{"id":"https://openalex.org/W4318043361","doi":"https://doi.org/10.3390/s23031317","title":"A Novel Fluorescent Aptamer Sensor with DNAzyme Signal Amplification for the Detection of CEA in Blood","display_name":"A Novel Fluorescent Aptamer Sensor with DNAzyme Signal Amplification for the Detection of CEA in Blood","publication_year":2023,"publication_date":"2023-01-24","ids":{"openalex":"https://openalex.org/W4318043361","doi":"https://doi.org/10.3390/s23031317","pmid":"https://pubmed.ncbi.nlm.nih.gov/36772357"},"language":"en","primary_location":{"id":"doi:10.3390/s23031317","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23031317","pdf_url":"https://www.mdpi.com/1424-8220/23/3/1317/pdf?version=1674552472","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/23/3/1317/pdf?version=1674552472","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112546526","display_name":"Qing-Min Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingmin Wei","raw_affiliation_strings":["Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China","institution_ids":["https://openalex.org/I27462735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054323273","display_name":"Huakui Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huakui Huang","raw_affiliation_strings":["Yulin Campus, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yulin Campus, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052931863","display_name":"Shulong Wang","orcid":"https://orcid.org/0000-0002-8560-2478"},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shulong Wang","raw_affiliation_strings":["Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China","institution_ids":["https://openalex.org/I27462735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045389130","display_name":"Fa Liu","orcid":"https://orcid.org/0000-0002-2909-9185"},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fa Liu","raw_affiliation_strings":["Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China","institution_ids":["https://openalex.org/I27462735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101723411","display_name":"Jiayao Xu","orcid":"https://orcid.org/0009-0003-8849-9407"},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayao Xu","raw_affiliation_strings":["Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China","institution_ids":["https://openalex.org/I27462735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102026196","display_name":"Zhihui Luo","orcid":"https://orcid.org/0000-0002-3842-3696"},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihui Luo","raw_affiliation_strings":["Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China"],"raw_orcid":"https://orcid.org/0000-0002-3842-3696","affiliations":[{"raw_affiliation_string":"Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, China","institution_ids":["https://openalex.org/I27462735"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052931863","https://openalex.org/A5102026196"],"corresponding_institution_ids":["https://openalex.org/I27462735"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2673},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2673},"fwci":0.375,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.52690115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"3","first_page":"1317","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.8689247369766235},{"id":"https://openalex.org/keywords/deoxyribozyme","display_name":"Deoxyribozyme","score":0.8483232259750366},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"Carcinoembryonic antigen","score":0.7053214311599731},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.6743677854537964},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5517135858535767},{"id":"https://openalex.org/keywords/primer","display_name":"Primer (cosmetics)","score":0.5198229551315308},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.4807972013950348},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.46917110681533813},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.42064839601516724},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35341012477874756},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25742894411087036},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21613800525665283},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.12461772561073303},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.11810177564620972},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.06503880023956299}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.8689247369766235},{"id":"https://openalex.org/C84211826","wikidata":"https://www.wikidata.org/wiki/Q5260078","display_name":"Deoxyribozyme","level":3,"score":0.8483232259750366},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.7053214311599731},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6743677854537964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5517135858535767},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.5198229551315308},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4807972013950348},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46917110681533813},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.42064839601516724},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35341012477874756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25742894411087036