of aging chemicals based on molecular events in living subjects","funder_award_id":"20K21851","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6977230712","display_name":"Creation of a multicolor bioluminescence platform for assaying bioactive small molecules","funder_award_id":"17H01215","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384341546.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W340483","https://openalex.org/W1591311438","https://openalex.org/W1959110222","https://openalex.org/W1970877840","https://openalex.org/W1972028384","https://openalex.org/W1979317853","https://openalex.org/W1990715554","https://openalex.org/W1993413587","https://openalex.org/W2005826297","https://openalex.org/W2012354469","https://openalex.org/W2021298125","https://openalex.org/W2035893701","https://openalex.org/W2054016656","https://openalex.org/W2068504842","https://openalex.org/W2069844653","https://openalex.org/W2088647854","https://openalex.org/W2095469139","https://openalex.org/W2103030436","https://openalex.org/W2106685495","https://openalex.org/W2161725945","https://openalex.org/W2167300757","https://openalex.org/W2226712470","https://openalex.org/W2293942633","https://openalex.org/W2312596908","https://openalex.org/W2328859984","https://openalex.org/W2330021477","https://openalex.org/W2409311989","https://openalex.org/W2470844118","https://openalex.org/W2738203605","https://openalex.org/W2741437365","https://openalex.org/W2788051494","https://openalex.org/W2804822363","https://openalex.org/W2991648392","https://openalex.org/W3088123214","https://openalex.org/W3106503083","https://openalex.org/W3122211996","https://openalex.org/W3177828909","https://openalex.org/W6720292265"],"related_works":["https://openalex.org/W2159907048","https://openalex.org/W2073076114","https://openalex.org/W2368899332","https://openalex.org/W1962763530","https://openalex.org/W2117132430","https://openalex.org/W2188407313","https://openalex.org/W2333796273","https://openalex.org/W2375935328","https://openalex.org/W2040231334","https://openalex.org/W1998624179"],"abstract_inverted_index":{"In":[0],"this":[1,190],"study,":[2],"a":[3,122],"series":[4],"of":[5,25,98,107,164,175,189,209],"new":[6,57,73,135,166,194],"artificial":[7],"luciferases":[8,204],"(ALucs)":[9],"was":[10,64],"created":[11,121],"using":[12,22],"sequential":[13],"insights":[14,195],"on":[15],"missing":[16,33],"peptide":[17,34,110,119],"blocks,":[18],"which":[19],"were":[20,42,101,170],"revealed":[21,115],"the":[23,32,37,56,94,99,105,108,117,126,131,153,165,173,207],"alignment":[24],"existing":[26],"ALuc":[27],"sequences.":[28],"Through":[29],"compensating":[30],"for":[31,212],"blocks":[35,120],"in":[36,86,148,168],"alignment,":[38],"10":[39],"sibling":[40],"sequences":[41],"artificially":[43],"fabricated":[44],"and":[45,77,83,158,180,201,214],"named":[46],"from":[47,67],"ALuc55":[48],"to":[49,104,205],"ALuc68.":[50],"The":[51,72,90,112,134,162,187],"phylogenetic":[52],"analysis":[53],"showed":[54,92],"that":[55,63,93,116],"ALucs":[58,74,100,136,167],"formed":[59],"an":[60],"independent":[61],"branch":[62],"genetically":[65],"isolated":[66],"other":[68],"natural":[69],"marine":[70,203],"luciferases.":[71],"successfully":[75],"survived":[76],"luminesced":[78],"with":[79,140,152],"native":[80],"coelenterazine":[81,160],"(nCTZ)":[82],"its":[84],"analogs":[85],"living":[87],"mammalian":[88],"cells.":[89],"results":[91],"bioluminescence":[95],"(BL)":[96],"intensities":[97],"interestingly":[102],"proportional":[103],"length":[106],"appended":[109,118],"blocks.":[111],"computational":[113],"modeling":[114],"flexible":[123],"region":[124],"near":[125],"active":[127],"site,":[128],"potentially":[129],"modulating":[130],"enzymatic":[132],"activities.":[133],"generated":[137],"various":[138],"colors":[139],"maximally":[141],"approximately":[142],"90":[143],"nm":[144],"redshifted":[145],"BL":[146],"spectra":[147],"orange":[149],"upon":[150],"reaction":[151],"authors\u2019":[154],"previously":[155],"reported":[156],"1-":[157],"2-series":[159],"analogs.":[161],"utilities":[163],"bioassays":[169,213],"demonstrated":[171],"through":[172],"construction":[174],"single-chain":[176],"molecular":[177,215],"strain":[178],"probes":[179],"protein":[181],"fragment":[182],"complementation":[183],"assay":[184],"(PCA)":[185],"probes.":[186],"success":[188],"study":[191],"can":[192,199],"guide":[193],"into":[196],"how":[197],"we":[198],"engineer":[200],"functionalize":[202],"expand":[206],"toolbox":[208],"optical":[210],"readouts":[211],"imaging.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
