{"id":"https://openalex.org/W4319844104","doi":"https://doi.org/10.3390/s23031338","title":"A Multiplex Molecular Cell-Based Sensor to Detect Ligands of PPARs: An Optimized Tool for Drug Discovery in Cyanobacteria","display_name":"A Multiplex Molecular Cell-Based Sensor to Detect Ligands of PPARs: An Optimized Tool for Drug Discovery in Cyanobacteria","publication_year":2023,"publication_date":"2023-01-25","ids":{"openalex":"https://openalex.org/W4319844104","doi":"https://doi.org/10.3390/s23031338","pmid":"https://pubmed.ncbi.nlm.nih.gov/36772378"},"language":"en","primary_location":{"id":"doi:10.3390/s23031338","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23031338","pdf_url":"https://www.mdpi.com/1424-8220/23/3/1338/pdf?version=1674638753","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/23/3/1338/pdf?version=1674638753","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056414597","display_name":"In\u00eas P\u00e1scoa","orcid":"https://orcid.org/0000-0003-2297-7480"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"In\u00eas P\u00e1scoa","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079529926","display_name":"Rita Biltes","orcid":"https://orcid.org/0000-0001-5410-4831"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita Biltes","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal","ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5410-4831","affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042694642","display_name":"Jo\u00e3o Sousa","orcid":"https://orcid.org/0000-0001-7105-6456"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Sousa","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal","ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017102378","display_name":"Marco Preto","orcid":"https://orcid.org/0000-0002-9697-5579"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marco Aur\u00e9lio Correia Preto","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-9697-5579","affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060421147","display_name":"V\u0131\u0301tor Vasconcelos","orcid":"https://orcid.org/0000-0003-3585-2417"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Vitor Vasconcelos","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-3585-2417","affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027950362","display_name":"L. Filipe C. Castro","orcid":"https://orcid.org/0000-0001-7697-386X"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Filipe Castro","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-7697-386X","affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"FCUP-Faculty of Sciences, Department of Biology, University of Porto, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011934913","display_name":"Raquel Ruivo","orcid":"https://orcid.org/0000-0003-2412-8730"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Raquel Ruivo","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-2412-8730","affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056242605","display_name":"Isabel Cunha","orcid":"https://orcid.org/0000-0002-6149-9840"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Isabel Cunha","raw_affiliation_strings":["CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-6149-9840","affiliations":[{"raw_affiliation_string":"CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056242605"],"corresponding_institution_ids":["https://openalex.org/I182534213"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.4036,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63774009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"23","issue":"3","first_page":"1338","last_page":"1338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transactivation","display_name":"Transactivation","score":0.7313274145126343},{"id":"https://openalex.org/keywords/mode-of-action","display_name":"Mode of action","score":0.6165305376052856},{"id":"https://openalex.org/keywords/multiplex","display_name":"Multiplex","score":0.6114517450332642},{"id":"https://openalex.org/keywords/reporter-gene","display_name":"Reporter gene","score":0.550796627998352},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5263867378234863},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.525320291519165},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5153529047966003},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptor","display_name":"Peroxisome proliferator-activated