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21613800525665283},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12461772561073303},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.11810177564620972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06503880023956299},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/s23031317","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23031317","pdf_url":"https://www.mdpi.com/1424-8220/23/3/1317/pdf?version=1674552472","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:36772357","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36772357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9920513","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9920513","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9920513/pdf/sensors-23-01317.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6903cfe841cd4d9cb2632cf64e9eb325","is_oa":true,"landing_page_url":"https://doaj.org/article/6903cfe841cd4d9cb2632cf64e9eb325","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 23, Iss 3, p 1317 (2023)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/23/3/1317/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s23031317","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 23; Issue 3; Pages: 1317","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s23031317","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s23031317","pdf_url":"https://www.mdpi.com/1424-8220/23/3/1317/pdf?version=1674552472","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.550000011920929,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3313323347","display_name":"\u57fa\u4e8e\u91d1\u5305\u7a7a\u5fc3\u78b3\u9178\u9499\u591a\u529f\u80fd\u7eb3\u7c73\u63a2\u9488\u7684\u67d1\u6a58\u9ec4\u9f99\u75c5\u83cc\u591a\u6a21\u6001\u68c0\u6d4b\u65b0\u6280\u672f\u7814\u7a76","funder_award_id":"22064018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329507","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4318043361.pdf"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1771973375","https://openalex.org/W1977685379","https://openalex.org/W1983934946","https://openalex.org/W2033640795","https://openalex.org/W2104525153","https://openalex.org/W2142786354","https://openalex.org/W2201606929","https://openalex.org/W2209215014","https://openalex.org/W2300862776","https://openalex.org/W2327218239","https://openalex.org/W2328625892","https://openalex.org/W2341681016","https://openalex.org/W2413008449","https://openalex.org/W2470032816","https://openalex.org/W2481710116","https://openalex.org/W2554946054","https://openalex.org/W2559744409","https://openalex.org/W2561459648","https://openalex.org/W2581073170","https://openalex.org/W2595100914","https://openalex.org/W2921086609","https://openalex.org/W3015973618","https://openalex.org/W3164252469","https://openalex.org/W3186881618","https://openalex.org/W3197272186","https://openalex.org/W3204573579","https://openalex.org/W3210119649","https://openalex.org/W4223551046"],"related_works":["https://openalex.org/W2014970772","https://openalex.org/W2913646003","https://openalex.org/W2033684641","https://openalex.org/W2967136651","https://openalex.org/W2081632393","https://openalex.org/W2147509954","https://openalex.org/W4389944751","https://openalex.org/W2378104911","https://openalex.org/W4247528507","https://openalex.org/W3006096734"],"abstract_inverted_index":{"Carcinoembryonic":[0],"antigen":[1],"(CEA)":[2],"is":[3,109],"a":[4,35,83,120,127,146,150,161],"tumor-specific":[5],"biomarker;":[6],"however,":[7],"its":[8],"low":[9],"levels":[10],"in":[11,51,63,86],"the":[12,24,47,54,57,60,64,69,74,79,87,103,106,133,140,169,175],"early":[13],"stages":[14],"of":[15,28,49,56,89,123,164,177],"cancer":[16],"make":[17],"it":[18,45],"difficult":[19],"to":[20,68,91,113,115],"detect.":[21],"To":[22],"address":[23],"need":[25],"for":[26,46,174],"analysis":[27,176],"ultra-low-level":[29],"substances,":[30],"we":[31],"designed":[32],"and":[33,43,72,81,111,149],"synthesized":[34],"fluorescent":[36],"aptamer":[37,61],"sensor":[38,170],"with":[39,78,95,143,160],"DNAzyme":[40],"signal":[41,129],"amplification":[42,130],"used":[44,173],"detection":[48,142,152,155,162],"CEA":[50,144],"blood.":[52,183],"In":[53,167],"presence":[55,88],"target":[58,70,107],"protein,":[59],"sequence":[62],"recognition":[65,117],"probe":[66],"binds":[67],"protein":[71,108],"opens":[73],"hairpin":[75],"structure,":[76],"hybridizes":[77],"primer":[80],"triggers":[82],"polymerization":[84,124],"reaction":[85],"polymerase":[90],"generate":[92],"double-stranded":[93],"DNA":[94],"two":[96],"restriction":[97],"endonuclease":[98],"Nb.BbvCl":[99],"cleavage":[100],"sites.":[101],"At":[102],"same":[104],"time,":[105],"displaced":[110],"continues":[112],"bind":[114],"another":[116],"probe,":[118],"triggering":[119],"new":[121],"round":[122],"reaction,":[125],"forming":[126],"cyclic":[128],"triggered":[131],"by":[132],"target.":[134],"The":[135,154],"experimental":[136],"results":[137],"show":[138],"that":[139],"blood":[141],"has":[145],"high":[147],"sensitivity":[148],"wide":[151],"range.":[153],"range:":[156],"10":[157],"fg/mL~10":[158],"ng/mL,":[159],"limit":[163],"5.2":[165],"fg/mL.":[166],"addition,":[168],"can":[171],"be":[172],"complex":[178],"biological":[179],"samples":[180],"such":[181],"as":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
