{"id":"https://openalex.org/W4323046261","doi":"https://doi.org/10.3390/s23052776","title":"Comparison of Chemical and Electrochemical Approaches to Abacavir Oxidative Stability Testing","display_name":"Comparison of Chemical and Electrochemical Approaches to Abacavir Oxidative Stability Testing","publication_year":2023,"publication_date":"2023-03-03","ids":{"openalex":"https://openalex.org/W4323046261","doi":"https://doi.org/10.3390/s23052776","pmid":"https://pubmed.ncbi.nlm.nih.gov/36904979"},"language":"en","primary_location":{"id":"doi:10.3390/s23052776","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23052776","pdf_url":"https://www.mdpi.com/1424-8220/23/5/2776/pdf?version=1678090721","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/23/5/2776/pdf?version=1678090721","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103278558","display_name":"Lucie Pra\u017e\u00e1kov\u00e1","orcid":"https://orcid.org/0009-0000-0920-6927"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Lucie Pra\u017e\u00e1kov\u00e1","raw_affiliation_strings":["Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, 12800 Prague, Czech Republic"],"affiliations":[{"raw_affiliation_string":"Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, 12800 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016882959","display_name":"Jan Fischer","orcid":"https://orcid.org/0000-0002-1005-7700"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Jan Fischer","raw_affiliation_strings":["Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, 12800 Prague, Czech Republic"],"affiliations":[{"raw_affiliation_string":"Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, 12800 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021779832","display_name":"Andrew Taylor","orcid":"https://orcid.org/0000-0002-6656-9748"},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122644","display_name":"Czech Academy of Sciences, Institute of Physics","ror":"https://ror.org/02yhj4v17","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122644"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Andrew Taylor","raw_affiliation_strings":["FZU\u2014Institute of Physics of the Czech Academy of Sciences, Na Slovance 1999/2, 18221 Prague, Czech Republic"],"affiliations":[{"raw_affiliation_string":"FZU\u2014Institute of Physics of the Czech Academy of Sciences, Na Slovance 1999/2, 18221 Prague, Czech Republic","institution_ids":["https://openalex.org/I4210122644","https://openalex.org/I202391551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009824021","display_name":"Anna Kub\u00ed\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-2808-9524"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Anna Kub\u00ed\u010dkov\u00e1","raw_affiliation_strings":["Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, 12800 Prague, Czech Republic"],"affiliations":[{"raw_affiliation_string":"Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, 12800 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009824021","https://openalex.org/A5016882959"],"corresponding_institution_ids":["https://openalex.org/I21250087"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.7987,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70553423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"23","issue":"5","first_page":"2776","last_page":"2776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7593705654144287},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"Hydrogen peroxide","score":0.7343164086341858},{"id":"https://openalex.org/keywords/electrochemistry","display_name":"Electrochemistry","score":0.6503419280052185},{"id":"https://openalex.org/keywords/platinum","display_name":"Platinum","score":0.6434527039527893},{"id":"https://openalex.org/keywords/abacavir","display_name":"Abacavir","score":0.6339836120605469},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.501692533493042},{"id":"https://openalex.org/keywords/degradation","display_name":"Degradation (telecommunications)","score":0.49322789907455444},{"id":"https://openalex.org/keywords/electrolyte","display_name":"Electrolyte","score":0.47317272424697876},{"id":"https://openalex.org/keywords/inorganic-chemistry","display_name":"Inorganic chemistry","score":0.4639347195625305},{"id":"https://openalex.org/keywords/nuclear-chemistry","display_name":"Nuclear chemistry","score":0.3769136071205139},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.14449605345726013},{"id":"https://openalex.org/keywords/catalysis","display_name":"Catalysis","score":0.07242095470428467}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7593705654144287},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.7343164086341858},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.6503419280052185},{"id":"https://openalex.org/C518104683","wikidata":"https://www.wikidata.org/wiki/Q880","display_name":"Platinum","level":3,"score":0.6434527039527893},{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.6339836120605469},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.501692533493042},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.49322789907455444},{"id":"https://openalex.org/C68801617","wikidata":"https://www.wikidata.org/wiki/Q162908","display_name":"Electrolyte","level":3,"score":0.47317272424697876},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.4639347195625305},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3769136071205139},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14449605345726013},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07242095470428467},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.0},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/s23052776","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23052776","pdf_url":"https://www.mdpi.com/1424-8220/23/5/2776/pdf?version=1678090721","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:36904979","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36904979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10007081","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10007081","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10007081/pdf/sensors-23-02776.