receptor","score":0.5052509903907776},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.47611531615257263},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.4587883949279785},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4316522777080536},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.41630181670188904},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.40847814083099365},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3728686571121216},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3421564996242523},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.334369957447052},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3260553479194641},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.251933753490448},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23682966828346252},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.19896063208580017}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7313274145126343},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.6165305376052856},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.6114517450332642},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.550796627998352},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5263867378234863},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.525320291519165},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5153529047966003},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5052509903907776},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.47611531615257263},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4587883949279785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4316522777080536},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.41630181670188904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40847814083099365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3728686571121216},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3421564996242523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.334369957447052},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3260553479194641},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.251933753490448},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23682966828346252},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19896063208580017}],"mesh":[{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/s23031338","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23031338","pdf_url":"https://www.mdpi.com/1424-8220/23/3/1338/pdf?version=1674638753","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:36772378","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36772378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9919141","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9919141","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9919141/pdf/sensors-23-01338.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b40dec502dc54ae0bbf175aa35fa03e0","is_oa":true,"landing_page_url":"https://doaj.org/article/b40dec502dc54ae0bbf175aa35fa03e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 23, Iss 3, p 1338 (2023)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/23/3/1338/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s23031338","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 23; Issue 3; Pages: 1338","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s23031338","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23031338","pdf_url":"https://www.mdpi.com/1424-8220/23/3/1338/pdf?version=1674638753","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1167214205","display_name":null,"funder_award_id":"COMPETE","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G1319873162","display_name":null,"funder_award_id":"UIDB/04423/2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G1578237752","display_name":null,"funder_award_id":"COMPETE","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2261371540","display_name":"Interdisciplinary Centre of Marine and Environmental Research","funder_award_id":"UIDP/04423/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3491971210","display_name":null,"funder_award_id":"COMPETE 2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4048552410","display_name":null,"funder_award_id":"UIDB/04423/2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4176497637","display_name":null,"funder_award_id":"COMPETE 2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4541367665","display_name":null,"funder_award_id":"UIDB/04423/2020 and UIDP/04423/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5454278309","display_name":null,"funder_award_id":"/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G562452873","display_name":null,"funder_award_id":"UIDP/04423/2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6142911603","display_name":"Dispositivos baseados em biossensores e elementos biomim\u00e9ticos de reconhecimento para a dete\u00e7\u00e3o e separa\u00e7\u00e3o de metabolitos de cianobact\u00e9rias com aplica\u00e7\u00f5es ecotoxicol\u00f3gicas e terap\u00eauticas","funder_award_id":"PTDC/BTA-GES/32359/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7552417000","display_name":"Interdisciplinary Centre of Marine and Environmental Research","funder_award_id":"UIDB/04423/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8050799814","display_name":null,"funder_award_id":"UIDP/04423/2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F5180962210","display_name":"COMPETE 