{"id":"https://openalex.org/W4224246157","doi":"https://doi.org/10.3390/s22083009","title":"Label-Free Uric Acid Estimation of Spot Urine Using Portable Device Based on UV Spectrophotometry","display_name":"Label-Free Uric Acid Estimation of Spot Urine Using Portable Device Based on UV Spectrophotometry","publication_year":2022,"publication_date":"2022-04-14","ids":{"openalex":"https://openalex.org/W4224246157","doi":"https://doi.org/10.3390/s22083009","pmid":"https://pubmed.ncbi.nlm.nih.gov/35458994"},"language":"en","primary_location":{"id":"doi:10.3390/s22083009","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22083009","pdf_url":"https://www.mdpi.com/1424-8220/22/8/3009/pdf?version=1650010576","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/22/8/3009/pdf?version=1650010576","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022523754","display_name":"Tsung-Jui Lin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsung-Jui Lin","raw_affiliation_strings":["Taiwan RedEye Biomedical Inc., Hsinchu City 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiwan RedEye Biomedical Inc., Hsinchu City 300, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076131304","display_name":"Kai-Ting Yen","orcid":"https://orcid.org/0000-0002-6777-126X"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Ting Yen","raw_affiliation_strings":["Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu City 300093, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-6777-126X","affiliations":[{"raw_affiliation_string":"Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu City 300093, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085641978","display_name":"Chien\u2010Fan Chen","orcid":"https://orcid.org/0000-0002-9878-336X"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Fan Chen","raw_affiliation_strings":["Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu City 300093, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu City 300093, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110850532","display_name":"Shuoting Yan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuo-Ting Yan","raw_affiliation_strings":["Taiwan RedEye Biomedical Inc., Hsinchu City 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiwan RedEye Biomedical Inc., Hsinchu City 300, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034488618","display_name":"K. W. Su","orcid":"https://orcid.org/0000-0003-4891-3303"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-Wei Su","raw_affiliation_strings":["College of Artificial Intelligence, National Yang Ming Chiao Tung University, Tainan City 711010, Taiwan","Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu City 300093, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4891-3303","affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, National Yang Ming Chiao Tung University, Tainan City 711010, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu City 300093, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001231573","display_name":"Ya-Ling Chiang","orcid":"https://orcid.org/0000-0002-2564-9653"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ya-Ling Chiang","raw_affiliation_strings":["Taiwan RedEye Biomedical Inc., Hsinchu City 300, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2564-9653","affiliations":[{"raw_affiliation_string":"Taiwan RedEye Biomedical Inc., Hsinchu City 300, Taiwan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001231573"],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":2.7304,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.90940974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"22","issue":"8","first_page":"3009","last_page":"3009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9678999781608582,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uric-acid","display_name":"Uric acid","score":0.9179718494415283},{"id":"https://openalex.org/keywords/urine","display_name":"Urine","score":0.782378077507019},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5403457283973694},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.5180706977844238},{"id":"https://openalex.org/keywords/spectrophotometry","display_name":"Spectrophotometry","score":0.5079100728034973},{"id":"https://openalex.org/keywords/reagent","display_name":"Reagent","score":0.45486918091773987},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2941775619983673},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.07056194543838501}],"concepts":[{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.9179718494415283},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.782378077507019},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5403457283973694},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5180706977844238},{"id":"https://openalex.org/C2780343419","wikidata":"https://www.wikidata.org/wiki/Q332084","display_name":"Spectrophotometry","level":2,"score":0.5079100728034973},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.45486918091773987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2941775619983673},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07056194543838501}],"mesh":[{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/s22083009","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22083009","pdf_url":"https://www.mdpi.com/1424-8220/22/8/3009/pdf?version=1650010576","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:35458994","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35458994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:70be1b992a344d2893a87103f1630d85","is_oa":true,"landing_page_url":"https://doaj.org/article/70be1b992a344d2893a87103f1630d85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 22, Iss 8, p 3009 (2022)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/22/8/3009/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s22083009","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 22; Issue 8; Pages: 3009","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:9025019","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9025019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s22083009","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22083009","pdf_url":"https://www.mdpi.com/1424-8220/22/8/3009/pdf?version=1650010576","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224246157.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W43853974","https://openalex.org/W1760008057","https://openalex.org/W1798312860","https://openalex.org/W1882916432","https://openalex.org/W1992198528","https://openalex.org/W2004632880","https://openalex.org/W2085642566","https://openalex.org/W2106362601","https://openalex.org/W2115631921","https://openalex.org/W2129116385","https://openalex.org/W2135099620","https://openalex.org/W2157156539","https://openalex.org/W2162043836","https://openalex.org/W2351685243","https://openalex.org/W2525221984","https://openalex.org/W2607957281","https://openalex.org/W2612496641","https://openalex.org/W2765598869","https://openalex.org/W2810317401","https://openalex.org/W2909811918","https://openalex.org/W2957527083","https://openalex.org/W2973295775","https://openalex.org/W3007130402","https://openalex.org/W3034280373","https://openalex.org/W4210968593","https://openalex.org/W6601767332","https://openalex.org/W6638407094","https://openalex.org/W6639451764","https://openalex.org/W6757701555"],"related_works":["https://openalex.org/W2349066402","https://openalex.org/W2387077136","https://openalex.org/W1942263737","https://openalex.org/W2020927774","https://openalex.org/W2885486694","https://openalex.org/W2020291030","https://openalex.org/W2251417272","https://openalex.org/W2090504238","https://openalex.org/W2388647562","https://openalex.org/W2349636938"],"abstract_inverted_index":{"The":[0,106],"maintenance":[1],"of":[2,17,28,65,74,80,113,118,138],"uric":[3,26,53,75,94,135],"acid":[4,27,54,76,85,95,136],"levels":[5,86,137],"is":[6,59,109],"crucial":[7],"for":[8,40,153],"the":[9,15,25,32,41,52,62,72,115,125],"human":[10],"body.":[11],"In":[12,124],"this":[13,128],"study,":[14],"feasibility":[16],"using":[18],"portable":[19,107],"ultraviolet":[20],"(UV)":[21],"spectrophotometry":[22],"to":[23,34,50,93],"measure":[24],"spot":[29,139],"urine":[30,66,140],"without":[31],"need":[33],"add":[35],"reagents":[36],"has":[37,47,67],"been":[38,48],"demonstrated":[39],"first":[42],"time.":[43],"UV":[44],"spectral":[45,90],"analysis":[46,102],"used":[49],"inspect":[51],"concentration":[55,73],"in":[56,133,150],"urine.":[57],"It":[58],"found":[60],"that":[61],"absorption":[63],"spectrum":[64],"a":[68,78,89,99],"high":[69],"correlation":[70],"with":[71,88,98,141],"at":[77],"wavelength":[79],"around":[81],"290-300":[82],"nm.":[83],"Uric":[84],"measured":[87,97],"analyzer":[91],"compared":[92],"concentrations":[96],"traditional":[100],"biochemical":[101],"showed":[103],"good":[104],"agreement.":[105],"prototype":[108],"label-free":[110],"and":[111,144],"capable":[112],"displaying":[114],"inspection":[116],"result":[117],"each":[119],"measurement":[120],"within":[121],"10":[122],"s.":[123],"long":[126],"run,":[127],"device":[129],"can":[130,145],"assist":[131],"people":[132],"checking":[134],"higher":[142],"frequency":[143],"adjust":[146],"diet":[147],"or":[148],"medication":[149],"real":[151],"time":[152],"more":[154],"efficient":[155],"health":[156],"management.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}