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1c97e0f873d545feb5505c7e930c10e6","is_oa":true,"landing_page_url":"https://doaj.org/article/1c97e0f873d545feb5505c7e930c10e6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 23, Iss 5, p 2776 (2023)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/23/5/2776/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s23052776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s23052776","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23052776","pdf_url":"https://www.mdpi.com/1424-8220/23/5/2776/pdf?version=1678090721","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[{"id":"https://openalex.org/G8061989341","display_name":null,"funder_award_id":"23-05688S","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4323046261.pdf"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W250172631","https://openalex.org/W1142106645","https://openalex.org/W1891945058","https://openalex.org/W1965085349","https://openalex.org/W1991259414","https://openalex.org/W1998761486","https://openalex.org/W2012618541","https://openalex.org/W2013096469","https://openalex.org/W2013263072","https://openalex.org/W2037983729","https://openalex.org/W2046273088","https://openalex.org/W2065452858","https://openalex.org/W2087441220","https://openalex.org/W2092917319","https://openalex.org/W2155543607","https://openalex.org/W2186246865","https://openalex.org/W2492552814","https://openalex.org/W2546576506","https://openalex.org/W2741747112","https://openalex.org/W2779316582","https://openalex.org/W2829944673","https://openalex.org/W2883965312","https://openalex.org/W2900680371","https://openalex.org/W2921440237","https://openalex.org/W3125427332","https://openalex.org/W3166556386","https://openalex.org/W3196169435","https://openalex.org/W3201147436","https://openalex.org/W4205239344","https://openalex.org/W4206906451","https://openalex.org/W4379796702","https://openalex.org/W6628299986","https://openalex.org/W6686743233","https://openalex.org/W6723424751","https://openalex.org/W6753173558","https://openalex.org/W6756414651","https://openalex.org/W6853130902"],"related_works":["https://openalex.org/W4237910206","https://openalex.org/W2020635017","https://openalex.org/W2787958367","https://openalex.org/W1970844378","https://openalex.org/W2147113749","https://openalex.org/W2804291736","https://openalex.org/W3029447800","https://openalex.org/W1976854377","https://openalex.org/W2032039529","https://openalex.org/W86370514"],"abstract_inverted_index":{"A":[0],"novel":[1],"electrochemical":[2,153],"approach":[3],"using":[4,34,56,90],"two":[5,86],"different":[6,187],"electrode":[7,108,119],"materials,":[8],"platinum":[9,107],"and":[10,31,41,48,69,93,97,115],"boron-doped":[11],"diamond":[12],"(BDD),":[13],"was":[14,169],"employed":[15],"to":[16,29,83,141],"study":[17],"the":[18,22,65,70,84,128,178,181,191,194],"oxidative":[19],"stability":[20,133],"of":[21,43,62,67,72,112,124,126,161,180,193],"drug":[23],"abacavir.":[24],"Abacavir":[25],"samples":[26],"were":[27,46,50,75,102],"subjected":[28],"oxidation":[30,55,145,154,168],"subsequently":[32],"analysed":[33],"chromatography":[35],"with":[36,52,146],"mass":[37,91],"detection.":[38],"The":[39,60,166,174],"type":[40],"amount":[42],"degradation":[44,68,73,87],"products":[45,74],"evaluated,":[47],"results":[49,101],"compared":[51,140],"traditional":[53],"chemical":[54],"3%":[57],"hydrogen":[58,147],"peroxide.":[59,148],"effect":[61],"pH":[63,172,175,192],"on":[64,104,158,190],"rate":[66,129],"formation":[71],"also":[76,176],"investigated.":[77],"In":[78],"general,":[79],"both":[80,159],"approaches":[81],"led":[82],"same":[85],"products,":[88,182],"identified":[89],"spectrometry,":[92],"characterised":[94],"by":[95],"319.20":[96],"m/z":[98],"247.19.":[99],"Similar":[100],"obtained":[103],"a":[105,110,116,137],"large-surface":[106],"at":[109,120,171],"potential":[111],"+1.15":[113],"V":[114],"BDD":[117],"disc":[118],"+4.0":[121],"V.":[122],"Degradation":[123],"20%":[125],"abacavir,":[127],"required":[130,143],"for":[131,144],"pharmaceutical":[132],"studies,":[134],"took":[135],"only":[136],"few":[138],"minutes":[139],"hours":[142],"Measurements":[149],"further":[150],"showed":[151],"that":[152],"in":[155,186],"ammonium":[156],"acetate":[157],"types":[160],"electrodes":[162],"is":[163],"strongly":[164],"pHdependent.":[165],"fastest":[167],"achieved":[170],"9.":[173],"affects":[177],"composition":[179],"which":[183],"are":[184],"formed":[185],"proportions":[188],"depending":[189],"electrolyte.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}