2020","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4319844104.pdf"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W64548748","https://openalex.org/W1568084954","https://openalex.org/W1647126819","https://openalex.org/W1919133853","https://openalex.org/W1977750618","https://openalex.org/W1983519362","https://openalex.org/W1983718158","https://openalex.org/W1991001144","https://openalex.org/W2020852287","https://openalex.org/W2022948223","https://openalex.org/W2036684426","https://openalex.org/W2052629350","https://openalex.org/W2064659767","https://openalex.org/W2065507327","https://openalex.org/W2068207796","https://openalex.org/W2073175037","https://openalex.org/W2087788651","https://openalex.org/W2087962857","https://openalex.org/W2104414696","https://openalex.org/W2107752044","https://openalex.org/W2128211963","https://openalex.org/W2159453872","https://openalex.org/W2159741127","https://openalex.org/W2287555786","https://openalex.org/W2439807060","https://openalex.org/W2552584145","https://openalex.org/W2578086024","https://openalex.org/W2605614532","https://openalex.org/W2609567109","https://openalex.org/W2615923439","https://openalex.org/W2743254891","https://openalex.org/W2769983566","https://openalex.org/W2772305927","https://openalex.org/W2781883277","https://openalex.org/W2788490137","https://openalex.org/W2796931681","https://openalex.org/W2797663479","https://openalex.org/W2892360918","https://openalex.org/W2899880389","https://openalex.org/W2915040626","https://openalex.org/W2937096712","https://openalex.org/W2944200396","https://openalex.org/W3006890961","https://openalex.org/W3011699708","https://openalex.org/W3022922270","https://openalex.org/W3036453277","https://openalex.org/W3083575255","https://openalex.org/W3096289954","https://openalex.org/W3110088015","https://openalex.org/W3125411853","https://openalex.org/W3158735209","https://openalex.org/W3170527091","https://openalex.org/W3177168998","https://openalex.org/W3177490685","https://openalex.org/W3193852162","https://openalex.org/W3214121295","https://openalex.org/W4205386617","https://openalex.org/W4206692212","https://openalex.org/W4211239758","https://openalex.org/W4221025073","https://openalex.org/W6602699249","https://openalex.org/W6633920486","https://openalex.org/W6748360791"],"related_works":["https://openalex.org/W2999117591","https://openalex.org/W2040211878","https://openalex.org/W2111819089","https://openalex.org/W53282253","https://openalex.org/W2102162801","https://openalex.org/W2013427049","https://openalex.org/W2086327217","https://openalex.org/W4236392182","https://openalex.org/W2153007028","https://openalex.org/W3145811630"],"abstract_inverted_index":{"Cyanobacteria":[0],"produce":[1],"a":[2,22,62,102,112,134,171],"wealth":[3],"of":[4,49,64,124,149,173,176],"secondary":[5],"metabolites.":[6],"Since":[7],"these":[8],"organisms":[9],"attach":[10],"fatty":[11],"acids":[12],"into":[13],"molecules":[14],"in":[15,46,111,156,161,185,189],"unprecedented":[16],"ways,":[17],"cyanobacteria":[18,178],"can":[19,71],"serve":[20],"as":[21,29,57],"novel":[23,95],"source":[24],"for":[25,31,61,94],"bioactive":[26],"compounds":[27],"acting":[28],"ligands":[30],"Peroxisome":[32],"Proliferator-Activated":[33],"Receptors":[34],"(PPAR).":[35],"PPARs":[36],"(PPAR\u03b1,":[37],"PPAR\u03b2/\u03b4":[38],"and":[39,52,87,100,108,132,142,158,188,201,210],"PPAR\u03b3)":[40],"are":[41],"ligand-activated":[42],"nuclear":[43],"receptors,":[44],"involved":[45],"the":[47,92,122,167],"regulation":[48],"various":[50],"metabolic":[51],"cellular":[53],"processes,":[54],"thus":[55],"serving":[56],"potential":[58],"drug":[59,117],"targets":[60],"variety":[63],"pathologies.":[65],"Yet,":[66],"given":[67],"that":[68],"PPARs'":[69],"agonists":[70],"have":[72,197,205],"pan-,":[73],"dual-":[74],"or":[75],"isoform-specific":[76],"action,":[77],"some":[78],"controversy":[79],"has":[80],"been":[81],"raised":[82],"over":[83],"currently":[84],"approved":[85],"drugs":[86],"their":[88],"side":[89],"effects,":[90],"highlighting":[91],"need":[93],"molecules.":[96],"Here,":[97],"we":[98],"expand":[99],"validate":[101],"cell-based":[103],"PPAR":[104],"transactivation":[105],"activity":[106],"biosensor,":[107],"test":[109],"it":[110],"screening":[113],"campaign":[114],"to":[115,128,137,144,196,204],"guide":[116],"discovery.":[118],"Biosensor":[119],"upgrades":[120],"included":[121],"use":[123],"different":[125,135],"reporter":[126,139],"genes":[127],"increase":[129],"signal":[130],"intensity":[131],"stability,":[133],"promoter":[136],"modulate":[138],"gene":[140],"expression,":[141],"multiplexing":[143],"improve":[145],"efficiency.":[146],"Sensor's":[147],"limit":[148],"detection":[150],"(LOD)":[151],"ranged":[152],"from":[153],"0.36-0.89":[154],"nM":[155,160],"uniplex":[157,190],"0.89-1.35":[159],"multiplex":[162,186],"mode.":[163],"In":[164],"triplex":[165],"mode,":[166,191],"sensor's":[168],"feature":[169],"screening,":[170],"total":[172],"848":[174],"fractions":[175],"96":[177],"extracts":[179],"were":[180,183],"screened.":[181],"Hits":[182],"confirmed":[184],"mode":[187],"yielding":[192],"one":[193],"strain":[194],"detected":[195],"action":[198,207],"on":[199,208],"PPAR\u03b1":[200,209],"three":[202],"strains":[203],"dual":[206],"-\u03b2.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
